MKGC: a curated molecular knowledgebase for gastric cancer
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  Summary of source.
Source Count
blood 4
cell line 365
exosomes in plasma 2
mice 62
plasma 2
PPLF 1
serum 6
tissue 259
  Browse for miRNA
Official
Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
MIR103A1 miRNA 29754469 qRT-PCR tissue China 33 33 - No Reports miR-103a-3p expression was regulated in GC tissues when compared with non-tissue samples, and was also upregulated in 18 poorly differentiated tumor tissues or in 24 tumor stage III/IV samples. target - - -
MIR103A1 miRNA 29754469 Cell proliferation assay; Cell colony formation assay;Flow cytometry cell line - - - - - No Reports miR-103a-3p increases GC cell growth, and miR-103a-3p overexpression promotes the S-G2/M transition in vitro. target - - -
MIR103A1 miRNA 29754469 Luciferase reporter assay cell line - - - - - No Reports miR-103a-3p directly regulates ATF7 expression in GC cells. target - - -
MIR106B miRNA 30907988 qRT-PCR; FISH tissue China 10 - - - No Reports miR-106b was increased in the metastasis tissues compared with non-metastasis tissues. mechanism - - -
MIR106B miRNA 30907988 Cell invasion and migration assays cell line - - - - - No Reports miR-106b inhibitor could promote the apoptosis of gastric cancer cells mechanism - - -
MIR106B miRNA 30907988 Luciferase reporter assay cell line - - - - - No Reports miR-106b targeted ALEX1 in gastric cancer cells mechanism - - -
MIR106B miRNA 30907988 Xenograft mice models mice - - - - - No Reports Down-regulation of miR-106b inhibited gastric cancer in vivo. mechanism - - -
MIR106B miRNA 29434197 Luciferase reporter assay; Immunoblotting cell line - - - - - No Reports miR-106b-5p targets p21 to regulate the cellular senescence in BRD4-inhibited cells. BRD4 regulates miR-106b-5p transcription via E2F for cellular senescence. target - - -
MIR107 miRNA 26406411 qRT-PCR tissue Iran 36 36 Up - Quantitative RT-PCR analysis on total RNA demonstrated significant overexpression of miR-107 in 36 GC tumor samples, in comparison to the its adjacent normal tissue of the same patients (p = 0.04) target - - -
MIR107 miRNA 26406411 qRT-PCR serum Iran 36 36 Up - significant elevated levels of miR-107 in serum of GC patients compared to controls diagnosis - - 0.63
MIR126 miRNA 25027343 qRT-PCR tissue China 15 15 Down - No Reports MiR-126 expression was frequently and markedly downregulated (p < 0.05) in human gastric cancer tissues. Moreover, overexpression of miR-126 significantly decreased (p < 0.05) the protein levels of Crk, which has previously been identified as a direct target of miR-126. Knockdown of Crk also markedly suppressed GC cells invasion. target - - -
MIR126 miRNA 25027343 qRT-PCR tissue China 110 - - - No Reports Low expression of miR-126 was significantly associated with lymph-node metastasis and poor histological grade. target - - -
MIR126 miRNA 25027343 Cell proliferation assay; Cell invasion assay cell line - - - - - No Reports Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. target - - -
MIR126 miRNA 28260063 qRT-PCR cell line - - - - - No Reports the expression levels of miR-126 were significantly downregulated in the GC cell lines compared with the GES-1 cells target - - -
MIR126 miRNA 28260063 Luciferase reporter assay cell line - - - - - No Reports ADAM9 is a direct target post-transcriptionally regulated by miR-126 in GC cells. target - - -
MIR1275 miRNA 31357957 qRT-PCR tissue China 120 120 Down - Not Related The expression of miR-1275 was reduced in GC tissues. We validated in 120 GC patients specimens that low miR-1275 expression levels were closely associated with lymph node metastasis, Borrmann type and poor prognosis. prognosis < 0.001 - -
MIR1275 miRNA 31357957 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Ectopic expression of miR-1275 inhibited the metastasis and invasion of GC cells. prognosis < 0.001 - -
MIR1275 miRNA 31357957 Xenograft mice models mice - - - - - No Reports Ectopic expression of miR-1275 inhibited the metastasis and invasion in vivo. prognosis < 0.001 - -
MIR1275 miRNA 31357957 Luciferase reporter assay cell line - - - - - No Reports JAZF1 is a direct target of miR-1275 in GC cells. prognosis < 0.001 - -
MIR129-1 miRNA 29879625 qRT-PCR tissue China 50 50 Up - No Reports miR-129-5p expression in GC tissues was significantly down regulated than that in adjacent normal tissues; patients with large tumor size and lymph node metastasis significantly associated with lower miR-129-5p expression in GC patients. Patients who had lower miR-129-5p expression predicted poor overall survival time in GC patients. prognosis < 0.05 - -
MIR129-1 miRNA 29879625 Luciferase reporter assay cell line - - - - - No Reports miR-129-5p could target the 3′UTR of ADAM9 mRNA and regulated its protein expression prognosis < 0.05 - -
MIR129-1 miRNA 29879625 Cell proliferation assay; Invasion assay cell line - - - - - No Reports miR-129-5p overexpression reduced cell proliferation, cell colony formation and cell invasion capacity prognosis < 0.05 - -
MIR1296 miRNA 30530570 qRT-PCR tissue China 40 40 - - No Reports miR-1296-5p was down-regulated in gastric cancer tissue and cell lines, and low expression levels of miR-1296-5p were associated with advanced clinical stage. mechanism - - -
MIR1296 miRNA 30530570 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports miR-1296-5p inhibited cell proliferation, migration, and invasion in SGC-7901 and MGC-803 cells. mechanism - - -
MIR1296 miRNA 30530570 Luciferase reporter assay cell line - - - - - No Reports CDK6 and EGFR as novel targets of miR-1296-5p by a luciferase activity assay mechanism - - -
MIR1303 miRNA 24647998 qRT-PCR tissue China 45 45 Up Up No Reports miR-1303 was significantly overexpressed whereas claudin-18 was downregulated in GC tissues and cell lines, which was significantly associated with tumor size, location invasion, histologic type and tumor-node-metastasis stage. target - - -
MIR1303 miRNA 24647998 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Cell proliferation rates were reduced, and cell invasion and migratory ability was significantly restricted in miR-1303 inhibitor-transfected groups. target - - -
MIR1303 miRNA 24647998 Luciferase reporter assay cell line - - - - - No Reports miR-1303 could bind to the putative binding sites in CLDN18 mRNA 3'-UTR and visibly lower the expression of claudin-18. The introduction of claudin-18 without 3'-UTR restored the miR-1303 promoting migration function. target - - -
MIR133A1 miRNA 25152372 qRT-PCR tissue China 180 180 Down Down No Reports The expression of miR-133 was significantly down-regulated in gastric cancer tissues compared with that in matched normal tissues. Expression of miR-133 is lower in patients above 65 years old than that of below 65 years old. There was a higher level of miR-133 in smaller size tumor. The expression level of miR-133 was lower in T3 and T4 groups than that in T1 and T2 groups. Decreased miR-133 expression was associated with peripheral organ injury and pathologic stages. The survival rate of high-expression group was significantly higher than that the low_x005fexpression group. prognosis 0.003 - -
MIR133A1 miRNA 25152372 Luciferase reporter assay cell line - - - - - No Reports CDC42 is the direct target of miR-133a prognosis 0.003 - -
MIR133A1 miRNA 25152372 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-133a supresses gastric cancer cell growth, migration and invasion. prognosis 0.003 - -
MIR135B miRNA 32119960 Luciferase reporter assay; RIP cell line - - - - - No Reports PCAT18 and CLDN11 are the direct targets of miR-135b target - - -
MIR135B miRNA 32119960 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports Over-expression of miR-135b promotes proliferation, migration and invasion of AGS cells via CLDN11 inhibition. target - - -
MIR136 miRNA 30468468 qRT-PCR cell line - - - - - No Reports miR-136 was significantly downregulated in the gastric cancer cell lines as compared to the normal cell line target - - -
MIR136 miRNA 30468468 Flow cytometry cell line - - - - - No Reports transfection of AGS cells with miR-136 promoted apoptosis target - - -
MIR137 miRNA 26102366 qRT-PCR tissue China 100 100 Down Down No Reports Expression of miR-137 in GC tissues was lower than that in adjacent tissues in statistically significant differences. The patients who have the lower levels of miR-137 expression were associated with high-grade and late-stage tumors. mechanism - - -
MIR137 miRNA 26102366 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports The re-introduction of miR-137 into gastric cancer cells was able to inhibit cell proliferation, migration and invasion. mechanism - - -
MIR137 miRNA 26102366 Xenograft mice models mice - - - - - No Reports The in vivo experiments demonstrated that the miR-137 overexpression can reduce the gastric cancer cell proliferation and metastasis. mechanism - - -
MIR137 miRNA 26102366 Luciferase reporter assay; Western blot cell line - - - - - No Reports miR-137 targets AKT2 in GC mechanism - - -
MIR142 miRNA 30178386 qRT-PCR tissue China 101 101 Down - No Reports MiR-142-5p downregulation was significantly associated with the recurrence (P = 0.031) and poor prognosis of GC (P = 0.043). CYR61 was identified as a novel direct target of miR-142-5p by bioinformatics analysis of target prediction and luciferase reporter. The re-expression and knockdown of CYR61 could, respectively, rescue the effects induced by miR-142-5p overexpression and knockdown. MiR-142-5p attenuated GC cell migration and invasion, at least partially, by inactivation of the canonical Wnt/β-catenin signaling pathway through CYR61. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Cell invasion and migration assays cell line - - - - - No Reports MiR-142-5p inhibited cancer cell migration and invasion both in vitro and in vivo. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Xenograft mice models mice - - - - - No Reports MiR-142-5p inhibited cancer cell migration and invasion in vivo. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Luciferase reporter assay cell line - - - - - No Reports CYR61 is a novel target of miR‑142‑5p in GC cells target/prognosis 0.001 - -
MIR143 miRNA 28404925 microarray chip; qRT-PCR tissue China 42 42 Down Down Related miR-143-3p was ignificantly increased miRNA in H. pylori-positive gastric cancer tissues and was significantly decreased in gastric cancer tissues and cells, which correlated with late stage and lymph node metastasis. target - - -
MIR143 miRNA 28404925 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Overexpression of miR-143-3p suppressed cell proliferation, induced apoptosis and inhibited cell migration and invasion. target - - -
MIR143 miRNA 28404925 Luciferase reporter assay cell line - - - - - No Reports AKT2 is a direct target of miR-143-3p target - - -
MIR145 miRNA 28490034 qRT-PCR tissue China 20 20 Up - No Reports miR-145 expression was significantly decreased in GC tissues compared with that in adjacent normal tissue samples, and miR-145 level had a significant negative correlation with CRNDE level. mechanism - - -
MIR145 miRNA 28490034 Luciferase reporter assay cell line - - - - - No Reports miR-145 target gene E2F3 was strongly expressed following CRNDE competitive molecular sponging of miR-145. mechanism - - -
MIR148A miRNA 27518872 qRT-PCR tissue China 41 41 Down - No Reports miR-148a expression was significantly down-regulated in gastric cancer tissues in comparison with the matched normal mucosal tissues, and its expression was statistically associated with lymph node metastasis. target - - -
MIR148A miRNA 27518872 Cell proliferation assay; Cell migration assays cell line - - - - - No Reports Ectopic expression of miR-148a inhibited tumor cell proliferation and migration in vitro. More importantly, siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. target - - -
MIR148A miRNA 27518872 Xenograft mice models mice - - - - - No Reports Ectopic expression of miR-148a inhibited tumor formation in vivo. target - - -
MIR148A miRNA 27518872 Luciferase reporter assay cell line - - - - - No Reports Cholecystokinin B receptor (CCK-BR) was a direct target of miR-148a target - - -
MIR152 miRNA 28427226 qRT-PCR tissue China 42 42 Down - No Reports The expression of miR-152 in human gastric cancer tissues were significantly lower than that in matched adjacent normal tissues. Meanwhile, lower miR-152 was also found in gastric cancer cell lines. The stage, tumor size and lymph node metastasis rate were significant higher in low-miR-152 group in clinical patients. target - - -
MIR152 miRNA 28427226 Cell proliferation assay cell line - - - - - No Reports Elevation of miR-152 enhanced T cells proliferation and effector cytokines production via inhibiting B7-H1/PD-1 pathway. target - - -
MIR152 miRNA 28427226 Luciferase reporter assay cell line - - - - - No Reports miR-152 directly bind to B7-H1 3' untranslated region in gastric cancer cell and inhibited B7-H1 expression. target - - -
MIR155 miRNA 26955820 qRT-PCR tissue China 60 60 Down Down No Reports miR-155 levels were significantly lower in both GC tissues and GC cell lines than in their normal controls, and its expression inversely correlated with tumor size and the pathologic stage. target - - -
MIR155 miRNA 26955820 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Enforced expression of miR-155 impaired GC cell proliferation, promoted G1 phase arrest and induced apoptosis in vitro. In addition, we identified cyclin D1 as the direct target of miR-155, and knockdown of cyclin D1 partially phenocopied the role of miR-155 in GC cells. target - - -
MIR155 miRNA 26955820 Luciferase reporter assay cell line - - - - - No Reports Cyclin D1 is a direct target of miR‐155 in GC cells target - - -
MIR15A miRNA 26894855 qRT-PCR tissue China 21 21 - - No Reports The expression of miR-15a is significantly reduced in gastric cancer and the protein expression levels of Bmi-1 are inversely correlated with miR-15a (P = 0.034) in gastric cancer patient samples. mechanism - - -
MIR15A miRNA 26894855 Cell proliferation assay cell line - - - - - No Reports miR-15a suppressed gastric cancer invasion; miR-15a suppressed the proliferation of gastric cancer cells via downregulation of Bmi-1. mechanism - - -
MIR15A miRNA 26894855 Luciferase reporter assay cell line - - - - - No Reports Bmi-1 is a direct target of miR-15a in gastric cancer cell lines. mechanism - - -
MIR15A miRNA 26894855 qRT-PCR; IHC tissue China 21 - - - No Reports The expression of Bmi-1 is inversely correlated with miR-15a in gastric tumor tissues mechanism - - -
MIR17 miRNA 20234369 qRT-PCR plasma Japan 69 30 Up - miR-17-5p were significantly higher in GC patients than in controls (P = 0.006) target - - -
MIR181A1 miRNA 24531888 qRT-PCR tissue China 9 9 - - No Reports Compared with three non-tumour tissues, the expression of miR-181a in three gastric cancer cells was significantly increased; miR-181a expression was inversely correlated with ATM. mechanism - - -
MIR181A1 miRNA 24531888 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports miR-181a affects the proliferation and metastatic potential of gastric cancer cells. mechanism - - -
MIR181A1 miRNA 24531888 Luciferase reporter assay - - - - - No Reports miR-181a Directly Inhibited the Expression of ATM Through ATM 3'UTR mechanism - - -
MIR187 miRNA 27864146 qRT-PCR tissue China 54 54 Up - No Reports miR-187 was significantly overexpressed in GC tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis (P = 0.048), and TNM stage (P = 0.035). target - - -
MIR187 miRNA 27864146 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports miR-187 significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells target - - -
MIR187 miRNA 27864146 Xenograft mice models mice - - - - - No Reports miR-187 promoted tumor growth in vivo target - - -
MIR187 miRNA 27864146 Luciferase reporter assay cell line - - - - - No Reports CRMP1 was a direct downstream target of miR-187 in GC.The effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation target - - -
MIR191 miRNA 24603541 qRT-PCR cell line China - - Up - Examination of miR-191 and miR-425 expression in four GC cell lines (HGC-27,MGC-803, MKN-45 and SGC-7901) indicated an obvious upregulation of miR-191/425 in HGC-27, MGC-803, and SGC-7901 cell lines when compared to adjacent non-tumor tissues and five normal gastric tissues from healthy people mechanism - - -
MIR191 miRNA 24603541 qRT-PCR tissue China 75 75 Up Up The miR-191 Cluster Is Highly Expressed in Gastric Cancer (GC) target - - -
MIR191 miRNA 24603541 qRT-PCR serum China 57 58 Up Up when using miR-16 as an endogenous control, the relative level of miR-191 in GC serum was significantly higher than those in the controls (p < 0.01) target,diagnosis - - 0.85
MIR1915 miRNA 31036603 qRT-PCR tissue China 60 60 Down - No Reports miR-1915-3p exhibited low expression level in differentiated gastric cancer cell lines and gastric cancer tissues. The expressions of miR-1915-3p were significantly correlated to the lymph node metastasis and overall survival of patients with gastric cancer. Further study showed that there was a negative correlation between miR-1915-3p and Bcl-2 (B cell lymphoma/leukemia-2) expression. prognosis 0.01 - -
MIR1915 miRNA 31036603 Cell proliferation assay,Cell apoptosis assay cell line - - - - - No Reports It was found that the miR-1915-3p inhibited the growth of gastric cancer cells and promoted cell apoptosis. prognosis 0.01 - -
MIR1915 miRNA 31036603 Luciferase reporter assay cell line - - - - - No Reports miR-1915-3p directly inhibits Bcl-2 expression at post-transcriptional level through its 3'-UTR. prognosis 0.01 - -
MIR193A miRNA 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports Ectopic expressions of miR-193a-5p and miR-193a-3p revealed that they both inhibited gastric cancer cell growth, but only miR-193a-3p significantly suppressed cell invasion ability. mechanism - - -
MIR193A miRNA 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct target of miR-193a-3p mechanism - - -
MIR193B miRNA 27071318 qRT-PCR tissue China 50 50 Down - No Reports miR-193b was significantly reduced in GC tissues compared with the adjacent normal gastric tissues. Moreover, lower-level of miR-193b was also associated with a more aggressive GC phenotype. mechanism - - -
MIR193B miRNA 27071318 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-193b can inhibit the proliferation, migration and invasion of HGC-27 and MGC-803 GC cells. mechanism - - -
MIR194-1 miRNA 27810403 qRT-PCR tissue China 43 43 Up - No Reports MiRNA-194 was found to be overexpressed in GC cell lines and 43 paired GC tissues. target - - -
MIR194-1 miRNA 27810403 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Overexpression of miRNA-194 promoted cell proliferation and migration, while inhibition of miRNA-194 blocked these processes. target - - -
MIR194-1 miRNA 27810403 Xenograft mice models mice - - - - - No Reports Inhibition of miRNA-194 decreased tumor volumes in nude mice. target - - -
MIR194-1 miRNA 27810403 Luciferase reporter assay cell line - - - - - No Reports SUFU is the functional target of miRNA-194 target - - -
MIR198 miRNA 30927924 Cell cytotoxicity assay; Clonogenic assay; Flow ytometry cell line - - - - - No Reports Overexpression of miR-198 inhibited cell viability and induced apoptosis in SGC7901CDDP and BGC823CDDP cells. mechanism - - -
MIR198 miRNA 30927924 Luciferase reporter assay: RNA pull-down; FISH cell line - - - - - No Reports circAKT3 and miR-198 were colocalized in the cytoplasm; circAKT3 exerts its function by sponging miR-198. mechanism - - -
MIR199A1 miRNA 30193607 qRT-PCR tissue China 51 51 Down - No Reports The relative expression of miR-199 in gastric carcinoma tissues was significantly lower than that in the adjacent normal tissue . target - - -
MIR199A1 miRNA 30193607 Cell proliferation assay; Cell migration assay cell line - - - - - No Reports Over-expression of miR-199 inhibited the proliferation and migration of GC cells. target - - -
MIR199A1 miRNA 30193607 Luciferase reporter assay cell line - - - - - No Reports miR-199 directly targeted on the 3' untranslated region of TBL1XR1. target - - -
MIR19A miRNA 25914465 qRT-PCR tissue China 50 50 Up Up No Reports miR­19a is increased in GC tissue samples and cell lines. Overexpression of miR-19a was significantly associated with metastasis of GC. target - - -
MIR19A miRNA 25914465 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Overexpression of miR-19a promoted the proliferation, migration and invasion. target - - -
MIR19A miRNA 25914465 Western blot cell line - - - - - No Reports Overexpressing miR­19a GC cells promoted phosphorylation of PI3K­AKT, and the phosphorylation of PI3K­AKT was blocked in the cells transfected with miR-19a mimic. target - - -
MIR203A miRNA 30837034 qRT-PCR tissue China 10 10 Down - No Reports miR-203 is downregulated in GC tissues and cell lines. Moreover, the low level of miR-203 was associated with increased expression of annexin A4 in GC tissues and cell lines. target - - -
MIR203A miRNA 30837034 Cell invasion and migration assays cell line - - - - - No Reports miR-203 Suppressed the Invasion and EMT of GC Cells Through Inhibition of Annexin A4 target - - -
MIR203A miRNA 30837034 Luciferase reporter assay cell line - - - - - No Reports miR-203 Directly Targets Annexin A4 in GC Cells target - - -
MIR203A miRNA 30837034 qRT-PCR; Western blot cell line - - - - - No Reports overexpression of miR-203 could inhibit EMT of GC cells target - - -
MIR203A miRNA 25373785 qRT-PCR tissue China 50 50 Down - Related miR-203 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with important functional consequences. mechanism - - -
MIR203A miRNA 25373785 Cell proliferation assay; Invasion and migration assays; Clonal formation assay cell line - - - - - No Reports Ectopic expression of miR-203 dramatically suppressed cell proliferation and invasion. We found that miR-203 strongly reduced the expression of CASK oncogene in GC cells. Similar to the restoring miR-203 expression, CASK down-regulation inhibited cell growth and invasion, whereas CASK over-expression rescued the suppressive effect of miR-203. These results can also be found in nude mice. In clinical specimens, CASK was over-expressed in tumors and H. pylori positive tissues and its mRNA levels were inversely correlated with miR-203 expression mechanism - - -
MIR203A miRNA 25373785 Luciferase reporter assay cell line - - - - - No Reports CASK was a direct target of miR-203 in GC cells. mechanism - - -
MIR203A miRNA 25373785 Xenograft mice models mice - - - - - No Reports MiR-203 suppressed tumor growth of GC cells in nude mice. mechanism - - -
MIR204 miRNA 29386218 CDX tissue 50gc, 50 non-gc - - Not Related LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage, lymph node metastasis, and shorter survival time. Furthermore, knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts. mechanism - - -
MIR204 miRNA 23152059 qRT-PCR tissue Italy 84 84 Down Down No Reports miR-204 is downregulated in gastric tumor samples and advanced stages of GC; miR-204 is a prognostic factor for GCs. prognosis 0.017 - -
MIR204 miRNA 23152059 Luciferase reporter assay cell line - - - - - No Reports miR-204-mediated targeting of Bcl-2 expression pro_x005fmotes apoptosis of GC cells. prognosis 0.017 - -
MIR204 miRNA 23152059 Cell migration assay; Cell colony formation assay; Cell apoptosis assay cell line - - - - - No Reports miR-204 overexpression affects cell migration, colony forming ability and chemoresistance. prognosis 0.017 - -
MIR208A miRNA 29886152 qRT-PCR tissue China 62 62 Up Up No Reports miR-208a expression was significantly increased in GC tissues compared with adjacent normal tissues. Higher miR-208a expression was association with lymph node metastasis and TNM stage in GC patients. Kaplan-Meier analysis verified that patients with higher miR-208a expression were significantly associated with shorter overall survival (OS) time. miR-208a expression negatively associated with MEG3. target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Cell proliferation assay; Cell invasion assay; cell line - - - - - No Reports Ectopic expression of miR-208a by treatment with miR-208a mimic promoted cell proliferation and invasion abilities, but downregulation of miR-208a by treatment with miR-208a inhibitor had an opposite effects. target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Luciferase reporter assay cell line - - - - - No Reports SFRP1 is a direct target of MiR-208a in GC cells target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Luciferase reporter assay; RIP cell line - - - - - No Reports MEG3 is a bona fide target for miR-208a in GC cells target/prognosis < 0.05 - -
MIR208A miRNA 27634902 qRT-PCR tissue China 16 16 Up - No Reports miR-208a-3p was up-regulated in GC tissues target - - -
MIR208A miRNA 27634902 Flow cytometry cell line - - - - - No Reports miR-208a-3p suppresses apoptosis of gastric cancer cells by targeting PDCD4 target - - -
MIR208A miRNA 27634902 Luciferase reporter assay cell line - - - - - No Reports PDCD4 is a direct target of miR-208a-3p target - - -
MIR208A miRNA 27634902 Xenograft mice models mice - - - - - No Reports miR-208a-3p promoted the development of tumor growth target - - -
MIR21 miRNA 30700111 Cell proliferation assay; Migration assay; Flow cytometer; Cell cycle assay cell line - - - - - No Reports Down-regulation of miR-21 markedly reduced gastric cancer cell proliferation and promoted cell apoptosis and repressed cell cycle progression; Silencing miR-21 dramatically blocked gastric cancer cell migration and movement. target - - -
MIR217 miRNA 30063010 qRT-PCR exosomes in plasma China 67 67 Up - No Reports Exosomal miR-217 was increased in the GC patients. mechanism - - -
MIR217 miRNA 30063010 qRT-PCR tissue China 67 67 Up - No Reports The expression of miR-217 was significantly up-regulated in GC tissues. mechanism - - -
MIR217 miRNA 30063010 Luciferase reporter assay cell line - - - - - No Reports CDH1 is a direct target of miR-217 mechanism - - -
MIR217 miRNA 30063010 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports miR-217 overexpression contributes to increased GC cells proliferation mechanism - - -
MIR222 miRNA 22432036 qRT-PCR serum - 82 82 UP - miR-222 demonstrated significantly elevated levels in GC group with more than 2-fold change(P<0.05) target - - 0.65
MIR222 miRNA 25129310 qRT-PCR plasma China 114 56 UP - In this study, our results demonstrated that the levels of circulating miR-222 in patients with GC were significantly increased, compared with CAG and healthy controls. In addition, higher level of circulating miR-222 had also been found in the plasma of CAG patients compared with healthy controls, indicating the dysregulated expression of miR-222 might be involved in the early events of GC malignancy. target;prognosis 22.428 % 25.267% 0.85
MIR27A miRNA 27409164 qRT-PCR tissue China 20 20 Up - No Reports Two isoforms of mature miR-27a, miR-27a-5p and miR-27-3p, were both frequently overexpressed in gastric cancer tissues and cell lines, whereas the expression level of miR-27-3p in gastric cancer was significantly higher than that of miR-27a-5p. target - - -
MIR27A miRNA 27409164 Cell proliferation assay; Invasion and migration assays; Flow cytometry; Apotosis assay cell line - - - - - No Reports Overexpression of miR-27a-3p, but not miR-27a-5p, markedly promoted gastric cancer cell proliferation in vitro. miR-27a-3p/BTG2 axis regulates cell cycle progression and apoptosis in gastric cancer cells target - - -
MIR27A miRNA 27409164 Xenograft mice models mice - - - - - No Reports miR-27a-3p promotes GC cell growth in vivo. target - - -
MIR27A miRNA 27409164 Luciferase reporter assay cell line - - - - - No Reports BTG2 was a direct and functional target of miR-27a-3p in gastric cancer and miR-27a-3p inhibition obviously up-regulated the expression of BTG2. target - - -
MIR29A miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR29A miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29a into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29A miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29a in GC cells. target - - -
MIR29B1 miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR29B1 miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29b into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29B1 miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29b in GC cells. target - - -
MIR29C miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR29C miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29c into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29C miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29c in GC cells. target - - -
MIR302B miRNA 28743112 qRT-PCR tissue China 20 20 Down - No Reports MiR-302b-3p expression was decreased in gastric cancer tissues and cell lines. mechanism - - -
MIR302B miRNA 28743112 Cell proliferation assay; Cell colony formation assay; Apoptosis assay; Flow cytometry cell line - - - - - No Reports Enforced expression of miR-302b suppressed cell proliferation and cell cycle G1-S transition and induced apoptosis. mechanism - - -
MIR302B miRNA 28743112 Luciferase reporter assay cell line - - - - - No Reports IGF-1R was found to be a direct target of miR-302b-3p, and silencing of IGF-1R resulted in the same biological effects as those induced by miR-302b-3p overexpression in gastric cancer cells. Both overexpression of miR-302b-3p and silencing of IGF-1R decreased AKT phosphorylation, which modulated AKT related cell cycle regulators (cyclin A2, cyclin D1, CDK2, and CDk6) and apoptotic protein Bax/Bcl-2. mechanism - - -
MIR320A miRNA 27086911 qRT-PCR tissue China 14 14 Down - No Reports miR-320a expression is decreased in human gastric cancer tissues and correlates inversely with expression of FoxM1, a key cell cycle regulator involved in gastric carcinoma. By contrast, the expression of P27KIP1, a downstream effector of FoxM1, correlates positively with miR-320a levels. mechanism - - -
MIR320A miRNA 27086911 Clone formation assay cell line - - - - - No Reports miR-320a inhibits gastric cancer cell proliferation by suppressing activity in the FoxM1-P27KIP1 axis. mechanism - - -
MIR320A miRNA 27086911 Xenograft mice models mice - - - - - No Reports nude mice injected with BGC-823 gastric cancer cells expressing a miR-320a inhibitor exhibit faster tumor growth than mice injected with control cells. mechanism - - -
MIR320A miRNA 27086911 Luciferase reporter assay cell line - - - - - No Reports FoxM1 is a direct target of miR-320a mechanism - - -
MIR320A miRNA 29152656 qRT-PCR tissue China 40 40 Down - No Reports Downregulated in GC tumor tissues; miR‑320a is negatively correlated with ADAM10 in tumors target - - -
MIR320A miRNA 29152656 Colony formation assay; MTS assay; Viability assay cell line - - - - - No Reports miR‑320a inhibits cell growth and enhances sensitivity of GC cells to cisplatin and suppresses tumor growth in vivo. target - - -
MIR320A miRNA 29152656 Luciferase reporter assay cell line - - - - - No Reports miR‑320a directly targets ADAM10 in GC cells. target - - -
MIR331 miRNA 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Transfection of miR-331-3p inhi- bitor promoted BGC-823 cells proliferation, invasion and migration; transfection of miR-331-3p mimic suppressed MGC-803 cells proliferation, invasion and migration. target - - -
MIR331 miRNA 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between miR-331-3p and TGFBR1, circCACTIN and miR-331-3p target - - -
MIR331 miRNA 31182928 qRT-PCR; Western blot cell line - - - - - No Reports Both TGFBR1 mRNA and protein expression were regulated by circCACTIN through miR-331-3p target - - -
MIR335 miRNA 21822301 qRT-PCR tissue China 70 70 No Down No Reports Low expression of miR-335 was significantly associated with lymph-node metastasis, poor pT stage, poor pN stage and invasion of lymphatic vessels. Patients with a better pT stage or pN stage had significantly higher miR-335 expression. Patients with a low expression of miR-335 tended to have metastasis invasion into lymphatic vessels. target - - -
MIR335 miRNA 21822301 Cell invasion assay; Tumor metastasis formation assay; MTT proliferation assay cell line - - - - - No Reports miR-335 suppresses gastric cancer invasion and metastasis in vitro, but has no significant effects on cell proliferation of gastric cancer target - - -
MIR335 miRNA 21822301 Luciferase reporter assay cell line - - - - - No Reports SP1 and Bcl-w are direct targets of miR-335. miR-335 suppresses gastric cancer invasion and metastasis by targeting Bcl-w and SP1 target - - -
MIR338 miRNA 30308487 qRT-PCR tissue China 53 53 Down - No Reports miR-338-3p was down-regulated in both GC tissues (53 paired samples) and cell lines (4 cancer cell lines). The decreased expression of miR-338-3p was found to be significantly associated with the Borrmann stage. target - - -
MIR338 miRNA 30308487 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-338-3p could suppress cell proliferation and induce cell apoptosis, suppresses metastasis target - - -
MIR338 miRNA 30308487 Bisulfite sequence cell line - - - - - No Reports hyper-methylation is the main cause of miR-338-3p depression target - - -
MIR338 miRNA 30308487 Luciferase reporter assay cell line - - - - - No Reports Rab14 is a direct target of miR-338-3p; miR-338-3p suppresses metastasis by targeting the Hhat-MMP signaling pathway target - - -
MIR338 miRNA 26617808 qRT-PCR tissue China 36 36 Down - No Reports Down-regulated in both gastric cancer cell lines and tissues. target - - -
MIR338 miRNA 26617808 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports Enforced expression of miR-338-3p inhibited proliferation, migration and invasion of gastric cancer cells in vitro target - - -
MIR338 miRNA 26617808 Luciferase reporter assay cell line - - - - - No Reports ADAM17 is a direct target of miR-338-3 and prescued the miR-338-3p mediated inhibition of cell proliferation, migration and invasion target - - -
MIR338 miRNA 25945841 qRT-PCR tissue China 20 20 Down Down No Reports miR-338-3p was significantly lower in GC tissues than in the corresponding adjacent noncancerous tissues; mRNA expression of miR-338-3p was even lower in advanced stages of GC compared to that observed in the early stages. target - - -
MIR338 miRNA 25945841 Cell invasion and migration assays cell line - - - - - No Reports miR-338-3p inhibited the migration and invasion of GC cells in vitro and inhibits the EMT process in GC cells. target - - -
MIR338 miRNA 25945841 Luciferase reporter assay cell line - - - - - No Reports miR-338-3p directly targeted zinc finger E-box-binding protein 2 (ZEB2) and metastasis-associated in colon cancer-1 (MACC1). target - - -
MIR340 miRNA 28057912 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Overexpression of miR-340 significantly reduced cell viability and proliferation, and induced cell apoptosis of GC cells target - - -
MIR34A miRNA 23264087 qRT-PCR cell line - - - - - No Reports miR-34a expression in gastric cancer cells was significantly reduced compared to the normal gastric epithelial cell line. mechanism - - -
MIR34A miRNA 23264087 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports In the overexpressing miR-34a in HGC-27 cells, cellular viability was significantly reduced, the proliferation index decreased significantly and cellular apoptosis was significantly increased, the number of cells passing through the transwell chamber was significantly reduced. mechanism - - -
MIR34A miRNA 24068565 qRT-PCR cell line - - - - - No Reports miR-34a expression was down-regulated in cisplatin-resistant cell lines mechanism - - -
MIR34A miRNA 24068565 Cell viability assay; Flow cytometry cell line - - - - - No Reports The over-expression of miR- 34a could improve the sensitivity of gastric cancer cells to cisplatin-based chemotherapies mechanism - - -
MIR381 miRNA 28193228 qRT-PCR tissue China 103 103 Down - No Reports MiR-381 was significantly down-regulated in gastric cancer tissues and cell lines. Low expression of miR-381 was negatively related to lymph node metastasis, advanced tumor stage and poor prognosis.miR-381 and TMEM16A revealed the improved prognostic accuracy for gastric cancer patients. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vitro. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Xenograft mice models mice - - - - - No Reports MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vivo. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Luciferase reporter assay; Western blot; IHC cell line - - - - - No Reports TMEM16A was identified as a direct target of miR-381 and the expression of miR-381 was inversely correlated with TMEM16A expression in gastric cancer tissues target/prognosis 0.024 0.037 -
MIR421 miRNA 25041019 qRT-PCR tissue China 50 50 Up - No Reports miR-421 was over-expressed in gastric cancer tissues and cell lines. Caspase-3 was negatively regulated by miR-421 at the post-transcriptional level. mechanism - - -
MIR421 miRNA 25041019 Cell proliferation assay cell line - - - - - No Reports The over-expression of miR-421 promoted gastric cancer cell growth and inhibited apoptosis of the BGC-823 gastric cancer cell line. mechanism - - -
MIR448 miRNA 26852749 qRT-PCR tissue China 40 40 Down - No Reports Downregulated in the GC cell and tissue mechanism - - -
MIR448 miRNA 26852749 Cell proliferation assay; Colony formation; Invasion assay cell line - - - - - No Reports miR-448 suppressed the GC cell proliferation, colony formation, and invasion mechanism - - -
MIR448 miRNA 26852749 Luciferase reporter assay cell line - - - - - No Reports ADAM10 was a direct target gene of miR-448 in GC cell mechanism - - -
MIR454 miRNA 30810117 ISH tissue China 30 30 Down - No Reports miR-454-3p expression of cancer tissues was significantly decreased compared with that of non-tumor tissues. lncRNA HOTAIR was negatively correlated with miR-454-3p expression in gastric cancer tissues. - - - -
MIR454 miRNA 30810117 Luciferase reporter assay cell line - - - - - No Reports STAT3 is the target gene of miR-454-3p. - - - -
MIR490 miRNA 32293550 qRT-PCR tissue China 30 30 Down - No Reports The level of miR-490-3p were decreased in gastric cancer tissues and negative correlated with the level of LINC00483 and MAPK1. Knockdown of LINC00483 or MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. Besides, inhibition of LINC00483 decreased xenograft tumor growth by regulating miR-490-3p/MAPK1 axis. mechanism - - -
MIR490 miRNA 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483 mechanism - - -
MIR490 miRNA 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Over expression of miR-490-3p resulted in obvious reduction in viability, migration and invasion as well as increase in apoptosis of GC cells. mechanism - - -
MIR494 miRNA 29568970 qRT-PCR blood China 50 50 Down - No Reports The expression level of miR-494 was lower in patients with GC than in healthy control subjects. The expression of miR-494 and BAG-1 exhibited opposing trends of in cinobufacini-treated cells, with miR-494 was upregulated and BAG-1 downregulated by cinobufacini. The miR-494 inhibitor partially reversed the cinobufacini-induced decreased expression of BAG-1. mechanism - - -
MIR494 miRNA 29568970 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Treatment with cinobufacini suppressed proliferation and promoted apoptosis of gastric cancer cells.knockdown of miR-494 in cinobufacini-treated cells promoted cell proliferation and inhibited cell apoptosis. Inhibition of BAG-1 in cinobufacini-treated cells partially abrogated the effects of miR-494 inhibitor on cell proliferation and apoptosis. mechanism - - -
MIR519D miRNA 29510377 qRT-PCR tissue China 20 20 Down No Reports miR-519d-3p was downregulated in GC tumor tissues,associated with the clinical stage and lymph node metastasis of GC tissues. Decreased miR-519d-3p expression was associated with advanced stage and lymph node metastasis of GC compared with controls. target - - -
MIR519D miRNA 29510377 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports miR-519d-3p inhibited MGC803 cell proliferation and invasion and delayed G1/S phase transition.miR-519d-3p/BCL6 axis inhibits cell proliferation, invasion, and cell cycle by regulating cyclin B1, E-cadherin, and MMP2 levels in GC cells. target - - -
MIR519D miRNA 29510377 Luciferase reporter assay cell line - - - - - No Reports BCL6 Is the Target of miR-519d-3p target - - -
MIR519D miRNA 29510377 qRT-PCR tissue China 20 20 Down No Reports miR-519d-3p was downregulated in GC tumor tissues,associated with the clinical stage and lymph node metastasis of GC tissues. Decreased miR-519d-3p expression was associated with advanced stage and lymph node metastasis of GC compared with controls. target - - -
MIR5590 miRNA 30029874 qRT-PCR tissue China 42 42 Down - No Reports In addition, Ago2-based RIP and dual-luciferase reporter were conducted to study the Next, were used to determine the role of miR-5590-3p in GC tumorigenicity in vivo. whereas . target - - -
MIR5590 miRNA 30029874 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports miR-5590-3p regulates GC cell proliferation and colony formation by G1/S transition target - - -
MIR5590 miRNA 30029874 Xenograft mouse models mice - - - - - No Reports Downregulation of miR-5590-3p promoted GC proliferation in vitro target - - -
MIR5590 miRNA 30029874 RIP and Luciferase reporter assay cell line - - - - - No Reports miR-5590-3p as a direct target of DDX5. target - - -
MIR582 miRNA 29228422 qRT-PCR tissue China 42 42 No Reports MiR-582-5p was downregulated in gastric cancer tissues when compared with para-carcinoma tissues. target - - -
MIR582 miRNA 29228422 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Overexpressed miR-582-5p could attenuate cell proliferation and viability capacities, as well as promoted cell apoptosis and cell cycle arrest at G0/G1 phase. target - - -
MIR582 miRNA 29228422 Luciferase reporter assay cell line - - - - - No Reports AKT3 was chosen as the target gene of miR-582-5p. Moreover, restoration of AKT3 could impair tumor suppression role of miR-582-5p on gastric cancer growth. target - - -
MIR589 miRNA 30012200 qRT-PCR tissue China 34 34 Up - No Reports MiR-589 expression was significantly higher in tumor tissues and gastric cancer cells than those in matched normal tissues and gastric epithelial cells, respectively. Overexpression of miR-589 is associated with tumor metastasis, invasion and poor prognosis of GC patients. target - - -
MIR589 miRNA 30012200 Cell invasion and migration assays cell line - - - - - No Reports Gain- and loss-of function experiments showed that miR-589 promoted cell migration, metastasis and invasion in vitro and lung metastasis in vivo. target - - -
MIR589 miRNA 30012200 nude mouse xenograft model mice - - - - - No Reports Endogenous overexpression of miR-589 promotes metastasis of GC cell in vivo target - - -
MIR589 miRNA 30012200 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports miR-589 directly targeted LIFR to activate PI3K/AKT/c-Jun signaling. c-Jun bound to the promoter region of miR-589 and activated its transcription. target - - -
MIR613 miRNA 28701053 qRT-PCR tissue China 52 52 Down - No Reports miR-613 was evidently downregulated in gastric cancer tissue and cell. target - - -
MIR613 miRNA 28701053 Luciferase reporter assay cell line - - - - - No Reports CDK9 is a direct target of miR-613 in gastric cancer target - - -
MIR613 miRNA 28701053 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports miR-613 suppressed cell proliferation and migration in gastric cancer target - - -
MIR615 miRNA 29501762 qRT-PCR tissue China 104 104 Up Up No Reports Aberrant high expression of miR-615-3p and low expression of CELF2 in gastric cancer both in vivo and in vitro. Moreover, miR-615-3p expression correlated to T and M stage. Higher expression of miR-615-3p correlated to shorter period of survival months. prognosis < 0.05 - -
MIR615 miRNA 29501762 Cell proliferation assay; Flow cytometry; Cell migration assay cell line - - - - - No Reports miR-615-3p inhibits apoptosis and promotes proliferation and migration ability in SGC7901 cell line. Overexpression of CELF2 could reverse miR-615-3p's oncogenic functions stated before. prognosis < 0.05 - -
MIR644A miRNA 27983935 qRT-PCR tissue China 107 107 Down Down No Reports The expression of miR-644a was suppressed in GC tissues and was associated with a later clinical stage and tumor metastasis. target - - -
MIR644A miRNA 27983935 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be correlated to its suppressive effect on the EMT process. target - - -
MIR644A miRNA 27983935 Luciferase reporter assay cell line - - - - - No Reports CtBP1 is a putative target gene of miR-644a in GC cells target - - -
MIR675 miRNA 28848149 qRT-PCR;Western blot tissue China 34 34 Up - No Reports miR-675 were increased in gastric cancer cell lines and tissues. H19 and miR-675 expression was positively correlated in gastric cancer tissues. target - - -
MIR675 miRNA 28848149 Luciferase reporter assay cell line - - - - - No Reports FADD is a potential target of miR-675; H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
MIR675 miRNA 28848149 Cell proliferation assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. target - - -
MIR675 miRNA 28848149 Xenograft mice models mice - - - - - No Reports There was a dramatic decrease in in tumor volume and weight in nude mice in which LV- shH19 infected SGC-7901 cell. co-infection with LV-miR675 partially reversed this tendency. target - - -
MIR711 miRNA 26735582 qRT-PCR tissue China 28 28 Down - No Reports The expression of miR-711 was lower in the cancer tissues than in the normal tissues. target - - -
MIR711 miRNA 26735582 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports miR-711 could suppress SGC-7901 cell growth in a time-dependent manner. target - - -
MIR711 miRNA 26735582 Flow cytometry; Western blot cell line - - - - - No Reports miR-711 was found to downregulate CDK4 expression target - - -
MIR874 miRNA 23800944 qRT-PCR tissue China 75 75 Down Down No Reports miR-874 was significantly down-regulated and reversely correlated with AQP3 protein levels in clinical samples. miR-874 expression level was lower in samples with moderately and poorly histological type, lymph node metastasis N1-N3 and stage III–IV. Analysis of the clinicopathological significance showed that miR-874 and AQP3 were closely correlated with GC characteristics. mechanism - - -
MIR874 miRNA 23800944 Cell proliferation assay; Invasion and migration assays; Flow Cytometry cell line - - - - - No Reports Functional analyses indicated that ectopic miR-874 expression suppressed the growth, migration, invasion and tumorigenicity of GC cells, whereas miR-874 knockdown promoted these phenotypes. Down-regulation of Bcl-2, MT1-MMP, MMP-2 and MMP-9 and upregulation of caspase-3 activity and Bax were involved in miR-874 inducing cell apoptosis, and inhibiting migration and invasion. mechanism - - -
MIR874 miRNA 23800944 Xenograft mice models mice - - - - - No Reports miR-874 suppresses the tumorigenicity in vivo mechanism - - -
MIR874 miRNA 23800944 Luciferase reporter assay cell line - - - - - No Reports miR-874 directly interacts with a putative binding site of AQP3-3'UTR mechanism - - -
MIR9-1 miRNA 21225631 qRT-PCR tissue Japan 27 - - - No Reports Amounts of miR-9 in the CDX2-negative group were significantly higher than those in the CDX2-positive group. mechanism - - -
MIR9-1 miRNA 21225631 Luciferase reporter assay cell line - - - - - No Reports MiR-9 interacts with a putative binding site in the CDX2 3'-UTR mechanism - - -
MIR9-1 miRNA 21225631 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Suppression of miR-9 and overexpression of CDX2 elicit the same phenomenon of cell cycle arrest mechanism - - -
MIR9-1 miRNA 23383271 qRT-PCR tissue China 86 86 Down - No Reports miR-9 was found to be down-regulated and inversely correlated with the expression of cyclin D1 and v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) in gastric cancer tissues and cell lines. The miR-9 expression was significantly lower in gastric cancer cases with deeper gastric wall invasion, lymph node metastasis, distant metastasis, and advanced TNM stage. mechanism - - -
MIR9-1 miRNA 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports miR-9 suppressed the in vitro proliferation of gastric cancer cells through targeting cyclin D1; miR-9 attenuated the in vitro migration and invasion of gastric cancer cells through targeting Ets1 mechanism - - -
MIR9-1 miRNA 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted cyclin D1 and Ets1 in gastric cancer cells mechanism - - -
MIR9-1 miRNA 23383271 Xenograft mice models mice - - - - - No Reports miR-9 attenuated the growth and metastasis of gastric cancer cells in vivo mechanism - - -
MIR99A miRNA 30156609 qRT-PCR tissue China 20 20 Down - No Reports The miR-99a expression in gastric tumor tissues was significantly lower than that in non-tumorous tissues. mechanism - - -
MIRLET7A1 miRNA 23519840 qRT-PCR serum China 80 45 Down - No Reports Let-7a miRNA expression was significantly lower in the serum of cancer patients than in the serum of healthy individuals. The serum let-7a level significantly correlated with its level in tumor tissues. mechanism - - -
MIRLET7A1 miRNA 23519840 qRT-PCR tissue China 80 40 Down - No Reports Let-7a miRNA expression was significantly lower in gastric adenocarcinoma tissues than in peritumoral tissues mechanism - - -
MIRLET7A1 miRNA 23519840 Cell invasion and migration assays cell line - - - - - No Reports Let-7a miRNA transfection significantly inhibited the migration and invasion in MNK-45 cells mechanism - - -
MIRLET7B miRNA 30237418 qRT-PCR cell line - - - - - No Reports let-7b-expression level of SGC7901/DDP cells was significantly lower than for its parental SGC7901 cells. target - - -
MIRLET7B miRNA 30237418 Cell proliferation assay; Flow cytometry; cell line - - - - - No Reports Upregulation of let-7b could reverse the DDP resistance of gastric cancer SGC7901/DDP cells by inducing cell viability inhibition and apoptosis when exposed to DDP treatment. target - - -
MIRLET7B miRNA 30237418 Luciferase reporter assay cell line - - - - - No Reports let-7b directly targets AURKB by binding to its 3'UTR region in DDP-resistant gastric cancer cells to DDP. target - - -
MIRLET7B miRNA 30237418 Xenograft mice models mice - - - - - No Reports Upregulation of let-7b inhibited tumor growth derived from DDP-resistant cells in vivo. target - - -
MIRLET7B miRNA 25288334 qRT-PCR tissue China 76 76 Down - No Reports let-7b was down-regulated in gastric cancer and its downregulation was associated with poor survival and correlated with lymph node metastasis. AKT2 mRNA expression showed negative correlation with the expression of let-7b in primary tumors. target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Cell proliferation assay; Invasion assay; Cell colony fomation assay cell line - - - - - No Reports suppressed the growth and invasive capacityof GC cells target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Xenograft mouse models mice - - - - - No Reports let-7b/g transfectants formed smaller xenografts than those scramble transfectants target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Luciferase reporter assay cell line - - - - - No Reports let-7b/g inhibited AKT2 expression by directly binding to its 3'UTR, reduced p-AKT (S473) activation and suppressed expression of the downstream effector pS6. target/prognosis - 0.001 -
MIRLET7B miRNA 25510669 qRT-PCR tissue China 47 47 Down - Related Let-7b was found downregulated remarkably in gastric cancer tissues and was correlated with Helicobacter pylori infection, tumor stage, and lymphatic metastasis. target - - -
MIRLET7B miRNA 25510669 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Ectopic expression of let-7b suppressed the growth, migration, invasion, and tumorigenicity of GC cells, whereas let-7b knockdown promoted these phenotypes. target - - -
MIRLET7B miRNA 25510669 Xenograft mice models mice - - - - - No Reports Let-7b suppresses the tumorigenicity in vivo. target - - -
MIRLET7B miRNA 25510669 Luciferase reporter assay cell line - - - - - No Reports Cthrc1 was a direct target of let-7b. target - - -
MIRLET7G miRNA 25288334 qRT-PCR tissue China 76 76 Down - No Reports let-7g was found down-regulated in gastric cancer and correlated with N-stage and lymph node metastasis. AKT2 mRNA expression showed negative correlation with the expression of let-7g in primary tumors. target - 0.051 -
MIRLET7G miRNA 25288334 Cell proliferation assay; Invasion assay; Cell colony fomation assay cell line - - - - - No Reports suppressed the growth and invasive capacityof GC cells target - 0.051 -
MIRLET7G miRNA 25288334 Xenograft mouse models mice - - - - - No Reports let-7b/g transfectants formed smaller xenografts than those scramble transfectants target - 0.051 -
MIRLET7G miRNA 25288334 Luciferase reporter assay cell line - - - - - No Reports let-7b/g inhibited AKT2 expression by directly binding to its 3'UTR, reduced p-AKT (S473) activation and suppressed expression of the downstream effector pS6. target - 0.051 -
  Summary of Functional Type.
Functional Type Count
diagnosis 5
prognosis 211
mechanism 143
target 360
target,diagnosis 1
target;prognosis 1
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
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