MKGC: a curated molecular knowledgebase for gastric cancer
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  Summary of source.
Source Count
blood 4
cell line 365
exosomes in plasma 2
mice 62
plasma 2
PPLF 1
serum 6
tissue 259
  Browse for protein-coding
Official
Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
ABCB1 protein-coding 1977924 Slot blot assay tissue Japan 13 5 Up - No Reports Moderately differentiated gastric carcinomas contained higher concentrations of MDR1 mRNA than poorly differentiated gastric carcinomas. - - - -
ABCB1 protein-coding 23801278 CRS-PCR blood China 365 367 - - No Reports The allele and genotype frequencies of c.159G > T and c.1564A > T were statistically different between gastric cancer patients and cancer-free controls. diagnosis - - -
ACOT7 protein-coding 32469171 qRT-PCR tissue China 10 10 Up - No Reports Upregulated in gastric tumor tissues and GC cell lines.Furthermore, NMRAL2P was downregulated in tumor tissues and GC cell lines. target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Cell proliferation assay;Migration assay;Flow cytometry cell line - - - - - No Reports ACOT7 gene silencing induced a less malignant phenotype and was closely correlated to reduced cell proliferation and migration, altered cell cycle, and increased apoptosis. target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Western blot tissue China 5 5 Up - No Reports Upregulated in GC tumor tissue at protein level target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Luciferase reporter assay cell line - - - - - No Reports NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. target/prognosis 0.025 - -
ACTN4 protein-coding 28581489 qRT-PCR tissue China 47 47 Up Up No Reports Upregulated in GC Tissue Samples target - - -
ACTN4 protein-coding 28581489 Western blot cell line - - - Up - No Reports Upregulated in GC Cell Lines target - - -
ACTN4 protein-coding 28581489 Adhesion assay;Migration assay;Invasion assay cell line - - - - - No Reports Downregulation of Actn4 enhances GC cell adhesion, suppresses migration and invasion of GC Cells target - - -
ADAM10 protein-coding 26852749 qRT-PCR tissue China 40 40 Up - No Reports Upregulated in GC tissues and cells - - - -
ADAM10 protein-coding 26852749 Cell proliferation assay;Colony formation;Invasion assay cell line - - - - - No Reports ADAM10 overexpression rescued the effect of miR-448-mediated GC cell proliferation, colony formation, and invasion - - - -
ADAM10 protein-coding 26852749 Luciferase reporter assay cell line - - - - - No Reports ADAM10 was a direct target gene of miR-448 in GC cell - - - -
ADAM10 protein-coding 29152656 qRT-PCR tissue China 40 40 Up - No Reports Upregulated in GC tumor tissue compared with normal tissues; the expression of miR-320a was negatively correlated with the mRNA levels of ADAM10 in tumor tissues. - - - -
ADAM10 protein-coding 29152656 Colony formation assay;MTS assay;Viability assay cell line - - - - - No Reports ADAM10 contributes to proliferation and desensitization of GC cells to cisplatin - - - -
ADAM10 protein-coding 29152656 Luciferase reporter assay cell line - - - - - No Reports miR‑320a directly targets ADAM10 in GC cells. - - - -
ADAM17 protein-coding 30569104 qRT-PCR tissue China 193 0 - - No Reports Survival times of patients were significantly associated with ADAM17 expression prognosis - - 0.618 (Mortality risk)
ADAM17 protein-coding 30569104 IHC tissue China 15 15 Up - No Reports ADAM17 expression in gastric tumor tissues was significantly upregulated compared to those in adjacent normal tissues, and was also upregulated in positive metastatic lymph node tissues relative to those in the negative tissues. prognosis - - 0.618 (Mortality risk)
ADAM17 protein-coding 30569104 Western blot tissue China 5 5 Up - No Reports ADAM17 expression was significantly upregulated in primary gastric tumor tissues and positive metastatic lymph node tissues prognosis - - 0.618 (Mortality risk)
ADAM17 protein-coding 30569104 Cell proliferation assay; Migration assay cell line - - - - - No Reports ADAM17 promotes the viability and migration of gastric cancer cells. prognosis - - 0.618 (Mortality risk)
ADAM9 protein-coding 29879625 qRT-PCR tissue China 50 50 Up - No Reports ADAM9 mRNA expression in GC tissues was significantly higher than that in adjacent normal tissues - - - -
ADAM9 protein-coding 29879625 Luciferase reporter assay cell line - - - - - No Reports ADMA9 was a target of miR-129-5p in GC cells. - - - -
ADAM9 protein-coding 29879625 Cell proliferation assay; Invasion assay cell line - - - - - No Reports - - - -
ADAM9 protein-coding 28260063 qRT-PCR tissue China 76 76 Up - No Reports The expression of ADAM9 was significantly correlated with patient clinicopathological features including tumor size, local invasion, lymph node metastasis and TNM stage. target - - -
ADAM9 protein-coding 28260063 IHC; Western blot tissue China 76 76 Up - No Reports ADAM9 is expressed frequently higher in GC tissues when compared with adjacent non-cancerous tissues target - - -
ADAM9 protein-coding 28260063 Cell proliferation assay; Cell cycle analysis. cell line - - - - - No Reports target - - -
ADAM9 protein-coding 28260063 Luciferase reporter assay cell line - - - - - No Reports ADAM9 is a direct target post-transcriptionally regulated by miR-126 in GC cells. target - - -
ADGRE5 protein-coding 26034356 Cell proliferation assay; Invasion assay cell line - - - - - No Reports Exosomes isolated from SGC/wt (high CD97 expression ) cells significantly promoted tumor cell proliferation in a dose-dependent manner in vitro. SGC/wt exosomes also significantly elevated the invasiveness of both SGC/wt and SGC/kd (low CD97 expression) cells as compared to the exosomes released by SGC/kd cells. mechanism - - -
ADRM1 protein-coding 24968865 Cell proliferation assay cell line - - - - - No Reports Overexpression of Adrm1 promoted cell proliferation of conditionally-immortalized, mouse ImSt gastric epithelial cells, with increased S1 phase fraction and decreased expression of p21(Cip1). These results collectively indicate that ADRM1 promoted gastric epithelial cell proliferation by cell cycle progression target - - -
ADRM1 protein-coding 24968865 Comparative genomic hybridization tissue Korea 32 - - - No Reports ADRM1 was the third most frequent target for gene amplification target - - -
ADRM1 protein-coding 24968865 Microarray tissue Korea 32 21 Up - No Reports ADRM1 was also overexpressed in 92 cancer patients than in 21 healthy volunteers target - - -
AFAP1L2 protein-coding 24387290 Clonogenic assay; Soft agar colony-forming assay; Flow cytometry; BrdU incorporation assay; Cell viability assay; Invasion and migration assay; Xenograft model cell line - - - - - No Reports The proliferation, migration, and invasion of GC cell lines were all significantly inhibited by knockdown of XB130. In a xenograft model, tumor growth was markedly inhibited after shXB130-transfected GC cells were implanted into nude mice. After XB130 knockdown, GC cells showed a more epithelial-like phenotype. Silencing of XB130 reduced the expression of p-Akt/Akt, upregulated expression of epithelial markers including E-cadherin, aβ-catenin and β-catenin, and downregulated mesenchymal markers including fibronectin and vimentin. target - - -
AGER protein-coding 24441189 IHC tissue China 40 40 Up - No Reports RAGE was highly expressed in cancer tissues, and correlated with lymph node metastases. target - - -
AGER protein-coding 24441189 Cell proliferation assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of RAGE reduced cell proliferation and invasion of gastric cancer with decreased expression of AKT, PCNA and MMP-2, and induced cell apoptosis and cycle arrest target - - -
AGO2 protein-coding 23775134 IHC tissue China 371 10 Up - No Reports Ago2 expression levels in primary GC and corresponding lymph node metastases were significantly higher compared with healthy controls. Ago2 was different between HER-2 positive and HER-2 negative groups. And there was a great correlation between Ago2 expression and the tumor differentiation, lymph node invasion and clinical stage. Ago2 was also correlated to patients' gender which may suggest a possible role of hormonal signal in the mechanisms of Ago2. mechanism - - -
AKAP12 protein-coding 15258566 MSP cell line - - - - - No Reports Two isoforms AKAP12A and AKAP12B are independently expressed and were absent from the majority of human gastric cancer cells. 5' CpG islands of both AKAP12A and AKAP12B are frequently hypermethylated in GC cells. DNA methylation is directly involved in the transcriptional silencing of AKAP12 in gastric cancer cells. mechanism - - -
AKAP12 protein-coding 15258566 Cell proliferation assay; Colony formation assay; cell line - - - - - No Reports The restoration of AKAP12A in AKAP12-nonexpressing cells reduced colony formation and induced apoptotic cell death mechanism - - -
AKAP12 protein-coding 15258566 Bisulfite sequencing tissue Korea 18 18 - - No Reports Hypermethylation of AKAP12A CpG island was also detected in 56% (10 of 18) of primary gastric tumors. mechanism - - -
AKT2 protein-coding 28404925 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Suppression of AKT2 significantly inhibited gasric cancer cell proliferation, induced cell apoptosis and inhibited the migration and invasion of GC cells. - - - -
AKT2 protein-coding 25428377 Immunoblot tissue China 20 20 Up - No Reports Upregulated in GC tissues and had the tendency of inversely relationship with miR-29s expression. - - - -
AKT3 protein-coding 29228422 qRT-PCR tissue China 42 42 Up - No Reports AKT3 was up-regulated in GC tissues when compared with matched normal tissues. target - - -
AKT3 protein-coding 29228422 Luciferase reporter assay cell line - - - - - No Reports AKT3 was chosen as the target gene of miR-582-5p. Moreover, restoration of AKT3 could impair tumor suppression role of miR-582-5p on gastric cancer growth. target - - -
ANGPTL6 protein-coding 31146977 qRT-PCR cell line - - - - - No Reports ANGPTL6 was overexpressed in Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) cell lins compared to that of common gastric cell lines; A high level of ANGPTL6 confers a poor prognosis and is correlated with the expression of CD34 (an endothelial cell marker). target - - -
ANGPTL6 protein-coding 31146977 HUVEC tube formation assay; HUVEC proliferation assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports ANGPTL6 promotes endothelial cell migration and tube formation, Moreover, ANGPTL6 knockdown inhibits cancer cell apoptosis and invasiveness. Mechanistically, ANGPTL6 activates the ERK1/2 and AKT pathways. Treatment of ERK1/2 or AKT inhibitor can attenuated cell migration and tube formation. target - - -
ANGPTL6 protein-coding 31146977 Xenograft mice models mice - - - - - No Reports ANGPTL6 loss results in tumor growth in vivo. target - - -
ANKRD40CL protein-coding 32293550 qRT-PCR tissue China 30 30 Up - No Reports LINC00483 level was increased in gastric cancer tissues and cells. . Besides, inhibition of LINC00483 decreased xenograft tumor growth by regulating miR-490-3p/MAPK1 axis. target - - -
ANKRD40CL protein-coding 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of LINC00483 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. target - - -
ANKRD40CL protein-coding 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483 target - - -
ANKRD40CL protein-coding 32293550 Xenograft mice models mice - - - - - No Reports Knockdown of LINC00483 decreases tumor growth in gastric cancer xenograft model. target - - -
ANXA4 protein-coding 30837034 qRT-PCR tissue China 10 10 Down - No Reports Upregulated in GC tissues when compared with normal tissues. Moreover, the low level of miR-203 was associated with increased expression of annexin A4 in GC tissues and cell lines. - - - -
ANXA4 protein-coding 30837034 Luciferase reporter assay cell line - - - - - No Reports miR-203 Directly Targets Annexin A4 in GC Cells - - - -
ANXA7 protein-coding 18449914 IHC tissue China 84 - - - No Reports The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor. The loss of expression of ANXA7 expression was significantly related to distant metastasis. - - - -
APBA2 protein-coding 24385013 RT-MSP tissue China 92 92 Up(Methylation) - No Reports The methylation status of the MINT2 gene was found to be significantly higher in tumor tissues than in adjacent normal tissues. No MINT2 methylation was found in healthy controls.(all P < 0.0001). diagnosis/prognosis - < 0.0001 0.710/0.696
APBA2 protein-coding 24385013 RT-MSP PPLF/blood China 92 - - - No Reports The frequency of MINT2 methylation in pairing PPLF and blood samples from 92 GC patients was 40.2% (37/92) and 39.1% (36/92), respectively. Methylated MINT2 in tumor tissues, pairing PPLF, and blood samples were very approximate. Aberrant MINT2 methylation in tumor tissues and pairing PPLF or blood samples were closely related to peritoneal dissemination, tumor progression, and poor prognosis. diagnosis/prognosis - < 0.0001 0.710/0.696
AQP3 protein-coding 23800944 Western blot tissue China 75 75 Up - Related The protein expression levels of AQP3 were significantly elevated in GCs compared with matched non-GC tissues. AQP3 protein level was closely associated with histological type and lymphatic invasion. H. pylori infection increases the protein level of AQP3 - - - -
ARHGAP5 protein-coding 30250020 IHC tissue China 90 90 Up - No Reports The expression of ARHGAP5 was increased in GC, and positively correlated with tumor size, tumor infiltration, lymph node metastasis, and clinical stage. And multivariate analyses indicated that ARHGAP5 served as an independent prognostic marker of GC. prognosis 0.002 - -
ARHGAP5 protein-coding 30250020 Cell invasion and migration assay; cell line - - - - - No Reports ARHGAP5 is involved in SIRT1-induced suppression of GC cell migration and invasion in vitro. prognosis 0.002 - -
ARHGAP5 protein-coding 30250020 Xenograft mice models mice - - - - - No Reports ARHGAP5 acts as an oncogene promoting GC metastasis in vivo. prognosis 0.002 - -
ARID1A protein-coding 22808142 qRT-PCR tissue China 66 66 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues. prognosis 0.003 - -
ARID1A protein-coding 22808142 Western blot tissue China 25 66 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues. prognosis 0.003 - -
ARID1A protein-coding 22808142 Cell proliferation assay; Colony Formation assay; cell line - - - - - No Reports Silencing the expression of ARID1A in GES1 significantly enhanced cell proliferation compared with mock siRNA treatment prognosis 0.003 - -
ARID1A protein-coding 22808142 IHC tissue China 224 - - - No Reports Loss of ARID1A expression was significantly correlated with depth of tumor infiltration (T stage) and tumor grade, but not with age, gender, tumor size, distant metastasis (M stage), and tumor locus or local lymph node metastasis. ARID1A expression as independent predictors of the overall survival of gastric cancer patients. prognosis 0.003 - -
ASCL2 protein-coding 29746925 qRT-PCR tissue China 24 24 Up - No Reports The mRNA levels of ASCL2 were significantly increased in GC tissues compared to ad- jacent non-tumor gastric epithelium; ASCL2 expression in GC correlated with poor histological differentiation, tumor cell invasion into lymph nodes, and higher TNM stages (III + IV). SMYD3 expression status correlates with ASCL2 in GC tissues. target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 IHC tissue China - - - - No Reports ASCL2 protein were detected in the nuclei of GC cells target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 qRT-PCR; FACS; Tumorsphere formation assay cell line - - - - - No Reports ASCL2+ cells showed increased propensity of growing as tumorspheres target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 Xenograft mice models mice - - - - - No Reports High levels of ASCL2 expression are necessary for stemness and tumorigenicity of ASCL2+ GC cells target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 ChIP-qPCR cell line - - - - - No Reports SMYD3 maintains high H3K4me3 levels on the ASCL2 promoter in ASCL2+ cells, indicating its potential role in regulating ASCL2 transcription and expression. target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 qRT-PCR; Western blot cell line - - - - - No Reports Depletion of SMYD3 inhibits Wnt-induced upregulation of ASCL2. target/prognosis < 0.001 - -
ASCL2 protein-coding 30106147 qRT-PCR:Western blot; IHC tissue China 32 32 Up - No Reports Expression of ASCL2 is highest in metastases, among adjacent normal tissues, primary gastric tumors and gastric metastases. target - - -
ASCL2 protein-coding 30106147 Cell invasion and migration assays cell line - - - - - No Reports ASCL2 expression contributes to cell migration and invasion in GC cells. target - - -
ASCL2 protein-coding 30106147 Western blot cell line - - - - - No Reports the expression of E-cadherin in ASCL2-overexpressing cell lines decreased, while Zeb-1, twist-related protein 1 (Twist), Integrin, Vimentin, 72 kDa type IV collagenase (MMP-2) and matrix metalloproteinase 9 (MMP-9) were upregulated in ASCL2-overexpressing cell lines target - - -
ASCL2 protein-coding 30106147 Luciferase reporter assay; ChIP cell line - - - - - No Reports ASCL2 may interact with the promoter of pre-miR223, and inhibit the maturation of miR223. target - - -
ATF7 protein-coding 29754469 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports siATF7 increased the accumulation of cells at the G2/M phase; ATF7 rescues the cellular phenotypes induced by miR-103a-3p in gastric cancer cells. - - - -
ATF7 protein-coding 29754469 Western blot cell line - - - - - No Reports both miR-103a-3p overexpression and ATF7 silencing promoted the expression of CDK2 - - - -
ATF7 protein-coding 29754469 Luciferase reporter assay cell line - - - - - No Reports miR-103a-3p directly regulates ATF7 expression in GC cells. - - - -
ATP6V1A protein-coding 28592880 ChIP-qPCR; qRT-PCR; Western blot cell line - - - - - No Reports YY1 transcriptionally regulates ATP6V1A, and the ATP6V1A core promoter region contains three YY1 binding sites. RNAi-mediated knockdown of YY1 in GC cells significantly decreased ATP6V1A mRNA and protein expression, while YY1 overexpression increased ATP6V1A expression level prognosis 0.01 - -
BAG3 protein-coding 30514177 qRT-PCR; Western blot cell line - - - - - No Reports BAG3 mRNA and protein levels were increased following treatment with HGF. HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. HGF-mediated BAG3 upregulation is regulated by an ERK and Egr1-dependent pathway. BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway. target - - -
BAG3 protein-coding 30514177 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. target - - -
BCL2L2 protein-coding 16707418 Cell invasion and migration assays - - - - - No Reports Bcl-w enhances GC cell invasion and migration. mechanism - - -
BCL2L2 protein-coding 16707418 Gelatin zymography; Western blot cell line - - - - - No Reports Bcl-w overexpression increased matrix metalloproteinase-2 (MMP-2) expression, and synthetic or natural inhibitors of MMP-2 abolished Bcl-w induced cell invasion. Bcl-w overexpression also activated phosphoinositide 3-kinase (PI3K), Akt, and Sp1. mechanism - - -
BCL6 protein-coding 29510377 qRT-PCR tissue China 20 20 Up - No Reports BCL6 was upregulated in GC tissues and cell lines and cor_x005frelated with a malignant phenotype in patients with GC. BCL6 overexpression partially abrogated the suppressive function of miR-519d in MGC803 cells - - - -
BIRC5 protein-coding 24337012 IHC; TMA tissue China 195 - - - No Reports The expression levels of survivin was significantly higher in patients with lymph node metastasis than in those without metastasis. Patients with high expression levels of survivin showed significantly less favorable survival rates compared with patients with low expression levels of those two genes. Moreover, patients with co-expression of the two genes usually had a poorer prognosis. prognosis 0.003 - -
BMI1 protein-coding 30156609 qRT-PCR; Cell transfection cell line - - - - - No Reports expression of BMI1 affected the expression of apoptosis_x005frelated proteins and thus inhibited the activation of the apoptotic pathway. Overexpression of BMI1 could activate the Notch and mTOR signaling pathways - - - -
BMI1 protein-coding 26894855 qRT-PCR tissue China 352 - - Down No Reports Gastric cancer patients survive better with higher expression levels of Bmi-1, and correlated with smaller tumor size, better pathological differentiation (I-II), less lymph node metastases, earlier T stages, non-metastatic disease (M0), earlier UICC stages. The expression of Bmi-1 is significantly different in stage I-II vs. stage III-IV patients. prognosis 0.024 - -
BMI1 protein-coding 26894855 Luciferase reporter assay cell line - - - - - No Reports Bmi-1 is a direct target of miR-15a in gastric cancer cell lines. prognosis 0.024 - -
BMI1 protein-coding 26894855 qRT-PCR; IHC tissue China 21 - - - No Reports The expression of Bmi-1 is inversely correlated with miR-15a in gastric tumor tissues prognosis 0.024 - -
BMI1 protein-coding 18041745 RT-PCR; Western blot tissue China 8 8 Up - No Reports RT-PCR and Western blotting showed that Bmi-1 was up-regulated at both the transcriptional and translational levels in the GC tissues compared with the adjacent non-cancerous tissues. prognosis < 0.01 - -
BMI1 protein-coding 18041745 IHC tissue China 146 - - - No Reports 99 of 146 paraffin-embedded GC samples expressed Bmi-1 extensively. Statistical analysis showed that Bmi-1 overexpression was highly correlated with tumor size, clinical stage, lymph node metastasis and T classification. Patients with Bmi-1 expression had shorter overall survival time than those without Bmi-1 expression (P < 0.01). Multivariate analysis indicated that Bmi-1 expression is an independent prognostic factor of GC. prognosis < 0.01 - -
BRD4 protein-coding 29434197 IHC tissue China 52 52 Up - No Reports BRD4 is highly overexpressed in gastric cancer tissues. target - - -
BRD4 protein-coding 29434197 Cell proliferation assay; Invasion and migration assay; cell line - - - - - No Reports The BET inhibitor JQ1 inhibits gastric cancer cell proliferation by inducing cellular senescence. BRD4 is involved in JQ1-induced cellular senescence. target - - -
BRD4 protein-coding 29434197 Luciferase reporter assay cell line - - - - - No Reports BRD4 regulates the 3′-UTR of p21. mRNA CDKN1A target - - -
BRD4 protein-coding 29434197 CHIP assay cell line - - - - - No Reports BRD4, together with E2F1, regulates miR-106b-5p transcription and cellular senescence. target - - -
BTG1 protein-coding 26050197 RT-PCR; Western blot; MS-PCR cell line - - - - - No Reports BTG1 protein expression (19 kDa) was detectable in gastric cancer and epithelial cell lines; BTG1 mRNA was high expressed in cancer and epithelial cells and a decreased level of methylation of BTG1 after treated with 5-Aza-dC. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG1 overexpression suppressed tumor growth and lung metastasis of gastric cancer cells. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 Xenograft mice models mice - - - - - No Reports BTG1 overexpression enhanced autophagy and apoptosis in xenograft models. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 RT-PCR tissue Japan 613 577 Down - No Reports BTG1 expression was statistically lower in gastric cancer than non-neoplastic mucosa and metastatic cancer in lymph node. BTG1 expression was positively correlated with depth of invasion, lymphatic and venous invasion, lymph node metastasis, TNM staging and worse prognosis. The diffuse-type carcinoma showed less BTG1 expression than intestinal- and mixed-type ones. target/prognosis 0.047 - -
BTG2 protein-coding 27409164 Cell proliferation assay; Invasion and migration assays; Flow cytometry; Apotosis assay cell line - - - - - No Reports Overexpression of BTG2 triggered G1/S cell cycle arrest, induced subsequent apoptosis, and inhibited C-myc activation following Ras/MEK/ERK signaling pathway, which involved in the biological effects of miR-27a-3p/BTG2 axis on gastric carcinogenesis and cancer progression. - - - -
BTG2 protein-coding 27409164 Luciferase reporter assay cell line - - - - - No Reports BTG2 was a direct and functional target of miR-27a-3p in gastric cancer and miR-27a-3p inhibition obviously up-regulated the expression of BTG2. - - - -
BTG3 protein-coding 25904053 Western blot; IHC tissue Japan 38 38 Down - No Reports BTG3 expression was decreased in gastric cancer in comparison to the adjacent mucosa, and positively correlated with venous invasion and dedifferentiation of cancer. target - - -
BTG3 protein-coding 25904053 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG3 overexpression inhibited proliferation, induced S/G2 arrest, differentiation, autophagy, apoptosis, suppressed migration and invasion target - - -
BTG3 protein-coding 25904053 qRT-PCR; Cell transfection cell line - - - - - No Reports BTG3 transfectants showed a higher mRNA expression of p27, Bax, 14-3-3, Caspase-3, Caspase-9, Beclin 1, NF-κB, IL-1, -2, -4, -10 and -17, but a lower mRNA expression of p21, MMP-9 and VEGF than the control and mock；exposed to cisplatin (DDP), MG132, paclitaxel, and SAHA, BTG3 transfectants showed a lower viability and a higher apoptotic level than the control in both concentration and time-dependent manners target - - -
BTG3 protein-coding 25904053 Xenograft mice models mice - - - - - No Reports BTG3 suppresses the growth of gastric cancer cells in nude mice. target - - -
BTG3 protein-coding 25238703 qRT-PCR; Western blot tissue China 18 18 Down - No Reports BTG3 was obviously down-regulated in GC tissues. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 IHC tissue China 131 131 - - No Reports The expression of BTG3 was obvi- ously lower in GC tissues than adjacent gastric mucosa. Its expression was positively correlated with distant metastasis. Patients with lower BTG3 expression had shorter overall survival time. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG3 suppressed the proliferation of GC cells in vitro. It also inhibited migration and invasion of GC cells in vitro. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 Xenograft mice models mice - - - - - No Reports BTG3 suppressed the proliferation of GC cells in vivo. target/prognosis 0.001 - -
BTG4 protein-coding 19576178 Bisulfite sequencing cell line - - - - - No Reports Most CpG dinucleotides were methylated in gastric cancer cell lines, the methylation was absent in GES-1 cells mechanism - - -
BTG4 protein-coding 19576178 qRT-PCR tissue China 38 38 - - No Reports BTG4 was significantly down-regulated in tumor tissues compared to normal tissues. mechanism - - -
BTG4 protein-coding 19576178 MS-PCR tissue China 38 38 - - No Reports BTG4 was methylated in 28 of 38 primary gastric cancers tested, no methylation was detected in normal gastric samples. Its hypermethylation was corrleated with the type of cell differentiation and metastasis mechanism - - -
BTG4 protein-coding 19576178 Flow cytometry; Cell growth assay cell line - - - - - No Reports BTG4 reexpression sensitizes gastric cancer cells to proapoptotic stimuli and reduces colony formation in vitro. mechanism - - -
BTG4 protein-coding 19576178 Xenograft mice models mice - - - - - No Reports BTG4 reexpression sensitizes tumor growth in mice. mechanism - - -
C1QTNF6 protein-coding 30431096 Gene microarray tissue China 64 64 Up - No Reports C1QTNF6 was up-regulated in GC tissues. target - - -
C1QTNF6 protein-coding 30431096 IHC tissue China 52 52 Up - No Reports C1QTNF6 was primarily expressed in the cytoplasm and exhibited a diffuse granular distribution. The expression rate of C1QTNF6 in GC tissues was significantly higher than that in the normal gastric tissues target - - -
C1QTNF6 protein-coding 30431096 Cell proliferation assay; Invasion and migration assays; Flow cytometry; Cell colony formation assay cell line - - - - - No Reports Interference of C1QTNF6 expression influenced the proliferation, migration and invasion ability of Gc cells in vitro. target - - -
C8orf76 protein-coding 30733230 CHIP assay tissue China 236 236 - - No Reports DNA copy-number of C8orf76 was frequently gained in gastric cancer. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 qRT-PCR tissue China 146 146 Up - No Reports C8orf76 was upregulated in 69.74% and 65.71% of two independent cohorts of gastric cancers and was positively associated with C8orf76 amplification. Multivariate analysis showed that gastric cancer patients with C8orf76 amplification (cohort I, n = 129; cohort II, n = 107) or overexpression (n = 356) had a significantly shortened survival. C8orf76 significantly promoted gastric cancer cell proliferation, cell-cycle transformation, and migration/invasion, but suppressed cell apoptosis. Silencing C8orf76 expression exerted opposite effects in vitro and significantly inhibited xenograft tumor growth, lung metastasis, and liver metastasis in nude mice. Silencing C8orf76 also significantly suppressed the growth of patient-derived organoids. Mechanically, C8orf76 activated MAPK/ERK signaling cascade. C8orf76 directly bound to the promoter region of lncRNA dual specificity phosphatase 5 pseudogene 1 (DUSP5P1) with a binding motif of AGGCTG and activated DUSP5P1 transcription. DUSP5P1 induced MAPK/ERK signaling and promoted gastric tumorigenesis. Knockdown DUSP5P1 abrogated the effect of C8orf76 in activating MAPK/ERK cascade and the tumor-promoting function. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 IHC tissue China 146 146 Up - No Reports C8orf76 protein expression was significantly higher in primary gastric tumors as compared with adjacent nontumor tissues. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 IHC tissue China 356 - - - No Reports High C8orf76 protein expression was significantly associated with more advanced tumor stage and diffuse-type gastric cancer. C8orf76 is a poor prognostic factor in patients with gastric cancer. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports C8orf76 promotes cell growth and cell-cycle progression, but inhibits cell apoptosis prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Xenograft mice models mice - - - - - No Reports C8orf76 promotes the growth of subcutaneous xenograft tumors in nude mice; C8orf76 promotes gastric cancer metastasis to lung and liver in vivo. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Patient-derived gastric cancer organoid model tissue - - - - - No Reports Knockdown of C8orf76 significantly suppressed the gastric cancer cell growth in three PDO models prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Luciferase reporter assay; Western blot; qRT-PCR; ChIP-PCR cell line - - - - - No Reports DUSP5P1 is a direct downstream target of C8orf76 prognosis < 0.0001 - -
CA11 protein-coding 11562744 RNA dot blot tissue China - - - - No Reports Strong expression of the CA l l gene was confirmed in normal stomach tissue - - - -
CA11 protein-coding 11562744 RT-PCR tissue China 50 50 Down - No Reports Expression of the CA11 gene in cancer tissue was down-regulated compared with normal tissue. Semi-quantitative RT-PCR also demonstrated that CA11 gene expression was decreased in 41 out of 50 (82%) of the gastric cancer tissues, when compared with normal stomach tissues, while no relationship was found between CA11 expression and various clinicopathological characteristics. - - - -
CA11 protein-coding 11562744 IHC tissue - - - - - No Reports Immunohistochemical analysis with anti CA11 antibody showed that CA11-positive staining was observed in the surface regions of normal gastric epithelium, but was found faintly or not at all in cancer tissues. - - - -
CA11 protein-coding 11562744 Cell coloney formation assay cell line - - - - - No Reports CA11 transfected MKN28 cells also displayed a marked decrease in the number of colony formations when compared to double normal controls. - - - -
CACUL1 protein-coding 24004834 qRT-PCR; IHC tissue China 43 43 Up Up Related CACUL1 was highly expressed in gastric cancer tissues and negatively correlated with gastric cancer differentiation and TNM stage. In addition, CACUL1 expression was high in H.pylori-infected tissues compared with H.pylori non-infected tissue. target - - -
CASK protein-coding 25373785 qRT-PCR tissue China 50 50 Down - Related CASK was over-expressed in tumors and H. pylori positive tissues and its mRNA levels were inversely correlated with miR-203 expression target - - -
CAV1 protein-coding 15757532 RT-PCR,IHC tissue China 56 29 Down Down No Reports Positive rate of Caveolin-1 was significantly lower in gastric cancer than in non-cancerous mucosa, intestinal metaplasia, and atypical hyperplasia (17.9% vs. 84.8%, 81.8%, and 57.1%, P<0.05). Positive rate of Caveolin-1 was lower in advanced gastric cancers than in gastric cancer of early stage (16.0% vs. 33.3%), but the difference was not significant (P>0.05). Positive rate of Caveolin-1 was significantly lower in diffuse gastric cancer than in gastric cancer of intestinal type (7.0% vs. 26.9%, P<0.05), significantly lower in the cases with lymph node metastases than in the cases without lymph node metastases (9.7% vs. 31.8%, P<0.05). Protein and mRNA levels of Caveolin-1 in gastric cancer and relevant adjuvant non-cancerous tissues have no significant difference, but its expression was low in MGC803 and BGC823 cells. - - - -
CBFB protein-coding 29386218 Luciferase reporter assay cell line - - - - - No Reports CBFB is a miR-204-5p target gene and promotes gastric cancer cell growth prognosis < 0.001 - -
CBFB protein-coding 29386218 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports CBFB promotes gastric cancer cell growth prognosis < 0.001 - -
CBFB protein-coding 29386218 Xenograft mice models mice - - - - - No Reports knockdown of CBFB could inhibit gastric cancer cell tumor growth in vivo prognosis < 0.001 - -
CCKBR protein-coding 27518872 Luciferase reporter assay cell line - - - - - No Reports Cholecystokinin B receptor (CCK-BR) was a direct target of miR-148a. target - - -
CCKBR protein-coding 27518872 Cell proliferation assay; Cell migration assay cell line - - - - - No Reports siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. target - - -
CCN1 protein-coding 30178386 IHC tissue China 159 42 Up - No Reports CYR61 protein in GC tissues was significantly higher than that in normal gastric tissues.CYR61 expression correlated with distant metastasis and recurrence. Positive CYR61 expression was significantly associated with poor overall survival. prognosis < 0.001 - -
CCN1 protein-coding 30178386 Luciferase reporter assay cell line - - - - - No Reports CYR61 is a novel target of miR‑142‑5p in GC cells prognosis < 0.001 - -
CCN1 protein-coding 27105510 IHC tissue China 214 214 Up - No Reports CYR61 is overexpressed in 44% of the GCA tumor samples. Expression of CYR61 is inversely correlated with cumulative survival of GCA patients (p<0. 001) and significantly associated only with metastatic pathological categories (with N category, p=0. 052; with TNM stage, p=0. 001). prognosis < 0.001 - -
CCN1 protein-coding 27105510 Cell invasion and migration assays cell line - - - - - No Reports knockdown of CYR61 in gastric cancer AGS cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis prognosis < 0.001 - -
CCND1 protein-coding 30810117 IHC tissue China 30 30 Up - No Reports Cyclin D1 protein expressions were significantly upregulated in cancer tissues.lncRNA HOTAIR was positively correlated with STAT3 and Cyclin D1 protein expressions in gastric cancer tissues. - - - -
CCND1 protein-coding 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports ETS1 or CCND1 knockdown significantly suppressed gastric cancer cell growth, similar to miR-193a-3p overexpression. mechanism - - -
CCND1 protein-coding 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct targets of miR-193a-3p mechanism - - -
CCND1 protein-coding 27071318 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Regulate cell growth of GC cells. - - - -
CCND1 protein-coding 26955820 qRT-PCR tissue China 60 60 Up - No Reports the cyclin D1 mRNA level was generally higher in GC samples when compared to their matched nontumor counterparts - - - -
CCND1 protein-coding 26955820 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports The enforced expression of si-CCND1 notably repressed cells proliferation, elicited cell cycle arrest at the G0– G1 stage and enhanced apoptosis in both cell lines. - - - -
CCND1 protein-coding 26955820 Luciferase reporter assay cell line - - - - - No Reports Cyclin D1 is a direct target of miR-155 in GC cells - - - -
CCND1 protein-coding 23383271 qRT-PCR tissue China 86 86 Up - No Reports cyclin D1 was found to be up-regulated and inversely correlated with the expression of miR-9 in gastric cancer tissues and cell lines. mechanism - - -
CCND1 protein-coding 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro. mechanism - - -
CCND1 protein-coding 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted the 3'-UTR of cyclin D1 and Ets1 mechanism - - -
CCND1 protein-coding 14691913 IHC tissue U.K. 67 67 Up - No Reports Cyclin D1 overexpression (≥5% expression) was seen in 55% of cancers; Cyclin D1 overexpression was associated with poor differentiation and signet ring cell type. - - - -
CCND1 protein-coding 26791264 qRT-PCR tissue China 48 48 Up - No Reports cyclin D1 mRNA expression were upregulated in GC tissues. A significant correlation was found between the expression of HOXA1 and cyclin D1. prognosis < 0.001 < 0.001 -
CCND1 protein-coding 26791264 IHC; Western blot tissue China 264 264 Up - No Reports cyclin D1 protein expression were upregulated in GC tissue; Overexpression of cyclin D1 was significantly associated with differentiation; Cyclin D1 was also significantly associ- ated with DFS and OS. prognosis < 0.001 < 0.001 -
CCND2 protein-coding 14612939 MS-PCR tissue Japan 34 21 Up(Methylation) Up(Methylation) No Reports Hypomethylation of the cyclin D2 promoter was found in 24 (71%) of the 34 tumor tissues and in 6 (29%) of the 21 corresponding non-neoplastic mucosa, the incidence being significantly different (p=0.002; Fisher's exact test). Moreover, hypomethylation of cyclin D2 was more common in stage III and IV tumors than in stage I and II tumors. mechanism - - -
CCND2 protein-coding 14612939 qRT-PCR tissue China 23 23 - - No Reports Levels of cyclin D2 mRNA expression in tumor tissues with cyclin D2 hypomethylation (33.08±45.78) tended to be higher than those with cyclin D2 hypermethylation; levels of cyclin D2 mRNA expression in tumor tissues with metastasis (35.88+45.56) were significantly higher than those in tumors without metastasis. mechanism - - -
CCR7 protein-coding 23519840 IHC tissue China 80 40 Up - No Reports CCR7 protein plays a key role in the metastasis and progression of gastric cancer. The elevated CCR7 protein expression may be caused by the deficiency of let-7a miRNA expression due to the downregulation of DICER1gene expression. The mechanism for the silencing of DICER1 gene expression requires further studies. - - - -
CD14 protein-coding 17438094 Reporter gene assays; PCR-RFLP methods blood China 470 470 - - Related Two SNPs (-651C>T and -260C>T) were identified, of which the -260CT and -260TT genotypes were associated with elevated risk of gastric carcinoma (OR, 1.77; 95% CI, 1.09-2.85 and OR, 1.95; 95% CI, 1.20-3.16, respectively). Haplotype analysis suggested a synergistic effect of the two SNPs (OR for the T(-651)-T(-260) haplotype, 3.39 versus OR for the C(-651)-T(-260) haplotype, 1.45; P = 0.02), which is consistent with reporter gene assays. A multiplicative joint effect between H. pylori infection and -260C>T polymorphism was observed (OR for the presence of both -260TT genotype and H. pylori infection, 4.03; 95% CI, 1.80-9.04). Patients had significantly higher sCD14 than controls (1,866 +/- 2,535 ng/mL versus 1,343 +/- 2,119 ng/mL; P < 0.001), and this difference was associated with the CD14 -260 polymorphism and H. pylori infection. - - - -
CD151 protein-coding 23533596 qRT-PCR; Western blot tissue China 20 20 Up - No Reports CD151 mRNA and protein expression was increased in HGC tissues and HGC cells than in nontumor tissues and HGEC cells. CD151 overexpression was significantly correlated with high TNM stage, depth of invasion and positive lymph node involvement (p<0.05), and Importantly, the postoperative 5-year overall survival of patients with CD151(low) and/or integrin a3(low) was higher than that of patients with CD151(high) and/or integrin a3(high). target/prognosis 0.007 - -
CD151 protein-coding 23533596 IHC tissue China 76 - - - No Reports CD151 protein immunoreactivity localized to the cell membrane. High expression of CD151 was significantly correlated with tumor size (p = 0.021), depth of invasion (p = 0.004), lymph node involvement (p =0.028) and high tumor stage (p = 0.002). Overexpression of CD151 are Independent Factors Predicting the Prognosis of HGC Patients. target/prognosis 0.007 - -
CD151 protein-coding 23533596 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Down-regulation of CD151 by vshRNA-CD151 impaired metastasis and invasion of HGC-27 cells, but did not affect cell proliferation. CD151-cDNA transfection rescued the metastatic potential and invasiveness of HGC-27-vshCD151 cells, but not those of HGC-27-vshintegrin a3 cells in vitro. target/prognosis 0.007 - -
CD151 protein-coding 23533596 Xenograft mice models mice - - - - - No Reports CD151 Promoted Metastasis of HGC Cells in vivo target/prognosis 0.007 - -
CD151 protein-coding 23533596 Co-ip assays cell line - - - - - No Reports CD151 formed a complex with integrin a3 in HGC cells. target/prognosis 0.007 - -
CD274 protein-coding 29073638 IHC tissue Korea 116 - - - No Reports Among 116 eligible patients, 57 (49.1%) and 66 patients (56.9%) were determined as iTu-PD-L1-positive and str-PD-L1-positive. Intraepithelial tumour cell PD-L1 positivity was found to be significantly associated with lymph node (LN) metastasis and a poor disease-free survival (DFS) (P=0.032), yet not overall survival (P=0.482). In a multivariate analysis, iTu-PD-L1 positivity was independently associated with a poor DFS (P=0.006, hazard ratio=12.085). prognosis 0.482 0.032 -
CD276 protein-coding 25120098 qRT-PCR tissue China 32 32 Up - No Reports B7-H3 expression was significantly higher in the gastric cancer group than that in the normal gaster group. target - - -
CD276 protein-coding 25120098 IHC tissue China 32 32 Up - No Reports B7-H3 expression was significantly higher in the gastric cancer group than that in the normal gaster group. target - - -
CD276 protein-coding 25120098 Cell invasion and migration assays cell line - - - - - No Reports B7-H3 knockdown by RNA interference decreased cell migration and Transwell invasion up to 50% in vitro. target - - -
CD276 protein-coding 25120098 Xenograft mice models mice - - - - - No Reports B7-H3 expression reduced gastric cancer metastasis in vivo。 target - - -
CDC42 protein-coding 25152372 Western blot tissue China 18 18 Up - No Reports The protein expression of CDC42 was significantly up-regulated in cancer tissues. mechanism - - -
CDC42 protein-coding 25152372 Luciferase reporter assay cell line - - - - - No Reports CDC42 is the direct target of miR-133a mechanism - - -
CDC42 protein-coding 26549550 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Knockdown of CDC42 significantly inhibited the proliferation of AGS and SGC7901 cells, and it was suggested that this inhibitory process may be due to cell cycle arrest at G1/S phase and downregulation of cyclin A, cyclin D1, cyclin E and proliferating cell nuclear antigen. Furthermore, knockdown of CDC42 markedly inhibited the migration and invasion of GC cells, and suppressed the expression of matrix metalloproteinase 9 target - - -
CDH1 protein-coding 30063010 qRT-PCR tissue China 67 67 Up - No Reports The mRNA level of CDH1 was found reduced in the GC tissues and there is a negative correlation between the expression of CDH1 and miR-217 in the GC samples. mechanism - - -
CDH1 protein-coding 30063010 Luciferase reporter assay cell line - - - - - No Reports CDH1 is a direct target of miR-217 mechanism - - -
CDH1 protein-coding 24023308 MS-PCR tissue Korea 72 72 - - No Reports MSP and PS revealed CDH1 promoter methylation in 73.6% (53/72) and 77.8% (56/72) of DGC samples, respectively. PS detected CDH1 methylation in 70.8% (51/72) and 72.2% (52/72) of matched normal mucosa from adjacent and remote foci, respectively. In comparison, CDH1 promoter methylation was detected in 12/24 normal gastric mucosa samples without DGC, and this difference was statistically significant (p=0.016). - - - -
CDK6 protein-coding 30530570 IHC tissue China 40 40 - - No Reports EGFR and CDK6 are up-regulated in GC and negatively correlated with miR-1296-5p - - - -
CDK6 protein-coding 30530570 Luciferase reporter assay cell line - - - - - No Reports EGFR and CDK6 are directly targets of miR-1296-5p - - - -
CDK9 protein-coding 28701053 qRT-PCR tissue China 52 52 Up - No Reports CDK9 was upregulated in gastric cancer and the CDK9 expression levels were inversely correlated with that of miR-613 in gastric cancer tissues. target - - -
CDK9 protein-coding 28701053 Luciferase reporter assay cell line - - - - - No Reports CDK9 is a direct target of miR-613 in gastric cancer target - - -
CDKL1 protein-coding 22369697 IHC tissue China 66 66 Up - No Reports High expression of CDKL1 protein was observed in gastric cancer tissues compared with matched adjacent tissues. Furthermore, we show that the reduction of CDKL1 with its siRNA stimulates the activation of Bcl-2-interacting killer (Bik) pro-apoptotic protein and attenuated the expression of proliferating cell nuclear antigen PCNA. target - - -
CDKL1 protein-coding 22369697 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports Loss of CDKL1 function in both SGC7901 and MGC-803 gastric cancer cells significantly decreases cellular proliferation and increases apoptosis (p < 0.01). target - - -
CDKN1A protein-coding 29434197 Luciferase reporter assay cell line - - - - - No Reports BRD4 regulates the 3′-UTR of p21. mRNA CDKN1A - - - -
CDKN1A protein-coding 25959498 qRT-PCR tissue China 55 55 Down - No Reports p21 mRNA level was significantly down-regulated in 72.7% of cancer tissues compared with paired normal tissues, which was positively correlated with decreased lncRNA GAS5 expression in tissue specimens - - - -
CDKN2A protein-coding 15818729 S-P tissue China 122 80 Down - No Reports The positive rates of P16 protein expression respectively were 96% (77/80) in normal gastric mucosa, 92% (45/50) in dysplastic gastric mucosa, 48% (58/122) in GC. The positive rates of P16 protein expression in GC were significantly lower than that in normal gastric mucosa and dysplastic gastric mucosa. The positive rate of P16 protein expression in mucoid carcinoma (10%, 1/10) was significantly lower than that in poorly differentiated carcinoma (51%, 21/41), undifferentiated carcinoma (58%, 15/26) and signet ring cell carcinoma (62%, 10/16) (P<0.05). The positive rates of P16 protein in 30 cases of paired primary and lymph node metastatic GC were 47% (14/30) and 17% (5/30) respectively, being significantly lower in the later than in the former. - - - -
CDKN2A protein-coding 15818729 PCR; PCR-SSCP tissue China 25 - - - No Reports There was no mutation in exon 2 of p16 gene in the 25 freshly resected primary GCs. But five cases in the 25 freshly resected primary GCs displayed deletion in exon 2 of p16 gene. - - - -
CEBPA protein-coding 20386538 IHC tissue Portugal 54 - - - No Reports In GC, C/EBPa staining was mostly nuclear with some residual cytoplasmic positivity. In GC, C/ EBPa was considered downregulated in 30% of the tumors. No statistical significant relationships were found between C/EBPa expression and any clin- icopathological features of the cases. mechanism - - -
CEBPA protein-coding 20386538 Cell proliferation assay cell line - - - - - No Reports We observed a significant decrease in proliferation in C/EBPa-transfected cells. mechanism - - -
CELF2 protein-coding 29501762 IHC tissue China 104 104 Down - No Reports CELF2 was predominately down regulated in 86 gastric cancer tissues and highly ex- pressed in 18 cancer tissues compared with para-cancer tissues (69 high expressed and 35 low expressed). CELF2 expression was associated with T, N and M stage. Lower expression of CELF2 correlated to shorter period of survival months. prognosis < 0.01 - -
CELF2 protein-coding 29501762 Cell proliferation assay; Flow cytometry; Cell migration assay cell line - - - - - No Reports Overexpressed CELF2 induced cell apoptosis and reduced proliferation ability. prognosis < 0.01 - -
CEMIP protein-coding 28422983 qRT-PCR tissue China 321 - - - No Reports KIAA1199 was upregulated in GC tissue and was an essential independent marker for poor prognosis. KIAA1199 mRNA expression was correlated with the clinical characteristics regarding depth of invasion (T-staging), distant metastasis (M-staging) and TNM staging of GC patients. target/prognosis < 0.001 - -
CEMIP protein-coding 28422983 IHC tissue China 123 - - - No Reports KIAA1199 protein expression was highly expressed in the cytoplasm of GC tissue cells and was correlated with depth of invasion, lymph node status (N-staging), metastasis and TNM staging target/prognosis < 0.001 - -
CEMIP protein-coding 28422983 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Knockdown KIAA1199 suppressed the proliferation, migration and invasion in GC cells. KIAA1199 stimulated the Wnt/β-catenin signaling pathway and the enzymatic activity of matrix metalloproteinase (MMP) family members and thus accelerated the epithelial-to-mesenchymal transition (EMT) progression in GC cells. target/prognosis < 0.001 - -
CHD1L protein-coding 24258459 qRT-PCR tissue China 34 34 Up - No Reports The gene expression levels of CHD1L were higher in fresh samples of GC than in paired adjacent noncancerous tissues. prognosis < 0.001 - -
CHD1L protein-coding 24258459 Western blot tissue China 34 34 Up - No Reports The protein expression levels of CHD1L were higher in fresh samples of GC than in paired adjacent noncancerous tissues. prognosis < 0.001 - -
CHD1L protein-coding 24258459 IHC tissue China 616 616 Up - No Reports Positive expression rates of CHD1L in GC and paired adjacent noncancerous tissues were 58.7 % (361/616) and 7.3 % (45/616), respectively. CHD1L positivity was significantly associated with clinical stage and distant metastasis. GC patients with positive CHD1L expression had shorter overall survival than those with negative CHD1L expression. Multivariate analysis showed that CHD1L was an independent prognostic marker for overall survival [Hazard Ratio (HR) = 5.952, 95 % confidence interval (CI) = 3.194-11.187, P = 0.0043]. prognosis < 0.001 - -
CHD5 protein-coding 19840376 qRT-PCR cell line - - - - - No Reports CHD5 expression was down-regulated in all of gastric cancer cell lines used (100%, 7/7). mechanism - - -
CHD5 protein-coding 19840376 MS-PCR; BGS tissue/cell line - - - - - No Reports Methylation of CHD5 promoter was detected in all of seven gastric cancer cell lines and in the majority of primary gastric carcinoma tissues examined (73%, 11/15). mechanism - - -
CHD5 protein-coding 19840376 Colony formation assay cell line - - - - - No Reports ectopic expression of CHD5 in gastric cancer cells led to a significant growth inhibition. mechanism - - -
CHFR protein-coding 20300977 MS-PCR; BGS tissue China 123 123 Up(Methylation) - No Reports The methylation frequencies of CHFR in cancer tissues were significantly higher than those in corresponding normal gastric mucosae. The methylation status of CHFR was inversely related to the tumor size, tumor invasion depth and tumor differentiation in GC patients mechanism - - -
CHFR protein-coding 20300977 RT-PCR; IHC tissue China 123 - - - No Reports The expression of the protein and mRNA decreased remarkably in the patients with aberrant promoter methylation of CHFR genes. mechanism - - -
CHFR protein-coding 20300977 IHC tissue China 123 - - - No Reports The protein expression of CHFR were significantly correlated with tumor differentiation. mechanism - - -
CIAPIN1 protein-coding 19471113 IHC tissue China 147 147 Down - No Reports The expression of CIAPIN1 in gastric antral mucosa was progressively reduced along the sequence of normal/inflammatory gastric mucosa-atrophy-intestinal metaplasia-dysplasia-adenocarcinoma. The downregulation of CIAPIN1 in cancerous tissues was further confirmed by western blotting. No relationship between the expression level of CIAPIN1 and the clinicopathological parameters such as age, gender, differentiation, TNM stage and the existence of metastasis was found in gastric cancer patients. mechanism - - -
CIAPIN1 protein-coding 19471113 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Ectopic expression of CIAPIN1 by cDNA transfection resulted in suppression of cell proliferation and inhibition of cell cycle progression while knockdown of CIAPIN1 with siRNA accelerated cell proliferation and promoted cell cycle progression in SGC7901 and MKN28 gastric cancer cells. mechanism - - -
CKS2 protein-coding 21617860 qRT-PCR tissue Japan 109 109 Up - No Reports The expression of CKS2 in gastric cancer is elevated relative to levels in normal tissue, and that CKS2 mRNA overexpression is associated with tumor differentiation, lymph node metastasis, distant metastasis, peritoneal dissemination and poor prognosis. In particular, CKS2 mRNA overexpression is associated with prognosis, as shown by multivariate analyses. prognosis - - -
CKS2 protein-coding 21617860 IHC tissue Japan 109 109 Up - No Reports Staining of CKS2 was markedly stronger in the human gastric cancer tissues than in the corresponding normal tissues. The expression of CKS2 was localized to the cell nucleus. prognosis - - -
CKS2 protein-coding 21617860 Cell proliferation assay; Cell invasion and migration assays; Flow cytometry cell line - - - - - No Reports The inhibition of cellular proliferation by CKS2-siRNA was observed in a gastric cancer cell line. prognosis - - -
CLCN3 protein-coding 30217218 IHC tissue China 90 90 Up - No Reports CLC-3 was overexpressed in human GC tissues and that overexpression of CLC-3 was a poor prognostic biomarker for GC patients (P = 0.012). Higher expression of CLC-3 was correlated with deeper tumor invasion (P = 0.006) and increased lymph node metastasis (P = 0.016) target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports Knockdown of CLC-3 inhibited cell proliferation and migration in vitro. target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Xenograft mice models mice - - - - - No Reports The expression and function of CLC-3 were regulated by XRCC5 in vivo target/prognosis 0.012 - -
CLDN18 protein-coding 24647998 Western blot tissue China 45 45 Down Down No Reports Claudin-18 was downregulated in tumor tissues with larger tumor size, intestinal histologic type, deeper local invasion and more advanced TNM stage. target - - -
CLDN18 protein-coding 24647998 Luciferase reporter assay cell line - - - - - No Reports miR-1303 could bind to the putative binding sites in CLDN18 mRNA 3'-UTR and visibly lower the expression of claudin-18. The introduction of claudin-18 without 3'-UTR restored the miR-1303 promoting migration function. target - - -
CLEC4M protein-coding 28403883 ELISA assay serum China 207 197 Up Up No Reports DC-SIGNR serum level was significantly increased in gastric cancer patients compared with healthy group. DC-SIGNR level was associated with an advanced pathological stage in gastric cancer patients. target - - -
CLEC4M protein-coding 28403883 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and DC-SIGNR overexpression promoted cell proliferation, migration and invasion. target - - -
CLEC4M protein-coding 28403883 Xenograft mice models mice - - - - - No Reports DC-SIGNR knockdown suppressed the liver metastasis in vivo. target - - -
CMTM3 protein-coding 24131472 qRT-PCR; Western blot tissue China 6 6 Down - No Reports CMTM3 expression was dramatically downregulated in primary gastric cancer tissues. prognosis 0.041 - -
CMTM3 protein-coding 24131472 IHC tissue China 350 222 Down - No Reports The expression of CMTM3 was remarkably weaker in gastric cancer tissues than in normal mucosae (P = 0.008), and was significantly correlated with gender (P = 0.033), tumor depth (P = 0.049), stage (P = 0.021), and histological grade (P = 0.022). CMTM3 expression was associated with prognosis in gastric cancer patients (P = 0.041), and was a significant independent prognostic indicator. prognosis 0.041 - -
CMTM3 protein-coding 24131472 Cell invasion and migration assay; cell line - - - - - No Reports Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells prognosis 0.041 - -
CMTM3 protein-coding 24131472 Xenograft mice models mice - - - - - No Reports In vivo experiments showed that peritoneal disseminated metastases were significantly suppressed by CMTM3. prognosis 0.041 - -
COL10A1 protein-coding 30154451 qRT-PCR; Western blot tissue China 30 30 Up - No Reports COL10A1 was up-regulated in GC. We observed a positive correlation between the expression patterns of SOX9 and COL10A1 in GC cells and tissues. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 qRT-PCR tissue China 103 - - - No Reports The mRNA expression level of COL10A1 was significantly associated with tumor size, lymphatic emboli, lymph node metastasis, serosal invasion, AJCC stage, and recur_x005frence risk. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 IHC tissue China 99 99 Up - No Reports The protein expression level of COL10A1 was significantly upregulated in GC tissues and showed high concordance. The protein expression levels of COL10A1 and SOX9 were significantly correlated with tumor size, tumor differentiation, lymph node metastasis, and serosal invasion. The protein expression level of COL10A1 was associated with AJCC stage. COL10A1 was associated with a poor prognosis in GC patients. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 Cell invasion and migration assay cell line - - - - - No Reports COL10A1 regulated the migration and invasion of GC cells. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 Xenograft mice models mice - - - - - No Reports Knockdown COL10A1 inhibited lung and abdominal cavity metastasis in a nude mouse model. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports SOX9 directly binds to the COL10A1 promoter and activates its transcription. prognosis 0.003/0.000 - -
COP1 protein-coding 23091414 qRT-PCR tissue China 40 40 Up - No Reports The COP1 expression level was significantly higher in the 25 (62.5%) tumor-bearing tissues, com_x005fpared with the adjacent non-tumor tissues prognosis < 0.001 - -
COP1 protein-coding 23091414 Western blot tissue China 22 22 Up - No Reports High COP1 protein expression in most tumor-bearing tissues compared with the matched adjacent non-tumor tissues. The correlated protein expression analysis revealed a negative correlation between COP1 and p53 in gastric cancer samples. prognosis < 0.001 - -
COP1 protein-coding 23091414 IHC tissue China 401 - - - No Reports High COP1 expression was significantly correlated with T stage (P=0.030), M stage (P=0.048) and TNM stage (P=0.022). High expression of COP1 was significantly correlated with poor survival in gastric cancer patients (P<0.001). Cox regression analyses showed that COP1 expression was an independent predictor of overall survival. prognosis < 0.001 - -
COPS7A protein-coding 31409899 qRT-PCR tissue China 84 29 Down - No Reports A significant decreased expression of COPS7A at mRNA levels in GC tissues compared with the non_x005ftumorous gastric tissues target - - -
COPS7A protein-coding 31409899 IHC tissue China 84 29 Down - No Reports A significant decreased expression of COPS7A at protein levels in GC tissues compared with the non_x005ftumorous gastric tissues. Lower COPS7A expression was found to be associated with larger tumor size and positive lymph node metastasis. target - - -
COPS7A protein-coding 31409899 RNA pull-down assay; RIP; Western blot cell line - - - - - No Reports KRT19P3 could bind COPS7A directly and might regulate COPS7A activity in GC target - - -
CORO1C protein-coding 22974233 IHC tissue China 152 - - - No Reports The expression of coronin 3 was higher in the highly metastatic sub-cell line MKN28-M, which we established in our laboratory. We also demonstrated that the expression of coronin 3 was remarkably higher in lymph lode metastases than in primary gastric cancer tissues, and over-expression of coronin 3 was correlated with the increased clinical stage and lymph lode metastasis. mechanism - - -
CORO1C protein-coding 22974233 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports Coronin 3 is expressed in the cytoplasm of gastric cancer cells. Coronin 3 promoted the migratory, invasive, and in vivo metastatic abilities of gastric cancer cells. mechanism - - -
CORO1C protein-coding 22974233 Xenograft mice models mice - - - - - No Reports Knockdown of coronin 3 significantly reduced liver metastasis in mice after tail vein injection of gastric cancer cells. mechanism - - -
CPXM2 protein-coding 31364750 qRT-PCR; Western blot tissue China 15 15 Up - No Reports CPXM2 mRNA and protein were elevated in the GC cases compared with the non-tumors. prognosis 0.007 - -
CPXM2 protein-coding 31364750 IHC tissue China 90 90 Up - No Reports CPXM2 was expressed mainly in the cytoplasm and on the cytosolic side of the membrane, while its expression was stronger in GCs than in non tumors. High CPXM2 expression was significantly associated with larger tumor size and later pTNM stages.High CPXM2 expression had shorter overall survival (OS) times than did those with low expression. prognosis 0.007 - -
CPXM2 protein-coding 31364750 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports CPXM2 promotes the proliferation and migration of cultured GC cells.CPXM2 may promote GC progression by modulating EMT prognosis 0.007 - -
CRK protein-coding 25027343 Cell proliferation assay; Cell invasion assay cell line - - - - - No Reports Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. target - - -
CRMP1 protein-coding 27864146 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports downregulation of CRMP1 increased cell proliferation and migration, and inhibited apoptosis in GC cells. Additionally, the inhibitory effect of the miR-187 inhibitor on cell migration was reversed by the downregulation of CRMP1. target - - -
CRMP1 protein-coding 27864146 Luciferase reporter assay cell line - - - - - No Reports CRMP1 was a direct downstream target of miR-187 in GC.The effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation target - - -
CTBP1 protein-coding 27983935 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Suppression of CtBP1 Inhibits Proliferation, Invasion, and EMT Progression in GC Cells mechanism - - -
CTBP1 protein-coding 27983935 Luciferase reporter assay cell line - - - - - No Reports CtBP1 is a putative target gene of miR-644a in GC cells mechanism - - -
CTHRC1 protein-coding 25510669 qRT-PCR tissue China 47 47 Down - No Reports Cthrc1 is upegulated in GC and inversely correlated with let-7b expression. mechanism - - -
CTHRC1 protein-coding 25510669 Luciferase reporter assay cell line - - - - - No Reports Cthrc1 was a direct target of let-7b. mechanism - - -
DDX5 protein-coding 30029874 qRT-PCR tissue China 42 42 Up - No Reports DDX5 expression in gastric cancer is significantly higher in corresponding non-cancerous gastric tissues, and the expression of miR-5590-3p and DDX5 was significantly negatively correlated in gastric cancer mechanism - - -
DDX5 protein-coding 30029874 RIP and Luciferase reporter assay cell line - - - - - No Reports miR-5590-3p as a direct target of DDX5 mechanism - - -
DICER1 protein-coding 23519840 IHC tissue China 80 40 Up - No Reports Dicer 1 protein expression was found to be significantly reduced; Dicer 1 protein positively correlated with let-7a miRNA level, but negatively correlated with CCR7 protein level in gastric adenocarcinoma; Negative Dicer 1 protein expression significantly correlated with lymph node metastasis, depth of invasion, high clinical TNM stage, and larger tumor size. low expression of Dicer 1 protein is significantly associated with the metastasis and progression of gastric cancer. - - - -
DNMT3A protein-coding 26350239 Western blot tissue China 35 35 Up - No Reports The average expression level of DNMT3A in the tumor tissues was signif_x005ficantly higher than that in the paired adjacent non-tumor tissues. DNMT3A overexpression was strongly correlated with tumor cell differentiation. target - - -
DNMT3A protein-coding 26350239 Cell proliferation assay; Flow Cytometry cell line - - - - - No Reports DNMT3A promotes tumor cell proliferation and cell growth by disrupting the G1/S checkpoint. target - - -
DNMT3A protein-coding 26350239 Xenograft mice models mice - - - - - No Reports DNMT3A promotes tumor cell proliferation in vivo target - - -
DNMT3A protein-coding 26350239 ChIP assay cell line - - - - - No Reports DNMT3A modulated p18INK4C by directly binding to and silencing the p18INK4C gene via promoter hypermethylation. target - - -
EGFR protein-coding 30530570 IHC tissue China 40 40 - - No Reports EGFR and CDK6 are up-regulated in GC and negatively correlated with miR-1296-5p mechanism - - -
EGFR protein-coding 30530570 Luciferase reporter assay cell line - - - - - No Reports EGFR and CDK6 are directly targets of miR-1296-5p mechanism - - -
ELAVL1 protein-coding 26819420 Cell proliferation assay cell line - - - - - No Reports Over-expression of HuR resulted in the increase in the cell activity of gastric cancer (P<0.001). Suppression of HuR decreased the cell activity of gastric cancer (P=0.001). mechanism - - -
ELAVL1 protein-coding 26819420 Western blot cell line - - - - - No Reports The protein level of HuR in the gastric cancer cells was higher than that in the control cells. mechanism - - -
EPHA8 protein-coding 31026069 IHC tissue China 206 92 Up - No Reports Upregulated in GC tissues compared with nontumor tissues; EphA8 expression was also strongly associated with differentiation level, tumor-node-metastasis stage, and poor 5 years survival. A panel of GC cell lines showed reduced proliferation, invasion, and migration capacities after RNA-mediated knockdown of EphA8, concomitant with downregulation of the proliferation-related proteins (cyclin A, cyclin D1, and cyclin-dependent kinase 4) and the metastasis-related (matrix metalloproteinases MMP2, and MMP9). EphA8 knockdown also decreased expression of the protease ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) and ADAM10-related protein AKT, suggesting an interaction between EphA8 and ADAM10. prognosis < 0.001 - -
EPHA8 protein-coding 31026069 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Knockdown of Epha8 reduces cell proliferation; EphA8 promotes GC cell migration and invasion prognosis < 0.001 - -
EPHA8 protein-coding 31026069 Western blot; Coimmuno precipitation experiments;Immunofluorescence microscopy cell line - - - - - No Reports EphA8 interacts with ADAM10 to affect GC cell growth prognosis < 0.001 - -
ERBB4 protein-coding 29620274 Western blot tissue China 27 27 Up - No Reports ERBB4 was highly expressed in gastric cancer tissues when compared to the normal stomach samples. target - - -
ERBB4 protein-coding 29620274 Cell proliferation assay cell line - - - - - No Reports Silencing of ERBB4 expression suppresses GC cell proliferation. target - - -
ERBB4 protein-coding 29620274 Xenograft mouse models mice - - - - - No Reports Silencing of ERBB4 expression suppresses tumor growth in vivo. target - - -
ERBB4 protein-coding 29620274 IHC mice - - - - - No Reports inhibitor of ERBB4 (AST-1306) significantly downregulated the expression level of the prolif- eration-related proteins PI3K and Akt target - - -
ETS1 protein-coding 29848678 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports ETS1 or CCND1 knockdown significantly suppressed gastric cancer cell growth, similar to miR-193a-3p overexpression. mechanism - - -
ETS1 protein-coding 29848678 Luciferase reporter assay cell line - - - - - No Reports ETS1 and CCND1 are direct targets of miR-193a-3p mechanism - - -
ETS1 protein-coding 23383271 qRT-PCR tissue China 86 86 Up - No Reports Ets1 was found to be up-regulated and inversely correlated with the expression of miR-9 in gastric cancer tissues and cell lines. mechanism - - -
ETS1 protein-coding 23383271 Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay cell line - - - - - No Reports Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro. mechanism - - -
ETS1 protein-coding 23383271 Luciferase reporter assay cell line - - - - - No Reports miR-9 directly targeted the 3'-UTR of cyclin D1 and Ets1 mechanism - - -
EZH2 protein-coding 30952377 IHC tissue China 89 89 Up - No Reports EZH2 levels were increased in gastric cancer tissues compared with adjacent normal tissues. Moreover, patients with high levels of EZH2 expression had a relatively poor prognosis. Furthermore, and vivo. Finally, we found that EZH2 influences gastric cancer cells proliferation partly through regulating p21 expression prognosis 0.001 - -
EZH2 protein-coding 30952377 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports knockdown of EZH2 expression by siRNA could impair cell proliferation and invasion both in vitro. prognosis 0.001 - -
EZH2 protein-coding 30952377 Xenograft mice models cell line - - - - - No Reports Knockdown of EZH2 inhibits gastric cancer cells tumorigenesis in vivo. prognosis 0.001 - -
EZH2 protein-coding 30952377 CHIP assay cell line - - - - - No Reports EZH2 could directly bind to P21 promoter region and mediate H3K27me3 modification. prognosis 0.001 - -
FADD protein-coding 28848149 qRT-PCR tissue China 34 34 Down - No Reports By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
FADD protein-coding 28848149 Luciferase reporter assay cell line - - - - - No Reports FADD is a potential target of miR-675; H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
FADD protein-coding 28848149 Cell proliferation assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports FADD mediates the pro-proliferation and anti-apoptosis function of miR-675 target - - -
FOXM1 protein-coding 27086911 qRT-PCR tissue China 14 14 Up - No Reports miR-320a expression correlates inversely with expression of FoxM1, a key cell cycle regulator involved in gastric carcinoma. FOXM1 expression was increased in GC tissues. mechanism - - -
FOXM1 protein-coding 27086911 Luciferase reporter assay cell line - - - - - No Reports FoxM1 is a direct target of miR-320a mechanism - - -
FZD7 protein-coding 29559846 IHC tissue China 251 60 Up - Not Related FZD7 was overexpressed in clinical GC samples, and thus was correlated with tumor invasion, lymphatic and organ metastasis, late TNM stages and poor patient survival. Furthermore, RNA interference-mediated . Moreover, ablation of FZD7 down-regulated EMT and the expression levels of cancer stem cell markers, and these inhibitions were associated with attenuated canonical Wnt/β-catenin signaling target/prognosis < 0.001 < 0.001 -
FZD7 protein-coding 29559846 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Knockdown of FZD7 suppressed gastric cancer cell growth, migration and invasion target/prognosis < 0.001 < 0.001 -
GNAQ protein-coding 28350126 IHC tissue China 280 280 Up No No Reports GNAQ was highly expressed in GC patient samples and GNAQ expression was related to patient age, GC differentiation status and adjuvant therapy, as determined by immunohistochemical assay. Mechanistic analysis revealed that knockdown of GNAQ significantly increased the expression of p53 and p21, and decreased cyclin A and p-CDK2 protein expression. Moreover, the phosphorylation of ERK and MEK was also decreased after knockdown of GNAQ as determined by western blotting assay target - - -
GNAQ protein-coding 28350126 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Silencing of GNAQ markedly suppressed proliferation and colony formation in GC cells, and arrested the cell cycle at the S phase. target - - -
GNAQ protein-coding 28350126 Western blot; cell transfection cell line - - - - - No Reports GNAQ directly or indirectly inhibits p53 and several key regulators of cell cycle signaling. GNAQ expression was required for MEK/ERK phosphorylation in MGC80-3 cells. target - - -
HOXA1 protein-coding 26791264 qRT-PCR tissue China 48 48 Up - No Reports HOXA1 mRNA expression were upregulated in GC tissues. Survival analysis indicated that HOXA1 expression were significantly associated with disease-free survival (DFS) and overall survival (OS). Patients with tumors that were positive for HOXA1 expression showed worse prognosis. Multivariate analysis confirmed that the combination of HOXA1 and cyclin D1 was an independent prognostic indicator for OS and DFS. prognosis < 0.001 < 0.001 -
HOXA1 protein-coding 26791264 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Knockdown of HOXA1 in GC cells inhibited cell proliferation, migration, and invasion in vitro; Knockdown of HOXA1 expression induces changes in the cell cycle of GC cells and decreases cyclin D1 expression prognosis < 0.001 < 0.001 -
HOXA1 protein-coding 26791264 Xenograft mice models mice - - - - - No Reports Knockdown of HOXA1 suppressed xenograft tumor formation in vivo prognosis < 0.001 < 0.001 -
HOXA1 protein-coding 26791264 IHC tissue China 264 264 Up - No Reports There was a correlation between HOXA1 and cyclin D1 in GC; prognosis < 0.001 < 0.001 -
HSPB8 protein-coding 29693129 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Knockdown of HSPB8 inhibits gastric cancer cell proliferation, promotes gastric cancer cell apoptosis - - - -
ITGA3 protein-coding 23533596 IHC tissue China 76 - - - No Reports The membranes of tumor cells stained positive for integrin a3. In all the tissues analyzed, high levels of integrin a3 expression were detected in 27 HGC tissue samples (35.52%).Patients with high integrin a3 expression were more likely to exhibit aggressive features. Patients with high Integrin a3 showed larger tumors (p =3.46E24), greater depth of invasion (p =0.001), higher tumor stage (p = 0.005), and more lymph node involvement (p = 0.040) than patients with low integrin a3 expression. Overexpression of Integrin a3 is Independent Factors Predicting the Prognosis of HGC Patients. target/prognosis < 0.0001 - -
ITGA3 protein-coding 23533596 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports silencing of integrin a3 markedly inhibited the invasion of HGC27 cells. target/prognosis < 0.0001 - -
ITGA3 protein-coding 23533596 Co-ip assays cell line - - - - - No Reports CD151 formed a complex with integrin a3 in HGC cells. target/prognosis < 0.0001 - -
JAZF1 protein-coding 31357957 Luciferase reporter assay cell line - - - - - No Reports JAZF1 is a direct target of miR-1275 in GC cells. prognosis <0.001 - -
JAZF1 protein-coding 31357957 qRT-PCR tissue China 120 120 Up - No Reports JAZF1 expression was increased in GC tissues and was positively associated with lymph node metastasis and Borrmann type. Better OS in GC patients with lower JAZF1 expression than in patients with higher JAZF1 expression. prognosis <0.001 - -
KDM4B protein-coding 24077348 Phase-contrast microscopy cell line - - - - - No Reports JMJD2B inhibition induces the epithelial morphology of gastric cancer cells target - - -
KDM4B protein-coding 24077348 qRT-PCR; Western blot cell line - - - - - No Reports JMJD2B repression results in downregulation of mesenchymal markers and upregulation of epithelial markers target - - -
KDM4B protein-coding 24077348 Luciferase reporter activity assay; ChIP assay; cell line - - - - - No Reports JMJD2B is physically associated with b-catenin to regulate vimentin promoter. target - - -
KDM4B protein-coding 24077348 Cell invasion and migration assay cell line - - - - - No Reports JMJD2B inhibition results in diminished invasion and metastasis in vitro target - - -
KDM4B protein-coding 24077348 Xenograft mice models mice - - - - - No Reports JMJD2B knockdown inhibits tumor metastasis in vivo. target - - -
KDM4B protein-coding 24077348 IHC tissue China 101 - - - No Reports JMJD2B expression was positively correlated with tumor size, differen_x005ftiation status, invasion, lymph node status, distant metastasis, and TNM stage of patients with gastric cancer target - - -
MAPK1 protein-coding 32293550 qRT-PCR; Western blot tissue China 30 30 Up - No Reports The mRNA level and protein level of MAPK1 were increased in gastric cancer tissues and cells. There was a positive correlation between levels of MAPK1 and LINC00483 in gastric cancer tissues. mechanism - - -
MAPK1 protein-coding 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. mechanism - - -
MAPK1 protein-coding 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 positively regulated MAPK1 by sponging miR‑490‑3p in gastric cancer cells mechanism - - -
NOTCH4 protein-coding 25511451 IHC tissue China 75 75 Up - No Reports Notch4 was activated by overexpressing exogenous intracellular domain of Notch4 (ICN4). Activated Notch4 expression levels were up-regulated in GC tissues target - - -
NOTCH4 protein-coding 25511451 Cell proliferation assay cell line - - - - - No Reports Notch4 activation promoted GC growth in vitro, while Notch4 inhibition using ICN4 siRNA had opposite effects. target - - -
NOTCH4 protein-coding 25511451 Xenograft mice models mice - - - - - No Reports Notch4 activation promotes tumor growth in vivo, while Notch4 inhibition inhibits tumor growth in vivo target - - -
PDCD4 protein-coding 27634902 IHC tissue China 16 16 Down - No Reports PDCD4 protein expression is down-regulated in GC tissues. target - - -
PDCD4 protein-coding 27634902 Flow cytometry cell line - - - - - No Reports MKN45 cells transfected with the PDCD4 siRNA showed suppression of cell apoptosis, whereas overexpression of PDCD4 significantly promoted cell apoptosis target - - -
PDCD4 protein-coding 27634902 Luciferase reporter assay cell line - - - - - No Reports PDCD4 is a direct target of miR-208a-3p target - - -
PDCD4 protein-coding 27634902 Xenograft mice models mice - - - - - No Reports PDCD4 inhabit the development of tumor growth target - - -
PIK3R1 protein-coding 30927924 qRT-PCR tissue China 44 - - - No Reports PIK3R1 was upregulated in DDP-resistant GC tissues samples when compared with CDDP-senestive groups. target - - -
PIK3R1 protein-coding 30927924 Western blot cell line - - - - - No Reports CDDP-resistant GC cells showed obvious increases in the expression of PIK3R1 mRNA and protein levels. target - - -
PIK3R1 protein-coding 30927924 Luciferase reporter assay; Western blot; qRT-PCR cell line - - - - - No Reports PIK3R1 is a direct target of miR-198; miR-198 mimics significantly inhibited PIK3R1 mRNA and protein levels and that ectopic PIK3R1 expression abolished the influence caused by miR-198 overexpression. target - - -
PKM protein-coding 28588255 IHC tissue China 88 88 Up - No Reports PKM2 protein was predominantly located in the nucleus and cytoplasma, and was observed to have higher IHC scores in gastric cancer samples than in peritumor tissues; PKM2 expression was positively correlated with lymph node metastasis, tumor invasion and TNM staging. target/prognosis 0.006 - -
PKM protein-coding 28588255 Cell proliferation assay; Cell colony formation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports knockdown of PKM2 can inhibit GC cell proliferation, G1-S phase transition,especially, attenuate GC cell migration target/prognosis 0.006 - -
PKM protein-coding 28588255 Xenograft mice models mice - - - - - No Reports PKM2 knockdown inhibits the tumor progression of GC in vivo. target/prognosis 0.006 - -
PKM protein-coding 28588255 Western blot; cell transduction cell line - - - - - No Reports PKM2 mediates cell migration and autophagy via the PI3K/Akt signaling pathway. target/prognosis 0.006 - -
POU2F1 protein-coding 25678401 IHC tissue China 77 77 Up - No Reports POU2F1 was overexpressed in GC tissues than in normal tissues, and its protein levels had a positive correlation with ACK1protein level. - - - -
POU2F1 protein-coding 25678401 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports POU2F1 directly binds to the ECD gene promoter and induces ECD expression. - - - -
POU2F1 protein-coding 25678401 Cell invasion and migration assays cell line - - - - - No Reports POU2F1 silencing blocked the migration, invasion, and EMT processes induced by ACK1 overexpression in gC cells - - - -
RASSF1 protein-coding 26735582 qRT-PCR tissue China 28 28 Down - No Reports The expression of RASSF1A was lower in the cancer tissues than in the normal tissues. target - - -
RASSF1 protein-coding 26735582 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports The expression of RASSF1A could suppress the viability, migration and invasion capacity of SGC-7901 cell in vitro. target - - -
RASSF1 protein-coding 26735582 miRNA microarray; qRT-PCR cell line - - - - - No Reports The expression of miR-711 was higher in the pcDNA3.1-RASSF1A-transfected SGC-7901 cells than in the pcDNA3.1-vector-transfected SGC-7901 cells. target - - -
RB1 protein-coding 15818729 S-P tissue China 122 80 Down - No Reports The positive rates of Rb protein expression respectively were 99% (79/80) in normal gastric mucosa, 80% (40/50) in dysplastic gastric mucosa, 60% (73/122) in GC. The positive rates of Rb protein expression in GC were significantly lower than that in normal gastric mucosa and dysplastic gastric mucosa (P<0.05). The positive rate of both P16 and Rb proteins was 16% (14/90), and the negative rate of both P16 and Rb proteins was 8% (7/90) in 90 GCs. The rate of positive P16 protein with negative Rb protein was 33% (30/90). The rate of negative P16 protein with positive Rb protein was 43% (39/90). There was reverse correlation between P16 and Rb expression in 90 GCs. - - - -
RB1 protein-coding 14691913 IHC tissue U.K. 67 67 - - No Reports pRb expression was lower in lymph node metastases than in the corresponding primary tumors; low pRb expression may be a powerful independent negative prognostic factor. prognosis 0.0027 - -
RUNX3 protein-coding 20300977 MS-PCR; BGS tissue China 123 123 Up(Methylation) - No Reports The methylation frequencies of Runx3 in cancer tissues were significantly higher than those in corresponding normal gastric mucosae. The methylation status of Runx3 was inversely related to the tumor size. - - - -
RUNX3 protein-coding 20300977 RT-PCR; IHC tissue China 123 - - - No Reports The expression of the protein and mRNA decreased remarkably in the patients with aberrant promoter methylation of Runx3 genes. - - - -
RUNX3 protein-coding 20300977 IHC tissue China 123 - - - No Reports The protein expression of Runx3 were significantly correlated with tumor invasion depth. - - - -
SFRP1 protein-coding 29886152 Cell proliferation assay; Cell invasion assay; cell line - - - - - No Reports SFRP1 partially reverses the effects of miR-208a on proliferation and invasion in GC target - - -
SFRP1 protein-coding 29886152 Luciferase reporter assay cell line - - - - - No Reports SFRP1 is a direct target of MiR-208a in GC cells target - - -
SIRT1 protein-coding 30250020 Cell invasion and migration assays cell line - - - - - No Reports knockdown of SIRT1 promoted GC cell migration and invasion in vitro and metastasis in vivo. Forced expression of SIRT1 in GC cells had the opposite effects. SIRT1 inhibited the expression of ARHGAP5 by physically associating with transcription factor c-JUN and deacetylating and inhibiting the transcriptional activity of c-JUN. target - - -
SIRT1 protein-coding 30250020 Xenograft mice models mice - - - - - No Reports SIRT1 inhibits metastasis of GC in vivo target - - -
SIRT1 protein-coding 30250020 Luciferase reporter assay cell line - - - - - No Reports SIRT1 inhibits expression of ARHGAP5 by physically interacting with and deacetylating c-JUN target - - -
SKP2 protein-coding 27572672 Western blot tissue China 47 19 Up - No Reports The expression levels of Skp2 in the gastric cancer tissues were significantly increased, compared with those in the normal gastric tissues target - - -
SKP2 protein-coding 27572672 Cell proliferation assay cell line - - - - - No Reports Defective regulation of Skp2 or the presence of Skp2 inhibitor contribute to decreased proliferation in human gastric cancer cell lines.Skp2 inhibitor inhibits the proliferation of gastric cancer cells in a dose‑dependent manner target - - -
SKP2 protein-coding 27572672 Xenograft mice models mice - - - - - No Reports Interference with the endogenous expression of Skp2 inhibits tumor cell growth in nude mice. target - - -
SOX9 protein-coding 30154451 qRT-PCR; Western blot tissue China 30 30 Up - No Reports SOX9 was up-regulated in GC. We observed a positive correlation between the expression patterns of SOX9 and COL10A1 in GC cells and tissues. prognosis 0 - -
SOX9 protein-coding 30154451 qRT-PCR tissue China 103 - - - No Reports The mRNA expression level of SOX9 was significantly associated with tumor size, lymphatic emboli, lymph node metastasis, serosal invasion, AJCC stage, and recur_x005frence risk. prognosis 0 - -
SOX9 protein-coding 30154451 IHC tissue China 99 99 Up - No Reports The protein expression level of SOX9 was significantly upregulated in GC tissues and showed high concordance. The protein expression levels of COL10A1 and SOX9 were significantly correlated with tumor size, tumor differentiation, lymph node metastasis, and serosal invasion. The protein expression level of COL10A1 was associated with AJCC stage. COL10A1 was associated with a poor prognosis in GC patients. prognosis 0 - -
SOX9 protein-coding 30154451 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports SOX9 directly binds to the COL10A1 promoter and activates its transcription. prognosis 0 - -
STAT3 protein-coding 30810117 IHC tissue China 30 30 Up - No Reports STAT3 protein expressions were significantly upregulated in cancer tissues.lncRNA HOTAIR was positively correlated with STAT3 and Cyclin D1 protein expressions in gastric cancer tissues. mechanism - - -
STAT3 protein-coding 30810117 Luciferase reporter assay cell line - - - - - No Reports STAT3 is the target gene of miR-454-3p. mechanism - - -
SUFU protein-coding 27810403 Luciferase reporter assay cell line - - - - - No Reports SUFU is the functional target of miRNA-194 target - - -
SUFU protein-coding 27810403 IHC tissue China 75 75 Down - No Reports SUFU was significantly down expressed in GCs compared to NSs. The expression level of SUFU was negatively associated with tumor stage. target - - -
SUFU protein-coding 27810403 qRT-PCR tissue China 20 20 Down - No Reports SUFU mRNA was significantly down expressed in GCs; a negative relationship between miRNA-194 and SUFU expression levels target - - -
TET2 protein-coding 31242038 qRT-PCR tissue China 192 - - - No Reports Patients with high TET2 expression had significantly longer survival time. prognosis < 0.01 - -
TET2 protein-coding 31242038 Apoptosis assay; Migration assay cell line - - - - - No Reports TET2 decreased gastric cancer cell survival and suppressed metastasis prognosis < 0.01 - -
TET2 protein-coding 31242038 Xenograft mouse model mice - - - - - No Reports TET2 suppresses tumor growth in vivo prognosis < 0.01 - -
TGFBR1 protein-coding 31182928 qRT-PCR tissue China 30 30 Up - No Reports TGFBR1 was significantly overexpressed in GC tissues.TGFBR1 expression was positively related to circCACTIN in si-circCACTIN group BGC-823 cells and LV-circCACTIN group MGC-803 cells. mechanism - - -
TGFBR1 protein-coding 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports TGFBR1 played a vital role in GC cells proliferation, invasion, migration, and EMT, which was positively regulated by circCACTIN. mechanism - - -
TGFBR1 protein-coding 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between miR-331-3p and TGFBR1. mechanism - - -
TMEM41A protein-coding 30015937 qRT-PCR tissue China 147 147 Up Up No Reports TMEM41A was highly expressed in GC tissues, its expression of TMEM41A was observed to be correlated with lymph node metastasis, distant metastasis and advanced tumor, node and metastasis stages.Patients with GC and high expression levels of TMEM41A exhibited a poorer disease‑free survival following radical tumor resection. target - - -
TMEM41A protein-coding 30015937 Cell proliferation assay; Invasion and migration assays; Cell immunofluorescence for cytoskeleton stain and autophagy cell line - - - - - No Reports Knockdown of TMEM41A in vitro decreased the GC cell migration ability by regulating epithelial-to-mesenchymal transition and cell autophagy, via the upregulation of E-cadherin and downregulating N-cadherin expression in GC cells. target - - -
TMEM41A protein-coding 30015937 Xenograft mice models mice - - - - - No Reports Knockdown of TMEM41A was also observed to affect tumor metastasis in nude mice. target - - -
TNK2 protein-coding 25678401 Western blot tissue China 6 6 Up - No Reports ACK1 protein level and ACK1 phosphorylation at Tyr 284 were frequently elevated in GC tissues. target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 IHC tissue China 77 77 Up - No Reports ACK1 overexpression in GC correlates with poor prognosis; positively associated with lymph node metastasis and a more advanced clinical stage in GC target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 Cell invasion and migration assays cell line - - - - - No Reports ACK1 induces EMT, invasion, and metastasis target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 Western blot; Luciferase reporter assay; IHC cell line - - - - - No Reports ACK1 up-regulates ECD expression by increasing the level of POU2F1. target/prognosis < 0.001 - -
VEGFC protein-coding 24337012 IHC; TMA tissue China 195 - - - No Reports The expression levels of VEGF-C was significantly higher in patients with lymph node metastasis than in those without metastasis. Patients with high expression levels of VEGF-C showed significantly less favorable survival rates compared with patients with low expression levels of it. prognosis 0.039 - -
XRCC5 protein-coding 30217218 IHC tissue China 90 90 Up - No Reports XRCC5 was localized to the nucleus, and its expression was higher in GC tissues than that in normal tissues. The expression of CLC-3 and XRCC5 was positively correlated. High expression of XRCC5 predicted a poor prognosis for GC patients. prognosis < 0.01 - -
XRCC5 protein-coding 30217218 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports knockdown of XRCC5 attenuated the cell clonogenicity, proliferation,invasion and migration. prognosis < 0.01 - -
XRCC5 protein-coding 30217218 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. prognosis < 0.01 - -
YBX1 protein-coding 25959498 RNA pull-down assay cell line - - - - - No Reports lncRNA GAS5 interacts with the transcriptional activator YBX1. target - - -
YBX1 protein-coding 25959498 Flow cytometry cell line - - - - - No Reports YBX1 depletion reduces G1 phase arrest by decreasing p21 expression. target - - -
ZNF143 protein-coding 27449034 qRT-PCR tissue China 53 53 Up - No Reports ZNF143 level is upregulated in gastric cancer and highly correlated with the presence of lymph node metastasis. target - - -
ZNF143 protein-coding 27449034 IHC tissue China 12 12 Up - No Reports Protein level of ZNF143 is higher in GC tssues and staining in the nucleus of GC cells target - - -
ZNF143 protein-coding 27449034 Cell invasion and migration assays cell line - - - - - No Reports ZNF143 knockdown inhibits the migration and invasion of gastric cancer cells, and overexpression contributes to the migration and invasion of GC cells. target - - -
ZNF143 protein-coding 27449034 Xenograft mice models mice - - - - - No Reports ZNF143 knockdown suppresses metastases of GC cells in vivo target - - -
ZNF143 protein-coding 27449034 Western blot; cell transfection cell line - - - - - No Reports Overexpression of ZNF143 re- duced the expression of epithelial cell marker (E-cadherin) and induced the expression mesenchymal cell marker (N-cadherin, Vimentin), related transcription factors (snail, slug), and upregulated the expression of phosphorylation AKT. target - - -
  Summary of Functional Type.
Functional Type Count
diagnosis 5
prognosis 211
mechanism 143
target 360
target,diagnosis 1
target;prognosis 1
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
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