MKGC: a curated molecular knowledgebase for gastric cancer
 Browse All GCs By
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Official
Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
AK023391 lncRNA 29282102 Xenograft mouse models mice - - - - - No Reports Knockdown of lncRNAAK023391 inhibits tumor growth in vivo prognosis 0.0024 - 0.56
ANGPTL6 protein-coding 31146977 Xenograft mice models mice - - - - - No Reports ANGPTL6 loss results in tumor growth in vivo. target - - -
ANKRD40CL protein-coding 32293550 Xenograft mice models mice - - - - - No Reports Knockdown of LINC00483 decreases tumor growth in gastric cancer xenograft model. target - - -
ARHGAP5 protein-coding 30250020 Xenograft mice models mice - - - - - No Reports ARHGAP5 acts as an oncogene promoting GC metastasis in vivo. prognosis 0.002 - -
ASCL2 protein-coding 29746925 Xenograft mice models mice - - - - - No Reports High levels of ASCL2 expression are necessary for stemness and tumorigenicity of ASCL2+ GC cells target/prognosis < 0.001 - -
BTG1 protein-coding 26050197 Xenograft mice models mice - - - - - No Reports BTG1 overexpression enhanced autophagy and apoptosis in xenograft models. target/prognosis 0.047 - -
BTG3 protein-coding 25904053 Xenograft mice models mice - - - - - No Reports BTG3 suppresses the growth of gastric cancer cells in nude mice. target - - -
BTG3 protein-coding 25238703 Xenograft mice models mice - - - - - No Reports BTG3 suppressed the proliferation of GC cells in vivo. target/prognosis 0.001 - -
BTG4 protein-coding 19576178 Xenograft mice models mice - - - - - No Reports BTG4 reexpression sensitizes tumor growth in mice. mechanism - - -
C8orf76 protein-coding 30733230 Xenograft mice models mice - - - - - No Reports C8orf76 promotes the growth of subcutaneous xenograft tumors in nude mice; C8orf76 promotes gastric cancer metastasis to lung and liver in vivo. prognosis < 0.0001 - -
CBFB protein-coding 29386218 Xenograft mice models mice - - - - - No Reports knockdown of CBFB could inhibit gastric cancer cell tumor growth in vivo prognosis < 0.001 - -
CD151 protein-coding 23533596 Xenograft mice models mice - - - - - No Reports CD151 Promoted Metastasis of HGC Cells in vivo target/prognosis 0.007 - -
CD276 protein-coding 25120098 Xenograft mice models mice - - - - - No Reports B7-H3 expression reduced gastric cancer metastasis in vivo。 target - - -
CLCN3 protein-coding 30217218 Xenograft mice models mice - - - - - No Reports The expression and function of CLC-3 were regulated by XRCC5 in vivo target/prognosis 0.012 - -
CLEC4M protein-coding 28403883 Xenograft mice models mice - - - - - No Reports DC-SIGNR knockdown suppressed the liver metastasis in vivo. target - - -
CMTM3 protein-coding 24131472 Xenograft mice models mice - - - - - No Reports In vivo experiments showed that peritoneal disseminated metastases were significantly suppressed by CMTM3. prognosis 0.041 - -
COL10A1 protein-coding 30154451 Xenograft mice models mice - - - - - No Reports Knockdown COL10A1 inhibited lung and abdominal cavity metastasis in a nude mouse model. prognosis 0.003/0.000 - -
CORO1C protein-coding 22974233 Xenograft mice models mice - - - - - No Reports Knockdown of coronin 3 significantly reduced liver metastasis in mice after tail vein injection of gastric cancer cells. mechanism - - -
DNMT3A protein-coding 26350239 Xenograft mice models mice - - - - - No Reports DNMT3A promotes tumor cell proliferation in vivo target - - -
DUSP5P1 lncRNA 30733230 Xenograft mice models mice - - - - - No Reports Significantly more proliferating cells and fewer apopto- tic cells were shown in DUSP5P1-transfected xenografts as compared with control group by Ki-67 and TUNEL assays. mechanism - - -
ERBB4 protein-coding 29620274 Xenograft mouse models mice - - - - - No Reports Silencing of ERBB4 expression suppresses tumor growth in vivo. target - - -
ERBB4 protein-coding 29620274 IHC mice - - - - - No Reports inhibitor of ERBB4 (AST-1306) significantly downregulated the expression level of the prolif- eration-related proteins PI3K and Akt target - - -
FLJ22763 lncRNA 30716442 Xenograft mice models mice - - - - - No Reports LncRNA FLJ22763 inhibits tumorigenesis of GC cells in vivo target/prognosis 0.003 - -
HOXA1 protein-coding 26791264 Xenograft mice models mice - - - - - No Reports Knockdown of HOXA1 suppressed xenograft tumor formation in vivo prognosis < 0.001 < 0.001 -
hsa_circ_0000199 circRNA 30927924 Xenograft mice models mice - - - - - No Reports circAKT3 promotes DNA damage repair and inhibits the apoptosis of GC cells in vivo. target/prognosis - 0.0293 0.91
hsa_circ_0092303 circRNA 31182928 Xenograft mice models mice - - - - - No Reports circCACTIN efficiently promoted GC tumor formation and EMT in vivo target - - -
KDM4B protein-coding 24077348 Xenograft mice models mice - - - - - No Reports JMJD2B knockdown inhibits tumor metastasis in vivo. target - - -
KRT19P3 lncRNA 31409899 Xenograft mice models mice - - - - - No Reports KRT19P3 suppressed GC cell migration and invasion and tumor growth in vivo. target/prognosis 0.0016 0.0028 -
LINC01234 lncRNA 29386218 Xenograft mice models mice - - - - - No Reports knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts. prognosis <0.001 <0.001 -
LINC02859 lncRNA 31207155 Xenograft mouse models mice - - - - - No Reports LOC101928316 Overexpression inhibited gastric cancer cells tumorigenesis in vivo target - - -
MIR106B miRNA 30907988 Xenograft mice models mice - - - - - No Reports Down-regulation of miR-106b inhibited gastric cancer in vivo. mechanism - - -
MIR1275 miRNA 31357957 Xenograft mice models mice - - - - - No Reports Ectopic expression of miR-1275 inhibited the metastasis and invasion in vivo. prognosis < 0.001 - -
MIR137 miRNA 26102366 Xenograft mice models mice - - - - - No Reports The in vivo experiments demonstrated that the miR-137 overexpression can reduce the gastric cancer cell proliferation and metastasis. mechanism - - -
MIR142 miRNA 30178386 Xenograft mice models mice - - - - - No Reports MiR-142-5p inhibited cancer cell migration and invasion in vivo. target/prognosis 0.001 - -
MIR148A miRNA 27518872 Xenograft mice models mice - - - - - No Reports Ectopic expression of miR-148a inhibited tumor formation in vivo. target - - -
MIR187 miRNA 27864146 Xenograft mice models mice - - - - - No Reports miR-187 promoted tumor growth in vivo target - - -
MIR194-1 miRNA 27810403 Xenograft mice models mice - - - - - No Reports Inhibition of miRNA-194 decreased tumor volumes in nude mice. target - - -
MIR203A miRNA 25373785 Xenograft mice models mice - - - - - No Reports MiR-203 suppressed tumor growth of GC cells in nude mice. mechanism - - -
MIR208A miRNA 27634902 Xenograft mice models mice - - - - - No Reports miR-208a-3p promoted the development of tumor growth target - - -
MIR27A miRNA 27409164 Xenograft mice models mice - - - - - No Reports miR-27a-3p promotes GC cell growth in vivo. target - - -
MIR320A miRNA 27086911 Xenograft mice models mice - - - - - No Reports nude mice injected with BGC-823 gastric cancer cells expressing a miR-320a inhibitor exhibit faster tumor growth than mice injected with control cells. mechanism - - -
MIR381 miRNA 28193228 Xenograft mice models mice - - - - - No Reports MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vivo. target/prognosis 0.024 0.037 -
MIR5590 miRNA 30029874 Xenograft mouse models mice - - - - - No Reports Downregulation of miR-5590-3p promoted GC proliferation in vitro target - - -
MIR589 miRNA 30012200 nude mouse xenograft model mice - - - - - No Reports Endogenous overexpression of miR-589 promotes metastasis of GC cell in vivo target - - -
MIR675 miRNA 28848149 Xenograft mice models mice - - - - - No Reports There was a dramatic decrease in in tumor volume and weight in nude mice in which LV- shH19 infected SGC-7901 cell. co-infection with LV-miR675 partially reversed this tendency. target - - -
MIR874 miRNA 23800944 Xenograft mice models mice - - - - - No Reports miR-874 suppresses the tumorigenicity in vivo mechanism - - -
MIR9-1 miRNA 23383271 Xenograft mice models mice - - - - - No Reports miR-9 attenuated the growth and metastasis of gastric cancer cells in vivo mechanism - - -
MIRLET7B miRNA 30237418 Xenograft mice models mice - - - - - No Reports Upregulation of let-7b inhibited tumor growth derived from DDP-resistant cells in vivo. target - - -
MIRLET7B miRNA 25288334 Xenograft mouse models mice - - - - - No Reports let-7b/g transfectants formed smaller xenografts than those scramble transfectants target/prognosis - 0.001 -
MIRLET7B miRNA 25510669 Xenograft mice models mice - - - - - No Reports Let-7b suppresses the tumorigenicity in vivo. target - - -
MIRLET7G miRNA 25288334 Xenograft mouse models mice - - - - - No Reports let-7b/g transfectants formed smaller xenografts than those scramble transfectants target - 0.051 -
NOTCH4 protein-coding 25511451 Xenograft mice models mice - - - - - No Reports Notch4 activation promotes tumor growth in vivo, while Notch4 inhibition inhibits tumor growth in vivo target - - -
PCAT18 lncRNA 32119960 Xenograft mice models mice - - - - - No Reports In in-vivo experiment, PCAT18 over-expression restrained tumor growth and metastasis. target - - -
PDCD4 protein-coding 27634902 Xenograft mice models mice - - - - - No Reports PDCD4 inhabit the development of tumor growth target - - -
PKM protein-coding 28588255 Xenograft mice models mice - - - - - No Reports PKM2 knockdown inhibits the tumor progression of GC in vivo. target/prognosis 0.006 - -
SIRT1 protein-coding 30250020 Xenograft mice models mice - - - - - No Reports SIRT1 inhibits metastasis of GC in vivo target - - -
SKP2 protein-coding 27572672 Xenograft mice models mice - - - - - No Reports Interference with the endogenous expression of Skp2 inhibits tumor cell growth in nude mice. target - - -
SNHG7 lncRNA 29131253 Xenograft mice models mice - - - - - No Reports Experiment on nude-mouse transplanted tumor model confirmed that after SNHG7 expression was interfered, in vivo tumor growth was inhibited. target - - -
SNORD105B snoRNA 29554660 Xenograft mice models mice - - - - - No Reports Promotes the growth of transplanted tumors in vivo. target - - -
TET2 protein-coding 31242038 Xenograft mouse model mice - - - - - No Reports TET2 suppresses tumor growth in vivo prognosis < 0.01 - -
TMEM41A protein-coding 30015937 Xenograft mice models mice - - - - - No Reports Knockdown of TMEM41A was also observed to affect tumor metastasis in nude mice. target - - -
ZNF143 protein-coding 27449034 Xenograft mice models mice - - - - - No Reports ZNF143 knockdown suppresses metastases of GC cells in vivo target - - -
  Summary of Gene Type.
Gene Type Count
circRNA 16
lncRNA 79
miRNA 240
protein-coding 361
pseudogene 3
snoRNA 5
  Summary of Functional Type.
Functional Type Count
diagnosis 5
prognosis 211
mechanism 143
target 360
target,diagnosis 1
target;prognosis 1
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
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