MKGC: a curated molecular knowledgebase for gastric cancer
 Browse All GCs By
  Summary of source.
Source Count
blood 4
cell line 365
exosomes in plasma 2
mice 62
plasma 2
PPLF 1
serum 6
tissue 259
  Summary of Gene Type.
Gene Type Count
circRNA 16
lncRNA 79
miRNA 240
protein-coding 361
pseudogene 3
snoRNA 5
  Browse for target
Official
Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
ACOT7 protein-coding 32469171 qRT-PCR tissue China 10 10 Up - No Reports Upregulated in gastric tumor tissues and GC cell lines.Furthermore, NMRAL2P was downregulated in tumor tissues and GC cell lines. target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Cell proliferation assay;Migration assay;Flow cytometry cell line - - - - - No Reports ACOT7 gene silencing induced a less malignant phenotype and was closely correlated to reduced cell proliferation and migration, altered cell cycle, and increased apoptosis. target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Western blot tissue China 5 5 Up - No Reports Upregulated in GC tumor tissue at protein level target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Luciferase reporter assay cell line - - - - - No Reports NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. target/prognosis 0.025 - -
ACTN4 protein-coding 28581489 qRT-PCR tissue China 47 47 Up Up No Reports Upregulated in GC Tissue Samples target - - -
ACTN4 protein-coding 28581489 Western blot cell line - - - Up - No Reports Upregulated in GC Cell Lines target - - -
ACTN4 protein-coding 28581489 Adhesion assay;Migration assay;Invasion assay cell line - - - - - No Reports Downregulation of Actn4 enhances GC cell adhesion, suppresses migration and invasion of GC Cells target - - -
ADAM9 protein-coding 28260063 qRT-PCR tissue China 76 76 Up - No Reports The expression of ADAM9 was significantly correlated with patient clinicopathological features including tumor size, local invasion, lymph node metastasis and TNM stage. target - - -
ADAM9 protein-coding 28260063 IHC; Western blot tissue China 76 76 Up - No Reports ADAM9 is expressed frequently higher in GC tissues when compared with adjacent non-cancerous tissues target - - -
ADAM9 protein-coding 28260063 Cell proliferation assay; Cell cycle analysis. cell line - - - - - No Reports target - - -
ADAM9 protein-coding 28260063 Luciferase reporter assay cell line - - - - - No Reports ADAM9 is a direct target post-transcriptionally regulated by miR-126 in GC cells. target - - -
ADRM1 protein-coding 24968865 Cell proliferation assay cell line - - - - - No Reports Overexpression of Adrm1 promoted cell proliferation of conditionally-immortalized, mouse ImSt gastric epithelial cells, with increased S1 phase fraction and decreased expression of p21(Cip1). These results collectively indicate that ADRM1 promoted gastric epithelial cell proliferation by cell cycle progression target - - -
ADRM1 protein-coding 24968865 Comparative genomic hybridization tissue Korea 32 - - - No Reports ADRM1 was the third most frequent target for gene amplification target - - -
ADRM1 protein-coding 24968865 Microarray tissue Korea 32 21 Up - No Reports ADRM1 was also overexpressed in 92 cancer patients than in 21 healthy volunteers target - - -
AFAP1L2 protein-coding 24387290 Clonogenic assay; Soft agar colony-forming assay; Flow cytometry; BrdU incorporation assay; Cell viability assay; Invasion and migration assay; Xenograft model cell line - - - - - No Reports The proliferation, migration, and invasion of GC cell lines were all significantly inhibited by knockdown of XB130. In a xenograft model, tumor growth was markedly inhibited after shXB130-transfected GC cells were implanted into nude mice. After XB130 knockdown, GC cells showed a more epithelial-like phenotype. Silencing of XB130 reduced the expression of p-Akt/Akt, upregulated expression of epithelial markers including E-cadherin, aβ-catenin and β-catenin, and downregulated mesenchymal markers including fibronectin and vimentin. target - - -
AGER protein-coding 24441189 IHC tissue China 40 40 Up - No Reports RAGE was highly expressed in cancer tissues, and correlated with lymph node metastases. target - - -
AGER protein-coding 24441189 Cell proliferation assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of RAGE reduced cell proliferation and invasion of gastric cancer with decreased expression of AKT, PCNA and MMP-2, and induced cell apoptosis and cycle arrest target - - -
AKT3 protein-coding 29228422 qRT-PCR tissue China 42 42 Up - No Reports AKT3 was up-regulated in GC tissues when compared with matched normal tissues. target - - -
AKT3 protein-coding 29228422 Luciferase reporter assay cell line - - - - - No Reports AKT3 was chosen as the target gene of miR-582-5p. Moreover, restoration of AKT3 could impair tumor suppression role of miR-582-5p on gastric cancer growth. target - - -
ANGPTL6 protein-coding 31146977 qRT-PCR cell line - - - - - No Reports ANGPTL6 was overexpressed in Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) cell lins compared to that of common gastric cell lines; A high level of ANGPTL6 confers a poor prognosis and is correlated with the expression of CD34 (an endothelial cell marker). target - - -
ANGPTL6 protein-coding 31146977 HUVEC tube formation assay; HUVEC proliferation assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports ANGPTL6 promotes endothelial cell migration and tube formation, Moreover, ANGPTL6 knockdown inhibits cancer cell apoptosis and invasiveness. Mechanistically, ANGPTL6 activates the ERK1/2 and AKT pathways. Treatment of ERK1/2 or AKT inhibitor can attenuated cell migration and tube formation. target - - -
ANGPTL6 protein-coding 31146977 Xenograft mice models mice - - - - - No Reports ANGPTL6 loss results in tumor growth in vivo. target - - -
ANKRD40CL protein-coding 32293550 qRT-PCR tissue China 30 30 Up - No Reports LINC00483 level was increased in gastric cancer tissues and cells. . Besides, inhibition of LINC00483 decreased xenograft tumor growth by regulating miR-490-3p/MAPK1 axis. target - - -
ANKRD40CL protein-coding 32293550 Cell viability assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports Knockdown of LINC00483 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. target - - -
ANKRD40CL protein-coding 32293550 Luciferase reporter assay cell line - - - - - No Reports LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483 target - - -
ANKRD40CL protein-coding 32293550 Xenograft mice models mice - - - - - No Reports Knockdown of LINC00483 decreases tumor growth in gastric cancer xenograft model. target - - -
ASCL2 protein-coding 29746925 qRT-PCR tissue China 24 24 Up - No Reports The mRNA levels of ASCL2 were significantly increased in GC tissues compared to ad- jacent non-tumor gastric epithelium; ASCL2 expression in GC correlated with poor histological differentiation, tumor cell invasion into lymph nodes, and higher TNM stages (III + IV). SMYD3 expression status correlates with ASCL2 in GC tissues. target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 IHC tissue China - - - - No Reports ASCL2 protein were detected in the nuclei of GC cells target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 qRT-PCR; FACS; Tumorsphere formation assay cell line - - - - - No Reports ASCL2+ cells showed increased propensity of growing as tumorspheres target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 Xenograft mice models mice - - - - - No Reports High levels of ASCL2 expression are necessary for stemness and tumorigenicity of ASCL2+ GC cells target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 ChIP-qPCR cell line - - - - - No Reports SMYD3 maintains high H3K4me3 levels on the ASCL2 promoter in ASCL2+ cells, indicating its potential role in regulating ASCL2 transcription and expression. target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 qRT-PCR; Western blot cell line - - - - - No Reports Depletion of SMYD3 inhibits Wnt-induced upregulation of ASCL2. target/prognosis < 0.001 - -
ASCL2 protein-coding 30106147 qRT-PCR:Western blot; IHC tissue China 32 32 Up - No Reports Expression of ASCL2 is highest in metastases, among adjacent normal tissues, primary gastric tumors and gastric metastases. target - - -
ASCL2 protein-coding 30106147 Cell invasion and migration assays cell line - - - - - No Reports ASCL2 expression contributes to cell migration and invasion in GC cells. target - - -
ASCL2 protein-coding 30106147 Western blot cell line - - - - - No Reports the expression of E-cadherin in ASCL2-overexpressing cell lines decreased, while Zeb-1, twist-related protein 1 (Twist), Integrin, Vimentin, 72 kDa type IV collagenase (MMP-2) and matrix metalloproteinase 9 (MMP-9) were upregulated in ASCL2-overexpressing cell lines target - - -
ASCL2 protein-coding 30106147 Luciferase reporter assay; ChIP cell line - - - - - No Reports ASCL2 may interact with the promoter of pre-miR223, and inhibit the maturation of miR223. target - - -
BAG3 protein-coding 30514177 qRT-PCR; Western blot cell line - - - - - No Reports BAG3 mRNA and protein levels were increased following treatment with HGF. HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. HGF-mediated BAG3 upregulation is regulated by an ERK and Egr1-dependent pathway. BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway. target - - -
BAG3 protein-coding 30514177 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. target - - -
BRD4 protein-coding 29434197 IHC tissue China 52 52 Up - No Reports BRD4 is highly overexpressed in gastric cancer tissues. target - - -
BRD4 protein-coding 29434197 Cell proliferation assay; Invasion and migration assay; cell line - - - - - No Reports The BET inhibitor JQ1 inhibits gastric cancer cell proliferation by inducing cellular senescence. BRD4 is involved in JQ1-induced cellular senescence. target - - -
BRD4 protein-coding 29434197 Luciferase reporter assay cell line - - - - - No Reports BRD4 regulates the 3′-UTR of p21. mRNA CDKN1A target - - -
BRD4 protein-coding 29434197 CHIP assay cell line - - - - - No Reports BRD4, together with E2F1, regulates miR-106b-5p transcription and cellular senescence. target - - -
BTG1 protein-coding 26050197 RT-PCR; Western blot; MS-PCR cell line - - - - - No Reports BTG1 protein expression (19 kDa) was detectable in gastric cancer and epithelial cell lines; BTG1 mRNA was high expressed in cancer and epithelial cells and a decreased level of methylation of BTG1 after treated with 5-Aza-dC. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG1 overexpression suppressed tumor growth and lung metastasis of gastric cancer cells. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 Xenograft mice models mice - - - - - No Reports BTG1 overexpression enhanced autophagy and apoptosis in xenograft models. target/prognosis 0.047 - -
BTG1 protein-coding 26050197 RT-PCR tissue Japan 613 577 Down - No Reports BTG1 expression was statistically lower in gastric cancer than non-neoplastic mucosa and metastatic cancer in lymph node. BTG1 expression was positively correlated with depth of invasion, lymphatic and venous invasion, lymph node metastasis, TNM staging and worse prognosis. The diffuse-type carcinoma showed less BTG1 expression than intestinal- and mixed-type ones. target/prognosis 0.047 - -
BTG3 protein-coding 25904053 Western blot; IHC tissue Japan 38 38 Down - No Reports BTG3 expression was decreased in gastric cancer in comparison to the adjacent mucosa, and positively correlated with venous invasion and dedifferentiation of cancer. target - - -
BTG3 protein-coding 25904053 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG3 overexpression inhibited proliferation, induced S/G2 arrest, differentiation, autophagy, apoptosis, suppressed migration and invasion target - - -
BTG3 protein-coding 25904053 qRT-PCR; Cell transfection cell line - - - - - No Reports BTG3 transfectants showed a higher mRNA expression of p27, Bax, 14-3-3, Caspase-3, Caspase-9, Beclin 1, NF-κB, IL-1, -2, -4, -10 and -17, but a lower mRNA expression of p21, MMP-9 and VEGF than the control and mock；exposed to cisplatin (DDP), MG132, paclitaxel, and SAHA, BTG3 transfectants showed a lower viability and a higher apoptotic level than the control in both concentration and time-dependent manners target - - -
BTG3 protein-coding 25904053 Xenograft mice models mice - - - - - No Reports BTG3 suppresses the growth of gastric cancer cells in nude mice. target - - -
BTG3 protein-coding 25238703 qRT-PCR; Western blot tissue China 18 18 Down - No Reports BTG3 was obviously down-regulated in GC tissues. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 IHC tissue China 131 131 - - No Reports The expression of BTG3 was obvi- ously lower in GC tissues than adjacent gastric mucosa. Its expression was positively correlated with distant metastasis. Patients with lower BTG3 expression had shorter overall survival time. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports BTG3 suppressed the proliferation of GC cells in vitro. It also inhibited migration and invasion of GC cells in vitro. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 Xenograft mice models mice - - - - - No Reports BTG3 suppressed the proliferation of GC cells in vivo. target/prognosis 0.001 - -
C1QTNF6 protein-coding 30431096 Gene microarray tissue China 64 64 Up - No Reports C1QTNF6 was up-regulated in GC tissues. target - - -
C1QTNF6 protein-coding 30431096 IHC tissue China 52 52 Up - No Reports C1QTNF6 was primarily expressed in the cytoplasm and exhibited a diffuse granular distribution. The expression rate of C1QTNF6 in GC tissues was significantly higher than that in the normal gastric tissues target - - -
C1QTNF6 protein-coding 30431096 Cell proliferation assay; Invasion and migration assays; Flow cytometry; Cell colony formation assay cell line - - - - - No Reports Interference of C1QTNF6 expression influenced the proliferation, migration and invasion ability of Gc cells in vitro. target - - -
CACUL1 protein-coding 24004834 qRT-PCR; IHC tissue China 43 43 Up Up Related CACUL1 was highly expressed in gastric cancer tissues and negatively correlated with gastric cancer differentiation and TNM stage. In addition, CACUL1 expression was high in H.pylori-infected tissues compared with H.pylori non-infected tissue. target - - -
CASK protein-coding 25373785 qRT-PCR tissue China 50 50 Down - Related CASK was over-expressed in tumors and H. pylori positive tissues and its mRNA levels were inversely correlated with miR-203 expression target - - -
CCAT1 lncRNA 28535628 qRT-PCR tissue China 62 62 Up - No Reports The expressions of CCAT1 mRNA in GC tissues were significantly higher than in the normal tissues.The expression of CCAT1 varied significantly among patients with different TNM stage, depth of invasion, and lymph node metastasis. target - - -
CCAT1 lncRNA 28535628 Cell proliferation assay cell line - - - - - No Reports Down-regulation of CCAT1 in MGC-803 and SGC-7901 cells significantly inhibited the cell proliferation. target - - -
CCEPR lncRNA 29771412 qRT-PCR tissue China 77 77 Up - No Reports Expression of lncRNA CCHE1 in the tumor cell lines was increased (p<0.05).Bcl-2 protein expression increased, but Bax protein expression decreased in lncRNA CCHE1 upregulation group (p<0.05); the effect was reversed in lncRNA CCHE1 down-regulation group (p<0.05). target - - -
CCEPR lncRNA 29771412 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Down-regulated lncRNA CCHE1 decreased proliferative activity and colony formation capacity.Cell cycle was promot_x005fed in lncRNA CCHE1 up-regulation group. target - - -
CCKBR protein-coding 27518872 Luciferase reporter assay cell line - - - - - No Reports Cholecystokinin B receptor (CCK-BR) was a direct target of miR-148a. target - - -
CCKBR protein-coding 27518872 Cell proliferation assay; Cell migration assay cell line - - - - - No Reports siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. target - - -
CD151 protein-coding 23533596 qRT-PCR; Western blot tissue China 20 20 Up - No Reports CD151 mRNA and protein expression was increased in HGC tissues and HGC cells than in nontumor tissues and HGEC cells. CD151 overexpression was significantly correlated with high TNM stage, depth of invasion and positive lymph node involvement (p<0.05), and Importantly, the postoperative 5-year overall survival of patients with CD151(low) and/or integrin a3(low) was higher than that of patients with CD151(high) and/or integrin a3(high). target/prognosis 0.007 - -
CD151 protein-coding 23533596 IHC tissue China 76 - - - No Reports CD151 protein immunoreactivity localized to the cell membrane. High expression of CD151 was significantly correlated with tumor size (p = 0.021), depth of invasion (p = 0.004), lymph node involvement (p =0.028) and high tumor stage (p = 0.002). Overexpression of CD151 are Independent Factors Predicting the Prognosis of HGC Patients. target/prognosis 0.007 - -
CD151 protein-coding 23533596 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Down-regulation of CD151 by vshRNA-CD151 impaired metastasis and invasion of HGC-27 cells, but did not affect cell proliferation. CD151-cDNA transfection rescued the metastatic potential and invasiveness of HGC-27-vshCD151 cells, but not those of HGC-27-vshintegrin a3 cells in vitro. target/prognosis 0.007 - -
CD151 protein-coding 23533596 Xenograft mice models mice - - - - - No Reports CD151 Promoted Metastasis of HGC Cells in vivo target/prognosis 0.007 - -
CD151 protein-coding 23533596 Co-ip assays cell line - - - - - No Reports CD151 formed a complex with integrin a3 in HGC cells. target/prognosis 0.007 - -
CD276 protein-coding 25120098 qRT-PCR tissue China 32 32 Up - No Reports B7-H3 expression was significantly higher in the gastric cancer group than that in the normal gaster group. target - - -
CD276 protein-coding 25120098 IHC tissue China 32 32 Up - No Reports B7-H3 expression was significantly higher in the gastric cancer group than that in the normal gaster group. target - - -
CD276 protein-coding 25120098 Cell invasion and migration assays cell line - - - - - No Reports B7-H3 knockdown by RNA interference decreased cell migration and Transwell invasion up to 50% in vitro. target - - -
CD276 protein-coding 25120098 Xenograft mice models mice - - - - - No Reports B7-H3 expression reduced gastric cancer metastasis in vivo。 target - - -
CDC42 protein-coding 26549550 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Knockdown of CDC42 significantly inhibited the proliferation of AGS and SGC7901 cells, and it was suggested that this inhibitory process may be due to cell cycle arrest at G1/S phase and downregulation of cyclin A, cyclin D1, cyclin E and proliferating cell nuclear antigen. Furthermore, knockdown of CDC42 markedly inhibited the migration and invasion of GC cells, and suppressed the expression of matrix metalloproteinase 9 target - - -
CDK9 protein-coding 28701053 qRT-PCR tissue China 52 52 Up - No Reports CDK9 was upregulated in gastric cancer and the CDK9 expression levels were inversely correlated with that of miR-613 in gastric cancer tissues. target - - -
CDK9 protein-coding 28701053 Luciferase reporter assay cell line - - - - - No Reports CDK9 is a direct target of miR-613 in gastric cancer target - - -
CDKL1 protein-coding 22369697 IHC tissue China 66 66 Up - No Reports High expression of CDKL1 protein was observed in gastric cancer tissues compared with matched adjacent tissues. Furthermore, we show that the reduction of CDKL1 with its siRNA stimulates the activation of Bcl-2-interacting killer (Bik) pro-apoptotic protein and attenuated the expression of proliferating cell nuclear antigen PCNA. target - - -
CDKL1 protein-coding 22369697 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports Loss of CDKL1 function in both SGC7901 and MGC-803 gastric cancer cells significantly decreases cellular proliferation and increases apoptosis (p < 0.01). target - - -
CDKN2B-AS1 lncRNA 31242038 PCR tissue China 192 - - - No Reports Patients with higher ANRIL survived worse. Expressions of TET2 and ANRIL were negatively correlated in the patient samples. target/prognosis < 0.001 - -
CDKN2B-AS1 lncRNA 31242038 Apoptosis assay; Migration assay cell line - - - - - No Reports ANRIL suppresses apoptosis in gastric cancer cell, enhances metastasis target/prognosis < 0.001 - -
CDKN2B-AS1 lncRNA 31242038 Xenograft tumor mouse model cell line - - - - - No Reports ANRIL promotes tumor growth in vivo target/prognosis < 0.001 - -
CDKN2B-AS1 lncRNA 30156609 qRT-PCR tissue China 20 20 Up - No Reports ANRIL level was elevated in gastric cancer tissues and cell lines. Furthermore, ANRIL silence down-regulated BMI1 via up-regulating miR-99a. BMI1 silence down-regulated Bcl-2 and key kinases in the Notch and mTOR pathways and up-regulated p16 and cleaved caspases. target - - -
CDKN2B-AS1 lncRNA 30156609 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Knockdown of ANRIL suppressed cell viability, migration, and invasion, and increased apoptosis through up-regulating miR-99a. target - - -
CDKN2B-AS1 lncRNA 30156609 qRT-PCR; Cell transfection cell line - - - - - No Reports ANRIL silence_x005finduced up-regulation of miR-99a was significantly reversed by miR-99a inhibitor.ANRIL knockdown down-regulated the expression of BMI1 by modulating miR-99a in gastric cancer cells in vitro target - - -
CEMIP protein-coding 28422983 qRT-PCR tissue China 321 - - - No Reports KIAA1199 was upregulated in GC tissue and was an essential independent marker for poor prognosis. KIAA1199 mRNA expression was correlated with the clinical characteristics regarding depth of invasion (T-staging), distant metastasis (M-staging) and TNM staging of GC patients. target/prognosis < 0.001 - -
CEMIP protein-coding 28422983 IHC tissue China 123 - - - No Reports KIAA1199 protein expression was highly expressed in the cytoplasm of GC tissue cells and was correlated with depth of invasion, lymph node status (N-staging), metastasis and TNM staging target/prognosis < 0.001 - -
CEMIP protein-coding 28422983 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Knockdown KIAA1199 suppressed the proliferation, migration and invasion in GC cells. KIAA1199 stimulated the Wnt/β-catenin signaling pathway and the enzymatic activity of matrix metalloproteinase (MMP) family members and thus accelerated the epithelial-to-mesenchymal transition (EMT) progression in GC cells. target/prognosis < 0.001 - -
CLCN3 protein-coding 30217218 IHC tissue China 90 90 Up - No Reports CLC-3 was overexpressed in human GC tissues and that overexpression of CLC-3 was a poor prognostic biomarker for GC patients (P = 0.012). Higher expression of CLC-3 was correlated with deeper tumor invasion (P = 0.006) and increased lymph node metastasis (P = 0.016) target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports Knockdown of CLC-3 inhibited cell proliferation and migration in vitro. target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Luciferase reporter assay;ChIP assay cell line - - - - - No Reports XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. target/prognosis 0.012 - -
CLCN3 protein-coding 30217218 Xenograft mice models mice - - - - - No Reports The expression and function of CLC-3 were regulated by XRCC5 in vivo target/prognosis 0.012 - -
CLDN18 protein-coding 24647998 Western blot tissue China 45 45 Down Down No Reports Claudin-18 was downregulated in tumor tissues with larger tumor size, intestinal histologic type, deeper local invasion and more advanced TNM stage. target - - -
CLDN18 protein-coding 24647998 Luciferase reporter assay cell line - - - - - No Reports miR-1303 could bind to the putative binding sites in CLDN18 mRNA 3'-UTR and visibly lower the expression of claudin-18. The introduction of claudin-18 without 3'-UTR restored the miR-1303 promoting migration function. target - - -
CLEC4M protein-coding 28403883 ELISA assay serum China 207 197 Up Up No Reports DC-SIGNR serum level was significantly increased in gastric cancer patients compared with healthy group. DC-SIGNR level was associated with an advanced pathological stage in gastric cancer patients. target - - -
CLEC4M protein-coding 28403883 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and DC-SIGNR overexpression promoted cell proliferation, migration and invasion. target - - -
CLEC4M protein-coding 28403883 Xenograft mice models mice - - - - - No Reports DC-SIGNR knockdown suppressed the liver metastasis in vivo. target - - -
COPS7A protein-coding 31409899 qRT-PCR tissue China 84 29 Down - No Reports A significant decreased expression of COPS7A at mRNA levels in GC tissues compared with the non_x005ftumorous gastric tissues target - - -
COPS7A protein-coding 31409899 IHC tissue China 84 29 Down - No Reports A significant decreased expression of COPS7A at protein levels in GC tissues compared with the non_x005ftumorous gastric tissues. Lower COPS7A expression was found to be associated with larger tumor size and positive lymph node metastasis. target - - -
COPS7A protein-coding 31409899 RNA pull-down assay; RIP; Western blot cell line - - - - - No Reports KRT19P3 could bind COPS7A directly and might regulate COPS7A activity in GC target - - -
CRK protein-coding 25027343 Cell proliferation assay; Cell invasion assay cell line - - - - - No Reports Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. target - - -
CRMP1 protein-coding 27864146 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports downregulation of CRMP1 increased cell proliferation and migration, and inhibited apoptosis in GC cells. Additionally, the inhibitory effect of the miR-187 inhibitor on cell migration was reversed by the downregulation of CRMP1. target - - -
CRMP1 protein-coding 27864146 Luciferase reporter assay cell line - - - - - No Reports CRMP1 was a direct downstream target of miR-187 in GC.The effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation target - - -
CRNDE lncRNA 28490034 qRT-PCR tissue China 20 20 Up - No Reports CRNDE was highly expressed in GC cell lines and tissues; target - - -
CRNDE lncRNA 28490034 Cell proliferation assay cell line - - - - - No Reports Overexpression of CRNDE increased GC cell viability and promoted colony formation. Knockdown of CRNDE did not result in loss of expression-related effects on cell proliferation and colony formation. target - - -
CRNDE lncRNA 28490034 Luciferase reporter assay cell line - - - - - No Reports miR-145 target gene E2F3 was strongly expressed following CRNDE competitive molecular sponging of miR-145. target - - -
DNMT3A protein-coding 26350239 Western blot tissue China 35 35 Up - No Reports The average expression level of DNMT3A in the tumor tissues was signif_x005ficantly higher than that in the paired adjacent non-tumor tissues. DNMT3A overexpression was strongly correlated with tumor cell differentiation. target - - -
DNMT3A protein-coding 26350239 Cell proliferation assay; Flow Cytometry cell line - - - - - No Reports DNMT3A promotes tumor cell proliferation and cell growth by disrupting the G1/S checkpoint. target - - -
DNMT3A protein-coding 26350239 Xenograft mice models mice - - - - - No Reports DNMT3A promotes tumor cell proliferation in vivo target - - -
DNMT3A protein-coding 26350239 ChIP assay cell line - - - - - No Reports DNMT3A modulated p18INK4C by directly binding to and silencing the p18INK4C gene via promoter hypermethylation. target - - -
ERBB4 protein-coding 29620274 Western blot tissue China 27 27 Up - No Reports ERBB4 was highly expressed in gastric cancer tissues when compared to the normal stomach samples. target - - -
ERBB4 protein-coding 29620274 Cell proliferation assay cell line - - - - - No Reports Silencing of ERBB4 expression suppresses GC cell proliferation. target - - -
ERBB4 protein-coding 29620274 Xenograft mouse models mice - - - - - No Reports Silencing of ERBB4 expression suppresses tumor growth in vivo. target - - -
ERBB4 protein-coding 29620274 IHC mice - - - - - No Reports inhibitor of ERBB4 (AST-1306) significantly downregulated the expression level of the prolif- eration-related proteins PI3K and Akt target - - -
FADD protein-coding 28848149 qRT-PCR tissue China 34 34 Down - No Reports By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
FADD protein-coding 28848149 Luciferase reporter assay cell line - - - - - No Reports FADD is a potential target of miR-675; H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
FADD protein-coding 28848149 Cell proliferation assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports FADD mediates the pro-proliferation and anti-apoptosis function of miR-675 target - - -
FLJ22763 lncRNA 30716442 qRT-PCR tissue China 5 5 Down - No Reports FLJ22763, a novel lncRNA, had significantly lower expression in GC tissues. target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 qRT-PCR tissue China 303 - - Down No Reports Decreased expression of FLJ22763 was positively correlated with a lower-level histological grade and the depth of invasion. Patients with high FLJ22763 expression levels had a higher five-year survival rate. target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports LncRNA FLJ22763 inhibits cells proliferation, migration, and invasion target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 Xenograft mice models mice - - - - - No Reports LncRNA FLJ22763 inhibits tumorigenesis of GC cells in vivo target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 qRT-PCR; Cell tranfection; Western blot cell line - - - - - No Reports FLJ22763 was negatively associated with ACLY, regulating the mRNA and protein levels of ACLY target/prognosis 0.003 - -
FZD7 protein-coding 29559846 IHC tissue China 251 60 Up - Not Related FZD7 was overexpressed in clinical GC samples, and thus was correlated with tumor invasion, lymphatic and organ metastasis, late TNM stages and poor patient survival. Furthermore, RNA interference-mediated . Moreover, ablation of FZD7 down-regulated EMT and the expression levels of cancer stem cell markers, and these inhibitions were associated with attenuated canonical Wnt/β-catenin signaling target/prognosis < 0.001 < 0.001 -
FZD7 protein-coding 29559846 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Knockdown of FZD7 suppressed gastric cancer cell growth, migration and invasion target/prognosis < 0.001 < 0.001 -
GAS5 lncRNA 25959498 qRT-PCR tissue China 55 55 Down - No Reports lncRNA GAS5 had lower expression in stomach cancer tissues than the normal counterparts. p21 expression correlates with lncRNA GAS5 expression in stomach cancer tissues. target - - -
GAS5 lncRNA 25959498 Flow cytometry cell line - - - - - No Reports lncRNA GAS5 knock-down abolishes cell cycle arrest at the G1 phase target - - -
GAS5 lncRNA 25959498 RNA pull-down assay cell line - - - - - No Reports lncRNA GAS5 interacts with the transcriptional activator YBX1. target - - -
GNAQ protein-coding 28350126 IHC tissue China 280 280 Up No No Reports GNAQ was highly expressed in GC patient samples and GNAQ expression was related to patient age, GC differentiation status and adjuvant therapy, as determined by immunohistochemical assay. Mechanistic analysis revealed that knockdown of GNAQ significantly increased the expression of p53 and p21, and decreased cyclin A and p-CDK2 protein expression. Moreover, the phosphorylation of ERK and MEK was also decreased after knockdown of GNAQ as determined by western blotting assay target - - -
GNAQ protein-coding 28350126 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Silencing of GNAQ markedly suppressed proliferation and colony formation in GC cells, and arrested the cell cycle at the S phase. target - - -
GNAQ protein-coding 28350126 Western blot; cell transfection cell line - - - - - No Reports GNAQ directly or indirectly inhibits p53 and several key regulators of cell cycle signaling. GNAQ expression was required for MEK/ERK phosphorylation in MGC80-3 cells. target - - -
hsa_circ_0000199 circRNA 30927924 qRT-PCR tissue China 149 0 - - No Reports The expression of circAKT3 was higher in CDDP-resistant GC tissues and cells than in CDDP-sensitive samples. It was an independent risk factor for disease-free survival. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Cell cytotoxicity assay; Clonogenic assay; Flow ytometry cell line - - - - - No Reports circAKT3 promotes DNA damage repair and inhibits the apoptosis of GC cells in vitro. Downregulation of circAKT3 facilitates cisplatin sensitivity of CDDP-resistant GC cells in vitro. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Luciferase reporter assay: RNA pull-down; FISH cell line - - - - - No Reports circAKT3 and miR-198 were colocalized in the cytoplasm; circAKT3 exerts its function by sponging miR-198. target/prognosis - 0.0293 0.91
hsa_circ_0000199 circRNA 30927924 Xenograft mice models mice - - - - - No Reports circAKT3 promotes DNA damage repair and inhibits the apoptosis of GC cells in vivo. target/prognosis - 0.0293 0.91
hsa_circ_0000993 circRNA 30215537 qRT-PCR cell line - - - - - No Reports hsa_circ_0000993 has a lower expression level in highly aggressive cell line BGC-823 as compared with poorly aggressive cell line SGC-7901 target - - -
hsa_circ_0000993 circRNA 30215537 FISH cell line - - - - - No Reports FISH showed that hsa circ 0000993 was expressed both in nucleus and cytoplasm and mainly in nucleus of gastric cancer cells. target - - -
hsa_circ_0000993 circRNA 30215537 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports Increased expression of hsa circ 0000993 was associated with decreased migration, invasion and proliferation of gastric cancer cells. target - - -
hsa_circ_0000993 circRNA 30215537 Luciferase reporter assay cell line - - - - - No Reports hsa_circ_0000993 acts as a miRNA sponge for miR-214-5p target - - -
hsa_circ_0092303 circRNA 31182928 qRT-PCR tissue China 30 30 Up - No Reports CircCACTIN expression was obviously up-regulated in GC tissues and cell lines. target - - -
hsa_circ_0092303 circRNA 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports CircCACTIN promotes proliferation, invasion, and migration of GC cells in vitro. target - - -
hsa_circ_0092303 circRNA 31182928 Xenograft mice models mice - - - - - No Reports circCACTIN efficiently promoted GC tumor formation and EMT in vivo target - - -
hsa_circ_0092303 circRNA 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between circCACTIN and miR-331-3p. target - - -
ITGA3 protein-coding 23533596 IHC tissue China 76 - - - No Reports The membranes of tumor cells stained positive for integrin a3. In all the tissues analyzed, high levels of integrin a3 expression were detected in 27 HGC tissue samples (35.52%).Patients with high integrin a3 expression were more likely to exhibit aggressive features. Patients with high Integrin a3 showed larger tumors (p =3.46E24), greater depth of invasion (p =0.001), higher tumor stage (p = 0.005), and more lymph node involvement (p = 0.040) than patients with low integrin a3 expression. Overexpression of Integrin a3 is Independent Factors Predicting the Prognosis of HGC Patients. target/prognosis < 0.0001 - -
ITGA3 protein-coding 23533596 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports silencing of integrin a3 markedly inhibited the invasion of HGC27 cells. target/prognosis < 0.0001 - -
ITGA3 protein-coding 23533596 Co-ip assays cell line - - - - - No Reports CD151 formed a complex with integrin a3 in HGC cells. target/prognosis < 0.0001 - -
KDM4B protein-coding 24077348 Phase-contrast microscopy cell line - - - - - No Reports JMJD2B inhibition induces the epithelial morphology of gastric cancer cells target - - -
KDM4B protein-coding 24077348 qRT-PCR; Western blot cell line - - - - - No Reports JMJD2B repression results in downregulation of mesenchymal markers and upregulation of epithelial markers target - - -
KDM4B protein-coding 24077348 Luciferase reporter activity assay; ChIP assay; cell line - - - - - No Reports JMJD2B is physically associated with b-catenin to regulate vimentin promoter. target - - -
KDM4B protein-coding 24077348 Cell invasion and migration assay cell line - - - - - No Reports JMJD2B inhibition results in diminished invasion and metastasis in vitro target - - -
KDM4B protein-coding 24077348 Xenograft mice models mice - - - - - No Reports JMJD2B knockdown inhibits tumor metastasis in vivo. target - - -
KDM4B protein-coding 24077348 IHC tissue China 101 - - - No Reports JMJD2B expression was positively correlated with tumor size, differen_x005ftiation status, invasion, lymph node status, distant metastasis, and TNM stage of patients with gastric cancer target - - -
KRT19P3 lncRNA 31409899 qRT-PCR tissue China 84 29 Down - No Reports KRT19P3 expression was significantly decreased in gastric cancer tissues. Lower expression of KRT19P3 was found to be associated with lager tumor size (≥ 5 cm), advanced TNM stage, Lauren's classification, and positive LNM. Patients with lower KRT19P3 expression had worse overall survival (OS) and disease-free sur_x005fvival (DFS) compared with those patients with higher KRT19P3 expression Univariate analysis demonstrated that patients with lower KRT19P3 expression tended to have a higher risk of death. target/prognosis 0.0016 0.0028 -
KRT19P3 lncRNA 31409899 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports KRT19P3 inhibited GC cell proliferation and induced apoptosis, suppressed GC cell migration and invasion in vitro. target/prognosis 0.0016 0.0028 -
KRT19P3 lncRNA 31409899 Xenograft mice models mice - - - - - No Reports KRT19P3 suppressed GC cell migration and invasion and tumor growth in vivo. target/prognosis 0.0016 0.0028 -
KRT19P3 lncRNA 31409899 RNA pull-down assay; RIP; Western blot cell line - - - - - No Reports KRT19P3 could bind COPS7A directly and might regulate COPS7A activity in GC target/prognosis 0.0016 0.0028 -
LINC01089 lncRNA 29717028 qRT-PCR tissue China 32 32 Up - No Reports lncRNA AK096174 was up-regulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in GC. Our data showed that AK096174 was highly expressed in the GC tissues and cell lines (SGC-7901, AGS, BGC-823, MGC-803), and patients with higher AK096174 expression had a poorer prognosis and shorter overall survival (OS). AK096174 knockdown inhibited the proliferation, migration, and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. Furthermore, mechanistic investigation showed that AK096174 positively correlated with the expression of WD repeat-containing protein 66 (WDR66) gene at the translational level. Knockdown of WRD66 attenuated the positive impact of AK096174 in GC cells target - - -
LINC01089 lncRNA 29717028 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports AK096174 knockdown inhibited the proliferation, migration, and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. target - - -
LINC02859 lncRNA 31207155 qRT-PCR tissue China 90 90 Down - No Reports LOC101928316 was significantly downregulated in gastric cancer (GC) tissues specimen, GC cell lines, and associated with the GC patients tumor, node, and metastasis (TNM) stage and degree of differentiation. target - - -
LINC02859 lncRNA 31207155 Cell proliferation assay; Invasion and migration assay; Flow cytometry cell line - - - - - No Reports LOC101928316 overexpression can significantly inhibit GC cell migration, invasion, and proliferation. target - - -
LINC02859 lncRNA 31207155 Xenograft mouse models mice - - - - - No Reports LOC101928316 Overexpression inhibited gastric cancer cells tumorigenesis in vivo target - - -
LINC02859 lncRNA 31207155 Western blot cell line - - - - - No Reports lenti-LOC101928316-Overexpression stable infected can remarkably inhibit the expression level of PI3K, p-AKT, mTOR, and p-mTOR in GC cells target - - -
MIR103A1 miRNA 29754469 qRT-PCR tissue China 33 33 - No Reports miR-103a-3p expression was regulated in GC tissues when compared with non-tissue samples, and was also upregulated in 18 poorly differentiated tumor tissues or in 24 tumor stage III/IV samples. target - - -
MIR103A1 miRNA 29754469 Cell proliferation assay; Cell colony formation assay;Flow cytometry cell line - - - - - No Reports miR-103a-3p increases GC cell growth, and miR-103a-3p overexpression promotes the S-G2/M transition in vitro. target - - -
MIR103A1 miRNA 29754469 Luciferase reporter assay cell line - - - - - No Reports miR-103a-3p directly regulates ATF7 expression in GC cells. target - - -
MIR106B miRNA 29434197 Luciferase reporter assay; Immunoblotting cell line - - - - - No Reports miR-106b-5p targets p21 to regulate the cellular senescence in BRD4-inhibited cells. BRD4 regulates miR-106b-5p transcription via E2F for cellular senescence. target - - -
MIR107 miRNA 26406411 qRT-PCR tissue Iran 36 36 Up - Quantitative RT-PCR analysis on total RNA demonstrated significant overexpression of miR-107 in 36 GC tumor samples, in comparison to the its adjacent normal tissue of the same patients (p = 0.04) target - - -
MIR126 miRNA 25027343 qRT-PCR tissue China 15 15 Down - No Reports MiR-126 expression was frequently and markedly downregulated (p < 0.05) in human gastric cancer tissues. Moreover, overexpression of miR-126 significantly decreased (p < 0.05) the protein levels of Crk, which has previously been identified as a direct target of miR-126. Knockdown of Crk also markedly suppressed GC cells invasion. target - - -
MIR126 miRNA 25027343 qRT-PCR tissue China 110 - - - No Reports Low expression of miR-126 was significantly associated with lymph-node metastasis and poor histological grade. target - - -
MIR126 miRNA 25027343 Cell proliferation assay; Cell invasion assay cell line - - - - - No Reports Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. target - - -
MIR126 miRNA 28260063 qRT-PCR cell line - - - - - No Reports the expression levels of miR-126 were significantly downregulated in the GC cell lines compared with the GES-1 cells target - - -
MIR126 miRNA 28260063 Luciferase reporter assay cell line - - - - - No Reports ADAM9 is a direct target post-transcriptionally regulated by miR-126 in GC cells. target - - -
MIR1303 miRNA 24647998 qRT-PCR tissue China 45 45 Up Up No Reports miR-1303 was significantly overexpressed whereas claudin-18 was downregulated in GC tissues and cell lines, which was significantly associated with tumor size, location invasion, histologic type and tumor-node-metastasis stage. target - - -
MIR1303 miRNA 24647998 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Cell proliferation rates were reduced, and cell invasion and migratory ability was significantly restricted in miR-1303 inhibitor-transfected groups. target - - -
MIR1303 miRNA 24647998 Luciferase reporter assay cell line - - - - - No Reports miR-1303 could bind to the putative binding sites in CLDN18 mRNA 3'-UTR and visibly lower the expression of claudin-18. The introduction of claudin-18 without 3'-UTR restored the miR-1303 promoting migration function. target - - -
MIR135B miRNA 32119960 Luciferase reporter assay; RIP cell line - - - - - No Reports PCAT18 and CLDN11 are the direct targets of miR-135b target - - -
MIR135B miRNA 32119960 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports Over-expression of miR-135b promotes proliferation, migration and invasion of AGS cells via CLDN11 inhibition. target - - -
MIR136 miRNA 30468468 qRT-PCR cell line - - - - - No Reports miR-136 was significantly downregulated in the gastric cancer cell lines as compared to the normal cell line target - - -
MIR136 miRNA 30468468 Flow cytometry cell line - - - - - No Reports transfection of AGS cells with miR-136 promoted apoptosis target - - -
MIR142 miRNA 30178386 qRT-PCR tissue China 101 101 Down - No Reports MiR-142-5p downregulation was significantly associated with the recurrence (P = 0.031) and poor prognosis of GC (P = 0.043). CYR61 was identified as a novel direct target of miR-142-5p by bioinformatics analysis of target prediction and luciferase reporter. The re-expression and knockdown of CYR61 could, respectively, rescue the effects induced by miR-142-5p overexpression and knockdown. MiR-142-5p attenuated GC cell migration and invasion, at least partially, by inactivation of the canonical Wnt/β-catenin signaling pathway through CYR61. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Cell invasion and migration assays cell line - - - - - No Reports MiR-142-5p inhibited cancer cell migration and invasion both in vitro and in vivo. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Xenograft mice models mice - - - - - No Reports MiR-142-5p inhibited cancer cell migration and invasion in vivo. target/prognosis 0.001 - -
MIR142 miRNA 30178386 Luciferase reporter assay cell line - - - - - No Reports CYR61 is a novel target of miR‑142‑5p in GC cells target/prognosis 0.001 - -
MIR143 miRNA 28404925 microarray chip; qRT-PCR tissue China 42 42 Down Down Related miR-143-3p was ignificantly increased miRNA in H. pylori-positive gastric cancer tissues and was significantly decreased in gastric cancer tissues and cells, which correlated with late stage and lymph node metastasis. target - - -
MIR143 miRNA 28404925 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Overexpression of miR-143-3p suppressed cell proliferation, induced apoptosis and inhibited cell migration and invasion. target - - -
MIR143 miRNA 28404925 Luciferase reporter assay cell line - - - - - No Reports AKT2 is a direct target of miR-143-3p target - - -
MIR148A miRNA 27518872 qRT-PCR tissue China 41 41 Down - No Reports miR-148a expression was significantly down-regulated in gastric cancer tissues in comparison with the matched normal mucosal tissues, and its expression was statistically associated with lymph node metastasis. target - - -
MIR148A miRNA 27518872 Cell proliferation assay; Cell migration assays cell line - - - - - No Reports Ectopic expression of miR-148a inhibited tumor cell proliferation and migration in vitro. More importantly, siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. target - - -
MIR148A miRNA 27518872 Xenograft mice models mice - - - - - No Reports Ectopic expression of miR-148a inhibited tumor formation in vivo. target - - -
MIR148A miRNA 27518872 Luciferase reporter assay cell line - - - - - No Reports Cholecystokinin B receptor (CCK-BR) was a direct target of miR-148a target - - -
MIR152 miRNA 28427226 qRT-PCR tissue China 42 42 Down - No Reports The expression of miR-152 in human gastric cancer tissues were significantly lower than that in matched adjacent normal tissues. Meanwhile, lower miR-152 was also found in gastric cancer cell lines. The stage, tumor size and lymph node metastasis rate were significant higher in low-miR-152 group in clinical patients. target - - -
MIR152 miRNA 28427226 Cell proliferation assay cell line - - - - - No Reports Elevation of miR-152 enhanced T cells proliferation and effector cytokines production via inhibiting B7-H1/PD-1 pathway. target - - -
MIR152 miRNA 28427226 Luciferase reporter assay cell line - - - - - No Reports miR-152 directly bind to B7-H1 3' untranslated region in gastric cancer cell and inhibited B7-H1 expression. target - - -
MIR155 miRNA 26955820 qRT-PCR tissue China 60 60 Down Down No Reports miR-155 levels were significantly lower in both GC tissues and GC cell lines than in their normal controls, and its expression inversely correlated with tumor size and the pathologic stage. target - - -
MIR155 miRNA 26955820 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports Enforced expression of miR-155 impaired GC cell proliferation, promoted G1 phase arrest and induced apoptosis in vitro. In addition, we identified cyclin D1 as the direct target of miR-155, and knockdown of cyclin D1 partially phenocopied the role of miR-155 in GC cells. target - - -
MIR155 miRNA 26955820 Luciferase reporter assay cell line - - - - - No Reports Cyclin D1 is a direct target of miR‐155 in GC cells target - - -
MIR17 miRNA 20234369 qRT-PCR plasma Japan 69 30 Up - miR-17-5p were significantly higher in GC patients than in controls (P = 0.006) target - - -
MIR187 miRNA 27864146 qRT-PCR tissue China 54 54 Up - No Reports miR-187 was significantly overexpressed in GC tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis (P = 0.048), and TNM stage (P = 0.035). target - - -
MIR187 miRNA 27864146 Cell proliferation assay; Cell invasion and migration assays; cell line - - - - - No Reports miR-187 significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells target - - -
MIR187 miRNA 27864146 Xenograft mice models mice - - - - - No Reports miR-187 promoted tumor growth in vivo target - - -
MIR187 miRNA 27864146 Luciferase reporter assay cell line - - - - - No Reports CRMP1 was a direct downstream target of miR-187 in GC.The effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation target - - -
MIR191 miRNA 24603541 qRT-PCR tissue China 75 75 Up Up The miR-191 Cluster Is Highly Expressed in Gastric Cancer (GC) target - - -
MIR191 miRNA 24603541 qRT-PCR serum China 57 58 Up Up when using miR-16 as an endogenous control, the relative level of miR-191 in GC serum was significantly higher than those in the controls (p < 0.01) target,diagnosis - - 0.85
MIR194-1 miRNA 27810403 qRT-PCR tissue China 43 43 Up - No Reports MiRNA-194 was found to be overexpressed in GC cell lines and 43 paired GC tissues. target - - -
MIR194-1 miRNA 27810403 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Overexpression of miRNA-194 promoted cell proliferation and migration, while inhibition of miRNA-194 blocked these processes. target - - -
MIR194-1 miRNA 27810403 Xenograft mice models mice - - - - - No Reports Inhibition of miRNA-194 decreased tumor volumes in nude mice. target - - -
MIR194-1 miRNA 27810403 Luciferase reporter assay cell line - - - - - No Reports SUFU is the functional target of miRNA-194 target - - -
MIR199A1 miRNA 30193607 qRT-PCR tissue China 51 51 Down - No Reports The relative expression of miR-199 in gastric carcinoma tissues was significantly lower than that in the adjacent normal tissue . target - - -
MIR199A1 miRNA 30193607 Cell proliferation assay; Cell migration assay cell line - - - - - No Reports Over-expression of miR-199 inhibited the proliferation and migration of GC cells. target - - -
MIR199A1 miRNA 30193607 Luciferase reporter assay cell line - - - - - No Reports miR-199 directly targeted on the 3' untranslated region of TBL1XR1. target - - -
MIR19A miRNA 25914465 qRT-PCR tissue China 50 50 Up Up No Reports miR­19a is increased in GC tissue samples and cell lines. Overexpression of miR-19a was significantly associated with metastasis of GC. target - - -
MIR19A miRNA 25914465 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Overexpression of miR-19a promoted the proliferation, migration and invasion. target - - -
MIR19A miRNA 25914465 Western blot cell line - - - - - No Reports Overexpressing miR­19a GC cells promoted phosphorylation of PI3K­AKT, and the phosphorylation of PI3K­AKT was blocked in the cells transfected with miR-19a mimic. target - - -
MIR203A miRNA 30837034 qRT-PCR tissue China 10 10 Down - No Reports miR-203 is downregulated in GC tissues and cell lines. Moreover, the low level of miR-203 was associated with increased expression of annexin A4 in GC tissues and cell lines. target - - -
MIR203A miRNA 30837034 Cell invasion and migration assays cell line - - - - - No Reports miR-203 Suppressed the Invasion and EMT of GC Cells Through Inhibition of Annexin A4 target - - -
MIR203A miRNA 30837034 Luciferase reporter assay cell line - - - - - No Reports miR-203 Directly Targets Annexin A4 in GC Cells target - - -
MIR203A miRNA 30837034 qRT-PCR; Western blot cell line - - - - - No Reports overexpression of miR-203 could inhibit EMT of GC cells target - - -
MIR208A miRNA 29886152 qRT-PCR tissue China 62 62 Up Up No Reports miR-208a expression was significantly increased in GC tissues compared with adjacent normal tissues. Higher miR-208a expression was association with lymph node metastasis and TNM stage in GC patients. Kaplan-Meier analysis verified that patients with higher miR-208a expression were significantly associated with shorter overall survival (OS) time. miR-208a expression negatively associated with MEG3. target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Cell proliferation assay; Cell invasion assay; cell line - - - - - No Reports Ectopic expression of miR-208a by treatment with miR-208a mimic promoted cell proliferation and invasion abilities, but downregulation of miR-208a by treatment with miR-208a inhibitor had an opposite effects. target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Luciferase reporter assay cell line - - - - - No Reports SFRP1 is a direct target of MiR-208a in GC cells target/prognosis < 0.05 - -
MIR208A miRNA 29886152 Luciferase reporter assay; RIP cell line - - - - - No Reports MEG3 is a bona fide target for miR-208a in GC cells target/prognosis < 0.05 - -
MIR208A miRNA 27634902 qRT-PCR tissue China 16 16 Up - No Reports miR-208a-3p was up-regulated in GC tissues target - - -
MIR208A miRNA 27634902 Flow cytometry cell line - - - - - No Reports miR-208a-3p suppresses apoptosis of gastric cancer cells by targeting PDCD4 target - - -
MIR208A miRNA 27634902 Luciferase reporter assay cell line - - - - - No Reports PDCD4 is a direct target of miR-208a-3p target - - -
MIR208A miRNA 27634902 Xenograft mice models mice - - - - - No Reports miR-208a-3p promoted the development of tumor growth target - - -
MIR21 miRNA 30700111 Cell proliferation assay; Migration assay; Flow cytometer; Cell cycle assay cell line - - - - - No Reports Down-regulation of miR-21 markedly reduced gastric cancer cell proliferation and promoted cell apoptosis and repressed cell cycle progression; Silencing miR-21 dramatically blocked gastric cancer cell migration and movement. target - - -
MIR222 miRNA 22432036 qRT-PCR serum - 82 82 UP - miR-222 demonstrated significantly elevated levels in GC group with more than 2-fold change(P<0.05) target - - 0.65
MIR222 miRNA 25129310 qRT-PCR plasma China 114 56 UP - In this study, our results demonstrated that the levels of circulating miR-222 in patients with GC were significantly increased, compared with CAG and healthy controls. In addition, higher level of circulating miR-222 had also been found in the plasma of CAG patients compared with healthy controls, indicating the dysregulated expression of miR-222 might be involved in the early events of GC malignancy. target;prognosis 22.428 % 25.267% 0.85
MIR27A miRNA 27409164 qRT-PCR tissue China 20 20 Up - No Reports Two isoforms of mature miR-27a, miR-27a-5p and miR-27-3p, were both frequently overexpressed in gastric cancer tissues and cell lines, whereas the expression level of miR-27-3p in gastric cancer was significantly higher than that of miR-27a-5p. target - - -
MIR27A miRNA 27409164 Cell proliferation assay; Invasion and migration assays; Flow cytometry; Apotosis assay cell line - - - - - No Reports Overexpression of miR-27a-3p, but not miR-27a-5p, markedly promoted gastric cancer cell proliferation in vitro. miR-27a-3p/BTG2 axis regulates cell cycle progression and apoptosis in gastric cancer cells target - - -
MIR27A miRNA 27409164 Xenograft mice models mice - - - - - No Reports miR-27a-3p promotes GC cell growth in vivo. target - - -
MIR27A miRNA 27409164 Luciferase reporter assay cell line - - - - - No Reports BTG2 was a direct and functional target of miR-27a-3p in gastric cancer and miR-27a-3p inhibition obviously up-regulated the expression of BTG2. target - - -
MIR29A miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR29A miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29a into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29A miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29a in GC cells. target - - -
MIR29B1 miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR29B1 miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29b into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29B1 miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29b in GC cells. target - - -
MIR29C miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR29C miRNA 25428377 Cell invasion assay cell line - - - - - No Reports Introduction of miR-29c into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. target - - -
MIR29C miRNA 25428377 Luciferase reporter assay cell line - - - - - No Reports AKT2 was the direct target of the miR-29c in GC cells. target - - -
MIR320A miRNA 29152656 qRT-PCR tissue China 40 40 Down - No Reports Downregulated in GC tumor tissues; miR‑320a is negatively correlated with ADAM10 in tumors target - - -
MIR320A miRNA 29152656 Colony formation assay; MTS assay; Viability assay cell line - - - - - No Reports miR‑320a inhibits cell growth and enhances sensitivity of GC cells to cisplatin and suppresses tumor growth in vivo. target - - -
MIR320A miRNA 29152656 Luciferase reporter assay cell line - - - - - No Reports miR‑320a directly targets ADAM10 in GC cells. target - - -
MIR331 miRNA 31182928 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports Transfection of miR-331-3p inhi- bitor promoted BGC-823 cells proliferation, invasion and migration; transfection of miR-331-3p mimic suppressed MGC-803 cells proliferation, invasion and migration. target - - -
MIR331 miRNA 31182928 Luciferase reporter assay cell line - - - - - No Reports Binding interaction exists between miR-331-3p and TGFBR1, circCACTIN and miR-331-3p target - - -
MIR331 miRNA 31182928 qRT-PCR; Western blot cell line - - - - - No Reports Both TGFBR1 mRNA and protein expression were regulated by circCACTIN through miR-331-3p target - - -
MIR335 miRNA 21822301 qRT-PCR tissue China 70 70 No Down No Reports Low expression of miR-335 was significantly associated with lymph-node metastasis, poor pT stage, poor pN stage and invasion of lymphatic vessels. Patients with a better pT stage or pN stage had significantly higher miR-335 expression. Patients with a low expression of miR-335 tended to have metastasis invasion into lymphatic vessels. target - - -
MIR335 miRNA 21822301 Cell invasion assay; Tumor metastasis formation assay; MTT proliferation assay cell line - - - - - No Reports miR-335 suppresses gastric cancer invasion and metastasis in vitro, but has no significant effects on cell proliferation of gastric cancer target - - -
MIR335 miRNA 21822301 Luciferase reporter assay cell line - - - - - No Reports SP1 and Bcl-w are direct targets of miR-335. miR-335 suppresses gastric cancer invasion and metastasis by targeting Bcl-w and SP1 target - - -
MIR338 miRNA 30308487 qRT-PCR tissue China 53 53 Down - No Reports miR-338-3p was down-regulated in both GC tissues (53 paired samples) and cell lines (4 cancer cell lines). The decreased expression of miR-338-3p was found to be significantly associated with the Borrmann stage. target - - -
MIR338 miRNA 30308487 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports miR-338-3p could suppress cell proliferation and induce cell apoptosis, suppresses metastasis target - - -
MIR338 miRNA 30308487 Bisulfite sequence cell line - - - - - No Reports hyper-methylation is the main cause of miR-338-3p depression target - - -
MIR338 miRNA 30308487 Luciferase reporter assay cell line - - - - - No Reports Rab14 is a direct target of miR-338-3p; miR-338-3p suppresses metastasis by targeting the Hhat-MMP signaling pathway target - - -
MIR338 miRNA 26617808 qRT-PCR tissue China 36 36 Down - No Reports Down-regulated in both gastric cancer cell lines and tissues. target - - -
MIR338 miRNA 26617808 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports Enforced expression of miR-338-3p inhibited proliferation, migration and invasion of gastric cancer cells in vitro target - - -
MIR338 miRNA 26617808 Luciferase reporter assay cell line - - - - - No Reports ADAM17 is a direct target of miR-338-3 and prescued the miR-338-3p mediated inhibition of cell proliferation, migration and invasion target - - -
MIR338 miRNA 25945841 qRT-PCR tissue China 20 20 Down Down No Reports miR-338-3p was significantly lower in GC tissues than in the corresponding adjacent noncancerous tissues; mRNA expression of miR-338-3p was even lower in advanced stages of GC compared to that observed in the early stages. target - - -
MIR338 miRNA 25945841 Cell invasion and migration assays cell line - - - - - No Reports miR-338-3p inhibited the migration and invasion of GC cells in vitro and inhibits the EMT process in GC cells. target - - -
MIR338 miRNA 25945841 Luciferase reporter assay cell line - - - - - No Reports miR-338-3p directly targeted zinc finger E-box-binding protein 2 (ZEB2) and metastasis-associated in colon cancer-1 (MACC1). target - - -
MIR340 miRNA 28057912 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports Overexpression of miR-340 significantly reduced cell viability and proliferation, and induced cell apoptosis of GC cells target - - -
MIR381 miRNA 28193228 qRT-PCR tissue China 103 103 Down - No Reports MiR-381 was significantly down-regulated in gastric cancer tissues and cell lines. Low expression of miR-381 was negatively related to lymph node metastasis, advanced tumor stage and poor prognosis.miR-381 and TMEM16A revealed the improved prognostic accuracy for gastric cancer patients. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Cell proliferation assay; Invasion and migration assays cell line - - - - - No Reports MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vitro. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Xenograft mice models mice - - - - - No Reports MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vivo. target/prognosis 0.024 0.037 -
MIR381 miRNA 28193228 Luciferase reporter assay; Western blot; IHC cell line - - - - - No Reports TMEM16A was identified as a direct target of miR-381 and the expression of miR-381 was inversely correlated with TMEM16A expression in gastric cancer tissues target/prognosis 0.024 0.037 -
MIR519D miRNA 29510377 qRT-PCR tissue China 20 20 Down No Reports miR-519d-3p was downregulated in GC tumor tissues,associated with the clinical stage and lymph node metastasis of GC tissues. Decreased miR-519d-3p expression was associated with advanced stage and lymph node metastasis of GC compared with controls. target - - -
MIR519D miRNA 29510377 Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports miR-519d-3p inhibited MGC803 cell proliferation and invasion and delayed G1/S phase transition.miR-519d-3p/BCL6 axis inhibits cell proliferation, invasion, and cell cycle by regulating cyclin B1, E-cadherin, and MMP2 levels in GC cells. target - - -
MIR519D miRNA 29510377 Luciferase reporter assay cell line - - - - - No Reports BCL6 Is the Target of miR-519d-3p target - - -
MIR519D miRNA 29510377 qRT-PCR tissue China 20 20 Down No Reports miR-519d-3p was downregulated in GC tumor tissues,associated with the clinical stage and lymph node metastasis of GC tissues. Decreased miR-519d-3p expression was associated with advanced stage and lymph node metastasis of GC compared with controls. target - - -
MIR5590 miRNA 30029874 qRT-PCR tissue China 42 42 Down - No Reports In addition, Ago2-based RIP and dual-luciferase reporter were conducted to study the Next, were used to determine the role of miR-5590-3p in GC tumorigenicity in vivo. whereas . target - - -
MIR5590 miRNA 30029874 Cell proliferation assay; Cell colony formation assay; cell line - - - - - No Reports miR-5590-3p regulates GC cell proliferation and colony formation by G1/S transition target - - -
MIR5590 miRNA 30029874 Xenograft mouse models mice - - - - - No Reports Downregulation of miR-5590-3p promoted GC proliferation in vitro target - - -
MIR5590 miRNA 30029874 RIP and Luciferase reporter assay cell line - - - - - No Reports miR-5590-3p as a direct target of DDX5. target - - -
MIR582 miRNA 29228422 qRT-PCR tissue China 42 42 No Reports MiR-582-5p was downregulated in gastric cancer tissues when compared with para-carcinoma tissues. target - - -
MIR582 miRNA 29228422 Cell proliferation assay; Cell colony formation assay; Flow cytometry cell line - - - - - No Reports Overexpressed miR-582-5p could attenuate cell proliferation and viability capacities, as well as promoted cell apoptosis and cell cycle arrest at G0/G1 phase. target - - -
MIR582 miRNA 29228422 Luciferase reporter assay cell line - - - - - No Reports AKT3 was chosen as the target gene of miR-582-5p. Moreover, restoration of AKT3 could impair tumor suppression role of miR-582-5p on gastric cancer growth. target - - -
MIR589 miRNA 30012200 qRT-PCR tissue China 34 34 Up - No Reports MiR-589 expression was significantly higher in tumor tissues and gastric cancer cells than those in matched normal tissues and gastric epithelial cells, respectively. Overexpression of miR-589 is associated with tumor metastasis, invasion and poor prognosis of GC patients. target - - -
MIR589 miRNA 30012200 Cell invasion and migration assays cell line - - - - - No Reports Gain- and loss-of function experiments showed that miR-589 promoted cell migration, metastasis and invasion in vitro and lung metastasis in vivo. target - - -
MIR589 miRNA 30012200 nude mouse xenograft model mice - - - - - No Reports Endogenous overexpression of miR-589 promotes metastasis of GC cell in vivo target - - -
MIR589 miRNA 30012200 Luciferase reporter assay; ChIP assay cell line - - - - - No Reports miR-589 directly targeted LIFR to activate PI3K/AKT/c-Jun signaling. c-Jun bound to the promoter region of miR-589 and activated its transcription. target - - -
MIR613 miRNA 28701053 qRT-PCR tissue China 52 52 Down - No Reports miR-613 was evidently downregulated in gastric cancer tissue and cell. target - - -
MIR613 miRNA 28701053 Luciferase reporter assay cell line - - - - - No Reports CDK9 is a direct target of miR-613 in gastric cancer target - - -
MIR613 miRNA 28701053 Cell proliferation assay; Invasion and migration assays; cell line - - - - - No Reports miR-613 suppressed cell proliferation and migration in gastric cancer target - - -
MIR644A miRNA 27983935 qRT-PCR tissue China 107 107 Down Down No Reports The expression of miR-644a was suppressed in GC tissues and was associated with a later clinical stage and tumor metastasis. target - - -
MIR644A miRNA 27983935 Cell proliferation assay; Cell invasion and migration assays cell line - - - - - No Reports Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be correlated to its suppressive effect on the EMT process. target - - -
MIR644A miRNA 27983935 Luciferase reporter assay cell line - - - - - No Reports CtBP1 is a putative target gene of miR-644a in GC cells target - - -
MIR675 miRNA 28848149 qRT-PCR;Western blot tissue China 34 34 Up - No Reports miR-675 were increased in gastric cancer cell lines and tissues. H19 and miR-675 expression was positively correlated in gastric cancer tissues. target - - -
MIR675 miRNA 28848149 Luciferase reporter assay cell line - - - - - No Reports FADD is a potential target of miR-675; H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
MIR675 miRNA 28848149 Cell proliferation assay; Colony formation assay; Flow cytometry cell line - - - - - No Reports Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. target - - -
MIR675 miRNA 28848149 Xenograft mice models mice - - - - - No Reports There was a dramatic decrease in in tumor volume and weight in nude mice in which LV- shH19 infected SGC-7901 cell. co-infection with LV-miR675 partially reversed this tendency. target - - -
MIR711 miRNA 26735582 qRT-PCR tissue China 28 28 Down - No Reports The expression of miR-711 was lower in the cancer tissues than in the normal tissues. target - - -
MIR711 miRNA 26735582 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports miR-711 could suppress SGC-7901 cell growth in a time-dependent manner. target - - -
MIR711 miRNA 26735582 Flow cytometry; Western blot cell line - - - - - No Reports miR-711 was found to downregulate CDK4 expression target - - -
MIRLET7B miRNA 30237418 qRT-PCR cell line - - - - - No Reports let-7b-expression level of SGC7901/DDP cells was significantly lower than for its parental SGC7901 cells. target - - -
MIRLET7B miRNA 30237418 Cell proliferation assay; Flow cytometry; cell line - - - - - No Reports Upregulation of let-7b could reverse the DDP resistance of gastric cancer SGC7901/DDP cells by inducing cell viability inhibition and apoptosis when exposed to DDP treatment. target - - -
MIRLET7B miRNA 30237418 Luciferase reporter assay cell line - - - - - No Reports let-7b directly targets AURKB by binding to its 3'UTR region in DDP-resistant gastric cancer cells to DDP. target - - -
MIRLET7B miRNA 30237418 Xenograft mice models mice - - - - - No Reports Upregulation of let-7b inhibited tumor growth derived from DDP-resistant cells in vivo. target - - -
MIRLET7B miRNA 25288334 qRT-PCR tissue China 76 76 Down - No Reports let-7b was down-regulated in gastric cancer and its downregulation was associated with poor survival and correlated with lymph node metastasis. AKT2 mRNA expression showed negative correlation with the expression of let-7b in primary tumors. target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Cell proliferation assay; Invasion assay; Cell colony fomation assay cell line - - - - - No Reports suppressed the growth and invasive capacityof GC cells target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Xenograft mouse models mice - - - - - No Reports let-7b/g transfectants formed smaller xenografts than those scramble transfectants target/prognosis - 0.001 -
MIRLET7B miRNA 25288334 Luciferase reporter assay cell line - - - - - No Reports let-7b/g inhibited AKT2 expression by directly binding to its 3'UTR, reduced p-AKT (S473) activation and suppressed expression of the downstream effector pS6. target/prognosis - 0.001 -
MIRLET7B miRNA 25510669 qRT-PCR tissue China 47 47 Down - Related Let-7b was found downregulated remarkably in gastric cancer tissues and was correlated with Helicobacter pylori infection, tumor stage, and lymphatic metastasis. target - - -
MIRLET7B miRNA 25510669 Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay cell line - - - - - No Reports Ectopic expression of let-7b suppressed the growth, migration, invasion, and tumorigenicity of GC cells, whereas let-7b knockdown promoted these phenotypes. target - - -
MIRLET7B miRNA 25510669 Xenograft mice models mice - - - - - No Reports Let-7b suppresses the tumorigenicity in vivo. target - - -
MIRLET7B miRNA 25510669 Luciferase reporter assay cell line - - - - - No Reports Cthrc1 was a direct target of let-7b. target - - -
MIRLET7G miRNA 25288334 qRT-PCR tissue China 76 76 Down - No Reports let-7g was found down-regulated in gastric cancer and correlated with N-stage and lymph node metastasis. AKT2 mRNA expression showed negative correlation with the expression of let-7g in primary tumors. target - 0.051 -
MIRLET7G miRNA 25288334 Cell proliferation assay; Invasion assay; Cell colony fomation assay cell line - - - - - No Reports suppressed the growth and invasive capacityof GC cells target - 0.051 -
MIRLET7G miRNA 25288334 Xenograft mouse models mice - - - - - No Reports let-7b/g transfectants formed smaller xenografts than those scramble transfectants target - 0.051 -
MIRLET7G miRNA 25288334 Luciferase reporter assay cell line - - - - - No Reports let-7b/g inhibited AKT2 expression by directly binding to its 3'UTR, reduced p-AKT (S473) activation and suppressed expression of the downstream effector pS6. target - 0.051 -
NOTCH4 protein-coding 25511451 IHC tissue China 75 75 Up - No Reports Notch4 was activated by overexpressing exogenous intracellular domain of Notch4 (ICN4). Activated Notch4 expression levels were up-regulated in GC tissues target - - -
NOTCH4 protein-coding 25511451 Cell proliferation assay cell line - - - - - No Reports Notch4 activation promoted GC growth in vitro, while Notch4 inhibition using ICN4 siRNA had opposite effects. target - - -
NOTCH4 protein-coding 25511451 Xenograft mice models mice - - - - - No Reports Notch4 activation promotes tumor growth in vivo, while Notch4 inhibition inhibits tumor growth in vivo target - - -
PCAT18 lncRNA 32119960 Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; cell line - - - - - No Reports PCAT18 down-expression promoted proliferation, migration and invasion of gastric cancer cells. target - - -
PCAT18 lncRNA 32119960 Xenograft mice models mice - - - - - No Reports In in-vivo experiment, PCAT18 over-expression restrained tumor growth and metastasis. target - - -
PCAT18 lncRNA 32119960 Luciferase reporter assay; RIP cell line - - - - - No Reports PCAT18 is the direct target of miR-135b target - - -
PDCD4 protein-coding 27634902 IHC tissue China 16 16 Down - No Reports PDCD4 protein expression is down-regulated in GC tissues. target - - -
PDCD4 protein-coding 27634902 Flow cytometry cell line - - - - - No Reports MKN45 cells transfected with the PDCD4 siRNA showed suppression of cell apoptosis, whereas overexpression of PDCD4 significantly promoted cell apoptosis target - - -
PDCD4 protein-coding 27634902 Luciferase reporter assay cell line - - - - - No Reports PDCD4 is a direct target of miR-208a-3p target - - -
PDCD4 protein-coding 27634902 Xenograft mice models mice - - - - - No Reports PDCD4 inhabit the development of tumor growth target - - -
PIK3R1 protein-coding 30927924 qRT-PCR tissue China 44 - - - No Reports PIK3R1 was upregulated in DDP-resistant GC tissues samples when compared with CDDP-senestive groups. target - - -
PIK3R1 protein-coding 30927924 Western blot cell line - - - - - No Reports CDDP-resistant GC cells showed obvious increases in the expression of PIK3R1 mRNA and protein levels. target - - -
PIK3R1 protein-coding 30927924 Luciferase reporter assay; Western blot; qRT-PCR cell line - - - - - No Reports PIK3R1 is a direct target of miR-198; miR-198 mimics significantly inhibited PIK3R1 mRNA and protein levels and that ectopic PIK3R1 expression abolished the influence caused by miR-198 overexpression. target - - -
PKM protein-coding 28588255 IHC tissue China 88 88 Up - No Reports PKM2 protein was predominantly located in the nucleus and cytoplasma, and was observed to have higher IHC scores in gastric cancer samples than in peritumor tissues; PKM2 expression was positively correlated with lymph node metastasis, tumor invasion and TNM staging. target/prognosis 0.006 - -
PKM protein-coding 28588255 Cell proliferation assay; Cell colony formation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports knockdown of PKM2 can inhibit GC cell proliferation, G1-S phase transition,especially, attenuate GC cell migration target/prognosis 0.006 - -
PKM protein-coding 28588255 Xenograft mice models mice - - - - - No Reports PKM2 knockdown inhibits the tumor progression of GC in vivo. target/prognosis 0.006 - -
PKM protein-coding 28588255 Western blot; cell transduction cell line - - - - - No Reports PKM2 mediates cell migration and autophagy via the PI3K/Akt signaling pathway. target/prognosis 0.006 - -
RASSF1 protein-coding 26735582 qRT-PCR tissue China 28 28 Down - No Reports The expression of RASSF1A was lower in the cancer tissues than in the normal tissues. target - - -
RASSF1 protein-coding 26735582 Cell proliferation assay; Invasion and migration assays; Flow cytometry cell line - - - - - No Reports The expression of RASSF1A could suppress the viability, migration and invasion capacity of SGC-7901 cell in vitro. target - - -
RASSF1 protein-coding 26735582 miRNA microarray; qRT-PCR cell line - - - - - No Reports The expression of miR-711 was higher in the pcDNA3.1-RASSF1A-transfected SGC-7901 cells than in the pcDNA3.1-vector-transfected SGC-7901 cells. target - - -
SFRP1 protein-coding 29886152 Cell proliferation assay; Cell invasion assay; cell line - - - - - No Reports SFRP1 partially reverses the effects of miR-208a on proliferation and invasion in GC target - - -
SFRP1 protein-coding 29886152 Luciferase reporter assay cell line - - - - - No Reports SFRP1 is a direct target of MiR-208a in GC cells target - - -
SIRT1 protein-coding 30250020 Cell invasion and migration assays cell line - - - - - No Reports knockdown of SIRT1 promoted GC cell migration and invasion in vitro and metastasis in vivo. Forced expression of SIRT1 in GC cells had the opposite effects. SIRT1 inhibited the expression of ARHGAP5 by physically associating with transcription factor c-JUN and deacetylating and inhibiting the transcriptional activity of c-JUN. target - - -
SIRT1 protein-coding 30250020 Xenograft mice models mice - - - - - No Reports SIRT1 inhibits metastasis of GC in vivo target - - -
SIRT1 protein-coding 30250020 Luciferase reporter assay cell line - - - - - No Reports SIRT1 inhibits expression of ARHGAP5 by physically interacting with and deacetylating c-JUN target - - -
SKP2 protein-coding 27572672 Western blot tissue China 47 19 Up - No Reports The expression levels of Skp2 in the gastric cancer tissues were significantly increased, compared with those in the normal gastric tissues target - - -
SKP2 protein-coding 27572672 Cell proliferation assay cell line - - - - - No Reports Defective regulation of Skp2 or the presence of Skp2 inhibitor contribute to decreased proliferation in human gastric cancer cell lines.Skp2 inhibitor inhibits the proliferation of gastric cancer cells in a dose‑dependent manner target - - -
SKP2 protein-coding 27572672 Xenograft mice models mice - - - - - No Reports Interference with the endogenous expression of Skp2 inhibits tumor cell growth in nude mice. target - - -
SNHG7 lncRNA 29131253 qRT-PCR tissue China 68 68 Up - No Reports The qRT-PCR experiment showed that in a total of 68 cases of cancer tissues and tumor-adjacent tissues, the relative expression of SNHG7 was upregulated in 48 cases of gastric cancer tissues and 5 gastric cancer cell lines. target - - -
SNHG7 lncRNA 29131253 Cell proliferation assay; Flow cytometry cell line - - - - - No Reports The in vitro experiments showed that after SNHG7 expression was interfered, the proliferation of gastric cancer cells was inhibited with an increase in apoptotic rate and arrest of cell cycle in G1/G0 phase. target - - -
SNHG7 lncRNA 29131253 Xenograft mice models mice - - - - - No Reports Experiment on nude-mouse transplanted tumor model confirmed that after SNHG7 expression was interfered, in vivo tumor growth was inhibited. target - - -
SNORD105B snoRNA 29554660 qRT-PCR tissue China 109 109 Up - No Reports The snord105b was upregulated in GC tissues and associated with tumor size, differentiation, and pathological stage in GC. target - - -
SNORD105B snoRNA 29554660 qRT-PCR serum China 68 25 Up - No Reports The snord105b was upregulated in GC serum samples when compared with healthy donors. target - - -
SNORD105B snoRNA 29554660 Cell proliferation assay; Invasion and migration assay; Clonogenic assay cell line - - - - - No Reports Snord105b promotes the proliferation, migration,invasion and clonogenictiy in multiple GC cell lines. The oncoqenic activity of snord105b was also confirmed with in vivo data. Mechanistically, snord105b specifically bound to ALDOA and affected C-myc, which plays a key role in carcinogenesis and tumor development. target - - -
SNORD105B snoRNA 29554660 RIP assay; CHIRP-MS cell line - - - - - No Reports Snord105b is associated with the ALDOA protein target - - -
SNORD105B snoRNA 29554660 Xenograft mice models mice - - - - - No Reports Promotes the growth of transplanted tumors in vivo. target - - -
SUFU protein-coding 27810403 Luciferase reporter assay cell line - - - - - No Reports SUFU is the functional target of miRNA-194 target - - -
SUFU protein-coding 27810403 IHC tissue China 75 75 Down - No Reports SUFU was significantly down expressed in GCs compared to NSs. The expression level of SUFU was negatively associated with tumor stage. target - - -
SUFU protein-coding 27810403 qRT-PCR tissue China 20 20 Down - No Reports SUFU mRNA was significantly down expressed in GCs; a negative relationship between miRNA-194 and SUFU expression levels target - - -
TMEM41A protein-coding 30015937 qRT-PCR tissue China 147 147 Up Up No Reports TMEM41A was highly expressed in GC tissues, its expression of TMEM41A was observed to be correlated with lymph node metastasis, distant metastasis and advanced tumor, node and metastasis stages.Patients with GC and high expression levels of TMEM41A exhibited a poorer disease‑free survival following radical tumor resection. target - - -
TMEM41A protein-coding 30015937 Cell proliferation assay; Invasion and migration assays; Cell immunofluorescence for cytoskeleton stain and autophagy cell line - - - - - No Reports Knockdown of TMEM41A in vitro decreased the GC cell migration ability by regulating epithelial-to-mesenchymal transition and cell autophagy, via the upregulation of E-cadherin and downregulating N-cadherin expression in GC cells. target - - -
TMEM41A protein-coding 30015937 Xenograft mice models mice - - - - - No Reports Knockdown of TMEM41A was also observed to affect tumor metastasis in nude mice. target - - -
TNK2 protein-coding 25678401 Western blot tissue China 6 6 Up - No Reports ACK1 protein level and ACK1 phosphorylation at Tyr 284 were frequently elevated in GC tissues. target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 IHC tissue China 77 77 Up - No Reports ACK1 overexpression in GC correlates with poor prognosis; positively associated with lymph node metastasis and a more advanced clinical stage in GC target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 Cell invasion and migration assays cell line - - - - - No Reports ACK1 induces EMT, invasion, and metastasis target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 Western blot; Luciferase reporter assay; IHC cell line - - - - - No Reports ACK1 up-regulates ECD expression by increasing the level of POU2F1. target/prognosis < 0.001 - -
UCA1 lncRNA 28569779 qRT-PCR tissue China 39 39 Up - No Reports UCA1 expressed highly in GC tissues and GC cells, overexpression of UCA1 indicated higher tumor stage and lymph node metastasis in GC patients. target - - -
YBX1 protein-coding 25959498 RNA pull-down assay cell line - - - - - No Reports lncRNA GAS5 interacts with the transcriptional activator YBX1. target - - -
YBX1 protein-coding 25959498 Flow cytometry cell line - - - - - No Reports YBX1 depletion reduces G1 phase arrest by decreasing p21 expression. target - - -
ZNF143 protein-coding 27449034 qRT-PCR tissue China 53 53 Up - No Reports ZNF143 level is upregulated in gastric cancer and highly correlated with the presence of lymph node metastasis. target - - -
ZNF143 protein-coding 27449034 IHC tissue China 12 12 Up - No Reports Protein level of ZNF143 is higher in GC tssues and staining in the nucleus of GC cells target - - -
ZNF143 protein-coding 27449034 Cell invasion and migration assays cell line - - - - - No Reports ZNF143 knockdown inhibits the migration and invasion of gastric cancer cells, and overexpression contributes to the migration and invasion of GC cells. target - - -
ZNF143 protein-coding 27449034 Xenograft mice models mice - - - - - No Reports ZNF143 knockdown suppresses metastases of GC cells in vivo target - - -
ZNF143 protein-coding 27449034 Western blot; cell transfection cell line - - - - - No Reports Overexpression of ZNF143 re- duced the expression of epithelial cell marker (E-cadherin) and induced the expression mesenchymal cell marker (N-cadherin, Vimentin), related transcription factors (snail, slug), and upregulated the expression of phosphorylation AKT. target - - -
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
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