Summary of Functional Type.
Summary of Interaction.
Interaction graph
The select node information.
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Related
Official
Symbol |
type |
pmid |
method |
Sample
Type |
Region |
Sample
Number
GC |
Sample
Number
nonGC |
Normal
vs.
GC |
Early-stage
vs.
advanced-stage |
Hpylori |
Result |
Functional
Type |
Overall
Survival |
Disease-free
Survival |
AUC |
| AQP3 |
protein-coding |
23800944 |
Western blot |
tissue |
China |
75 |
75 |
Up |
- |
Related |
The protein expression levels of AQP3 were significantly elevated in GCs compared with matched non-GC tissues. AQP3 protein level was closely associated with histological type and lymphatic invasion. H. pylori infection increases the protein level of AQP3 |
- |
- |
- |
- |
| CACUL1 |
protein-coding |
24004834 |
qRT-PCR; IHC |
tissue |
China |
43 |
43 |
Up |
Up |
Related |
CACUL1 was highly expressed in gastric cancer tissues and negatively correlated with gastric cancer differentiation and TNM stage. In addition, CACUL1 expression was high in H.pylori-infected tissues compared with H.pylori non-infected tissue. |
target |
- |
- |
- |
| CASK |
protein-coding |
25373785 |
qRT-PCR |
tissue |
China |
50 |
50 |
Down |
- |
Related |
CASK was over-expressed in tumors and H. pylori positive tissues and its mRNA levels were inversely correlated with miR-203 expression |
target |
- |
- |
- |
| CD14 |
protein-coding |
17438094 |
Reporter gene assays; PCR-RFLP methods |
blood |
China |
470 |
470 |
- |
- |
Related |
Two SNPs (-651C>T and -260C>T) were identified, of which the -260CT and -260TT genotypes were associated with elevated risk of gastric carcinoma (OR, 1.77; 95% CI, 1.09-2.85 and OR, 1.95; 95% CI, 1.20-3.16, respectively). Haplotype analysis suggested a synergistic effect of the two SNPs (OR for the T(-651)-T(-260) haplotype, 3.39 versus OR for the C(-651)-T(-260) haplotype, 1.45; P = 0.02), which is consistent with reporter gene assays. A multiplicative joint effect between H. pylori infection and -260C>T polymorphism was observed (OR for the presence of both -260TT genotype and H. pylori infection, 4.03; 95% CI, 1.80-9.04). Patients had significantly higher sCD14 than controls (1,866 +/- 2,535 ng/mL versus 1,343 +/- 2,119 ng/mL; P < 0.001), and this difference was associated with the CD14 -260 polymorphism and H. pylori infection. |
- |
- |
- |
- |
| MIR143 |
miRNA |
28404925 |
microarray chip; qRT-PCR |
tissue |
China |
42 |
42 |
Down |
Down |
Related |
miR-143-3p was ignificantly increased miRNA in H. pylori-positive gastric cancer tissues and was significantly decreased in gastric cancer tissues and cells, which correlated with late stage and lymph node metastasis. |
target |
- |
- |
- |
| MIR203A |
miRNA |
25373785 |
qRT-PCR |
tissue |
China |
50 |
50 |
Down |
- |
Related |
miR-203 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with important functional consequences. |
mechanism |
- |
- |
- |
| MIRLET7B |
miRNA |
25510669 |
qRT-PCR |
tissue |
China |
47 |
47 |
Down |
- |
Related |
Let-7b was found downregulated remarkably in gastric cancer tissues and was correlated with Helicobacter pylori infection, tumor stage, and lymphatic metastasis. |
target |
- |
- |
- |
