MKGC: a curated molecular knowledgebase for gastric cancer
 Browse All GCs By
  Summary of source.
Source Count
blood 4
cell line 365
exosomes in plasma 2
mice 62
plasma 2
PPLF 1
serum 6
tissue 259
  Summary of Gene Type.
Gene Type Count
circRNA 16
lncRNA 79
miRNA 240
protein-coding 361
pseudogene 3
snoRNA 5
  Browse for mechanism
Official
Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
ADGRE5 protein-coding 26034356 Cell proliferation assay; Invasion assay cell line - - - - - No Reports Exosomes isolated from SGC/wt (high CD97 expression ) cells significantly promoted tumor cell proliferation in a dose-dependent manner in vitro. SGC/wt exosomes also significantly elevated the invasiveness of both SGC/wt and SGC/kd (low CD97 expression) cells as compared to the exosomes released by SGC/kd cells. mechanism - - -
AGO2 protein-coding 23775134 IHC tissue China 371 10 Up - No Reports Ago2 expression levels in primary GC and corresponding lymph node metastases were significantly higher compared with healthy controls. Ago2 was different between HER-2 positive and HER-2 negative groups. And there was a great correlation between Ago2 expression and the tumor differentiation, lymph node invasion and clinical stage. Ago2 was also correlated to patients' gender which may suggest a possible role of hormonal signal in the mechanisms of Ago2. mechanism - - -
AKAP12 protein-coding 15258566 MSP cell line - - - - - No Reports Two isoforms AKAP12A and AKAP12B are independently expressed and were absent from the majority of human gastric cancer cells. 5' CpG islands of both AKAP12A and AKAP12B are frequently hypermethylated in GC cells. DNA methylation is directly involved in the transcriptional silencing of AKAP12 in gastric cancer cells. mechanism - - -
AKAP12 protein-coding 15258566 Cell proliferation assay; Colony formation assay; cell line - - - - - No Reports The restoration of AKAP12A in AKAP12-nonexpressing cells reduced colony formation and induced apoptotic cell death mechanism - - -
AKAP12 protein-coding 15258566 Bisulfite sequencing tissue Korea 18 18 - - No Reports Hypermethylation of AKAP12A CpG island was also detected in 56% (10 of 18) of primary gastric tumors. mechanism - - -
BCL2L2 protein-coding 16707418 Cell invasion and migration assays - - - - - No Reports Bcl-w enhances GC cell invasion and migration. mechanism - - -
BCL2L2 protein-coding 16707418 Gelatin zymography; Western blot cell line - - - - - No Reports Bcl-w overexpression increased matrix metalloproteinase-2 (MMP-2) expression, and synthetic or natural inhibitors of MMP-2 abolished Bcl-w induced cell invasion. Bcl-w overexpression also activated phosphoinositide 3-kinase (PI3K), Akt, and Sp1. mechanism - - -
BTG4 protein-coding 19576178 Bisulfite sequencing cell line - - - - - No Reports Most CpG dinucleotides were methylated in gastric cancer cell lines, the methylation was absent in GES-1 cells mechanism - - -
BTG4 protein-coding 19576178 qRT-PCR tissue China 38 38 - - No Reports BTG4 was significantly down-regulated in tumor tissues compared to normal tissues. mechanism - - -
BTG4 protein-coding 19576178 MS-PCR tissue China 38 38 - - No Reports BTG4 was methylated in 28 of 38 primary gastric cancers tested, no methylation was detected in normal gastric samples. Its hypermethylation was corrleated with the type of cell differentiation and metastasis mechanism - - -
BTG4 protein-coding 19576178 Flow cytometry; Cell growth assay cell line - - - - - No Reports BTG4 reexpression sensitizes gastric cancer cells to proapoptotic stimuli and reduces colony formation in vitro. mechanism - - -
BTG4 protein-coding 19576178 Xenograft mice models mice - - - - - No Reports BTG4 reexpression sensitizes tumor growth in mice. mechanism - - -
CCND1 protein-coding 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports ETS1 or CCND1 knockdown significantly suppressed gastric cancer cell growth, similar to miR-193a-3p overexpression. mechanism - - -
CCND1 protein-coding 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct targets of miR-193a-3p mechanism - - -
CCND1 protein-coding 23383271 qRT-PCR tissue China 86 86 Up - No Reports cyclin D1 was found to be up-regulated and inversely correlated with the expression of miR-9 in gastric cancer tissues and cell lines. mechanism - - -
CCND1 protein-coding 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro. mechanism - - -
CCND1 protein-coding 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted the 3'-UTR of cyclin D1 and Ets1 mechanism - - -
CCND2 protein-coding 14612939 MS-PCR tissue Japan 34 21 Up(Methylation) Up(Methylation) No Reports Hypomethylation of the cyclin D2 promoter was found in 24 (71%) of the 34 tumor tissues and in 6 (29%) of the 21 corresponding non-neoplastic mucosa, the incidence being significantly different (p=0.002; Fisher's exact test). Moreover, hypomethylation of cyclin D2 was more common in stage III and IV tumors than in stage I and II tumors. mechanism - - -
CCND2 protein-coding 14612939 qRT-PCR tissue China 23 23 - - No Reports Levels of cyclin D2 mRNA expression in tumor tissues with cyclin D2 hypomethylation (33.08±45.78) tended to be higher than those with cyclin D2 hypermethylation; levels of cyclin D2 mRNA expression in tumor tissues with metastasis (35.88+45.56) were significantly higher than those in tumors without metastasis. mechanism - - -
CDC42 protein-coding 25152372 Western blot tissue China 18 18 Up - No Reports The protein expression of CDC42 was significantly up-regulated in cancer tissues. mechanism - - -
CDC42 protein-coding 25152372 Luciferase reporter assay cell line - - - - - No Reports CDC42 is the direct target of miR-133a mechanism - - -
CDH1 protein-coding 30063010 qRT-PCR tissue China 67 67 Up - No Reports The mRNA level of CDH1 was found reduced in the GC tissues and there is a negative correlation between the expression of CDH1 and miR-217 in the GC samples. mechanism - - -
CDH1 protein-coding 30063010 Luciferase reporter assay cell line - - - - - No Reports CDH1 is a direct target of miR-217 mechanism - - -
CEBPA protein-coding 20386538 IHC tissue Portugal 54 - - - No Reports In GC, C/EBPa staining was mostly nuclear with some residual cytoplasmic positivity. In GC, C/ EBPa was considered downregulated in 30% of the tumors. No statistical significant relationships were found between C/EBPa expression and any clin- icopathological features of the cases. mechanism - - -
CEBPA protein-coding 20386538 Cell proliferation assay cell line - - - - - No Reports We observed a significant decrease in proliferation in C/EBPa-transfected cells. mechanism - - -
CHD5 protein-coding 19840376 qRT-PCR cell line - - - - - No Reports CHD5 expression was down-regulated in all of gastric cancer cell lines used (100%, 7/7). mechanism - - -
CHD5 protein-coding 19840376 MS-PCR; BGS tissue/cell line - - - - - No Reports Methylation of CHD5 promoter was detected in all of seven gastric cancer cell lines and in the majority of primary gastric carcinoma tissues examined (73%, 11/15). mechanism - - -
CHD5 protein-coding 19840376 Colony formation assay cell line - - - - - No Reports ectopic expression of CHD5 in gastric cancer cells led to a significant growth inhibition. mechanism - - -
CHFR protein-coding 20300977 MS-PCR; BGS tissue China 123 123 Up(Methylation) - No Reports The methylation frequencies of CHFR in cancer tissues were significantly higher than those in corresponding normal gastric mucosae. The methylation status of CHFR was inversely related to the tumor size, tumor invasion depth and tumor differentiation in GC patients mechanism - - -
CHFR protein-coding 20300977 RT-PCR; IHC tissue China 123 - - - No Reports The expression of the protein and mRNA decreased remarkably in the patients with aberrant promoter methylation of CHFR genes. mechanism - - -
CHFR protein-coding 20300977 IHC tissue China 123 - - - No Reports The protein expression of CHFR were significantly correlated with tumor differentiation. mechanism - - -
CIAPIN1 protein-coding 19471113 IHC tissue China 147 147 Down - No Reports The expression of CIAPIN1 in gastric antral mucosa was progressively reduced along the sequence of normal/inflammatory gastric mucosa-atrophy-intestinal metaplasia-dysplasia-adenocarcinoma. The downregulation of CIAPIN1 in cancerous tissues was further confirmed by western blotting. No relationship between the expression level of CIAPIN1 and the clinicopathological parameters such as age, gender, differentiation, TNM stage and the existence of metastasis was found in gastric cancer patients. mechanism - - -
CIAPIN1 protein-coding 19471113 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Ectopic expression of CIAPIN1 by cDNA transfection resulted in suppression of cell proliferation and inhibition of cell cycle progression while knockdown of CIAPIN1 with siRNA accelerated cell proliferation and promoted cell cycle progression in SGC7901 and MKN28 gastric cancer cells. mechanism - - -
CORO1C protein-coding 22974233 IHC tissue China 152 - - - No Reports The expression of coronin 3 was higher in the highly metastatic sub-cell line MKN28-M, which we established in our laboratory. We also demonstrated that the expression of coronin 3 was remarkably higher in lymph lode metastases than in primary gastric cancer tissues, and over-expression of coronin 3 was correlated with the increased clinical stage and lymph lode metastasis. mechanism - - -
CORO1C protein-coding 22974233 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports Coronin 3 is expressed in the cytoplasm of gastric cancer cells. Coronin 3 promoted the migratory, invasive, and in vivo metastatic abilities of gastric cancer cells. mechanism - - -
CORO1C protein-coding 22974233 Xenograft mice models mice - - - - - No Reports Knockdown of coronin 3 significantly reduced liver metastasis in mice after tail vein injection of gastric cancer cells. mechanism - - -
CTBP1 protein-coding 27983935 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Suppression of CtBP1 Inhibits Proliferation, Invasion, and EMT Progression in GC Cells mechanism - - -
CTBP1 protein-coding 27983935 Luciferase reporter assay cell line - - - - - No Reports CtBP1 is a putative target gene of miR-644a in GC cells mechanism - - -
CTHRC1 protein-coding 25510669 qRT-PCR tissue China 47 47 Down - No Reports Cthrc1 is upegulated in GC and inversely correlated with let-7b expression. mechanism - - -
CTHRC1 protein-coding 25510669 Luciferase reporter assay cell line - - - - - No Reports Cthrc1 was a direct target of let-7b. mechanism - - -
DDX5 protein-coding 30029874 qRT-PCR tissue China 42 42 Up - No Reports DDX5 expression in gastric cancer is significantly higher in corresponding non-cancerous gastric tissues, and the expression of miR-5590-3p and DDX5 was significantly negatively correlated in gastric cancer mechanism - - -
DDX5 protein-coding 30029874 RIP and Luciferase reporter assay cell line - - - - - No Reports miR-5590-3p as a direct target of DDX5 mechanism - - -
DUSP5P1 lncRNA 30733230 Luciferase reporter assay; Western blot; qRT-PCR; ChIP-PCR cell line - - - - - No Reports DUSP5P1 is a direct downstream target of C8orf76 mechanism - - -
DUSP5P1 lncRNA 30733230 Cell proliferation assay; Cell colony formation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports DUSP5P1 promotes gastric cancer cell growth in vitro. mechanism - - -
DUSP5P1 lncRNA 30733230 Xenograft mice models mice - - - - - No Reports Significantly more proliferating cells and fewer apopto- tic cells were shown in DUSP5P1-transfected xenografts as compared with control group by Ki-67 and TUNEL assays. mechanism - - -
EGFR protein-coding 30530570 IHC tissue China 40 40 - - No Reports EGFR and CDK6 are up-regulated in GC and negatively correlated with miR-1296-5p mechanism - - -
EGFR protein-coding 30530570 Luciferase reporter assay cell line - - - - - No Reports EGFR and CDK6 are directly targets of miR-1296-5p mechanism - - -
ELAVL1 protein-coding 26819420 Cell proliferation assay cell line - - - - - No Reports Over-expression of HuR resulted in the increase in the cell activity of gastric cancer (P<0.001). Suppression of HuR decreased the cell activity of gastric cancer (P=0.001). mechanism - - -
ELAVL1 protein-coding 26819420 Western blot cell line - - - - - No Reports The protein level of HuR in the gastric cancer cells was higher than that in the control cells. mechanism - - -
ETS1 protein-coding 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports ETS1 or CCND1 knockdown significantly suppressed gastric cancer cell growth, similar to miR-193a-3p overexpression. mechanism - - -
ETS1 protein-coding 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct targets of miR-193a-3p mechanism - - -
ETS1 protein-coding 23383271 qRT-PCR tissue China 86 86 Up - No Reports Ets1 was found to be up-regulated and inversely correlated with the expression of miR-9 in gastric cancer tissues and cell lines. mechanism - - -
ETS1 protein-coding 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro. mechanism - - -
ETS1 protein-coding 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted the 3'-UTR of cyclin D1 and Ets1 mechanism - - -
FOXM1 protein-coding 27086911 qRT-PCR tissue China 14 14 Up - No Reports miR-320a expression correlates inversely with expression of FoxM1, a key cell cycle regulator involved in gastric carcinoma. FOXM1 expression was increased in GC tissues. mechanism - - -
FOXM1 protein-coding 27086911 Luciferase reporter assay cell line - - - - - No Reports FoxM1 is a direct target of miR-320a mechanism - - -
H19 lncRNA 28848149 qRT-PCR tissue China 34 34 Up - No Reports H19 was increased in gastric cancer cell lines and tissues. Overexpression of H19 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 inhibited these effects. By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. mechanism - - -
H19 lncRNA 28848149 Cell proliferation assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. mechanism - - -
HOTAIR lncRNA 30810117 ISH tissue China 30 30 Up - No Reports HOTAIR expression of cancer tissues was significantly increased compared with that of non_x005ftumor tissues; lncRNA HOTAIR was negatively correlated with miR-454-3p expression in gastric cancer tissues. mechanism - - -
HOTAIR lncRNA 30810117 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports HOTAIR knockdown had anti-tumor effects that suppressed gastric cancer cell proliferation by increasing cell apoptosis and keeping the cell cycle in G1 phase. mechanism - - -
MAPK1 protein-coding 32293550 qRT-PCR; Western blot tissue China 30 30 Up - No Reports The mRNA level and protein level of MAPK1 were increased in gastric cancer tissues and cells. There was a positive correlation between levels of MAPK1 and LINC00483 in gastric cancer tissues. mechanism - - -
MAPK1 protein-coding 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. mechanism - - -
MAPK1 protein-coding 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 positively regulated MAPK1 by sponging miR‑490‑3p in gastric cancer cells mechanism - - -
MIR106B miRNA 30907988 qRT-PCR; FISH tissue China 10 - - - No Reports miR-106b was increased in the metastasis tissues compared with non-metastasis tissues. mechanism - - -
MIR106B miRNA 30907988 Cell invasion and migration assays cell line - - - - - No Reports miR-106b inhibitor could promote the apoptosis of gastric cancer cells mechanism - - -
MIR106B miRNA 30907988 Luciferase reporter assay cell line - - - - - No Reports miR-106b targeted ALEX1 in gastric cancer cells mechanism - - -
MIR106B miRNA 30907988 Xenograft mice models mice - - - - - No Reports Down-regulation of miR-106b inhibited gastric cancer in vivo. mechanism - - -
MIR1296 miRNA 30530570 qRT-PCR tissue China 40 40 - - No Reports miR-1296-5p was down-regulated in gastric cancer tissue and cell lines, and low expression levels of miR-1296-5p were associated with advanced clinical stage. mechanism - - -
MIR1296 miRNA 30530570 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports miR-1296-5p inhibited cell proliferation, migration, and invasion in SGC-7901 and MGC-803 cells. mechanism - - -
MIR1296 miRNA 30530570 Luciferase reporter assay cell line - - - - - No Reports CDK6 and EGFR as novel targets of miR-1296-5p by a luciferase activity assay mechanism - - -
MIR137 miRNA 26102366 qRT-PCR tissue China 100 100 Down Down No Reports Expression of miR-137 in GC tissues was lower than that in adjacent tissues in statistically significant differences. The patients who have the lower levels of miR-137 expression were associated with high-grade and late-stage tumors. mechanism - - -
MIR137 miRNA 26102366 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports The re-introduction of miR-137 into gastric cancer cells was able to inhibit cell proliferation, migration and invasion. mechanism - - -
MIR137 miRNA 26102366 Xenograft mice models mice - - - - - No Reports The in vivo experiments demonstrated that the miR-137 overexpression can reduce the gastric cancer cell proliferation and metastasis. mechanism - - -
MIR137 miRNA 26102366 Luciferase reporter assay; Western blot cell line - - - - - No Reports miR-137 targets AKT2 in GC mechanism - - -
MIR145 miRNA 28490034 qRT-PCR tissue China 20 20 Up - No Reports miR-145 expression was significantly decreased in GC tissues compared with that in adjacent normal tissue samples, and miR-145 level had a significant negative correlation with CRNDE level. mechanism - - -
MIR145 miRNA 28490034 Luciferase reporter assay cell line - - - - - No Reports miR-145 target gene E2F3 was strongly expressed following CRNDE competitive molecular sponging of miR-145. mechanism - - -
MIR15A miRNA 26894855 qRT-PCR tissue China 21 21 - - No Reports The expression of miR-15a is significantly reduced in gastric cancer and the protein expression levels of Bmi-1 are inversely correlated with miR-15a (P = 0.034) in gastric cancer patient samples. mechanism - - -
MIR15A miRNA 26894855 Cell proliferation assay cell line - - - - - No Reports miR-15a suppressed gastric cancer invasion; miR-15a suppressed the proliferation of gastric cancer cells via downregulation of Bmi-1. mechanism - - -
MIR15A miRNA 26894855 Luciferase reporter assay cell line - - - - - No Reports Bmi-1 is a direct target of miR-15a in gastric cancer cell lines. mechanism - - -
MIR15A miRNA 26894855 qRT-PCR; IHC tissue China 21 - - - No Reports The expression of Bmi-1 is inversely correlated with miR-15a in gastric tumor tissues mechanism - - -
MIR181A1 miRNA 24531888 qRT-PCR tissue China 9 9 - - No Reports Compared with three non-tumour tissues, the expression of miR-181a in three gastric cancer cells was significantly increased; miR-181a expression was inversely correlated with ATM. mechanism - - -
MIR181A1 miRNA 24531888 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports miR-181a affects the proliferation and metastatic potential of gastric cancer cells. mechanism - - -
MIR181A1 miRNA 24531888 Luciferase reporter assay - - - - - No Reports miR-181a Directly Inhibited the Expression of ATM Through ATM 3'UTR mechanism - - -
MIR191 miRNA 24603541 qRT-PCR cell line China - - Up - Examination of miR-191 and miR-425 expression in four GC cell lines (HGC-27,MGC-803, MKN-45 and SGC-7901) indicated an obvious upregulation of miR-191/425 in HGC-27, MGC-803, and SGC-7901 cell lines when compared to adjacent non-tumor tissues and five normal gastric tissues from healthy people mechanism - - -
MIR193A miRNA 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports Ectopic expressions of miR-193a-5p and miR-193a-3p revealed that they both inhibited gastric cancer cell growth, but only miR-193a-3p significantly suppressed cell invasion ability. mechanism - - -
MIR193A miRNA 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct target of miR-193a-3p mechanism - - -
MIR193B miRNA 27071318 qRT-PCR tissue China 50 50 Down - No Reports miR-193b was significantly reduced in GC tissues compared with the adjacent normal gastric tissues. Moreover, lower-level of miR-193b was also associated with a more aggressive GC phenotype. mechanism - - -
MIR193B miRNA 27071318 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-193b can inhibit the proliferation, migration and invasion of HGC-27 and MGC-803 GC cells. mechanism - - -
MIR198 miRNA 30927924 Cell cytotoxicity assay; Clonogenic assay; Flow ytometry cell line - - - - - No Reports Overexpression of miR-198 inhibited cell viability and induced apoptosis in SGC7901CDDP and BGC823CDDP cells. mechanism - - -
MIR198 miRNA 30927924 Luciferase reporter assay: RNA pull-down; FISH cell line - - - - - No Reports circAKT3 and miR-198 were colocalized in the cytoplasm; circAKT3 exerts its function by sponging miR-198. mechanism - - -
MIR203A miRNA 25373785 qRT-PCR tissue China 50 50 Down - Related miR-203 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with important functional consequences. mechanism - - -
MIR203A miRNA 25373785 Cell proliferation assay; Invasion and migration assays; Clonal formation assay cell line - - - - - No Reports Ectopic expression of miR-203 dramatically suppressed cell proliferation and invasion. We found that miR-203 strongly reduced the expression of CASK oncogene in GC cells. Similar to the restoring miR-203 expression, CASK down-regulation inhibited cell growth and invasion, whereas CASK over-expression rescued the suppressive effect of miR-203. These results can also be found in nude mice. In clinical specimens, CASK was over-expressed in tumors and H. pylori positive tissues and its mRNA levels were inversely correlated with miR-203 expression mechanism - - -
MIR203A miRNA 25373785 Luciferase reporter assay cell line - - - - - No Reports CASK was a direct target of miR-203 in GC cells. mechanism - - -
MIR203A miRNA 25373785 Xenograft mice models mice - - - - - No Reports MiR-203 suppressed tumor growth of GC cells in nude mice. mechanism - - -
MIR204 miRNA 29386218 CDX tissue 50gc, 50 non-gc - - Not Related LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage, lymph node metastasis, and shorter survival time. Furthermore, knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts. mechanism - - -
MIR217 miRNA 30063010 qRT-PCR exosomes in plasma China 67 67 Up - No Reports Exosomal miR-217 was increased in the GC patients. mechanism - - -
MIR217 miRNA 30063010 qRT-PCR tissue China 67 67 Up - No Reports The expression of miR-217 was significantly up-regulated in GC tissues. mechanism - - -
MIR217 miRNA 30063010 Luciferase reporter assay cell line - - - - - No Reports CDH1 is a direct target of miR-217 mechanism - - -
MIR217 miRNA 30063010 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports miR-217 overexpression contributes to increased GC cells proliferation mechanism - - -
MIR302B miRNA 28743112 qRT-PCR tissue China 20 20 Down - No Reports MiR-302b-3p expression was decreased in gastric cancer tissues and cell lines. mechanism - - -
MIR302B miRNA 28743112 Cell proliferation assay; Cell colony formation assay; Apoptosis assay; Flow cytometry cell line - - - - - No Reports Enforced expression of miR-302b suppressed cell proliferation and cell cycle G1-S transition and induced apoptosis. mechanism - - -
MIR302B miRNA 28743112 Luciferase reporter assay cell line - - - - - No Reports IGF-1R was found to be a direct target of miR-302b-3p, and silencing of IGF-1R resulted in the same biological effects as those induced by miR-302b-3p overexpression in gastric cancer cells. Both overexpression of miR-302b-3p and silencing of IGF-1R decreased AKT phosphorylation, which modulated AKT related cell cycle regulators (cyclin A2, cyclin D1, CDK2, and CDk6) and apoptotic protein Bax/Bcl-2. mechanism - - -
MIR320A miRNA 27086911 qRT-PCR tissue China 14 14 Down - No Reports miR-320a expression is decreased in human gastric cancer tissues and correlates inversely with expression of FoxM1, a key cell cycle regulator involved in gastric carcinoma. By contrast, the expression of P27KIP1, a downstream effector of FoxM1, correlates positively with miR-320a levels. mechanism - - -
MIR320A miRNA 27086911 Clone formation assay cell line - - - - - No Reports miR-320a inhibits gastric cancer cell proliferation by suppressing activity in the FoxM1-P27KIP1 axis. mechanism - - -
MIR320A miRNA 27086911 Xenograft mice models mice - - - - - No Reports nude mice injected with BGC-823 gastric cancer cells expressing a miR-320a inhibitor exhibit faster tumor growth than mice injected with control cells. mechanism - - -
MIR320A miRNA 27086911 Luciferase reporter assay cell line - - - - - No Reports FoxM1 is a direct target of miR-320a mechanism - - -
MIR34A miRNA 23264087 qRT-PCR cell line - - - - - No Reports miR-34a expression in gastric cancer cells was significantly reduced compared to the normal gastric epithelial cell line. mechanism - - -
MIR34A miRNA 23264087 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports In the overexpressing miR-34a in HGC-27 cells, cellular viability was significantly reduced, the proliferation index decreased significantly and cellular apoptosis was significantly increased, the number of cells passing through the transwell chamber was significantly reduced. mechanism - - -
MIR34A miRNA 24068565 qRT-PCR cell line - - - - - No Reports miR-34a expression was down-regulated in cisplatin-resistant cell lines mechanism - - -
MIR34A miRNA 24068565 Cell viability assay; Flow cytometry cell line - - - - - No Reports The over-expression of miR- 34a could improve the sensitivity of gastric cancer cells to cisplatin-based chemotherapies mechanism - - -
MIR421 miRNA 25041019 qRT-PCR tissue China 50 50 Up - No Reports miR-421 was over-expressed in gastric cancer tissues and cell lines. Caspase-3 was negatively regulated by miR-421 at the post-transcriptional level. mechanism - - -
MIR421 miRNA 25041019 Cell proliferation assay cell line - - - - - No Reports The over-expression of miR-421 promoted gastric cancer cell growth and inhibited apoptosis of the BGC-823 gastric cancer cell line. mechanism - - -
MIR448 miRNA 26852749 qRT-PCR tissue China 40 40 Down - No Reports Downregulated in the GC cell and tissue mechanism - - -
MIR448 miRNA 26852749 Cell proliferation assay; Colony formation; Invasion assay cell line - - - - - No Reports miR-448 suppressed the GC cell proliferation, colony formation, and invasion mechanism - - -
MIR448 miRNA 26852749 Luciferase reporter assay cell line - - - - - No Reports ADAM10 was a direct target gene of miR-448 in GC cell mechanism - - -
MIR490 miRNA 32293550 qRT-PCR tissue China 30 30 Down - No Reports The level of miR-490-3p were decreased in gastric cancer tissues and negative correlated with the level of LINC00483 and MAPK1. Knockdown of LINC00483 or MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. Besides, inhibition of LINC00483 decreased xenograft tumor growth by regulating miR-490-3p/MAPK1 axis. mechanism - - -
MIR490 miRNA 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483 mechanism - - -
MIR490 miRNA 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Over expression of miR-490-3p resulted in obvious reduction in viability, migration and invasion as well as increase in apoptosis of GC cells. mechanism - - -
MIR494 miRNA 29568970 qRT-PCR blood China 50 50 Down - No Reports The expression level of miR-494 was lower in patients with GC than in healthy control subjects. The expression of miR-494 and BAG-1 exhibited opposing trends of in cinobufacini-treated cells, with miR-494 was upregulated and BAG-1 downregulated by cinobufacini. The miR-494 inhibitor partially reversed the cinobufacini-induced decreased expression of BAG-1. mechanism - - -
MIR494 miRNA 29568970 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Treatment with cinobufacini suppressed proliferation and promoted apoptosis of gastric cancer cells.knockdown of miR-494 in cinobufacini-treated cells promoted cell proliferation and inhibited cell apoptosis. Inhibition of BAG-1 in cinobufacini-treated cells partially abrogated the effects of miR-494 inhibitor on cell proliferation and apoptosis. mechanism - - -
MIR874 miRNA 23800944 qRT-PCR tissue China 75 75 Down Down No Reports miR-874 was significantly down-regulated and reversely correlated with AQP3 protein levels in clinical samples. miR-874 expression level was lower in samples with moderately and poorly histological type, lymph node metastasis N1-N3 and stage III–IV. Analysis of the clinicopathological significance showed that miR-874 and AQP3 were closely correlated with GC characteristics. mechanism - - -
MIR874 miRNA 23800944 Cell proliferation assay; Invasion and migration assays; Flow Cytometry cell line - - - - - No Reports Functional analyses indicated that ectopic miR-874 expression suppressed the growth, migration, invasion and tumorigenicity of GC cells, whereas miR-874 knockdown promoted these phenotypes. Down-regulation of Bcl-2, MT1-MMP, MMP-2 and MMP-9 and upregulation of caspase-3 activity and Bax were involved in miR-874 inducing cell apoptosis, and inhibiting migration and invasion. mechanism - - -
MIR874 miRNA 23800944 Xenograft mice models mice - - - - - No Reports miR-874 suppresses the tumorigenicity in vivo mechanism - - -
MIR874 miRNA 23800944 Luciferase reporter assay cell line - - - - - No Reports miR-874 directly interacts with a putative binding site of AQP3-3'UTR mechanism - - -
MIR9-1 miRNA 21225631 qRT-PCR tissue Japan 27 - - - No Reports Amounts of miR-9 in the CDX2-negative group were significantly higher than those in the CDX2-positive group. mechanism - - -
MIR9-1 miRNA 21225631 Luciferase reporter assay cell line - - - - - No Reports MiR-9 interacts with a putative binding site in the CDX2 3'-UTR mechanism - - -
MIR9-1 miRNA 21225631 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Suppression of miR-9 and overexpression of CDX2 elicit the same phenomenon of cell cycle arrest mechanism - - -
MIR9-1 miRNA 23383271 qRT-PCR tissue China 86 86 Down - No Reports miR-9 was found to be down-regulated and inversely correlated with the expression of cyclin D1 and v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) in gastric cancer tissues and cell lines. The miR-9 expression was significantly lower in gastric cancer cases with deeper gastric wall invasion, lymph node metastasis, distant metastasis, and advanced TNM stage. mechanism - - -
MIR9-1 miRNA 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports miR-9 suppressed the in vitro proliferation of gastric cancer cells through targeting cyclin D1; miR-9 attenuated the in vitro migration and invasion of gastric cancer cells through targeting Ets1 mechanism - - -
MIR9-1 miRNA 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted cyclin D1 and Ets1 in gastric cancer cells mechanism - - -
MIR9-1 miRNA 23383271 Xenograft mice models mice - - - - - No Reports miR-9 attenuated the growth and metastasis of gastric cancer cells in vivo mechanism - - -
MIR99A miRNA 30156609 qRT-PCR tissue China 20 20 Down - No Reports The miR-99a expression in gastric tumor tissues was significantly lower than that in non-tumorous tissues. mechanism - - -
MIRLET7A1 miRNA 23519840 qRT-PCR serum China 80 45 Down - No Reports Let-7a miRNA expression was significantly lower in the serum of cancer patients than in the serum of healthy individuals. The serum let-7a level significantly correlated with its level in tumor tissues. mechanism - - -
MIRLET7A1 miRNA 23519840 qRT-PCR tissue China 80 40 Down - No Reports Let-7a miRNA expression was significantly lower in gastric adenocarcinoma tissues than in peritumoral tissues mechanism - - -
MIRLET7A1 miRNA 23519840 Cell invasion and migration assays cell line - - - - - No Reports Let-7a miRNA transfection significantly inhibited the migration and invasion in MNK-45 cells mechanism - - -
NMRAL2P pseudogene/lncRNA 32469171 qRT-PCR tissue China 10 10 Down - No Reports NMRAL2P was downregulated in tumor tissues and GC cell lines. mechanism - - -
NMRAL2P pseudogene/lncRNA 32469171 Cell proliferation assay; Flow cytometry; Transwell assay cell line - - - - - No Reports NMRAL2P overexpression induced a more malignant phenotype and significantly inhibited the expression of ACOT7. mechanism - - -
NMRAL2P pseudogene/lncRNA 32469171 Luciferase reporter assay cell line - - - - - No Reports NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. mechanism - - -
STAT3 protein-coding 30810117 IHC tissue China 30 30 Up - No Reports STAT3 protein expressions were significantly upregulated in cancer tissues.lncRNA HOTAIR was positively correlated with STAT3 and Cyclin D1 protein expressions in gastric cancer tissues. mechanism - - -
STAT3 protein-coding 30810117 Luciferase reporter assay cell line - - - - - No Reports STAT3 is the target gene of miR-454-3p. mechanism - - -
TGFBR1 protein-coding 31182928 qRT-PCR tissue China 30 30 Up - No Reports TGFBR1 was significantly overexpressed in GC tissues.TGFBR1 expression was positively related to circCACTIN in si-circCACTIN group BGC-823 cells and LV-circCACTIN group MGC-803 cells. mechanism - - -
TGFBR1 protein-coding 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports TGFBR1 played a vital role in GC cells proliferation, invasion, migration, and EMT, which was positively regulated by circCACTIN. mechanism - - -
TGFBR1 protein-coding 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between miR-331-3p and TGFBR1. mechanism - - -
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
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