MKGC: a curated molecular knowledgebase for gastric cancer
 Browse All GCs By
  Browse for cell line
Official
Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
ACOT7 protein-coding 32469171 Cell proliferation assay;Migration assay;Flow cytometry cell line - - - - - No Reports ACOT7 gene silencing induced a less malignant phenotype and was closely correlated to reduced cell proliferation and migration, altered cell cycle, and increased apoptosis. target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Luciferase reporter assay cell line - - - - - No Reports NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. target/prognosis 0.025 - -
ACTN4 protein-coding 28581489 Western blot cell line - - - Up - No Reports Upregulated in GC Cell Lines target - - -
ACTN4 protein-coding 28581489 Adhesion assay;Migration assay;Invasion assay cell line - - - - - No Reports Downregulation of Actn4 enhances GC cell adhesion, suppresses migration and invasion of GC Cells target - - -
ADAM10 protein-coding 26852749 Cell proliferation assay;Colony formation;Invasion assay cell line - - - - - No Reports ADAM10 overexpression rescued the effect of miR-448-mediated GC cell proliferation, colony formation, and invasion - - - -
ADAM10 protein-coding 26852749 Luciferase reporter assay cell line - - - - - No Reports ADAM10 was a direct target gene of miR-448 in GC cell - - - -
ADAM10 protein-coding 29152656 Colony formation assay;MTS assay;Viability assay cell line - - - - - No Reports ADAM10 contributes to proliferation and desensitization of GC cells to cisplatin - - - -
ADAM10 protein-coding 29152656 Luciferase reporter assay cell line - - - - - No Reports miR‑320a directly targets ADAM10 in GC cells. - - - -
ADAM17 protein-coding 30569104 Cell proliferation assay; Migration assay cell line - - - - - No Reports ADAM17 promotes the viability and migration of gastric cancer cells. prognosis - - 0.618 (Mortality risk)
ADAM9 protein-coding 29879625 Luciferase reporter assay cell line - - - - - No Reports ADMA9 was a target of miR-129-5p in GC cells. - - - -
ADAM9 protein-coding 29879625 Cell proliferation assay; Invasion assay cell line - - - - - No Reports - - - -
ADAM9 protein-coding 28260063 Cell proliferation assay; Cell cycle analysis. cell line - - - - - No Reports target - - -
ADAM9 protein-coding 28260063 Luciferase reporter assay cell line - - - - - No Reports ADAM9 is a direct target post-transcriptionally regulated by miR-126 in GC cells. target - - -
ADGRE5 protein-coding 26034356 Cell proliferation assay; Invasion assay cell line - - - - - No Reports Exosomes isolated from SGC/wt (high CD97 expression ) cells significantly promoted tumor cell proliferation in a dose-dependent manner in vitro. SGC/wt exosomes also significantly elevated the invasiveness of both SGC/wt and SGC/kd (low CD97 expression) cells as compared to the exosomes released by SGC/kd cells. mechanism - - -
ADRM1 protein-coding 24968865 Cell proliferation assay cell line - - - - - No Reports Overexpression of Adrm1 promoted cell proliferation of conditionally-immortalized, mouse ImSt gastric epithelial cells, with increased S1 phase fraction and decreased expression of p21(Cip1). These results collectively indicate that ADRM1 promoted gastric epithelial cell proliferation by cell cycle progression target - - -
AFAP1-AS1 lncRNA 28451917 Cell proliferation assay; Colony formation assay; Cell apoptosis assay cell line - - - - - No Reports AFAP1-AS1 knockdown suppressed cell viability of SGC7901 transfected with si-AFAP1-AS1. The number of apoptotic SGC7901 cell transfected with si-AFAP1-AS1 was increased by 3.4-fold comparing to that of control. - - - -
AFAP1-AS1 lncRNA 28975981 Cell proliferation assay; Invasion assay; cell line - - - - - No Reports Knockdown of lncRNA AFAP1-AS1 significantly inhibited the cell proliferation and cell cycle progression. Reduced lncRNA AFAP1-AS1 also inhibited the cell invasion ability via regulating cell epithelial-mesenchymal transition (EMT) phenomenon in GC. prognosis 0.001 - -
AFAP1L2 protein-coding 24387290 Clonogenic assay; Soft agar colony-forming assay; Flow cytometry; BrdU incorporation assay; Cell viability assay; Invasion and migration assay; Xenograft model cell line - - - - - No Reports The proliferation, migration, and invasion of GC cell lines were all significantly inhibited by knockdown of XB130. In a xenograft model, tumor growth was markedly inhibited after shXB130-transfected GC cells were implanted into nude mice. After XB130 knockdown, GC cells showed a more epithelial-like phenotype. Silencing of XB130 reduced the expression of p-Akt/Akt, upregulated expression of epithelial markers including E-cadherin, aβ-catenin and β-catenin, and downregulated mesenchymal markers including fibronectin and vimentin. target - - -
AGAP2-AS1 lncRNA 28209205 Cell proliferation assay; Invasion and migration assay; Cell apoptosis assay; Tumor formation assay cell line - - - - - No Reports Knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. prognosis 0.002 0.025 -
AGAP2-AS1 lncRNA 28209205 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports SP1 could bind to all of these promoter regions of AGAP2-AS1 prognosis 0.002 0.025 -
AGAP2-AS1 lncRNA 28209205 RNA immunoprecipitation cell line - - - - - No Reports AGAP2-AS1 functions as an oncogenic lncRNA by interacting with LSD1 and EZH2 and suppressing CDKN1A (P21) and E-cadherin transcription. prognosis 0.002 0.025 -
AGER protein-coding 24441189 Cell proliferation assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of RAGE reduced cell proliferation and invasion of gastric cancer with decreased expression of AKT, PCNA and MMP-2, and induced cell apoptosis and cycle arrest target - - -
AK023391 lncRNA 29282102 Cell viability assay; Invasion and migration assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports Knockdown of AK023391 inhibits the proliferation, colony formation, DNA synthesis, migration, invasion of GC cells, and induces apoptosis and cell cycle arrest. prognosis 0.0024 - 0.56
AK023391 lncRNA 29282102 IHC; Western blot cell line - - - - - No Reports LncRNA AK023391 is involved in the regulation of the PI3K/Akt signaling pathway prognosis 0.0024 - 0.56
AKAP12 protein-coding 15258566 MSP cell line - - - - - No Reports Two isoforms AKAP12A and AKAP12B are independently expressed and were absent from the majority of human gastric cancer cells. 5' CpG islands of both AKAP12A and AKAP12B are frequently hypermethylated in GC cells. DNA methylation is directly involved in the transcriptional silencing of AKAP12 in gastric cancer cells. mechanism - - -
AKAP12 protein-coding 15258566 Cell proliferation assay; Colony formation assay; cell line - - - - - No Reports The restoration of AKAP12A in AKAP12-nonexpressing cells reduced colony formation and induced apoptotic cell death mechanism - - -
AKT2 protein-coding 28404925 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Suppression of AKT2 significantly inhibited gasric cancer cell proliferation, induced cell apoptosis and inhibited the migration and invasion of GC cells. - - - -
AKT3 protein-coding 29228422 Luciferase reporter assay cell line - - - - - No Reports AKT3 was chosen as the target gene of miR-582-5p. Moreover, restoration of AKT3 could impair tumor suppression role of miR-582-5p on gastric cancer growth. target - - -
ANGPTL6 protein-coding 31146977 qRT-PCR cell line - - - - - No Reports ANGPTL6 was overexpressed in Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) cell lins compared to that of common gastric cell lines; A high level of ANGPTL6 confers a poor prognosis and is correlated with the expression of CD34 (an endothelial cell marker). target - - -
ANGPTL6 protein-coding 31146977 HUVEC tube formation assay; HUVEC proliferation assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports ANGPTL6 promotes endothelial cell migration and tube formation, Moreover, ANGPTL6 knockdown inhibits cancer cell apoptosis and invasiveness. Mechanistically, ANGPTL6 activates the ERK1/2 and AKT pathways. Treatment of ERK1/2 or AKT inhibitor can attenuated cell migration and tube formation. target - - -
ANKRD40CL protein-coding 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of LINC00483 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. target - - -
ANKRD40CL protein-coding 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483 target - - -
ANXA4 protein-coding 30837034 Luciferase reporter assay cell line - - - - - No Reports miR-203 Directly Targets Annexin A4 in GC Cells - - - -
ARHGAP5 protein-coding 30250020 Cell invasion and migration assay; cell line - - - - - No Reports ARHGAP5 is involved in SIRT1-induced suppression of GC cell migration and invasion in vitro. prognosis 0.002 - -
ARID1A protein-coding 22808142 Cell proliferation assay; Colony Formation assay; cell line - - - - - No Reports Silencing the expression of ARID1A in GES1 significantly enhanced cell proliferation compared with mock siRNA treatment prognosis 0.003 - -
ASCL2 protein-coding 29746925 qRT-PCR; FACS; Tumorsphere formation assay cell line - - - - - No Reports ASCL2+ cells showed increased propensity of growing as tumorspheres target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 ChIP-qPCR cell line - - - - - No Reports SMYD3 maintains high H3K4me3 levels on the ASCL2 promoter in ASCL2+ cells, indicating its potential role in regulating ASCL2 transcription and expression. target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 qRT-PCR; Western blot cell line - - - - - No Reports Depletion of SMYD3 inhibits Wnt-induced upregulation of ASCL2. target/prognosis < 0.001 - -
ASCL2 protein-coding 30106147 Cell invasion and migration assays cell line - - - - - No Reports ASCL2 expression contributes to cell migration and invasion in GC cells. target - - -
ASCL2 protein-coding 30106147 Western blot cell line - - - - - No Reports the expression of E-cadherin in ASCL2-overexpressing cell lines decreased, while Zeb-1, twist-related protein 1 (Twist), Integrin, Vimentin, 72 kDa type IV collagenase (MMP-2) and matrix metalloproteinase 9 (MMP-9) were upregulated in ASCL2-overexpressing cell lines target - - -
ASCL2 protein-coding 30106147 Luciferase reporter assay; ChIP cell line - - - - - No Reports ASCL2 may interact with the promoter of pre-miR223, and inhibit the maturation of miR223. target - - -
ATF7 protein-coding 29754469 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports siATF7 increased the accumulation of cells at the G2/M phase; ATF7 rescues the cellular phenotypes induced by miR-103a-3p in gastric cancer cells. - - - -
ATF7 protein-coding 29754469 Western blot cell line - - - - - No Reports both miR-103a-3p overexpression and ATF7 silencing promoted the expression of CDK2 - - - -
ATF7 protein-coding 29754469 Luciferase reporter assay cell line - - - - - No Reports miR-103a-3p directly regulates ATF7 expression in GC cells. - - - -
ATP6V1A protein-coding 28592880 ChIP-qPCR; qRT-PCR; Western blot cell line - - - - - No Reports YY1 transcriptionally regulates ATP6V1A, and the ATP6V1A core promoter region contains three YY1 binding sites. RNAi-mediated knockdown of YY1 in GC cells significantly decreased ATP6V1A mRNA and protein expression, while YY1 overexpression increased ATP6V1A expression level prognosis 0.01 - -
BAG3 protein-coding 30514177 qRT-PCR; Western blot cell line - - - - - No Reports BAG3 mRNA and protein levels were increased following treatment with HGF. HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. HGF-mediated BAG3 upregulation is regulated by an ERK and Egr1-dependent pathway. BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway. target - - -
BAG3 protein-coding 30514177 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. target - - -
BCL2L2 protein-coding 16707418 Gelatin zymography; Western blot cell line - - - - - No Reports Bcl-w overexpression increased matrix metalloproteinase-2 (MMP-2) expression, and synthetic or natural inhibitors of MMP-2 abolished Bcl-w induced cell invasion. Bcl-w overexpression also activated phosphoinositide 3-kinase (PI3K), Akt, and Sp1. mechanism - - -
BMI1 protein-coding 30156609 qRT-PCR; Cell transfection cell line - - - - - No Reports expression of BMI1 affected the expression of apoptosis_x005frelated proteins and thus inhibited the activation of the apoptotic pathway. Overexpression of BMI1 could activate the Notch and mTOR signaling pathways - - - -
BMI1 protein-coding 26894855 Luciferase reporter assay cell line - - - - - No Reports Bmi-1 is a direct target of miR-15a in gastric cancer cell lines. prognosis 0.024 - -
BNC2-AS1 lncRNA 30549996 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports BNC2-AS1-knockdown significantly suppressed gastric cancer cell proliferation, migration and suppressed gastric cancer cell invasion - - - -
BRD4 protein-coding 29434197 Cell proliferation assay; Invasion and migration assay; cell line - - - - - No Reports The BET inhibitor JQ1 inhibits gastric cancer cell proliferation by inducing cellular senescence. BRD4 is involved in JQ1-induced cellular senescence. target - - -
BRD4 protein-coding 29434197 Luciferase reporter assay cell line - - - - - No Reports BRD4 regulates the 3′-UTR of p21. mRNA CDKN1A target - - -
BRD4 protein-coding 29434197 CHIP assay cell line - - - - - No Reports BRD4, together with E2F1, regulates miR-106b-5p transcription and cellular senescence. target - - -
BTG1 protein-coding 26050197 RT-PCR; Western blot; MS-PCR cell line - - - - - No Reports BTG1 protein expression (19 kDa) was detectable in gastric cancer and epithelial cell lines; BTG1 mRNA was high expressed in cancer and epithelial cells and a decreased level of methylation of BTG1 after treated with 5-Aza-dC. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG1 overexpression suppressed tumor growth and lung metastasis of gastric cancer cells. target/prognosis 0.047 - -
BTG2 protein-coding 27409164 Cell proliferation assay; Invasion and migration assays; Flow cytometry; Apotosis assay cell line - - - - - No Reports Overexpression of BTG2 triggered G1/S cell cycle arrest, induced subsequent apoptosis, and inhibited C-myc activation following Ras/MEK/ERK signaling pathway, which involved in the biological effects of miR-27a-3p/BTG2 axis on gastric carcinogenesis and cancer progression. - - - -
BTG2 protein-coding 27409164 Luciferase reporter assay cell line - - - - - No Reports BTG2 was a direct and functional target of miR-27a-3p in gastric cancer and miR-27a-3p inhibition obviously up-regulated the expression of BTG2. - - - -
BTG3 protein-coding 25904053 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG3 overexpression inhibited proliferation, induced S/G2 arrest, differentiation, autophagy, apoptosis, suppressed migration and invasion target - - -
BTG3 protein-coding 25904053 qRT-PCR; Cell transfection cell line - - - - - No Reports BTG3 transfectants showed a higher mRNA expression of p27, Bax, 14-3-3, Caspase-3, Caspase-9, Beclin 1, NF-κB, IL-1, -2, -4, -10 and -17, but a lower mRNA expression of p21, MMP-9 and VEGF than the control and mock；exposed to cisplatin (DDP), MG132, paclitaxel, and SAHA, BTG3 transfectants showed a lower viability and a higher apoptotic level than the control in both concentration and time-dependent manners target - - -
BTG3 protein-coding 25238703 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG3 suppressed the proliferation of GC cells in vitro. It also inhibited migration and invasion of GC cells in vitro. target/prognosis 0.001 - -
BTG4 protein-coding 19576178 Bisulfite sequencing cell line - - - - - No Reports Most CpG dinucleotides were methylated in gastric cancer cell lines, the methylation was absent in GES-1 cells mechanism - - -
BTG4 protein-coding 19576178 Flow cytometry; Cell growth assay cell line - - - - - No Reports BTG4 reexpression sensitizes gastric cancer cells to proapoptotic stimuli and reduces colony formation in vitro. mechanism - - -
C1QTNF6 protein-coding 30431096 Cell proliferation assay; Invasion and migration assays; Flow cytometry; Cell colony formation assay cell line - - - - - No Reports Interference of C1QTNF6 expression influenced the proliferation, migration and invasion ability of Gc cells in vitro. target - - -
C8orf76 protein-coding 30733230 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports C8orf76 promotes cell growth and cell-cycle progression, but inhibits cell apoptosis prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Luciferase reporter assay; Western blot; qRT-PCR; ChIP-PCR cell line - - - - - No Reports DUSP5P1 is a direct downstream target of C8orf76 prognosis < 0.0001 - -
CA11 protein-coding 11562744 Cell coloney formation assay cell line - - - - - No Reports CA11 transfected MKN28 cells also displayed a marked decrease in the number of colony formations when compared to double normal controls. - - - -
CASC15 lncRNA 29272000 Cell proliferation assay cell line - - - - - No Reports Overexpression of LncRNA CASC15 promoted the proliferation of MKN28 cells. prognosis 0.013 - -
CBFB protein-coding 29386218 Luciferase reporter assay cell line - - - - - No Reports CBFB is a miR-204-5p target gene and promotes gastric cancer cell growth prognosis < 0.001 - -
CBFB protein-coding 29386218 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports CBFB promotes gastric cancer cell growth prognosis < 0.001 - -
CCAT1 lncRNA 28535628 Cell proliferation assay cell line - - - - - No Reports Down-regulation of CCAT1 in MGC-803 and SGC-7901 cells significantly inhibited the cell proliferation. target - - -
CCAT2 lncRNA 28248065 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Silencing of lncRNA CCAT2 inhibits gastric cancer cell proliferation and invasion. prognosis < 0.05 - -
CCEPR lncRNA 29771412 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Down-regulated lncRNA CCHE1 decreased proliferative activity and colony formation capacity.Cell cycle was promot_x005fed in lncRNA CCHE1 up-regulation group. target - - -
CCKBR protein-coding 27518872 Luciferase reporter assay cell line - - - - - No Reports Cholecystokinin B receptor (CCK-BR) was a direct target of miR-148a. target - - -
CCKBR protein-coding 27518872 Cell proliferation assay; Cell migration assay cell line - - - - - No Reports siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. target - - -
CCN1 protein-coding 30178386 Luciferase reporter assay cell line - - - - - No Reports CYR61 is a novel target of miR‑142‑5p in GC cells prognosis < 0.001 - -
CCN1 protein-coding 27105510 Cell invasion and migration assays cell line - - - - - No Reports knockdown of CYR61 in gastric cancer AGS cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis prognosis < 0.001 - -
CCND1 protein-coding 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports ETS1 or CCND1 knockdown significantly suppressed gastric cancer cell growth, similar to miR-193a-3p overexpression. mechanism - - -
CCND1 protein-coding 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct targets of miR-193a-3p mechanism - - -
CCND1 protein-coding 27071318 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Regulate cell growth of GC cells. - - - -
CCND1 protein-coding 26955820 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports The enforced expression of si-CCND1 notably repressed cells proliferation, elicited cell cycle arrest at the G0– G1 stage and enhanced apoptosis in both cell lines. - - - -
CCND1 protein-coding 26955820 Luciferase reporter assay cell line - - - - - No Reports Cyclin D1 is a direct target of miR-155 in GC cells - - - -
CCND1 protein-coding 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro. mechanism - - -
CCND1 protein-coding 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted the 3'-UTR of cyclin D1 and Ets1 mechanism - - -
CD151 protein-coding 23533596 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Down-regulation of CD151 by vshRNA-CD151 impaired metastasis and invasion of HGC-27 cells, but did not affect cell proliferation. CD151-cDNA transfection rescued the metastatic potential and invasiveness of HGC-27-vshCD151 cells, but not those of HGC-27-vshintegrin a3 cells in vitro. target/prognosis 0.007 - -
CD151 protein-coding 23533596 Co-ip assays cell line - - - - - No Reports CD151 formed a complex with integrin a3 in HGC cells. target/prognosis 0.007 - -
CD276 protein-coding 25120098 Cell invasion and migration assays cell line - - - - - No Reports B7-H3 knockdown by RNA interference decreased cell migration and Transwell invasion up to 50% in vitro. target - - -
CDC42 protein-coding 25152372 Luciferase reporter assay cell line - - - - - No Reports CDC42 is the direct target of miR-133a mechanism - - -
CDC42 protein-coding 26549550 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Knockdown of CDC42 significantly inhibited the proliferation of AGS and SGC7901 cells, and it was suggested that this inhibitory process may be due to cell cycle arrest at G1/S phase and downregulation of cyclin A, cyclin D1, cyclin E and proliferating cell nuclear antigen. Furthermore, knockdown of CDC42 markedly inhibited the migration and invasion of GC cells, and suppressed the expression of matrix metalloproteinase 9 target - - -
CDH1 protein-coding 30063010 Luciferase reporter assay cell line - - - - - No Reports CDH1 is a direct target of miR-217 mechanism - - -
CDK6 protein-coding 30530570 Luciferase reporter assay cell line - - - - - No Reports EGFR and CDK6 are directly targets of miR-1296-5p - - - -
CDK9 protein-coding 28701053 Luciferase reporter assay cell line - - - - - No Reports CDK9 is a direct target of miR-613 in gastric cancer target - - -
CDKL1 protein-coding 22369697 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports Loss of CDKL1 function in both SGC7901 and MGC-803 gastric cancer cells significantly decreases cellular proliferation and increases apoptosis (p < 0.01). target - - -
CDKN1A protein-coding 29434197 Luciferase reporter assay cell line - - - - - No Reports BRD4 regulates the 3′-UTR of p21. mRNA CDKN1A - - - -
CDKN2B-AS1 lncRNA 31242038 Apoptosis assay; Migration assay cell line - - - - - No Reports ANRIL suppresses apoptosis in gastric cancer cell, enhances metastasis target/prognosis < 0.001 - -
CDKN2B-AS1 lncRNA 31242038 Xenograft tumor mouse model cell line - - - - - No Reports ANRIL promotes tumor growth in vivo target/prognosis < 0.001 - -
CDKN2B-AS1 lncRNA 30156609 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Knockdown of ANRIL suppressed cell viability, migration, and invasion, and increased apoptosis through up-regulating miR-99a. target - - -
CDKN2B-AS1 lncRNA 30156609 qRT-PCR; Cell transfection cell line - - - - - No Reports ANRIL silence_x005finduced up-regulation of miR-99a was significantly reversed by miR-99a inhibitor.ANRIL knockdown down-regulated the expression of BMI1 by modulating miR-99a in gastric cancer cells in vitro target - - -
CEBPA protein-coding 20386538 Cell proliferation assay cell line - - - - - No Reports We observed a significant decrease in proliferation in C/EBPa-transfected cells. mechanism - - -
CELF2 protein-coding 29501762 Cell proliferation assay; Flow cytometry; Cell migration assay cell line - - - - - No Reports Overexpressed CELF2 induced cell apoptosis and reduced proliferation ability. prognosis < 0.01 - -
CEMIP protein-coding 28422983 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Knockdown KIAA1199 suppressed the proliferation, migration and invasion in GC cells. KIAA1199 stimulated the Wnt/β-catenin signaling pathway and the enzymatic activity of matrix metalloproteinase (MMP) family members and thus accelerated the epithelial-to-mesenchymal transition (EMT) progression in GC cells. target/prognosis < 0.001 - -
CHD5 protein-coding 19840376 qRT-PCR cell line - - - - - No Reports CHD5 expression was down-regulated in all of gastric cancer cell lines used (100%, 7/7). mechanism - - -
CHD5 protein-coding 19840376 MS-PCR; BGS tissue/cell line - - - - - No Reports Methylation of CHD5 promoter was detected in all of seven gastric cancer cell lines and in the majority of primary gastric carcinoma tissues examined (73%, 11/15). mechanism - - -
CHD5 protein-coding 19840376 Colony formation assay cell line - - - - - No Reports ectopic expression of CHD5 in gastric cancer cells led to a significant growth inhibition. mechanism - - -
CIAPIN1 protein-coding 19471113 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Ectopic expression of CIAPIN1 by cDNA transfection resulted in suppression of cell proliferation and inhibition of cell cycle progression while knockdown of CIAPIN1 with siRNA accelerated cell proliferation and promoted cell cycle progression in SGC7901 and MKN28 gastric cancer cells. mechanism - - -
CKS2 protein-coding 21617860 Cell proliferation assay; Cell invasion and migration assays; Flow cytometry cell line - - - - - No Reports The inhibition of cellular proliferation by CKS2-siRNA was observed in a gastric cancer cell line. prognosis - - -
CLCN3 protein-coding 30217218 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports Knockdown of CLC-3 inhibited cell proliferation and migration in vitro. target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. target/prognosis 0.012 - -
CLDN18 protein-coding 24647998 Luciferase reporter assay cell line - - - - - No Reports miR-1303 could bind to the putative binding sites in CLDN18 mRNA 3'-UTR and visibly lower the expression of claudin-18. The introduction of claudin-18 without 3'-UTR restored the miR-1303 promoting migration function. target - - -
CLEC4M protein-coding 28403883 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and DC-SIGNR overexpression promoted cell proliferation, migration and invasion. target - - -
CMTM3 protein-coding 24131472 Cell invasion and migration assay; cell line - - - - - No Reports Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells prognosis 0.041 - -
COL10A1 protein-coding 30154451 Cell invasion and migration assay cell line - - - - - No Reports COL10A1 regulated the migration and invasion of GC cells. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports SOX9 directly binds to the COL10A1 promoter and activates its transcription. prognosis 0.003/0.000 - -
COPS7A protein-coding 31409899 RNA pull-down assay; RIP; Western blot cell line - - - - - No Reports KRT19P3 could bind COPS7A directly and might regulate COPS7A activity in GC target - - -
CORO1C protein-coding 22974233 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports Coronin 3 is expressed in the cytoplasm of gastric cancer cells. Coronin 3 promoted the migratory, invasive, and in vivo metastatic abilities of gastric cancer cells. mechanism - - -
CPXM2 protein-coding 31364750 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports CPXM2 promotes the proliferation and migration of cultured GC cells.CPXM2 may promote GC progression by modulating EMT prognosis 0.007 - -
CRK protein-coding 25027343 Cell proliferation assay; Cell invasion assay cell line - - - - - No Reports Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. target - - -
CRMP1 protein-coding 27864146 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports downregulation of CRMP1 increased cell proliferation and migration, and inhibited apoptosis in GC cells. Additionally, the inhibitory effect of the miR-187 inhibitor on cell migration was reversed by the downregulation of CRMP1. target - - -
CRMP1 protein-coding 27864146 Luciferase reporter assay cell line - - - - - No Reports CRMP1 was a direct downstream target of miR-187 in GC.The effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation target - - -
CRNDE lncRNA 28490034 Cell proliferation assay cell line - - - - - No Reports Overexpression of CRNDE increased GC cell viability and promoted colony formation. Knockdown of CRNDE did not result in loss of expression-related effects on cell proliferation and colony formation. target - - -
CRNDE lncRNA 28490034 Luciferase reporter assay cell line - - - - - No Reports miR-145 target gene E2F3 was strongly expressed following CRNDE competitive molecular sponging of miR-145. target - - -
CRNDE lncRNA 29243780 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Knockdown of CRNDE inhibited cell proliferation, migration and invasion of GC. prognosis 0.0066 - -
CRNDE lncRNA 29243780 Western blot; cell transfection cell line - - - - - No Reports CRNDE exerted its oncogenic role by affecting PI3K/AKT signaling pathways. prognosis 0.0066 - -
CTBP1 protein-coding 27983935 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Suppression of CtBP1 Inhibits Proliferation, Invasion, and EMT Progression in GC Cells mechanism - - -
CTBP1 protein-coding 27983935 Luciferase reporter assay cell line - - - - - No Reports CtBP1 is a putative target gene of miR-644a in GC cells mechanism - - -
CTHRC1 protein-coding 25510669 Luciferase reporter assay cell line - - - - - No Reports Cthrc1 was a direct target of let-7b. mechanism - - -
DDX5 protein-coding 30029874 RIP and Luciferase reporter assay cell line - - - - - No Reports miR-5590-3p as a direct target of DDX5 mechanism - - -
DNMT3A protein-coding 26350239 Cell proliferation assay; Flow Cytometry cell line - - - - - No Reports DNMT3A promotes tumor cell proliferation and cell growth by disrupting the G1/S checkpoint. target - - -
DNMT3A protein-coding 26350239 ChIP assay cell line - - - - - No Reports DNMT3A modulated p18INK4C by directly binding to and silencing the p18INK4C gene via promoter hypermethylation. target - - -
DUSP5P1 lncRNA 30733230 Luciferase reporter assay; Western blot; qRT-PCR; ChIP-PCR cell line - - - - - No Reports DUSP5P1 is a direct downstream target of C8orf76 mechanism - - -
DUSP5P1 lncRNA 30733230 Cell proliferation assay; Cell colony formation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports DUSP5P1 promotes gastric cancer cell growth in vitro. mechanism - - -
EGFR protein-coding 30530570 Luciferase reporter assay cell line - - - - - No Reports EGFR and CDK6 are directly targets of miR-1296-5p mechanism - - -
ELAVL1 protein-coding 26819420 Cell proliferation assay cell line - - - - - No Reports Over-expression of HuR resulted in the increase in the cell activity of gastric cancer (P<0.001). Suppression of HuR decreased the cell activity of gastric cancer (P=0.001). mechanism - - -
ELAVL1 protein-coding 26819420 Western blot cell line - - - - - No Reports The protein level of HuR in the gastric cancer cells was higher than that in the control cells. mechanism - - -
EPHA8 protein-coding 31026069 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Knockdown of Epha8 reduces cell proliferation; EphA8 promotes GC cell migration and invasion prognosis < 0.001 - -
EPHA8 protein-coding 31026069 Western blot; Coimmuno precipitation experiments;Immunofluorescence microscopy cell line - - - - - No Reports EphA8 interacts with ADAM10 to affect GC cell growth prognosis < 0.001 - -
ERBB4 protein-coding 29620274 Cell proliferation assay cell line - - - - - No Reports Silencing of ERBB4 expression suppresses GC cell proliferation. target - - -
ETS1 protein-coding 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports ETS1 or CCND1 knockdown significantly suppressed gastric cancer cell growth, similar to miR-193a-3p overexpression. mechanism - - -
ETS1 protein-coding 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct targets of miR-193a-3p mechanism - - -
ETS1 protein-coding 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro. mechanism - - -
ETS1 protein-coding 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted the 3'-UTR of cyclin D1 and Ets1 mechanism - - -
EZH2 protein-coding 30952377 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports knockdown of EZH2 expression by siRNA could impair cell proliferation and invasion both in vitro. prognosis 0.001 - -
EZH2 protein-coding 30952377 Xenograft mice models cell line - - - - - No Reports Knockdown of EZH2 inhibits gastric cancer cells tumorigenesis in vivo. prognosis 0.001 - -
EZH2 protein-coding 30952377 CHIP assay cell line - - - - - No Reports EZH2 could directly bind to P21 promoter region and mediate H3K27me3 modification. prognosis 0.001 - -
FADD protein-coding 28848149 Luciferase reporter assay cell line - - - - - No Reports FADD is a potential target of miR-675; H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
FADD protein-coding 28848149 Cell proliferation assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports FADD mediates the pro-proliferation and anti-apoptosis function of miR-675 target - - -
FLJ22763 lncRNA 30716442 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports LncRNA FLJ22763 inhibits cells proliferation, migration, and invasion target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 qRT-PCR; Cell tranfection; Western blot cell line - - - - - No Reports FLJ22763 was negatively associated with ACLY, regulating the mRNA and protein levels of ACLY target/prognosis 0.003 - -
FOXM1 protein-coding 27086911 Luciferase reporter assay cell line - - - - - No Reports FoxM1 is a direct target of miR-320a mechanism - - -
FZD7 protein-coding 29559846 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Knockdown of FZD7 suppressed gastric cancer cell growth, migration and invasion target/prognosis < 0.001 < 0.001 -
GAS5 lncRNA 25959498 Flow cytometry cell line - - - - - No Reports lncRNA GAS5 knock-down abolishes cell cycle arrest at the G1 phase target - - -
GAS5 lncRNA 25959498 RNA pull-down assay cell line - - - - - No Reports lncRNA GAS5 interacts with the transcriptional activator YBX1. target - - -
GNAQ protein-coding 28350126 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Silencing of GNAQ markedly suppressed proliferation and colony formation in GC cells, and arrested the cell cycle at the S phase. target - - -
GNAQ protein-coding 28350126 Western blot; cell transfection cell line - - - - - No Reports GNAQ directly or indirectly inhibits p53 and several key regulators of cell cycle signaling. GNAQ expression was required for MEK/ERK phosphorylation in MGC80-3 cells. target - - -
H19 lncRNA 28848149 Cell proliferation assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. mechanism - - -
HOTAIR lncRNA 30810117 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports HOTAIR knockdown had anti-tumor effects that suppressed gastric cancer cell proliferation by increasing cell apoptosis and keeping the cell cycle in G1 phase. mechanism - - -
HOXA1 protein-coding 26791264 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Knockdown of HOXA1 in GC cells inhibited cell proliferation, migration, and invasion in vitro; Knockdown of HOXA1 expression induces changes in the cell cycle of GC cells and decreases cyclin D1 expression prognosis < 0.001 < 0.001 -
hsa_circ_0000199 circRNA 30927924 Cell cytotoxicity assay; Clonogenic assay; Flow ytometry cell line - - - - - No Reports circAKT3 promotes DNA damage repair and inhibits the apoptosis of GC cells in vitro. Downregulation of circAKT3 facilitates cisplatin sensitivity of CDDP-resistant GC cells in vitro. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Luciferase reporter assay: RNA pull-down; FISH cell line - - - - - No Reports circAKT3 and miR-198 were colocalized in the cytoplasm; circAKT3 exerts its function by sponging miR-198. target/prognosis - 0.0293 0.91
hsa_circ_0000993 circRNA 30215537 qRT-PCR cell line - - - - - No Reports hsa_circ_0000993 has a lower expression level in highly aggressive cell line BGC-823 as compared with poorly aggressive cell line SGC-7901 target - - -
hsa_circ_0000993 circRNA 30215537 FISH cell line - - - - - No Reports FISH showed that hsa circ 0000993 was expressed both in nucleus and cytoplasm and mainly in nucleus of gastric cancer cells. target - - -
hsa_circ_0000993 circRNA 30215537 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports Increased expression of hsa circ 0000993 was associated with decreased migration, invasion and proliferation of gastric cancer cells. target - - -
hsa_circ_0000993 circRNA 30215537 Luciferase reporter assay cell line - - - - - No Reports hsa_circ_0000993 acts as a miRNA sponge for miR-214-5p target - - -
hsa_circ_0004771 circRNA 30717751 Pull-down assay; Luciferase reporter cell line - - - - - No Reports circNRIP1 serves as a miRNA sponge of miR-149-5p prognosis 0.0019 0.004 -
hsa_circ_0004771 circRNA 30717751 Cell proliferation assay; Invasion and migration assay; Clonogenic assay cell line - - - - - No Reports Knockdown of circNRIP1 inhibits the proliferation, migration, invasion and expression level of AKT1 in GC cells in vitro prognosis 0.0019 0.004 -
hsa_circ_0092303 circRNA 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports CircCACTIN promotes proliferation, invasion, and migration of GC cells in vitro. target - - -
hsa_circ_0092303 circRNA 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between circCACTIN and miR-331-3p. target - - -
HSPB8 protein-coding 29693129 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Knockdown of HSPB8 inhibits gastric cancer cell proliferation, promotes gastric cancer cell apoptosis - - - -
ITGA3 protein-coding 23533596 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports silencing of integrin a3 markedly inhibited the invasion of HGC27 cells. target/prognosis < 0.0001 - -
ITGA3 protein-coding 23533596 Co-ip assays cell line - - - - - No Reports CD151 formed a complex with integrin a3 in HGC cells. target/prognosis < 0.0001 - -
JAZF1 protein-coding 31357957 Luciferase reporter assay cell line - - - - - No Reports JAZF1 is a direct target of miR-1275 in GC cells. prognosis <0.001 - -
KDM4B protein-coding 24077348 Phase-contrast microscopy cell line - - - - - No Reports JMJD2B inhibition induces the epithelial morphology of gastric cancer cells target - - -
KDM4B protein-coding 24077348 qRT-PCR; Western blot cell line - - - - - No Reports JMJD2B repression results in downregulation of mesenchymal markers and upregulation of epithelial markers target - - -
KDM4B protein-coding 24077348 Luciferase reporter activity assay; ChIP assay; cell line - - - - - No Reports JMJD2B is physically associated with b-catenin to regulate vimentin promoter. target - - -
KDM4B protein-coding 24077348 Cell invasion and migration assay cell line - - - - - No Reports JMJD2B inhibition results in diminished invasion and metastasis in vitro target - - -
KRT19P3 lncRNA 31409899 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports KRT19P3 inhibited GC cell proliferation and induced apoptosis, suppressed GC cell migration and invasion in vitro. target/prognosis 0.0016 0.0028 -
KRT19P3 lncRNA 31409899 RNA pull-down assay; RIP; Western blot cell line - - - - - No Reports KRT19P3 could bind COPS7A directly and might regulate COPS7A activity in GC target/prognosis 0.0016 0.0028 -
LINC01089 lncRNA 29717028 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports AK096174 knockdown inhibited the proliferation, migration, and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. target - - -
LINC01234 lncRNA 29386218 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports promote cell proliferation and cell tomorigenesis, suppress apotosis and G1 arrest prognosis <0.001 <0.001 -
LINC01234 lncRNA 29386218 Immunoprecipitation assays cell line - - - - - No Reports LINC01234 binds directly to Ago2 prognosis <0.001 <0.001 -
LINC01234 lncRNA 29386218 Luciferase reporter assay cell line - - - - - No Reports miR-204-5p directly target LINC01234 prognosis <0.001 <0.001 -
LINC02859 lncRNA 31207155 Cell proliferation assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports LOC101928316 overexpression can significantly inhibit GC cell migration, invasion, and proliferation. target - - -
LINC02859 lncRNA 31207155 Western blot cell line - - - - - No Reports lenti-LOC101928316-Overexpression stable infected can remarkably inhibit the expression level of PI3K, p-AKT, mTOR, and p-mTOR in GC cells target - - -
MAPK1 protein-coding 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. mechanism - - -
MAPK1 protein-coding 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 positively regulated MAPK1 by sponging miR‑490‑3p in gastric cancer cells mechanism - - -
MIR103A1 miRNA 29754469 Cell proliferation assay; Cell colony formation assay;Flow cytometry cell line - - - - - No Reports miR-103a-3p increases GC cell growth, and miR-103a-3p overexpression promotes the S-G2/M transition in vitro. target - - -
MIR103A1 miRNA 29754469 Luciferase reporter assay cell line - - - - - No Reports miR-103a-3p directly regulates ATF7 expression in GC cells. target - - -
MIR106B miRNA 30907988 Cell invasion and migration assays cell line - - - - - No Reports miR-106b inhibitor could promote the apoptosis of gastric cancer cells mechanism - - -
MIR106B miRNA 30907988 Luciferase reporter assay cell line - - - - - No Reports miR-106b targeted ALEX1 in gastric cancer cells mechanism - - -
MIR106B miRNA 29434197 Luciferase reporter assay; Immunoblotting cell line - - - - - No Reports miR-106b-5p targets p21 to regulate the cellular senescence in BRD4-inhibited cells. BRD4 regulates miR-106b-5p transcription via E2F for cellular senescence. target - - -
MIR126 miRNA 25027343 Cell proliferation assay; Cell invasion assay cell line - - - - - No Reports Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. target - - -
MIR126 miRNA 28260063 qRT-PCR cell line - - - - - No Reports the expression levels of miR-126 were significantly downregulated in the GC cell lines compared with the GES-1 cells target - - -
MIR126 miRNA 28260063 Luciferase reporter assay cell line - - - - - No Reports ADAM9 is a direct target post-transcriptionally regulated by miR-126 in GC cells. target - - -
MIR1275 miRNA 31357957 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Ectopic expression of miR-1275 inhibited the metastasis and invasion of GC cells. prognosis < 0.001 - -
MIR1275 miRNA 31357957 Luciferase reporter assay cell line - - - - - No Reports JAZF1 is a direct target of miR-1275 in GC cells. prognosis < 0.001 - -
MIR129-1 miRNA 29879625 Luciferase reporter assay cell line - - - - - No Reports miR-129-5p could target the 3′UTR of ADAM9 mRNA and regulated its protein expression prognosis < 0.05 - -
MIR129-1 miRNA 29879625 Cell proliferation assay; Invasion assay cell line - - - - - No Reports miR-129-5p overexpression reduced cell proliferation, cell colony formation and cell invasion capacity prognosis < 0.05 - -
MIR1296 miRNA 30530570 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports miR-1296-5p inhibited cell proliferation, migration, and invasion in SGC-7901 and MGC-803 cells. mechanism - - -
MIR1296 miRNA 30530570 Luciferase reporter assay cell line - - - - - No Reports CDK6 and EGFR as novel targets of miR-1296-5p by a luciferase activity assay mechanism - - -
MIR1303 miRNA 24647998 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Cell proliferation rates were reduced, and cell invasion and migratory ability was significantly restricted in miR-1303 inhibitor-transfected groups. target - - -
MIR1303 miRNA 24647998 Luciferase reporter assay cell line - - - - - No Reports miR-1303 could bind to the putative binding sites in CLDN18 mRNA 3'-UTR and visibly lower the expression of claudin-18. The introduction of claudin-18 without 3'-UTR restored the miR-1303 promoting migration function. target - - -
MIR133A1 miRNA 25152372 Luciferase reporter assay cell line - - - - - No Reports CDC42 is the direct target of miR-133a prognosis 0.003 - -
MIR133A1 miRNA 25152372 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-133a supresses gastric cancer cell growth, migration and invasion. prognosis 0.003 - -
MIR135B miRNA 32119960 Luciferase reporter assay; RIP cell line - - - - - No Reports PCAT18 and CLDN11 are the direct targets of miR-135b target - - -
MIR135B miRNA 32119960 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports Over-expression of miR-135b promotes proliferation, migration and invasion of AGS cells via CLDN11 inhibition. target - - -
MIR136 miRNA 30468468 qRT-PCR cell line - - - - - No Reports miR-136 was significantly downregulated in the gastric cancer cell lines as compared to the normal cell line target - - -
MIR136 miRNA 30468468 Flow cytometry cell line - - - - - No Reports transfection of AGS cells with miR-136 promoted apoptosis target - - -
MIR137 miRNA 26102366 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports The re-introduction of miR-137 into gastric cancer cells was able to inhibit cell proliferation, migration and invasion. mechanism - - -
MIR137 miRNA 26102366 Luciferase reporter assay; Western blot cell line - - - - - No Reports miR-137 targets AKT2 in GC mechanism - - -
MIR142 miRNA 30178386 Cell invasion and migration assays cell line - - - - - No Reports MiR-142-5p inhibited cancer cell migration and invasion both in vitro and in vivo. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Luciferase reporter assay cell line - - - - - No Reports CYR61 is a novel target of miR‑142‑5p in GC cells target/prognosis 0.001 - -
MIR143 miRNA 28404925 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Overexpression of miR-143-3p suppressed cell proliferation, induced apoptosis and inhibited cell migration and invasion. target - - -
MIR143 miRNA 28404925 Luciferase reporter assay cell line - - - - - No Reports AKT2 is a direct target of miR-143-3p target - - -
MIR145 miRNA 28490034 Luciferase reporter assay cell line - - - - - No Reports miR-145 target gene E2F3 was strongly expressed following CRNDE competitive molecular sponging of miR-145. mechanism - - -
MIR148A miRNA 27518872 Cell proliferation assay; Cell migration assays cell line - - - - - No Reports Ectopic expression of miR-148a inhibited tumor cell proliferation and migration in vitro. More importantly, siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. target - - -
MIR148A miRNA 27518872 Luciferase reporter assay cell line - - - - - No Reports Cholecystokinin B receptor (CCK-BR) was a direct target of miR-148a target - - -
MIR152 miRNA 28427226 Cell proliferation assay cell line - - - - - No Reports Elevation of miR-152 enhanced T cells proliferation and effector cytokines production via inhibiting B7-H1/PD-1 pathway. target - - -
MIR152 miRNA 28427226 Luciferase reporter assay cell line - - - - - No Reports miR-152 directly bind to B7-H1 3' untranslated region in gastric cancer cell and inhibited B7-H1 expression. target - - -
MIR155 miRNA 26955820 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Enforced expression of miR-155 impaired GC cell proliferation, promoted G1 phase arrest and induced apoptosis in vitro. In addition, we identified cyclin D1 as the direct target of miR-155, and knockdown of cyclin D1 partially phenocopied the role of miR-155 in GC cells. target - - -
MIR155 miRNA 26955820 Luciferase reporter assay cell line - - - - - No Reports Cyclin D1 is a direct target of miR‐155 in GC cells target - - -
MIR15A miRNA 26894855 Cell proliferation assay cell line - - - - - No Reports miR-15a suppressed gastric cancer invasion; miR-15a suppressed the proliferation of gastric cancer cells via downregulation of Bmi-1. mechanism - - -
MIR15A miRNA 26894855 Luciferase reporter assay cell line - - - - - No Reports Bmi-1 is a direct target of miR-15a in gastric cancer cell lines. mechanism - - -
MIR181A1 miRNA 24531888 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports miR-181a affects the proliferation and metastatic potential of gastric cancer cells. mechanism - - -
MIR187 miRNA 27864146 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports miR-187 significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells target - - -
MIR187 miRNA 27864146 Luciferase reporter assay cell line - - - - - No Reports CRMP1 was a direct downstream target of miR-187 in GC.The effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation target - - -
MIR191 miRNA 24603541 qRT-PCR cell line China - - Up - Examination of miR-191 and miR-425 expression in four GC cell lines (HGC-27,MGC-803, MKN-45 and SGC-7901) indicated an obvious upregulation of miR-191/425 in HGC-27, MGC-803, and SGC-7901 cell lines when compared to adjacent non-tumor tissues and five normal gastric tissues from healthy people mechanism - - -
MIR1915 miRNA 31036603 Cell proliferation assay,Cell apoptosis assay cell line - - - - - No Reports It was found that the miR-1915-3p inhibited the growth of gastric cancer cells and promoted cell apoptosis. prognosis 0.01 - -
MIR1915 miRNA 31036603 Luciferase reporter assay cell line - - - - - No Reports miR-1915-3p directly inhibits Bcl-2 expression at post-transcriptional level through its 3'-UTR. prognosis 0.01 - -
MIR193A miRNA 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports Ectopic expressions of miR-193a-5p and miR-193a-3p revealed that they both inhibited gastric cancer cell growth, but only miR-193a-3p significantly suppressed cell invasion ability. mechanism - - -
MIR193A miRNA 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct target of miR-193a-3p mechanism - - -
MIR193B miRNA 27071318 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-193b can inhibit the proliferation, migration and invasion of HGC-27 and MGC-803 GC cells. mechanism - - -
MIR194-1 miRNA 27810403 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Overexpression of miRNA-194 promoted cell proliferation and migration, while inhibition of miRNA-194 blocked these processes. target - - -
MIR194-1 miRNA 27810403 Luciferase reporter assay cell line - - - - - No Reports SUFU is the functional target of miRNA-194 target - - -
MIR198 miRNA 30927924 Cell cytotoxicity assay; Clonogenic assay; Flow ytometry cell line - - - - - No Reports Overexpression of miR-198 inhibited cell viability and induced apoptosis in SGC7901CDDP and BGC823CDDP cells. mechanism - - -
MIR198 miRNA 30927924 Luciferase reporter assay: RNA pull-down; FISH cell line - - - - - No Reports circAKT3 and miR-198 were colocalized in the cytoplasm; circAKT3 exerts its function by sponging miR-198. mechanism - - -
MIR199A1 miRNA 30193607 Cell proliferation assay; Cell migration assay cell line - - - - - No Reports Over-expression of miR-199 inhibited the proliferation and migration of GC cells. target - - -
MIR199A1 miRNA 30193607 Luciferase reporter assay cell line - - - - - No Reports miR-199 directly targeted on the 3' untranslated region of TBL1XR1. target - - -
MIR19A miRNA 25914465 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Overexpression of miR-19a promoted the proliferation, migration and invasion. target - - -
MIR19A miRNA 25914465 Western blot cell line - - - - - No Reports Overexpressing miR­19a GC cells promoted phosphorylation of PI3K­AKT, and the phosphorylation of PI3K­AKT was blocked in the cells transfected with miR-19a mimic. target - - -
MIR203A miRNA 30837034 Cell invasion and migration assays cell line - - - - - No Reports miR-203 Suppressed the Invasion and EMT of GC Cells Through Inhibition of Annexin A4 target - - -
MIR203A miRNA 30837034 Luciferase reporter assay cell line - - - - - No Reports miR-203 Directly Targets Annexin A4 in GC Cells target - - -
MIR203A miRNA 30837034 qRT-PCR; Western blot cell line - - - - - No Reports overexpression of miR-203 could inhibit EMT of GC cells target - - -
MIR203A miRNA 25373785 Cell proliferation assay; Invasion and migration assays; Clonal formation assay cell line - - - - - No Reports Ectopic expression of miR-203 dramatically suppressed cell proliferation and invasion. We found that miR-203 strongly reduced the expression of CASK oncogene in GC cells. Similar to the restoring miR-203 expression, CASK down-regulation inhibited cell growth and invasion, whereas CASK over-expression rescued the suppressive effect of miR-203. These results can also be found in nude mice. In clinical specimens, CASK was over-expressed in tumors and H. pylori positive tissues and its mRNA levels were inversely correlated with miR-203 expression mechanism - - -
MIR203A miRNA 25373785 Luciferase reporter assay cell line - - - - - No Reports CASK was a direct target of miR-203 in GC cells. mechanism - - -
MIR204 miRNA 23152059 Luciferase reporter assay cell line - - - - - No Reports miR-204-mediated targeting of Bcl-2 expression pro_x005fmotes apoptosis of GC cells. prognosis 0.017 - -
MIR204 miRNA 23152059 Cell migration assay; Cell colony formation assay; Cell apoptosis assay cell line - - - - - No Reports miR-204 overexpression affects cell migration, colony forming ability and chemoresistance. prognosis 0.017 - -
MIR208A miRNA 29886152 Cell proliferation assay; Cell invasion assay; cell line - - - - - No Reports Ectopic expression of miR-208a by treatment with miR-208a mimic promoted cell proliferation and invasion abilities, but downregulation of miR-208a by treatment with miR-208a inhibitor had an opposite effects. target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Luciferase reporter assay cell line - - - - - No Reports SFRP1 is a direct target of MiR-208a in GC cells target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Luciferase reporter assay; RIP cell line - - - - - No Reports MEG3 is a bona fide target for miR-208a in GC cells target/prognosis < 0.05 - -
MIR208A miRNA 27634902 Flow cytometry cell line - - - - - No Reports miR-208a-3p suppresses apoptosis of gastric cancer cells by targeting PDCD4 target - - -
MIR208A miRNA 27634902 Luciferase reporter assay cell line - - - - - No Reports PDCD4 is a direct target of miR-208a-3p target - - -
MIR21 miRNA 30700111 Cell proliferation assay; Migration assay; Flow cytometer; Cell cycle assay cell line - - - - - No Reports Down-regulation of miR-21 markedly reduced gastric cancer cell proliferation and promoted cell apoptosis and repressed cell cycle progression; Silencing miR-21 dramatically blocked gastric cancer cell migration and movement. target - - -
MIR217 miRNA 30063010 Luciferase reporter assay cell line - - - - - No Reports CDH1 is a direct target of miR-217 mechanism - - -
MIR217 miRNA 30063010 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports miR-217 overexpression contributes to increased GC cells proliferation mechanism - - -
MIR27A miRNA 27409164 Cell proliferation assay; Invasion and migration assays; Flow cytometry; Apotosis assay cell line - - - - - No Reports Overexpression of miR-27a-3p, but not miR-27a-5p, markedly promoted gastric cancer cell proliferation in vitro. miR-27a-3p/BTG2 axis regulates cell cycle progression and apoptosis in gastric cancer cells target - - -
MIR27A miRNA 27409164 Luciferase reporter assay cell line - - - - - No Reports BTG2 was a direct and functional target of miR-27a-3p in gastric cancer and miR-27a-3p inhibition obviously up-regulated the expression of BTG2. target - - -
MIR29A miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29a into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29A miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29a in GC cells. target - - -
MIR29B1 miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29b into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29B1 miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29b in GC cells. target - - -
MIR29C miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29c into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29C miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29c in GC cells. target - - -
MIR302B miRNA 28743112 Cell proliferation assay; Cell colony formation assay; Apoptosis assay; Flow cytometry cell line - - - - - No Reports Enforced expression of miR-302b suppressed cell proliferation and cell cycle G1-S transition and induced apoptosis. mechanism - - -
MIR302B miRNA 28743112 Luciferase reporter assay cell line - - - - - No Reports IGF-1R was found to be a direct target of miR-302b-3p, and silencing of IGF-1R resulted in the same biological effects as those induced by miR-302b-3p overexpression in gastric cancer cells. Both overexpression of miR-302b-3p and silencing of IGF-1R decreased AKT phosphorylation, which modulated AKT related cell cycle regulators (cyclin A2, cyclin D1, CDK2, and CDk6) and apoptotic protein Bax/Bcl-2. mechanism - - -
MIR320A miRNA 27086911 Clone formation assay cell line - - - - - No Reports miR-320a inhibits gastric cancer cell proliferation by suppressing activity in the FoxM1-P27KIP1 axis. mechanism - - -
MIR320A miRNA 27086911 Luciferase reporter assay cell line - - - - - No Reports FoxM1 is a direct target of miR-320a mechanism - - -
MIR320A miRNA 29152656 Colony formation assay; MTS assay; Viability assay cell line - - - - - No Reports miR‑320a inhibits cell growth and enhances sensitivity of GC cells to cisplatin and suppresses tumor growth in vivo. target - - -
MIR320A miRNA 29152656 Luciferase reporter assay cell line - - - - - No Reports miR‑320a directly targets ADAM10 in GC cells. target - - -
MIR331 miRNA 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Transfection of miR-331-3p inhi- bitor promoted BGC-823 cells proliferation, invasion and migration; transfection of miR-331-3p mimic suppressed MGC-803 cells proliferation, invasion and migration. target - - -
MIR331 miRNA 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between miR-331-3p and TGFBR1, circCACTIN and miR-331-3p target - - -
MIR331 miRNA 31182928 qRT-PCR; Western blot cell line - - - - - No Reports Both TGFBR1 mRNA and protein expression were regulated by circCACTIN through miR-331-3p target - - -
MIR335 miRNA 21822301 Cell invasion assay; Tumor metastasis formation assay; MTT proliferation assay cell line - - - - - No Reports miR-335 suppresses gastric cancer invasion and metastasis in vitro, but has no significant effects on cell proliferation of gastric cancer target - - -
MIR335 miRNA 21822301 Luciferase reporter assay cell line - - - - - No Reports SP1 and Bcl-w are direct targets of miR-335. miR-335 suppresses gastric cancer invasion and metastasis by targeting Bcl-w and SP1 target - - -
MIR338 miRNA 30308487 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-338-3p could suppress cell proliferation and induce cell apoptosis, suppresses metastasis target - - -
MIR338 miRNA 30308487 Bisulfite sequence cell line - - - - - No Reports hyper-methylation is the main cause of miR-338-3p depression target - - -
MIR338 miRNA 30308487 Luciferase reporter assay cell line - - - - - No Reports Rab14 is a direct target of miR-338-3p; miR-338-3p suppresses metastasis by targeting the Hhat-MMP signaling pathway target - - -
MIR338 miRNA 26617808 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports Enforced expression of miR-338-3p inhibited proliferation, migration and invasion of gastric cancer cells in vitro target - - -
MIR338 miRNA 26617808 Luciferase reporter assay cell line - - - - - No Reports ADAM17 is a direct target of miR-338-3 and prescued the miR-338-3p mediated inhibition of cell proliferation, migration and invasion target - - -
MIR338 miRNA 25945841 Cell invasion and migration assays cell line - - - - - No Reports miR-338-3p inhibited the migration and invasion of GC cells in vitro and inhibits the EMT process in GC cells. target - - -
MIR338 miRNA 25945841 Luciferase reporter assay cell line - - - - - No Reports miR-338-3p directly targeted zinc finger E-box-binding protein 2 (ZEB2) and metastasis-associated in colon cancer-1 (MACC1). target - - -
MIR340 miRNA 28057912 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Overexpression of miR-340 significantly reduced cell viability and proliferation, and induced cell apoptosis of GC cells target - - -
MIR34A miRNA 23264087 qRT-PCR cell line - - - - - No Reports miR-34a expression in gastric cancer cells was significantly reduced compared to the normal gastric epithelial cell line. mechanism - - -
MIR34A miRNA 23264087 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports In the overexpressing miR-34a in HGC-27 cells, cellular viability was significantly reduced, the proliferation index decreased significantly and cellular apoptosis was significantly increased, the number of cells passing through the transwell chamber was significantly reduced. mechanism - - -
MIR34A miRNA 24068565 qRT-PCR cell line - - - - - No Reports miR-34a expression was down-regulated in cisplatin-resistant cell lines mechanism - - -
MIR34A miRNA 24068565 Cell viability assay; Flow cytometry cell line - - - - - No Reports The over-expression of miR- 34a could improve the sensitivity of gastric cancer cells to cisplatin-based chemotherapies mechanism - - -
MIR381 miRNA 28193228 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vitro. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Luciferase reporter assay; Western blot; IHC cell line - - - - - No Reports TMEM16A was identified as a direct target of miR-381 and the expression of miR-381 was inversely correlated with TMEM16A expression in gastric cancer tissues target/prognosis 0.024 0.037 -
MIR421 miRNA 25041019 Cell proliferation assay cell line - - - - - No Reports The over-expression of miR-421 promoted gastric cancer cell growth and inhibited apoptosis of the BGC-823 gastric cancer cell line. mechanism - - -
MIR448 miRNA 26852749 Cell proliferation assay; Colony formation; Invasion assay cell line - - - - - No Reports miR-448 suppressed the GC cell proliferation, colony formation, and invasion mechanism - - -
MIR448 miRNA 26852749 Luciferase reporter assay cell line - - - - - No Reports ADAM10 was a direct target gene of miR-448 in GC cell mechanism - - -
MIR454 miRNA 30810117 Luciferase reporter assay cell line - - - - - No Reports STAT3 is the target gene of miR-454-3p. - - - -
MIR490 miRNA 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483 mechanism - - -
MIR490 miRNA 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Over expression of miR-490-3p resulted in obvious reduction in viability, migration and invasion as well as increase in apoptosis of GC cells. mechanism - - -
MIR494 miRNA 29568970 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Treatment with cinobufacini suppressed proliferation and promoted apoptosis of gastric cancer cells.knockdown of miR-494 in cinobufacini-treated cells promoted cell proliferation and inhibited cell apoptosis. Inhibition of BAG-1 in cinobufacini-treated cells partially abrogated the effects of miR-494 inhibitor on cell proliferation and apoptosis. mechanism - - -
MIR519D miRNA 29510377 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports miR-519d-3p inhibited MGC803 cell proliferation and invasion and delayed G1/S phase transition.miR-519d-3p/BCL6 axis inhibits cell proliferation, invasion, and cell cycle by regulating cyclin B1, E-cadherin, and MMP2 levels in GC cells. target - - -
MIR519D miRNA 29510377 Luciferase reporter assay cell line - - - - - No Reports BCL6 Is the Target of miR-519d-3p target - - -
MIR5590 miRNA 30029874 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports miR-5590-3p regulates GC cell proliferation and colony formation by G1/S transition target - - -
MIR5590 miRNA 30029874 RIP and Luciferase reporter assay cell line - - - - - No Reports miR-5590-3p as a direct target of DDX5. target - - -
MIR582 miRNA 29228422 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Overexpressed miR-582-5p could attenuate cell proliferation and viability capacities, as well as promoted cell apoptosis and cell cycle arrest at G0/G1 phase. target - - -
MIR582 miRNA 29228422 Luciferase reporter assay cell line - - - - - No Reports AKT3 was chosen as the target gene of miR-582-5p. Moreover, restoration of AKT3 could impair tumor suppression role of miR-582-5p on gastric cancer growth. target - - -
MIR589 miRNA 30012200 Cell invasion and migration assays cell line - - - - - No Reports Gain- and loss-of function experiments showed that miR-589 promoted cell migration, metastasis and invasion in vitro and lung metastasis in vivo. target - - -
MIR589 miRNA 30012200 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports miR-589 directly targeted LIFR to activate PI3K/AKT/c-Jun signaling. c-Jun bound to the promoter region of miR-589 and activated its transcription. target - - -
MIR613 miRNA 28701053 Luciferase reporter assay cell line - - - - - No Reports CDK9 is a direct target of miR-613 in gastric cancer target - - -
MIR613 miRNA 28701053 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports miR-613 suppressed cell proliferation and migration in gastric cancer target - - -
MIR615 miRNA 29501762 Cell proliferation assay; Flow cytometry; Cell migration assay cell line - - - - - No Reports miR-615-3p inhibits apoptosis and promotes proliferation and migration ability in SGC7901 cell line. Overexpression of CELF2 could reverse miR-615-3p's oncogenic functions stated before. prognosis < 0.05 - -
MIR644A miRNA 27983935 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be correlated to its suppressive effect on the EMT process. target - - -
MIR644A miRNA 27983935 Luciferase reporter assay cell line - - - - - No Reports CtBP1 is a putative target gene of miR-644a in GC cells target - - -
MIR675 miRNA 28848149 Luciferase reporter assay cell line - - - - - No Reports FADD is a potential target of miR-675; H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
MIR675 miRNA 28848149 Cell proliferation assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. target - - -
MIR711 miRNA 26735582 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports miR-711 could suppress SGC-7901 cell growth in a time-dependent manner. target - - -
MIR711 miRNA 26735582 Flow cytometry; Western blot cell line - - - - - No Reports miR-711 was found to downregulate CDK4 expression target - - -
MIR874 miRNA 23800944 Cell proliferation assay; Invasion and migration assays; Flow Cytometry cell line - - - - - No Reports Functional analyses indicated that ectopic miR-874 expression suppressed the growth, migration, invasion and tumorigenicity of GC cells, whereas miR-874 knockdown promoted these phenotypes. Down-regulation of Bcl-2, MT1-MMP, MMP-2 and MMP-9 and upregulation of caspase-3 activity and Bax were involved in miR-874 inducing cell apoptosis, and inhibiting migration and invasion. mechanism - - -
MIR874 miRNA 23800944 Luciferase reporter assay cell line - - - - - No Reports miR-874 directly interacts with a putative binding site of AQP3-3'UTR mechanism - - -
MIR9-1 miRNA 21225631 Luciferase reporter assay cell line - - - - - No Reports MiR-9 interacts with a putative binding site in the CDX2 3'-UTR mechanism - - -
MIR9-1 miRNA 21225631 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Suppression of miR-9 and overexpression of CDX2 elicit the same phenomenon of cell cycle arrest mechanism - - -
MIR9-1 miRNA 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports miR-9 suppressed the in vitro proliferation of gastric cancer cells through targeting cyclin D1; miR-9 attenuated the in vitro migration and invasion of gastric cancer cells through targeting Ets1 mechanism - - -
MIR9-1 miRNA 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted cyclin D1 and Ets1 in gastric cancer cells mechanism - - -
MIRLET7A1 miRNA 23519840 Cell invasion and migration assays cell line - - - - - No Reports Let-7a miRNA transfection significantly inhibited the migration and invasion in MNK-45 cells mechanism - - -
MIRLET7B miRNA 30237418 qRT-PCR cell line - - - - - No Reports let-7b-expression level of SGC7901/DDP cells was significantly lower than for its parental SGC7901 cells. target - - -
MIRLET7B miRNA 30237418 Cell proliferation assay; Flow cytometry; cell line - - - - - No Reports Upregulation of let-7b could reverse the DDP resistance of gastric cancer SGC7901/DDP cells by inducing cell viability inhibition and apoptosis when exposed to DDP treatment. target - - -
MIRLET7B miRNA 30237418 Luciferase reporter assay cell line - - - - - No Reports let-7b directly targets AURKB by binding to its 3'UTR region in DDP-resistant gastric cancer cells to DDP. target - - -
MIRLET7B miRNA 25288334 Cell proliferation assay; Invasion assay; Cell colony fomation assay cell line - - - - - No Reports suppressed the growth and invasive capacityof GC cells target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Luciferase reporter assay cell line - - - - - No Reports let-7b/g inhibited AKT2 expression by directly binding to its 3'UTR, reduced p-AKT (S473) activation and suppressed expression of the downstream effector pS6. target/prognosis - 0.001 -
MIRLET7B miRNA 25510669 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Ectopic expression of let-7b suppressed the growth, migration, invasion, and tumorigenicity of GC cells, whereas let-7b knockdown promoted these phenotypes. target - - -
MIRLET7B miRNA 25510669 Luciferase reporter assay cell line - - - - - No Reports Cthrc1 was a direct target of let-7b. target - - -
MIRLET7G miRNA 25288334 Cell proliferation assay; Invasion assay; Cell colony fomation assay cell line - - - - - No Reports suppressed the growth and invasive capacityof GC cells target - 0.051 -
MIRLET7G miRNA 25288334 Luciferase reporter assay cell line - - - - - No Reports let-7b/g inhibited AKT2 expression by directly binding to its 3'UTR, reduced p-AKT (S473) activation and suppressed expression of the downstream effector pS6. target - 0.051 -
NMRAL2P pseudogene/lncRNA 32469171 Cell proliferation assay; Flow cytometry; Transwell assay cell line - - - - - No Reports NMRAL2P overexpression induced a more malignant phenotype and significantly inhibited the expression of ACOT7. mechanism - - -
NMRAL2P pseudogene/lncRNA 32469171 Luciferase reporter assay cell line - - - - - No Reports NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. mechanism - - -
NOTCH4 protein-coding 25511451 Cell proliferation assay cell line - - - - - No Reports Notch4 activation promoted GC growth in vitro, while Notch4 inhibition using ICN4 siRNA had opposite effects. target - - -
PCAT18 lncRNA 32119960 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports PCAT18 down-expression promoted proliferation, migration and invasion of gastric cancer cells. target - - -
PCAT18 lncRNA 32119960 Luciferase reporter assay; RIP cell line - - - - - No Reports PCAT18 is the direct target of miR-135b target - - -
PDCD4 protein-coding 27634902 Flow cytometry cell line - - - - - No Reports MKN45 cells transfected with the PDCD4 siRNA showed suppression of cell apoptosis, whereas overexpression of PDCD4 significantly promoted cell apoptosis target - - -
PDCD4 protein-coding 27634902 Luciferase reporter assay cell line - - - - - No Reports PDCD4 is a direct target of miR-208a-3p target - - -
PIK3R1 protein-coding 30927924 Western blot cell line - - - - - No Reports CDDP-resistant GC cells showed obvious increases in the expression of PIK3R1 mRNA and protein levels. target - - -
PIK3R1 protein-coding 30927924 Luciferase reporter assay; Western blot; qRT-PCR cell line - - - - - No Reports PIK3R1 is a direct target of miR-198; miR-198 mimics significantly inhibited PIK3R1 mRNA and protein levels and that ectopic PIK3R1 expression abolished the influence caused by miR-198 overexpression. target - - -
PKM protein-coding 28588255 Cell proliferation assay; Cell colony formation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports knockdown of PKM2 can inhibit GC cell proliferation, G1-S phase transition,especially, attenuate GC cell migration target/prognosis 0.006 - -
PKM protein-coding 28588255 Western blot; cell transduction cell line - - - - - No Reports PKM2 mediates cell migration and autophagy via the PI3K/Akt signaling pathway. target/prognosis 0.006 - -
POU2F1 protein-coding 25678401 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports POU2F1 directly binds to the ECD gene promoter and induces ECD expression. - - - -
POU2F1 protein-coding 25678401 Cell invasion and migration assays cell line - - - - - No Reports POU2F1 silencing blocked the migration, invasion, and EMT processes induced by ACK1 overexpression in gC cells - - - -
RASSF1 protein-coding 26735582 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports The expression of RASSF1A could suppress the viability, migration and invasion capacity of SGC-7901 cell in vitro. target - - -
RASSF1 protein-coding 26735582 miRNA microarray; qRT-PCR cell line - - - - - No Reports The expression of miR-711 was higher in the pcDNA3.1-RASSF1A-transfected SGC-7901 cells than in the pcDNA3.1-vector-transfected SGC-7901 cells. target - - -
SFRP1 protein-coding 29886152 Cell proliferation assay; Cell invasion assay; cell line - - - - - No Reports SFRP1 partially reverses the effects of miR-208a on proliferation and invasion in GC target - - -
SFRP1 protein-coding 29886152 Luciferase reporter assay cell line - - - - - No Reports SFRP1 is a direct target of MiR-208a in GC cells target - - -
SIRT1 protein-coding 30250020 Cell invasion and migration assays cell line - - - - - No Reports knockdown of SIRT1 promoted GC cell migration and invasion in vitro and metastasis in vivo. Forced expression of SIRT1 in GC cells had the opposite effects. SIRT1 inhibited the expression of ARHGAP5 by physically associating with transcription factor c-JUN and deacetylating and inhibiting the transcriptional activity of c-JUN. target - - -
SIRT1 protein-coding 30250020 Luciferase reporter assay cell line - - - - - No Reports SIRT1 inhibits expression of ARHGAP5 by physically interacting with and deacetylating c-JUN target - - -
SKP2 protein-coding 27572672 Cell proliferation assay cell line - - - - - No Reports Defective regulation of Skp2 or the presence of Skp2 inhibitor contribute to decreased proliferation in human gastric cancer cell lines.Skp2 inhibitor inhibits the proliferation of gastric cancer cells in a dose‑dependent manner target - - -
SNHG7 lncRNA 29131253 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports The in vitro experiments showed that after SNHG7 expression was interfered, the proliferation of gastric cancer cells was inhibited with an increase in apoptotic rate and arrest of cell cycle in G1/G0 phase. target - - -
SNORD105B snoRNA 29554660 Cell proliferation assay; Invasion and migration assay; Clonogenic assay cell line - - - - - No Reports Snord105b promotes the proliferation, migration,invasion and clonogenictiy in multiple GC cell lines. The oncoqenic activity of snord105b was also confirmed with in vivo data. Mechanistically, snord105b specifically bound to ALDOA and affected C-myc, which plays a key role in carcinogenesis and tumor development. target - - -
SNORD105B snoRNA 29554660 RIP assay; CHIRP-MS cell line - - - - - No Reports Snord105b is associated with the ALDOA protein target - - -
SOX9 protein-coding 30154451 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports SOX9 directly binds to the COL10A1 promoter and activates its transcription. prognosis 0 - -
STAT3 protein-coding 30810117 Luciferase reporter assay cell line - - - - - No Reports STAT3 is the target gene of miR-454-3p. mechanism - - -
SUFU protein-coding 27810403 Luciferase reporter assay cell line - - - - - No Reports SUFU is the functional target of miRNA-194 target - - -
TET2 protein-coding 31242038 Apoptosis assay; Migration assay cell line - - - - - No Reports TET2 decreased gastric cancer cell survival and suppressed metastasis prognosis < 0.01 - -
TGFBR1 protein-coding 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports TGFBR1 played a vital role in GC cells proliferation, invasion, migration, and EMT, which was positively regulated by circCACTIN. mechanism - - -
TGFBR1 protein-coding 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between miR-331-3p and TGFBR1. mechanism - - -
TMEM41A protein-coding 30015937 Cell proliferation assay; Invasion and migration assays; Cell immunofluorescence for cytoskeleton stain and autophagy cell line - - - - - No Reports Knockdown of TMEM41A in vitro decreased the GC cell migration ability by regulating epithelial-to-mesenchymal transition and cell autophagy, via the upregulation of E-cadherin and downregulating N-cadherin expression in GC cells. target - - -
TNK2 protein-coding 25678401 Cell invasion and migration assays cell line - - - - - No Reports ACK1 induces EMT, invasion, and metastasis target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 Western blot; Luciferase reporter assay; IHC cell line - - - - - No Reports ACK1 up-regulates ECD expression by increasing the level of POU2F1. target/prognosis < 0.001 - -
XRCC5 protein-coding 30217218 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports knockdown of XRCC5 attenuated the cell clonogenicity, proliferation,invasion and migration. prognosis < 0.01 - -
XRCC5 protein-coding 30217218 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. prognosis < 0.01 - -
YBX1 protein-coding 25959498 RNA pull-down assay cell line - - - - - No Reports lncRNA GAS5 interacts with the transcriptional activator YBX1. target - - -
YBX1 protein-coding 25959498 Flow cytometry cell line - - - - - No Reports YBX1 depletion reduces G1 phase arrest by decreasing p21 expression. target - - -
ZNF143 protein-coding 27449034 Cell invasion and migration assays cell line - - - - - No Reports ZNF143 knockdown inhibits the migration and invasion of gastric cancer cells, and overexpression contributes to the migration and invasion of GC cells. target - - -
ZNF143 protein-coding 27449034 Western blot; cell transfection cell line - - - - - No Reports Overexpression of ZNF143 re- duced the expression of epithelial cell marker (E-cadherin) and induced the expression mesenchymal cell marker (N-cadherin, Vimentin), related transcription factors (snail, slug), and upregulated the expression of phosphorylation AKT. target - - -
  Summary of Gene Type.
Gene Type Count
circRNA 16
lncRNA 79
miRNA 240
protein-coding 361
pseudogene 3
snoRNA 5
  Summary of Functional Type.
Functional Type Count
diagnosis 5
prognosis 211
mechanism 143
target 360
target,diagnosis 1
target;prognosis 1
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
About Us      Admin
备案/许可证编号：苏ICP备2021043822号