MKGC: a curated molecular knowledgebase for gastric cancer
 Browse All GCs By
  Summary of source.
Source Count
blood 4
cell line 365
exosomes in plasma 2
mice 62
plasma 2
PPLF 1
serum 6
tissue 259
  Summary of Gene Type.
Gene Type Count
circRNA 16
lncRNA 79
miRNA 240
protein-coding 361
pseudogene 3
snoRNA 5
  Browse for prognosis
Official
Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
ACOT7 protein-coding 32469171 qRT-PCR tissue China 10 10 Up - No Reports Upregulated in gastric tumor tissues and GC cell lines.Furthermore, NMRAL2P was downregulated in tumor tissues and GC cell lines. target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Cell proliferation assay;Migration assay;Flow cytometry cell line - - - - - No Reports ACOT7 gene silencing induced a less malignant phenotype and was closely correlated to reduced cell proliferation and migration, altered cell cycle, and increased apoptosis. target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Western blot tissue China 5 5 Up - No Reports Upregulated in GC tumor tissue at protein level target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Luciferase reporter assay cell line - - - - - No Reports NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. target/prognosis 0.025 - -
ADAM17 protein-coding 30569104 qRT-PCR tissue China 193 0 - - No Reports Survival times of patients were significantly associated with ADAM17 expression prognosis - - 0.618 (Mortality risk)
ADAM17 protein-coding 30569104 IHC tissue China 15 15 Up - No Reports ADAM17 expression in gastric tumor tissues was significantly upregulated compared to those in adjacent normal tissues, and was also upregulated in positive metastatic lymph node tissues relative to those in the negative tissues. prognosis - - 0.618 (Mortality risk)
ADAM17 protein-coding 30569104 Western blot tissue China 5 5 Up - No Reports ADAM17 expression was significantly upregulated in primary gastric tumor tissues and positive metastatic lymph node tissues prognosis - - 0.618 (Mortality risk)
ADAM17 protein-coding 30569104 Cell proliferation assay; Migration assay cell line - - - - - No Reports ADAM17 promotes the viability and migration of gastric cancer cells. prognosis - - 0.618 (Mortality risk)
AFAP1-AS1 lncRNA 28975981 qRT-PCR tissue China 91 91 Up Up No Reports AFAP1-AS1 expression was dramatically increased in GC tissues and cells, compared with noncancerous gastric tissues and control cells. The higher lncRNA AFAP1-AS1 expression was positively correlated with lymph node metastasis, TNM stage and worse overall survival (OS) time in GC patients. AFAP1-AS1 expression levels were independent prognostic factors of OS in GC patients. prognosis 0.001 - -
AFAP1-AS1 lncRNA 28975981 Cell proliferation assay; Invasion assay; cell line - - - - - No Reports Knockdown of lncRNA AFAP1-AS1 significantly inhibited the cell proliferation and cell cycle progression. Reduced lncRNA AFAP1-AS1 also inhibited the cell invasion ability via regulating cell epithelial-mesenchymal transition (EMT) phenomenon in GC. prognosis 0.001 - -
AGAP2-AS1 lncRNA 28209205 qRT-PCR tissue China 50 50 Up - No Reports AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Higher AGAP2-AS1 level was associated with larger tumors, advanced pathological stage, and lymph node metastasis. prognosis 0.002 0.025 -
AGAP2-AS1 lncRNA 28209205 Cell proliferation assay; Invasion and migration assay; Cell apoptosis assay; Tumor formation assay cell line - - - - - No Reports Knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. prognosis 0.002 0.025 -
AGAP2-AS1 lncRNA 28209205 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports SP1 could bind to all of these promoter regions of AGAP2-AS1 prognosis 0.002 0.025 -
AGAP2-AS1 lncRNA 28209205 RNA immunoprecipitation cell line - - - - - No Reports AGAP2-AS1 functions as an oncogenic lncRNA by interacting with LSD1 and EZH2 and suppressing CDKN1A (P21) and E-cadherin transcription. prognosis 0.002 0.025 -
AK023391 lncRNA 29282102 qRT-PCR; Microarray tissue China 5 5 Up - No Reports Expression of lncRNA AK023391 was significantly upregulated in gastric cancer samples and cell lines in comparison to adjacent normal tissues prognosis 0.0024 - 0.56
AK023391 lncRNA 29282102 FISH tissue China 77 77 Up - No Reports AK023391 expression was upregulated in GC and was mainly localized in the cytoplasm of the tissue cell, and was positively correlated with poor survival in patients with gastric cancer. The multivariate Cox regression model revealed that AK023391 expression acted as an independent prognostic factor for survival in patients with gastric cancer. prognosis 0.0024 - 0.56
AK023391 lncRNA 29282102 Cell viability assay; Invasion and migration assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports Knockdown of AK023391 inhibits the proliferation, colony formation, DNA synthesis, migration, invasion of GC cells, and induces apoptosis and cell cycle arrest. prognosis 0.0024 - 0.56
AK023391 lncRNA 29282102 IHC; Western blot cell line - - - - - No Reports LncRNA AK023391 is involved in the regulation of the PI3K/Akt signaling pathway prognosis 0.0024 - 0.56
AK023391 lncRNA 29282102 Xenograft mouse models mice - - - - - No Reports Knockdown of lncRNAAK023391 inhibits tumor growth in vivo prognosis 0.0024 - 0.56
APBA2 protein-coding 24385013 RT-MSP tissue China 92 92 Up(Methylation) - No Reports The methylation status of the MINT2 gene was found to be significantly higher in tumor tissues than in adjacent normal tissues. No MINT2 methylation was found in healthy controls.(all P < 0.0001). diagnosis/prognosis - < 0.0001 0.710/0.696
APBA2 protein-coding 24385013 RT-MSP PPLF/blood China 92 - - - No Reports The frequency of MINT2 methylation in pairing PPLF and blood samples from 92 GC patients was 40.2% (37/92) and 39.1% (36/92), respectively. Methylated MINT2 in tumor tissues, pairing PPLF, and blood samples were very approximate. Aberrant MINT2 methylation in tumor tissues and pairing PPLF or blood samples were closely related to peritoneal dissemination, tumor progression, and poor prognosis. diagnosis/prognosis - < 0.0001 0.710/0.696
ARHGAP5 protein-coding 30250020 IHC tissue China 90 90 Up - No Reports The expression of ARHGAP5 was increased in GC, and positively correlated with tumor size, tumor infiltration, lymph node metastasis, and clinical stage. And multivariate analyses indicated that ARHGAP5 served as an independent prognostic marker of GC. prognosis 0.002 - -
ARHGAP5 protein-coding 30250020 Cell invasion and migration assay; cell line - - - - - No Reports ARHGAP5 is involved in SIRT1-induced suppression of GC cell migration and invasion in vitro. prognosis 0.002 - -
ARHGAP5 protein-coding 30250020 Xenograft mice models mice - - - - - No Reports ARHGAP5 acts as an oncogene promoting GC metastasis in vivo. prognosis 0.002 - -
ARID1A protein-coding 22808142 qRT-PCR tissue China 66 66 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues. prognosis 0.003 - -
ARID1A protein-coding 22808142 Western blot tissue China 25 66 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues. prognosis 0.003 - -
ARID1A protein-coding 22808142 Cell proliferation assay; Colony Formation assay; cell line - - - - - No Reports Silencing the expression of ARID1A in GES1 significantly enhanced cell proliferation compared with mock siRNA treatment prognosis 0.003 - -
ARID1A protein-coding 22808142 IHC tissue China 224 - - - No Reports Loss of ARID1A expression was significantly correlated with depth of tumor infiltration (T stage) and tumor grade, but not with age, gender, tumor size, distant metastasis (M stage), and tumor locus or local lymph node metastasis. ARID1A expression as independent predictors of the overall survival of gastric cancer patients. prognosis 0.003 - -
ASCL2 protein-coding 29746925 qRT-PCR tissue China 24 24 Up - No Reports The mRNA levels of ASCL2 were significantly increased in GC tissues compared to ad- jacent non-tumor gastric epithelium; ASCL2 expression in GC correlated with poor histological differentiation, tumor cell invasion into lymph nodes, and higher TNM stages (III + IV). SMYD3 expression status correlates with ASCL2 in GC tissues. target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 IHC tissue China - - - - No Reports ASCL2 protein were detected in the nuclei of GC cells target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 qRT-PCR; FACS; Tumorsphere formation assay cell line - - - - - No Reports ASCL2+ cells showed increased propensity of growing as tumorspheres target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 Xenograft mice models mice - - - - - No Reports High levels of ASCL2 expression are necessary for stemness and tumorigenicity of ASCL2+ GC cells target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 ChIP-qPCR cell line - - - - - No Reports SMYD3 maintains high H3K4me3 levels on the ASCL2 promoter in ASCL2+ cells, indicating its potential role in regulating ASCL2 transcription and expression. target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 qRT-PCR; Western blot cell line - - - - - No Reports Depletion of SMYD3 inhibits Wnt-induced upregulation of ASCL2. target/prognosis < 0.001 - -
ATP6V1A protein-coding 28592880 ChIP-qPCR; qRT-PCR; Western blot cell line - - - - - No Reports YY1 transcriptionally regulates ATP6V1A, and the ATP6V1A core promoter region contains three YY1 binding sites. RNAi-mediated knockdown of YY1 in GC cells significantly decreased ATP6V1A mRNA and protein expression, while YY1 overexpression increased ATP6V1A expression level prognosis 0.01 - -
BANCR lncRNA 26054683 qRT-PCR tissue China 20 20 Up - No Reports The expression of BANCR was increased in gastric cancer tissues compared with paired adjacent normal tissues. prognosis < 0.001 - -
BANCR lncRNA 26054683 qRT-PCR tissue China 184 - - - No Reports High expression of BANCR was positively associated with clinical stage, tumor depth, lymph node metastasis and distant metastasis in gastric cancer patients. prognosis < 0.001 - -
BIRC5 protein-coding 24337012 IHC; TMA tissue China 195 - - - No Reports The expression levels of survivin was significantly higher in patients with lymph node metastasis than in those without metastasis. Patients with high expression levels of survivin showed significantly less favorable survival rates compared with patients with low expression levels of those two genes. Moreover, patients with co-expression of the two genes usually had a poorer prognosis. prognosis 0.003 - -
BMI1 protein-coding 26894855 qRT-PCR tissue China 352 - - Down No Reports Gastric cancer patients survive better with higher expression levels of Bmi-1, and correlated with smaller tumor size, better pathological differentiation (I-II), less lymph node metastases, earlier T stages, non-metastatic disease (M0), earlier UICC stages. The expression of Bmi-1 is significantly different in stage I-II vs. stage III-IV patients. prognosis 0.024 - -
BMI1 protein-coding 26894855 Luciferase reporter assay cell line - - - - - No Reports Bmi-1 is a direct target of miR-15a in gastric cancer cell lines. prognosis 0.024 - -
BMI1 protein-coding 26894855 qRT-PCR; IHC tissue China 21 - - - No Reports The expression of Bmi-1 is inversely correlated with miR-15a in gastric tumor tissues prognosis 0.024 - -
BMI1 protein-coding 18041745 RT-PCR; Western blot tissue China 8 8 Up - No Reports RT-PCR and Western blotting showed that Bmi-1 was up-regulated at both the transcriptional and translational levels in the GC tissues compared with the adjacent non-cancerous tissues. prognosis < 0.01 - -
BMI1 protein-coding 18041745 IHC tissue China 146 - - - No Reports 99 of 146 paraffin-embedded GC samples expressed Bmi-1 extensively. Statistical analysis showed that Bmi-1 overexpression was highly correlated with tumor size, clinical stage, lymph node metastasis and T classification. Patients with Bmi-1 expression had shorter overall survival time than those without Bmi-1 expression (P < 0.01). Multivariate analysis indicated that Bmi-1 expression is an independent prognostic factor of GC. prognosis < 0.01 - -
BTG1 protein-coding 26050197 RT-PCR; Western blot; MS-PCR cell line - - - - - No Reports BTG1 protein expression (19 kDa) was detectable in gastric cancer and epithelial cell lines; BTG1 mRNA was high expressed in cancer and epithelial cells and a decreased level of methylation of BTG1 after treated with 5-Aza-dC. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG1 overexpression suppressed tumor growth and lung metastasis of gastric cancer cells. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 Xenograft mice models mice - - - - - No Reports BTG1 overexpression enhanced autophagy and apoptosis in xenograft models. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 RT-PCR tissue Japan 613 577 Down - No Reports BTG1 expression was statistically lower in gastric cancer than non-neoplastic mucosa and metastatic cancer in lymph node. BTG1 expression was positively correlated with depth of invasion, lymphatic and venous invasion, lymph node metastasis, TNM staging and worse prognosis. The diffuse-type carcinoma showed less BTG1 expression than intestinal- and mixed-type ones. target/prognosis 0.047 - -
BTG3 protein-coding 25238703 qRT-PCR; Western blot tissue China 18 18 Down - No Reports BTG3 was obviously down-regulated in GC tissues. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 IHC tissue China 131 131 - - No Reports The expression of BTG3 was obvi- ously lower in GC tissues than adjacent gastric mucosa. Its expression was positively correlated with distant metastasis. Patients with lower BTG3 expression had shorter overall survival time. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG3 suppressed the proliferation of GC cells in vitro. It also inhibited migration and invasion of GC cells in vitro. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 Xenograft mice models mice - - - - - No Reports BTG3 suppressed the proliferation of GC cells in vivo. target/prognosis 0.001 - -
C8orf76 protein-coding 30733230 CHIP assay tissue China 236 236 - - No Reports DNA copy-number of C8orf76 was frequently gained in gastric cancer. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 qRT-PCR tissue China 146 146 Up - No Reports C8orf76 was upregulated in 69.74% and 65.71% of two independent cohorts of gastric cancers and was positively associated with C8orf76 amplification. Multivariate analysis showed that gastric cancer patients with C8orf76 amplification (cohort I, n = 129; cohort II, n = 107) or overexpression (n = 356) had a significantly shortened survival. C8orf76 significantly promoted gastric cancer cell proliferation, cell-cycle transformation, and migration/invasion, but suppressed cell apoptosis. Silencing C8orf76 expression exerted opposite effects in vitro and significantly inhibited xenograft tumor growth, lung metastasis, and liver metastasis in nude mice. Silencing C8orf76 also significantly suppressed the growth of patient-derived organoids. Mechanically, C8orf76 activated MAPK/ERK signaling cascade. C8orf76 directly bound to the promoter region of lncRNA dual specificity phosphatase 5 pseudogene 1 (DUSP5P1) with a binding motif of AGGCTG and activated DUSP5P1 transcription. DUSP5P1 induced MAPK/ERK signaling and promoted gastric tumorigenesis. Knockdown DUSP5P1 abrogated the effect of C8orf76 in activating MAPK/ERK cascade and the tumor-promoting function. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 IHC tissue China 146 146 Up - No Reports C8orf76 protein expression was significantly higher in primary gastric tumors as compared with adjacent nontumor tissues. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 IHC tissue China 356 - - - No Reports High C8orf76 protein expression was significantly associated with more advanced tumor stage and diffuse-type gastric cancer. C8orf76 is a poor prognostic factor in patients with gastric cancer. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports C8orf76 promotes cell growth and cell-cycle progression, but inhibits cell apoptosis prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Xenograft mice models mice - - - - - No Reports C8orf76 promotes the growth of subcutaneous xenograft tumors in nude mice; C8orf76 promotes gastric cancer metastasis to lung and liver in vivo. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Patient-derived gastric cancer organoid model tissue - - - - - No Reports Knockdown of C8orf76 significantly suppressed the gastric cancer cell growth in three PDO models prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Luciferase reporter assay; Western blot; qRT-PCR; ChIP-PCR cell line - - - - - No Reports DUSP5P1 is a direct downstream target of C8orf76 prognosis < 0.0001 - -
CASC15 lncRNA 29272000 qRT-PCR tissue China 60 42 Up Up No Reports Expression of lncRNA CASC15 in gastric cancer tissue was higher than normal gastric epithelium. Clinical data analysis showed that the expression level of CASC15 was correlated with tumor size and TNM stage in clinical patients. prognosis 0.013 - -
CASC15 lncRNA 29272000 Cell proliferation assay cell line - - - - - No Reports Overexpression of LncRNA CASC15 promoted the proliferation of MKN28 cells. prognosis 0.013 - -
CBFB protein-coding 29386218 Luciferase reporter assay cell line - - - - - No Reports CBFB is a miR-204-5p target gene and promotes gastric cancer cell growth prognosis < 0.001 - -
CBFB protein-coding 29386218 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports CBFB promotes gastric cancer cell growth prognosis < 0.001 - -
CBFB protein-coding 29386218 Xenograft mice models mice - - - - - No Reports knockdown of CBFB could inhibit gastric cancer cell tumor growth in vivo prognosis < 0.001 - -
CCAT1 lncRNA 28239816 qRT-PCR tissue China 240 240 Up - No Reports The expression of CARLo-5 in gastric cancer tissues was significantly higher than that of their matched adjacent normal tissues. High CARLo-5 expression was found to be closely correlated with advanced T stage, positive distant metastasis, lymph node involvement, and poor differentiation. Kaplan-Meier analysis demonstrated that gastric cancer patients with high CARLo-5 expression had poorer OS (p < 0.001) and RFS (p < 0.001). Finally, univariate and multivariate Cox analysis indicated that high CARLo-5 expression were independent predictors for both OS and RFS. prognosis < 0.001 - -
CCAT2 lncRNA 28248065 qRT-PCR tissue China 208 208 Up - No Reports lncRNA CCAT2 was upregulated in GC tissues (P=0.000), and positively correlated with TNM stage (P=0.029), lymphatic invasion (P=0.042) and nervous invasion (P=0.024) in GC patients. Furthermore, we also found that high expression of lncRNA CCAT2 was an unfavorable prognostic factor in GC patients. prognosis < 0.05 - -
CCAT2 lncRNA 28248065 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Silencing of lncRNA CCAT2 inhibits gastric cancer cell proliferation and invasion. prognosis < 0.05 - -
CCAT2 lncRNA 25755774 qRT-PCR tissue China 85 85 Up - No Reports Expression levels of lncRNA CCAT2 in gastric cancer tissues were significantly higher than those in adjacent non-tumor tissues. High lncRNA CCAT2 expression was observed to be closely correlated with higher incidence of lymph node metastasis and distance metastasis. Moreover, patients with high lncRNA CCAT2 expression had shorter overall survival and progression-free survival compared with the low lncRNA CCAT2 group. Multivariate analyses indicated that high lncRNA CCAT2 expression was an independent poor prognostic factor for gastric cancer patients. prognosis 0.003 - -
CCN1 protein-coding 30178386 IHC tissue China 159 42 Up - No Reports CYR61 protein in GC tissues was significantly higher than that in normal gastric tissues.CYR61 expression correlated with distant metastasis and recurrence. Positive CYR61 expression was significantly associated with poor overall survival. prognosis < 0.001 - -
CCN1 protein-coding 30178386 Luciferase reporter assay cell line - - - - - No Reports CYR61 is a novel target of miR‑142‑5p in GC cells prognosis < 0.001 - -
CCN1 protein-coding 27105510 IHC tissue China 214 214 Up - No Reports CYR61 is overexpressed in 44% of the GCA tumor samples. Expression of CYR61 is inversely correlated with cumulative survival of GCA patients (p<0. 001) and significantly associated only with metastatic pathological categories (with N category, p=0. 052; with TNM stage, p=0. 001). prognosis < 0.001 - -
CCN1 protein-coding 27105510 Cell invasion and migration assays cell line - - - - - No Reports knockdown of CYR61 in gastric cancer AGS cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis prognosis < 0.001 - -
CCND1 protein-coding 26791264 qRT-PCR tissue China 48 48 Up - No Reports cyclin D1 mRNA expression were upregulated in GC tissues. A significant correlation was found between the expression of HOXA1 and cyclin D1. prognosis < 0.001 < 0.001 -
CCND1 protein-coding 26791264 IHC; Western blot tissue China 264 264 Up - No Reports cyclin D1 protein expression were upregulated in GC tissue; Overexpression of cyclin D1 was significantly associated with differentiation; Cyclin D1 was also significantly associ- ated with DFS and OS. prognosis < 0.001 < 0.001 -
CD151 protein-coding 23533596 qRT-PCR; Western blot tissue China 20 20 Up - No Reports CD151 mRNA and protein expression was increased in HGC tissues and HGC cells than in nontumor tissues and HGEC cells. CD151 overexpression was significantly correlated with high TNM stage, depth of invasion and positive lymph node involvement (p<0.05), and Importantly, the postoperative 5-year overall survival of patients with CD151(low) and/or integrin a3(low) was higher than that of patients with CD151(high) and/or integrin a3(high). target/prognosis 0.007 - -
CD151 protein-coding 23533596 IHC tissue China 76 - - - No Reports CD151 protein immunoreactivity localized to the cell membrane. High expression of CD151 was significantly correlated with tumor size (p = 0.021), depth of invasion (p = 0.004), lymph node involvement (p =0.028) and high tumor stage (p = 0.002). Overexpression of CD151 are Independent Factors Predicting the Prognosis of HGC Patients. target/prognosis 0.007 - -
CD151 protein-coding 23533596 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Down-regulation of CD151 by vshRNA-CD151 impaired metastasis and invasion of HGC-27 cells, but did not affect cell proliferation. CD151-cDNA transfection rescued the metastatic potential and invasiveness of HGC-27-vshCD151 cells, but not those of HGC-27-vshintegrin a3 cells in vitro. target/prognosis 0.007 - -
CD151 protein-coding 23533596 Xenograft mice models mice - - - - - No Reports CD151 Promoted Metastasis of HGC Cells in vivo target/prognosis 0.007 - -
CD151 protein-coding 23533596 Co-ip assays cell line - - - - - No Reports CD151 formed a complex with integrin a3 in HGC cells. target/prognosis 0.007 - -
CD274 protein-coding 29073638 IHC tissue Korea 116 - - - No Reports Among 116 eligible patients, 57 (49.1%) and 66 patients (56.9%) were determined as iTu-PD-L1-positive and str-PD-L1-positive. Intraepithelial tumour cell PD-L1 positivity was found to be significantly associated with lymph node (LN) metastasis and a poor disease-free survival (DFS) (P=0.032), yet not overall survival (P=0.482). In a multivariate analysis, iTu-PD-L1 positivity was independently associated with a poor DFS (P=0.006, hazard ratio=12.085). prognosis 0.482 0.032 -
CDKN2B-AS1 lncRNA 31242038 PCR tissue China 192 - - - No Reports Patients with higher ANRIL survived worse. Expressions of TET2 and ANRIL were negatively correlated in the patient samples. target/prognosis < 0.001 - -
CDKN2B-AS1 lncRNA 31242038 Apoptosis assay; Migration assay cell line - - - - - No Reports ANRIL suppresses apoptosis in gastric cancer cell, enhances metastasis target/prognosis < 0.001 - -
CDKN2B-AS1 lncRNA 31242038 Xenograft tumor mouse model cell line - - - - - No Reports ANRIL promotes tumor growth in vivo target/prognosis < 0.001 - -
CELF2 protein-coding 29501762 IHC tissue China 104 104 Down - No Reports CELF2 was predominately down regulated in 86 gastric cancer tissues and highly ex- pressed in 18 cancer tissues compared with para-cancer tissues (69 high expressed and 35 low expressed). CELF2 expression was associated with T, N and M stage. Lower expression of CELF2 correlated to shorter period of survival months. prognosis < 0.01 - -
CELF2 protein-coding 29501762 Cell proliferation assay; Flow cytometry; Cell migration assay cell line - - - - - No Reports Overexpressed CELF2 induced cell apoptosis and reduced proliferation ability. prognosis < 0.01 - -
CEMIP protein-coding 28422983 qRT-PCR tissue China 321 - - - No Reports KIAA1199 was upregulated in GC tissue and was an essential independent marker for poor prognosis. KIAA1199 mRNA expression was correlated with the clinical characteristics regarding depth of invasion (T-staging), distant metastasis (M-staging) and TNM staging of GC patients. target/prognosis < 0.001 - -
CEMIP protein-coding 28422983 IHC tissue China 123 - - - No Reports KIAA1199 protein expression was highly expressed in the cytoplasm of GC tissue cells and was correlated with depth of invasion, lymph node status (N-staging), metastasis and TNM staging target/prognosis < 0.001 - -
CEMIP protein-coding 28422983 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Knockdown KIAA1199 suppressed the proliferation, migration and invasion in GC cells. KIAA1199 stimulated the Wnt/β-catenin signaling pathway and the enzymatic activity of matrix metalloproteinase (MMP) family members and thus accelerated the epithelial-to-mesenchymal transition (EMT) progression in GC cells. target/prognosis < 0.001 - -
CHD1L protein-coding 24258459 qRT-PCR tissue China 34 34 Up - No Reports The gene expression levels of CHD1L were higher in fresh samples of GC than in paired adjacent noncancerous tissues. prognosis < 0.001 - -
CHD1L protein-coding 24258459 Western blot tissue China 34 34 Up - No Reports The protein expression levels of CHD1L were higher in fresh samples of GC than in paired adjacent noncancerous tissues. prognosis < 0.001 - -
CHD1L protein-coding 24258459 IHC tissue China 616 616 Up - No Reports Positive expression rates of CHD1L in GC and paired adjacent noncancerous tissues were 58.7 % (361/616) and 7.3 % (45/616), respectively. CHD1L positivity was significantly associated with clinical stage and distant metastasis. GC patients with positive CHD1L expression had shorter overall survival than those with negative CHD1L expression. Multivariate analysis showed that CHD1L was an independent prognostic marker for overall survival [Hazard Ratio (HR) = 5.952, 95 % confidence interval (CI) = 3.194-11.187, P = 0.0043]. prognosis < 0.001 - -
CKS2 protein-coding 21617860 qRT-PCR tissue Japan 109 109 Up - No Reports The expression of CKS2 in gastric cancer is elevated relative to levels in normal tissue, and that CKS2 mRNA overexpression is associated with tumor differentiation, lymph node metastasis, distant metastasis, peritoneal dissemination and poor prognosis. In particular, CKS2 mRNA overexpression is associated with prognosis, as shown by multivariate analyses. prognosis - - -
CKS2 protein-coding 21617860 IHC tissue Japan 109 109 Up - No Reports Staining of CKS2 was markedly stronger in the human gastric cancer tissues than in the corresponding normal tissues. The expression of CKS2 was localized to the cell nucleus. prognosis - - -
CKS2 protein-coding 21617860 Cell proliferation assay; Cell invasion and migration assays; Flow cytometry cell line - - - - - No Reports The inhibition of cellular proliferation by CKS2-siRNA was observed in a gastric cancer cell line. prognosis - - -
CLCN3 protein-coding 30217218 IHC tissue China 90 90 Up - No Reports CLC-3 was overexpressed in human GC tissues and that overexpression of CLC-3 was a poor prognostic biomarker for GC patients (P = 0.012). Higher expression of CLC-3 was correlated with deeper tumor invasion (P = 0.006) and increased lymph node metastasis (P = 0.016) target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports Knockdown of CLC-3 inhibited cell proliferation and migration in vitro. target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Xenograft mice models mice - - - - - No Reports The expression and function of CLC-3 were regulated by XRCC5 in vivo target/prognosis 0.012 - -
CMTM3 protein-coding 24131472 qRT-PCR; Western blot tissue China 6 6 Down - No Reports CMTM3 expression was dramatically downregulated in primary gastric cancer tissues. prognosis 0.041 - -
CMTM3 protein-coding 24131472 IHC tissue China 350 222 Down - No Reports The expression of CMTM3 was remarkably weaker in gastric cancer tissues than in normal mucosae (P = 0.008), and was significantly correlated with gender (P = 0.033), tumor depth (P = 0.049), stage (P = 0.021), and histological grade (P = 0.022). CMTM3 expression was associated with prognosis in gastric cancer patients (P = 0.041), and was a significant independent prognostic indicator. prognosis 0.041 - -
CMTM3 protein-coding 24131472 Cell invasion and migration assay; cell line - - - - - No Reports Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells prognosis 0.041 - -
CMTM3 protein-coding 24131472 Xenograft mice models mice - - - - - No Reports In vivo experiments showed that peritoneal disseminated metastases were significantly suppressed by CMTM3. prognosis 0.041 - -
COL10A1 protein-coding 30154451 qRT-PCR; Western blot tissue China 30 30 Up - No Reports COL10A1 was up-regulated in GC. We observed a positive correlation between the expression patterns of SOX9 and COL10A1 in GC cells and tissues. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 qRT-PCR tissue China 103 - - - No Reports The mRNA expression level of COL10A1 was significantly associated with tumor size, lymphatic emboli, lymph node metastasis, serosal invasion, AJCC stage, and recur_x005frence risk. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 IHC tissue China 99 99 Up - No Reports The protein expression level of COL10A1 was significantly upregulated in GC tissues and showed high concordance. The protein expression levels of COL10A1 and SOX9 were significantly correlated with tumor size, tumor differentiation, lymph node metastasis, and serosal invasion. The protein expression level of COL10A1 was associated with AJCC stage. COL10A1 was associated with a poor prognosis in GC patients. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 Cell invasion and migration assay cell line - - - - - No Reports COL10A1 regulated the migration and invasion of GC cells. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 Xenograft mice models mice - - - - - No Reports Knockdown COL10A1 inhibited lung and abdominal cavity metastasis in a nude mouse model. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports SOX9 directly binds to the COL10A1 promoter and activates its transcription. prognosis 0.003/0.000 - -
COP1 protein-coding 23091414 qRT-PCR tissue China 40 40 Up - No Reports The COP1 expression level was significantly higher in the 25 (62.5%) tumor-bearing tissues, com_x005fpared with the adjacent non-tumor tissues prognosis < 0.001 - -
COP1 protein-coding 23091414 Western blot tissue China 22 22 Up - No Reports High COP1 protein expression in most tumor-bearing tissues compared with the matched adjacent non-tumor tissues. The correlated protein expression analysis revealed a negative correlation between COP1 and p53 in gastric cancer samples. prognosis < 0.001 - -
COP1 protein-coding 23091414 IHC tissue China 401 - - - No Reports High COP1 expression was significantly correlated with T stage (P=0.030), M stage (P=0.048) and TNM stage (P=0.022). High expression of COP1 was significantly correlated with poor survival in gastric cancer patients (P<0.001). Cox regression analyses showed that COP1 expression was an independent predictor of overall survival. prognosis < 0.001 - -
CPXM2 protein-coding 31364750 qRT-PCR; Western blot tissue China 15 15 Up - No Reports CPXM2 mRNA and protein were elevated in the GC cases compared with the non-tumors. prognosis 0.007 - -
CPXM2 protein-coding 31364750 IHC tissue China 90 90 Up - No Reports CPXM2 was expressed mainly in the cytoplasm and on the cytosolic side of the membrane, while its expression was stronger in GCs than in non tumors. High CPXM2 expression was significantly associated with larger tumor size and later pTNM stages.High CPXM2 expression had shorter overall survival (OS) times than did those with low expression. prognosis 0.007 - -
CPXM2 protein-coding 31364750 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports CPXM2 promotes the proliferation and migration of cultured GC cells.CPXM2 may promote GC progression by modulating EMT prognosis 0.007 - -
CRNDE lncRNA 29243780 qRT-PCR tissue China 118 118 Up - No Reports Expression of CRNDE was higher in GC tissues and cells compared with the normal gastric tissue and normal gastric cell lines. High expression of CRNDE was correlated with invasion depth, TNM stage and lymph node metastasis. Furthermore, high CRNDE expression was associated with shorter overall survival of GC patients. Multivariate analysis confirmed that high CRNDE expression was a significant independent predictor of poor survival in GC. prognosis 0.0066 - -
CRNDE lncRNA 29243780 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Knockdown of CRNDE inhibited cell proliferation, migration and invasion of GC. prognosis 0.0066 - -
CRNDE lncRNA 29243780 Western blot; cell transfection cell line - - - - - No Reports CRNDE exerted its oncogenic role by affecting PI3K/AKT signaling pathways. prognosis 0.0066 - -
EPHA8 protein-coding 31026069 IHC tissue China 206 92 Up - No Reports Upregulated in GC tissues compared with nontumor tissues; EphA8 expression was also strongly associated with differentiation level, tumor-node-metastasis stage, and poor 5 years survival. A panel of GC cell lines showed reduced proliferation, invasion, and migration capacities after RNA-mediated knockdown of EphA8, concomitant with downregulation of the proliferation-related proteins (cyclin A, cyclin D1, and cyclin-dependent kinase 4) and the metastasis-related (matrix metalloproteinases MMP2, and MMP9). EphA8 knockdown also decreased expression of the protease ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) and ADAM10-related protein AKT, suggesting an interaction between EphA8 and ADAM10. prognosis < 0.001 - -
EPHA8 protein-coding 31026069 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Knockdown of Epha8 reduces cell proliferation; EphA8 promotes GC cell migration and invasion prognosis < 0.001 - -
EPHA8 protein-coding 31026069 Western blot; Coimmuno precipitation experiments;Immunofluorescence microscopy cell line - - - - - No Reports EphA8 interacts with ADAM10 to affect GC cell growth prognosis < 0.001 - -
EZH2 protein-coding 30952377 IHC tissue China 89 89 Up - No Reports EZH2 levels were increased in gastric cancer tissues compared with adjacent normal tissues. Moreover, patients with high levels of EZH2 expression had a relatively poor prognosis. Furthermore, and vivo. Finally, we found that EZH2 influences gastric cancer cells proliferation partly through regulating p21 expression prognosis 0.001 - -
EZH2 protein-coding 30952377 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports knockdown of EZH2 expression by siRNA could impair cell proliferation and invasion both in vitro. prognosis 0.001 - -
EZH2 protein-coding 30952377 Xenograft mice models cell line - - - - - No Reports Knockdown of EZH2 inhibits gastric cancer cells tumorigenesis in vivo. prognosis 0.001 - -
EZH2 protein-coding 30952377 CHIP assay cell line - - - - - No Reports EZH2 could directly bind to P21 promoter region and mediate H3K27me3 modification. prognosis 0.001 - -
FLJ22763 lncRNA 30716442 qRT-PCR tissue China 5 5 Down - No Reports FLJ22763, a novel lncRNA, had significantly lower expression in GC tissues. target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 qRT-PCR tissue China 303 - - Down No Reports Decreased expression of FLJ22763 was positively correlated with a lower-level histological grade and the depth of invasion. Patients with high FLJ22763 expression levels had a higher five-year survival rate. target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports LncRNA FLJ22763 inhibits cells proliferation, migration, and invasion target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 Xenograft mice models mice - - - - - No Reports LncRNA FLJ22763 inhibits tumorigenesis of GC cells in vivo target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 qRT-PCR; Cell tranfection; Western blot cell line - - - - - No Reports FLJ22763 was negatively associated with ACLY, regulating the mRNA and protein levels of ACLY target/prognosis 0.003 - -
FZD7 protein-coding 29559846 IHC tissue China 251 60 Up - Not Related FZD7 was overexpressed in clinical GC samples, and thus was correlated with tumor invasion, lymphatic and organ metastasis, late TNM stages and poor patient survival. Furthermore, RNA interference-mediated . Moreover, ablation of FZD7 down-regulated EMT and the expression levels of cancer stem cell markers, and these inhibitions were associated with attenuated canonical Wnt/β-catenin signaling target/prognosis < 0.001 < 0.001 -
FZD7 protein-coding 29559846 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Knockdown of FZD7 suppressed gastric cancer cell growth, migration and invasion target/prognosis < 0.001 < 0.001 -
HOXA1 protein-coding 26791264 qRT-PCR tissue China 48 48 Up - No Reports HOXA1 mRNA expression were upregulated in GC tissues. Survival analysis indicated that HOXA1 expression were significantly associated with disease-free survival (DFS) and overall survival (OS). Patients with tumors that were positive for HOXA1 expression showed worse prognosis. Multivariate analysis confirmed that the combination of HOXA1 and cyclin D1 was an independent prognostic indicator for OS and DFS. prognosis < 0.001 < 0.001 -
HOXA1 protein-coding 26791264 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Knockdown of HOXA1 in GC cells inhibited cell proliferation, migration, and invasion in vitro; Knockdown of HOXA1 expression induces changes in the cell cycle of GC cells and decreases cyclin D1 expression prognosis < 0.001 < 0.001 -
HOXA1 protein-coding 26791264 Xenograft mice models mice - - - - - No Reports Knockdown of HOXA1 suppressed xenograft tumor formation in vivo prognosis < 0.001 < 0.001 -
HOXA1 protein-coding 26791264 IHC tissue China 264 264 Up - No Reports There was a correlation between HOXA1 and cyclin D1 in GC; prognosis < 0.001 < 0.001 -
hsa_circ_0000199 circRNA 30927924 qRT-PCR tissue China 149 0 - - No Reports The expression of circAKT3 was higher in CDDP-resistant GC tissues and cells than in CDDP-sensitive samples. It was an independent risk factor for disease-free survival. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Cell cytotoxicity assay; Clonogenic assay; Flow ytometry cell line - - - - - No Reports circAKT3 promotes DNA damage repair and inhibits the apoptosis of GC cells in vitro. Downregulation of circAKT3 facilitates cisplatin sensitivity of CDDP-resistant GC cells in vitro. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Luciferase reporter assay: RNA pull-down; FISH cell line - - - - - No Reports circAKT3 and miR-198 were colocalized in the cytoplasm; circAKT3 exerts its function by sponging miR-198. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Xenograft mice models mice - - - - - No Reports circAKT3 promotes DNA damage repair and inhibits the apoptosis of GC cells in vivo. target/prognosis - 0.0293 0.91
hsa_circ_0004771 circRNA 30717751 qRT-PCR tissue China 80 80 Up - No Reports Upregulated in GC tissues and GC cells. prognosis 0.0019 0.004 -
hsa_circ_0004771 circRNA 30717751 qRT-PCR exosomes in plasma China 40 40 Up - No Reports circNRIP1 can be transmitted by exosomal communication between GC cells, and exosomal circNRIP1 promoted tumour metastasis in vivo. prognosis 0.0019 0.004 -
hsa_circ_0004771 circRNA 30717751 Pull-down assay; Luciferase reporter cell line - - - - - No Reports circNRIP1 serves as a miRNA sponge of miR-149-5p prognosis 0.0019 0.004 -
hsa_circ_0004771 circRNA 30717751 Cell proliferation assay; Invasion and migration assay; Clonogenic assay cell line - - - - - No Reports Knockdown of circNRIP1 inhibits the proliferation, migration, invasion and expression level of AKT1 in GC cells in vitro prognosis 0.0019 0.004 -
ITGA3 protein-coding 23533596 IHC tissue China 76 - - - No Reports The membranes of tumor cells stained positive for integrin a3. In all the tissues analyzed, high levels of integrin a3 expression were detected in 27 HGC tissue samples (35.52%).Patients with high integrin a3 expression were more likely to exhibit aggressive features. Patients with high Integrin a3 showed larger tumors (p =3.46E24), greater depth of invasion (p =0.001), higher tumor stage (p = 0.005), and more lymph node involvement (p = 0.040) than patients with low integrin a3 expression. Overexpression of Integrin a3 is Independent Factors Predicting the Prognosis of HGC Patients. target/prognosis < 0.0001 - -
ITGA3 protein-coding 23533596 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports silencing of integrin a3 markedly inhibited the invasion of HGC27 cells. target/prognosis < 0.0001 - -
ITGA3 protein-coding 23533596 Co-ip assays cell line - - - - - No Reports CD151 formed a complex with integrin a3 in HGC cells. target/prognosis < 0.0001 - -
JAZF1 protein-coding 31357957 Luciferase reporter assay cell line - - - - - No Reports JAZF1 is a direct target of miR-1275 in GC cells. prognosis <0.001 - -
JAZF1 protein-coding 31357957 qRT-PCR tissue China 120 120 Up - No Reports JAZF1 expression was increased in GC tissues and was positively associated with lymph node metastasis and Borrmann type. Better OS in GC patients with lower JAZF1 expression than in patients with higher JAZF1 expression. prognosis <0.001 - -
KRT19P3 lncRNA 31409899 qRT-PCR tissue China 84 29 Down - No Reports KRT19P3 expression was significantly decreased in gastric cancer tissues. Lower expression of KRT19P3 was found to be associated with lager tumor size (≥ 5 cm), advanced TNM stage, Lauren's classification, and positive LNM. Patients with lower KRT19P3 expression had worse overall survival (OS) and disease-free sur_x005fvival (DFS) compared with those patients with higher KRT19P3 expression Univariate analysis demonstrated that patients with lower KRT19P3 expression tended to have a higher risk of death. target/prognosis 0.0016 0.0028 -
KRT19P3 lncRNA 31409899 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports KRT19P3 inhibited GC cell proliferation and induced apoptosis, suppressed GC cell migration and invasion in vitro. target/prognosis 0.0016 0.0028 -
KRT19P3 lncRNA 31409899 Xenograft mice models mice - - - - - No Reports KRT19P3 suppressed GC cell migration and invasion and tumor growth in vivo. target/prognosis 0.0016 0.0028 -
KRT19P3 lncRNA 31409899 RNA pull-down assay; RIP; Western blot cell line - - - - - No Reports KRT19P3 could bind COPS7A directly and might regulate COPS7A activity in GC target/prognosis 0.0016 0.0028 -
LINC01234 lncRNA 29386218 qRT-PCR tissue China 50 50 Up - No Reports LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage, lymph node metastasis, and shorter survival time. prognosis <0.001 <0.001 -
LINC01234 lncRNA 29386218 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports promote cell proliferation and cell tomorigenesis, suppress apotosis and G1 arrest prognosis <0.001 <0.001 -
LINC01234 lncRNA 29386218 Xenograft mice models mice - - - - - No Reports knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts. prognosis <0.001 <0.001 -
LINC01234 lncRNA 29386218 Immunoprecipitation assays cell line - - - - - No Reports LINC01234 binds directly to Ago2 prognosis <0.001 <0.001 -
LINC01234 lncRNA 29386218 Luciferase reporter assay cell line - - - - - No Reports miR-204-5p directly target LINC01234 prognosis <0.001 <0.001 -
MIR1275 miRNA 31357957 qRT-PCR tissue China 120 120 Down - Not Related The expression of miR-1275 was reduced in GC tissues. We validated in 120 GC patients specimens that low miR-1275 expression levels were closely associated with lymph node metastasis, Borrmann type and poor prognosis. prognosis < 0.001 - -
MIR1275 miRNA 31357957 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Ectopic expression of miR-1275 inhibited the metastasis and invasion of GC cells. prognosis < 0.001 - -
MIR1275 miRNA 31357957 Xenograft mice models mice - - - - - No Reports Ectopic expression of miR-1275 inhibited the metastasis and invasion in vivo. prognosis < 0.001 - -
MIR1275 miRNA 31357957 Luciferase reporter assay cell line - - - - - No Reports JAZF1 is a direct target of miR-1275 in GC cells. prognosis < 0.001 - -
MIR129-1 miRNA 29879625 qRT-PCR tissue China 50 50 Up - No Reports miR-129-5p expression in GC tissues was significantly down regulated than that in adjacent normal tissues; patients with large tumor size and lymph node metastasis significantly associated with lower miR-129-5p expression in GC patients. Patients who had lower miR-129-5p expression predicted poor overall survival time in GC patients. prognosis < 0.05 - -
MIR129-1 miRNA 29879625 Luciferase reporter assay cell line - - - - - No Reports miR-129-5p could target the 3′UTR of ADAM9 mRNA and regulated its protein expression prognosis < 0.05 - -
MIR129-1 miRNA 29879625 Cell proliferation assay; Invasion assay cell line - - - - - No Reports miR-129-5p overexpression reduced cell proliferation, cell colony formation and cell invasion capacity prognosis < 0.05 - -
MIR133A1 miRNA 25152372 qRT-PCR tissue China 180 180 Down Down No Reports The expression of miR-133 was significantly down-regulated in gastric cancer tissues compared with that in matched normal tissues. Expression of miR-133 is lower in patients above 65 years old than that of below 65 years old. There was a higher level of miR-133 in smaller size tumor. The expression level of miR-133 was lower in T3 and T4 groups than that in T1 and T2 groups. Decreased miR-133 expression was associated with peripheral organ injury and pathologic stages. The survival rate of high-expression group was significantly higher than that the low_x005fexpression group. prognosis 0.003 - -
MIR133A1 miRNA 25152372 Luciferase reporter assay cell line - - - - - No Reports CDC42 is the direct target of miR-133a prognosis 0.003 - -
MIR133A1 miRNA 25152372 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-133a supresses gastric cancer cell growth, migration and invasion. prognosis 0.003 - -
MIR142 miRNA 30178386 qRT-PCR tissue China 101 101 Down - No Reports MiR-142-5p downregulation was significantly associated with the recurrence (P = 0.031) and poor prognosis of GC (P = 0.043). CYR61 was identified as a novel direct target of miR-142-5p by bioinformatics analysis of target prediction and luciferase reporter. The re-expression and knockdown of CYR61 could, respectively, rescue the effects induced by miR-142-5p overexpression and knockdown. MiR-142-5p attenuated GC cell migration and invasion, at least partially, by inactivation of the canonical Wnt/β-catenin signaling pathway through CYR61. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Cell invasion and migration assays cell line - - - - - No Reports MiR-142-5p inhibited cancer cell migration and invasion both in vitro and in vivo. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Xenograft mice models mice - - - - - No Reports MiR-142-5p inhibited cancer cell migration and invasion in vivo. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Luciferase reporter assay cell line - - - - - No Reports CYR61 is a novel target of miR‑142‑5p in GC cells target/prognosis 0.001 - -
MIR1915 miRNA 31036603 qRT-PCR tissue China 60 60 Down - No Reports miR-1915-3p exhibited low expression level in differentiated gastric cancer cell lines and gastric cancer tissues. The expressions of miR-1915-3p were significantly correlated to the lymph node metastasis and overall survival of patients with gastric cancer. Further study showed that there was a negative correlation between miR-1915-3p and Bcl-2 (B cell lymphoma/leukemia-2) expression. prognosis 0.01 - -
MIR1915 miRNA 31036603 Cell proliferation assay,Cell apoptosis assay cell line - - - - - No Reports It was found that the miR-1915-3p inhibited the growth of gastric cancer cells and promoted cell apoptosis. prognosis 0.01 - -
MIR1915 miRNA 31036603 Luciferase reporter assay cell line - - - - - No Reports miR-1915-3p directly inhibits Bcl-2 expression at post-transcriptional level through its 3'-UTR. prognosis 0.01 - -
MIR204 miRNA 23152059 qRT-PCR tissue Italy 84 84 Down Down No Reports miR-204 is downregulated in gastric tumor samples and advanced stages of GC; miR-204 is a prognostic factor for GCs. prognosis 0.017 - -
MIR204 miRNA 23152059 Luciferase reporter assay cell line - - - - - No Reports miR-204-mediated targeting of Bcl-2 expression pro_x005fmotes apoptosis of GC cells. prognosis 0.017 - -
MIR204 miRNA 23152059 Cell migration assay; Cell colony formation assay; Cell apoptosis assay cell line - - - - - No Reports miR-204 overexpression affects cell migration, colony forming ability and chemoresistance. prognosis 0.017 - -
MIR208A miRNA 29886152 qRT-PCR tissue China 62 62 Up Up No Reports miR-208a expression was significantly increased in GC tissues compared with adjacent normal tissues. Higher miR-208a expression was association with lymph node metastasis and TNM stage in GC patients. Kaplan-Meier analysis verified that patients with higher miR-208a expression were significantly associated with shorter overall survival (OS) time. miR-208a expression negatively associated with MEG3. target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Cell proliferation assay; Cell invasion assay; cell line - - - - - No Reports Ectopic expression of miR-208a by treatment with miR-208a mimic promoted cell proliferation and invasion abilities, but downregulation of miR-208a by treatment with miR-208a inhibitor had an opposite effects. target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Luciferase reporter assay cell line - - - - - No Reports SFRP1 is a direct target of MiR-208a in GC cells target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Luciferase reporter assay; RIP cell line - - - - - No Reports MEG3 is a bona fide target for miR-208a in GC cells target/prognosis < 0.05 - -
MIR222 miRNA 25129310 qRT-PCR plasma China 114 56 UP - In this study, our results demonstrated that the levels of circulating miR-222 in patients with GC were significantly increased, compared with CAG and healthy controls. In addition, higher level of circulating miR-222 had also been found in the plasma of CAG patients compared with healthy controls, indicating the dysregulated expression of miR-222 might be involved in the early events of GC malignancy. target;prognosis 22.428 % 25.267% 0.85
MIR381 miRNA 28193228 qRT-PCR tissue China 103 103 Down - No Reports MiR-381 was significantly down-regulated in gastric cancer tissues and cell lines. Low expression of miR-381 was negatively related to lymph node metastasis, advanced tumor stage and poor prognosis.miR-381 and TMEM16A revealed the improved prognostic accuracy for gastric cancer patients. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vitro. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Xenograft mice models mice - - - - - No Reports MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vivo. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Luciferase reporter assay; Western blot; IHC cell line - - - - - No Reports TMEM16A was identified as a direct target of miR-381 and the expression of miR-381 was inversely correlated with TMEM16A expression in gastric cancer tissues target/prognosis 0.024 0.037 -
MIR615 miRNA 29501762 qRT-PCR tissue China 104 104 Up Up No Reports Aberrant high expression of miR-615-3p and low expression of CELF2 in gastric cancer both in vivo and in vitro. Moreover, miR-615-3p expression correlated to T and M stage. Higher expression of miR-615-3p correlated to shorter period of survival months. prognosis < 0.05 - -
MIR615 miRNA 29501762 Cell proliferation assay; Flow cytometry; Cell migration assay cell line - - - - - No Reports miR-615-3p inhibits apoptosis and promotes proliferation and migration ability in SGC7901 cell line. Overexpression of CELF2 could reverse miR-615-3p's oncogenic functions stated before. prognosis < 0.05 - -
MIRLET7B miRNA 25288334 qRT-PCR tissue China 76 76 Down - No Reports let-7b was down-regulated in gastric cancer and its downregulation was associated with poor survival and correlated with lymph node metastasis. AKT2 mRNA expression showed negative correlation with the expression of let-7b in primary tumors. target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Cell proliferation assay; Invasion assay; Cell colony fomation assay cell line - - - - - No Reports suppressed the growth and invasive capacityof GC cells target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Xenograft mouse models mice - - - - - No Reports let-7b/g transfectants formed smaller xenografts than those scramble transfectants target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Luciferase reporter assay cell line - - - - - No Reports let-7b/g inhibited AKT2 expression by directly binding to its 3'UTR, reduced p-AKT (S473) activation and suppressed expression of the downstream effector pS6. target/prognosis - 0.001 -
PKM protein-coding 28588255 IHC tissue China 88 88 Up - No Reports PKM2 protein was predominantly located in the nucleus and cytoplasma, and was observed to have higher IHC scores in gastric cancer samples than in peritumor tissues; PKM2 expression was positively correlated with lymph node metastasis, tumor invasion and TNM staging. target/prognosis 0.006 - -
PKM protein-coding 28588255 Cell proliferation assay; Cell colony formation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports knockdown of PKM2 can inhibit GC cell proliferation, G1-S phase transition,especially, attenuate GC cell migration target/prognosis 0.006 - -
PKM protein-coding 28588255 Xenograft mice models mice - - - - - No Reports PKM2 knockdown inhibits the tumor progression of GC in vivo. target/prognosis 0.006 - -
PKM protein-coding 28588255 Western blot; cell transduction cell line - - - - - No Reports PKM2 mediates cell migration and autophagy via the PI3K/Akt signaling pathway. target/prognosis 0.006 - -
RB1 protein-coding 14691913 IHC tissue U.K. 67 67 - - No Reports pRb expression was lower in lymph node metastases than in the corresponding primary tumors; low pRb expression may be a powerful independent negative prognostic factor. prognosis 0.0027 - -
SOX9 protein-coding 30154451 qRT-PCR; Western blot tissue China 30 30 Up - No Reports SOX9 was up-regulated in GC. We observed a positive correlation between the expression patterns of SOX9 and COL10A1 in GC cells and tissues. prognosis 0 - -
SOX9 protein-coding 30154451 qRT-PCR tissue China 103 - - - No Reports The mRNA expression level of SOX9 was significantly associated with tumor size, lymphatic emboli, lymph node metastasis, serosal invasion, AJCC stage, and recur_x005frence risk. prognosis 0 - -
SOX9 protein-coding 30154451 IHC tissue China 99 99 Up - No Reports The protein expression level of SOX9 was significantly upregulated in GC tissues and showed high concordance. The protein expression levels of COL10A1 and SOX9 were significantly correlated with tumor size, tumor differentiation, lymph node metastasis, and serosal invasion. The protein expression level of COL10A1 was associated with AJCC stage. COL10A1 was associated with a poor prognosis in GC patients. prognosis 0 - -
SOX9 protein-coding 30154451 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports SOX9 directly binds to the COL10A1 promoter and activates its transcription. prognosis 0 - -
TET2 protein-coding 31242038 qRT-PCR tissue China 192 - - - No Reports Patients with high TET2 expression had significantly longer survival time. prognosis < 0.01 - -
TET2 protein-coding 31242038 Apoptosis assay; Migration assay cell line - - - - - No Reports TET2 decreased gastric cancer cell survival and suppressed metastasis prognosis < 0.01 - -
TET2 protein-coding 31242038 Xenograft mouse model mice - - - - - No Reports TET2 suppresses tumor growth in vivo prognosis < 0.01 - -
TNK2 protein-coding 25678401 Western blot tissue China 6 6 Up - No Reports ACK1 protein level and ACK1 phosphorylation at Tyr 284 were frequently elevated in GC tissues. target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 IHC tissue China 77 77 Up - No Reports ACK1 overexpression in GC correlates with poor prognosis; positively associated with lymph node metastasis and a more advanced clinical stage in GC target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 Cell invasion and migration assays cell line - - - - - No Reports ACK1 induces EMT, invasion, and metastasis target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 Western blot; Luciferase reporter assay; IHC cell line - - - - - No Reports ACK1 up-regulates ECD expression by increasing the level of POU2F1. target/prognosis < 0.001 - -
VEGFC protein-coding 24337012 IHC; TMA tissue China 195 - - - No Reports The expression levels of VEGF-C was significantly higher in patients with lymph node metastasis than in those without metastasis. Patients with high expression levels of VEGF-C showed significantly less favorable survival rates compared with patients with low expression levels of it. prognosis 0.039 - -
XRCC5 protein-coding 30217218 IHC tissue China 90 90 Up - No Reports XRCC5 was localized to the nucleus, and its expression was higher in GC tissues than that in normal tissues. The expression of CLC-3 and XRCC5 was positively correlated. High expression of XRCC5 predicted a poor prognosis for GC patients. prognosis < 0.01 - -
XRCC5 protein-coding 30217218 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports knockdown of XRCC5 attenuated the cell clonogenicity, proliferation,invasion and migration. prognosis < 0.01 - -
XRCC5 protein-coding 30217218 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. prognosis < 0.01 - -
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
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