MKGC: a curated molecular knowledgebase for gastric cancer
 Browse All GCs By
  Summary of source.
Source Count
blood 4
cell line 365
exosomes in plasma 2
mice 62
plasma 2
PPLF 1
serum 6
tissue 259
  Browse for circRNA
Official
Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
hsa_circ_0000199 circRNA 30927924 qRT-PCR tissue China 149 0 - - No Reports The expression of circAKT3 was higher in CDDP-resistant GC tissues and cells than in CDDP-sensitive samples. It was an independent risk factor for disease-free survival. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Cell cytotoxicity assay; Clonogenic assay; Flow ytometry cell line - - - - - No Reports circAKT3 promotes DNA damage repair and inhibits the apoptosis of GC cells in vitro. Downregulation of circAKT3 facilitates cisplatin sensitivity of CDDP-resistant GC cells in vitro. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Luciferase reporter assay: RNA pull-down; FISH cell line - - - - - No Reports circAKT3 and miR-198 were colocalized in the cytoplasm; circAKT3 exerts its function by sponging miR-198. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Xenograft mice models mice - - - - - No Reports circAKT3 promotes DNA damage repair and inhibits the apoptosis of GC cells in vivo. target/prognosis - 0.0293 0.91
hsa_circ_0000993 circRNA 30215537 qRT-PCR cell line - - - - - No Reports hsa_circ_0000993 has a lower expression level in highly aggressive cell line BGC-823 as compared with poorly aggressive cell line SGC-7901 target - - -
hsa_circ_0000993 circRNA 30215537 FISH cell line - - - - - No Reports FISH showed that hsa circ 0000993 was expressed both in nucleus and cytoplasm and mainly in nucleus of gastric cancer cells. target - - -
hsa_circ_0000993 circRNA 30215537 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports Increased expression of hsa circ 0000993 was associated with decreased migration, invasion and proliferation of gastric cancer cells. target - - -
hsa_circ_0000993 circRNA 30215537 Luciferase reporter assay cell line - - - - - No Reports hsa_circ_0000993 acts as a miRNA sponge for miR-214-5p target - - -
hsa_circ_0004771 circRNA 30717751 qRT-PCR tissue China 80 80 Up - No Reports Upregulated in GC tissues and GC cells. prognosis 0.0019 0.004 -
hsa_circ_0004771 circRNA 30717751 qRT-PCR exosomes in plasma China 40 40 Up - No Reports circNRIP1 can be transmitted by exosomal communication between GC cells, and exosomal circNRIP1 promoted tumour metastasis in vivo. prognosis 0.0019 0.004 -
hsa_circ_0004771 circRNA 30717751 Pull-down assay; Luciferase reporter cell line - - - - - No Reports circNRIP1 serves as a miRNA sponge of miR-149-5p prognosis 0.0019 0.004 -
hsa_circ_0004771 circRNA 30717751 Cell proliferation assay; Invasion and migration assay; Clonogenic assay cell line - - - - - No Reports Knockdown of circNRIP1 inhibits the proliferation, migration, invasion and expression level of AKT1 in GC cells in vitro prognosis 0.0019 0.004 -
hsa_circ_0092303 circRNA 31182928 qRT-PCR tissue China 30 30 Up - No Reports CircCACTIN expression was obviously up-regulated in GC tissues and cell lines. target - - -
hsa_circ_0092303 circRNA 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports CircCACTIN promotes proliferation, invasion, and migration of GC cells in vitro. target - - -
hsa_circ_0092303 circRNA 31182928 Xenograft mice models mice - - - - - No Reports circCACTIN efficiently promoted GC tumor formation and EMT in vivo target - - -
hsa_circ_0092303 circRNA 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between circCACTIN and miR-331-3p. target - - -
  Summary of Functional Type.
Functional Type Count
diagnosis 5
prognosis 211
mechanism 143
target 360
target,diagnosis 1
target;prognosis 1
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
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