MKGC: a curated molecular knowledgebase for gastric cancer
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Symbol		 type pmid method Sample
Type		 Region Sample
Number
GC		 Sample
Number
nonGC		 Normal
vs.
GC		 Early-stage
vs.
advanced-stage		 Hpylori Result Functional
Type		 Overall
Survival		 Disease-free
Survival		 AUC
ABCB1 protein-coding 1977924 Slot blot assay tissue Japan 13 5 Up - No Reports Moderately differentiated gastric carcinomas contained higher concentrations of MDR1 mRNA than poorly differentiated gastric carcinomas. - - - -
ABHD11-AS1 lncRNA 24984296 qRT-PCR tissue China 75 75 Up - No Reports Compared with adjacent non-tumor tissues the expression level of ABHD11-AS1 in gastric cancer tissues was significantly increased (P = 0.027). The expression level was also significantly related with the differentiation (P = 0.022), Lauren histologic classification (P = 0.004) and carbohydrate antigen 19-9 (CA19-9) (P = 0.007), and the area under ROC curve was up to 0.613 diagnosis - - 0.613
ACOT7 protein-coding 32469171 qRT-PCR tissue China 10 10 Up - No Reports Upregulated in gastric tumor tissues and GC cell lines.Furthermore, NMRAL2P was downregulated in tumor tissues and GC cell lines. target/prognosis 0.025 - -
ACOT7 protein-coding 32469171 Western blot tissue China 5 5 Up - No Reports Upregulated in GC tumor tissue at protein level target/prognosis 0.025 - -
ACTN4 protein-coding 28581489 qRT-PCR tissue China 47 47 Up Up No Reports Upregulated in GC Tissue Samples target - - -
ADAM10 protein-coding 26852749 qRT-PCR tissue China 40 40 Up - No Reports Upregulated in GC tissues and cells - - - -
ADAM10 protein-coding 29152656 qRT-PCR tissue China 40 40 Up - No Reports Upregulated in GC tumor tissue compared with normal tissues; the expression of miR-320a was negatively correlated with the mRNA levels of ADAM10 in tumor tissues. - - - -
ADAM17 protein-coding 30569104 qRT-PCR tissue China 193 0 - - No Reports Survival times of patients were significantly associated with ADAM17 expression prognosis - - 0.618 (Mortality risk)
ADAM17 protein-coding 30569104 IHC tissue China 15 15 Up - No Reports ADAM17 expression in gastric tumor tissues was significantly upregulated compared to those in adjacent normal tissues, and was also upregulated in positive metastatic lymph node tissues relative to those in the negative tissues. prognosis - - 0.618 (Mortality risk)
ADAM17 protein-coding 30569104 Western blot tissue China 5 5 Up - No Reports ADAM17 expression was significantly upregulated in primary gastric tumor tissues and positive metastatic lymph node tissues prognosis - - 0.618 (Mortality risk)
ADAM9 protein-coding 29879625 qRT-PCR tissue China 50 50 Up - No Reports ADAM9 mRNA expression in GC tissues was significantly higher than that in adjacent normal tissues - - - -
ADAM9 protein-coding 28260063 qRT-PCR tissue China 76 76 Up - No Reports The expression of ADAM9 was significantly correlated with patient clinicopathological features including tumor size, local invasion, lymph node metastasis and TNM stage. target - - -
ADAM9 protein-coding 28260063 IHC; Western blot tissue China 76 76 Up - No Reports ADAM9 is expressed frequently higher in GC tissues when compared with adjacent non-cancerous tissues target - - -
ADRM1 protein-coding 24968865 Comparative genomic hybridization tissue Korea 32 - - - No Reports ADRM1 was the third most frequent target for gene amplification target - - -
ADRM1 protein-coding 24968865 Microarray tissue Korea 32 21 Up - No Reports ADRM1 was also overexpressed in 92 cancer patients than in 21 healthy volunteers target - - -
AFAP1-AS1 lncRNA 28451917 qRT-PCR tissue China 20 20 Up - No Reports AFAP1-AS1 was up-regulated in GC tissues and GC cells. - - - -
AFAP1-AS1 lncRNA 28975981 qRT-PCR tissue China 91 91 Up Up No Reports AFAP1-AS1 expression was dramatically increased in GC tissues and cells, compared with noncancerous gastric tissues and control cells. The higher lncRNA AFAP1-AS1 expression was positively correlated with lymph node metastasis, TNM stage and worse overall survival (OS) time in GC patients. AFAP1-AS1 expression levels were independent prognostic factors of OS in GC patients. prognosis 0.001 - -
AGAP2-AS1 lncRNA 28209205 qRT-PCR tissue China 50 50 Up - No Reports AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Higher AGAP2-AS1 level was associated with larger tumors, advanced pathological stage, and lymph node metastasis. prognosis 0.002 0.025 -
AGER protein-coding 24441189 IHC tissue China 40 40 Up - No Reports RAGE was highly expressed in cancer tissues, and correlated with lymph node metastases. target - - -
AGO2 protein-coding 23775134 IHC tissue China 371 10 Up - No Reports Ago2 expression levels in primary GC and corresponding lymph node metastases were significantly higher compared with healthy controls. Ago2 was different between HER-2 positive and HER-2 negative groups. And there was a great correlation between Ago2 expression and the tumor differentiation, lymph node invasion and clinical stage. Ago2 was also correlated to patients' gender which may suggest a possible role of hormonal signal in the mechanisms of Ago2. mechanism - - -
AK023391 lncRNA 29282102 qRT-PCR; Microarray tissue China 5 5 Up - No Reports Expression of lncRNA AK023391 was significantly upregulated in gastric cancer samples and cell lines in comparison to adjacent normal tissues prognosis 0.0024 - 0.56
AK023391 lncRNA 29282102 FISH tissue China 77 77 Up - No Reports AK023391 expression was upregulated in GC and was mainly localized in the cytoplasm of the tissue cell, and was positively correlated with poor survival in patients with gastric cancer. The multivariate Cox regression model revealed that AK023391 expression acted as an independent prognostic factor for survival in patients with gastric cancer. prognosis 0.0024 - 0.56
AKAP12 protein-coding 15258566 Bisulfite sequencing tissue Korea 18 18 - - No Reports Hypermethylation of AKAP12A CpG island was also detected in 56% (10 of 18) of primary gastric tumors. mechanism - - -
AKT2 protein-coding 25428377 Immunoblot tissue China 20 20 Up - No Reports Upregulated in GC tissues and had the tendency of inversely relationship with miR-29s expression. - - - -
AKT3 protein-coding 29228422 qRT-PCR tissue China 42 42 Up - No Reports AKT3 was up-regulated in GC tissues when compared with matched normal tissues. target - - -
ANKRD40CL protein-coding 32293550 qRT-PCR tissue China 30 30 Up - No Reports LINC00483 level was increased in gastric cancer tissues and cells. . Besides, inhibition of LINC00483 decreased xenograft tumor growth by regulating miR-490-3p/MAPK1 axis. target - - -
ANXA4 protein-coding 30837034 qRT-PCR tissue China 10 10 Down - No Reports Upregulated in GC tissues when compared with normal tissues. Moreover, the low level of miR-203 was associated with increased expression of annexin A4 in GC tissues and cell lines. - - - -
ANXA7 protein-coding 18449914 IHC tissue China 84 - - - No Reports The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor. The loss of expression of ANXA7 expression was significantly related to distant metastasis. - - - -
APBA2 protein-coding 24385013 RT-MSP tissue China 92 92 Up(Methylation) - No Reports The methylation status of the MINT2 gene was found to be significantly higher in tumor tissues than in adjacent normal tissues. No MINT2 methylation was found in healthy controls.(all P < 0.0001). diagnosis/prognosis - < 0.0001 0.710/0.696
AQP3 protein-coding 23800944 Western blot tissue China 75 75 Up - Related The protein expression levels of AQP3 were significantly elevated in GCs compared with matched non-GC tissues. AQP3 protein level was closely associated with histological type and lymphatic invasion. H. pylori infection increases the protein level of AQP3 - - - -
ARHGAP5 protein-coding 30250020 IHC tissue China 90 90 Up - No Reports The expression of ARHGAP5 was increased in GC, and positively correlated with tumor size, tumor infiltration, lymph node metastasis, and clinical stage. And multivariate analyses indicated that ARHGAP5 served as an independent prognostic marker of GC. prognosis 0.002 - -
ARID1A protein-coding 22808142 qRT-PCR tissue China 66 66 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues. prognosis 0.003 - -
ARID1A protein-coding 22808142 Western blot tissue China 25 66 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues. prognosis 0.003 - -
ARID1A protein-coding 22808142 IHC tissue China 224 - - - No Reports Loss of ARID1A expression was significantly correlated with depth of tumor infiltration (T stage) and tumor grade, but not with age, gender, tumor size, distant metastasis (M stage), and tumor locus or local lymph node metastasis. ARID1A expression as independent predictors of the overall survival of gastric cancer patients. prognosis 0.003 - -
ASCL2 protein-coding 29746925 qRT-PCR tissue China 24 24 Up - No Reports The mRNA levels of ASCL2 were significantly increased in GC tissues compared to ad- jacent non-tumor gastric epithelium; ASCL2 expression in GC correlated with poor histological differentiation, tumor cell invasion into lymph nodes, and higher TNM stages (III + IV). SMYD3 expression status correlates with ASCL2 in GC tissues. target/prognosis < 0.001 - -
ASCL2 protein-coding 29746925 IHC tissue China - - - - No Reports ASCL2 protein were detected in the nuclei of GC cells target/prognosis < 0.001 - -
ASCL2 protein-coding 30106147 qRT-PCR:Western blot; IHC tissue China 32 32 Up - No Reports Expression of ASCL2 is highest in metastases, among adjacent normal tissues, primary gastric tumors and gastric metastases. target - - -
BANCR lncRNA 26054683 qRT-PCR tissue China 20 20 Up - No Reports The expression of BANCR was increased in gastric cancer tissues compared with paired adjacent normal tissues. prognosis < 0.001 - -
BANCR lncRNA 26054683 qRT-PCR tissue China 184 - - - No Reports High expression of BANCR was positively associated with clinical stage, tumor depth, lymph node metastasis and distant metastasis in gastric cancer patients. prognosis < 0.001 - -
BCL6 protein-coding 29510377 qRT-PCR tissue China 20 20 Up - No Reports BCL6 was upregulated in GC tissues and cell lines and cor_x005frelated with a malignant phenotype in patients with GC. BCL6 overexpression partially abrogated the suppressive function of miR-519d in MGC803 cells - - - -
BIRC5 protein-coding 24337012 IHC; TMA tissue China 195 - - - No Reports The expression levels of survivin was significantly higher in patients with lymph node metastasis than in those without metastasis. Patients with high expression levels of survivin showed significantly less favorable survival rates compared with patients with low expression levels of those two genes. Moreover, patients with co-expression of the two genes usually had a poorer prognosis. prognosis 0.003 - -
BMI1 protein-coding 26894855 qRT-PCR tissue China 352 - - Down No Reports Gastric cancer patients survive better with higher expression levels of Bmi-1, and correlated with smaller tumor size, better pathological differentiation (I-II), less lymph node metastases, earlier T stages, non-metastatic disease (M0), earlier UICC stages. The expression of Bmi-1 is significantly different in stage I-II vs. stage III-IV patients. prognosis 0.024 - -
BMI1 protein-coding 26894855 qRT-PCR; IHC tissue China 21 - - - No Reports The expression of Bmi-1 is inversely correlated with miR-15a in gastric tumor tissues prognosis 0.024 - -
BMI1 protein-coding 18041745 RT-PCR; Western blot tissue China 8 8 Up - No Reports RT-PCR and Western blotting showed that Bmi-1 was up-regulated at both the transcriptional and translational levels in the GC tissues compared with the adjacent non-cancerous tissues. prognosis < 0.01 - -
BMI1 protein-coding 18041745 IHC tissue China 146 - - - No Reports 99 of 146 paraffin-embedded GC samples expressed Bmi-1 extensively. Statistical analysis showed that Bmi-1 overexpression was highly correlated with tumor size, clinical stage, lymph node metastasis and T classification. Patients with Bmi-1 expression had shorter overall survival time than those without Bmi-1 expression (P < 0.01). Multivariate analysis indicated that Bmi-1 expression is an independent prognostic factor of GC. prognosis < 0.01 - -
BRD4 protein-coding 29434197 IHC tissue China 52 52 Up - No Reports BRD4 is highly overexpressed in gastric cancer tissues. target - - -
BTG1 protein-coding 26050197 RT-PCR tissue Japan 613 577 Down - No Reports BTG1 expression was statistically lower in gastric cancer than non-neoplastic mucosa and metastatic cancer in lymph node. BTG1 expression was positively correlated with depth of invasion, lymphatic and venous invasion, lymph node metastasis, TNM staging and worse prognosis. The diffuse-type carcinoma showed less BTG1 expression than intestinal- and mixed-type ones. target/prognosis 0.047 - -
BTG3 protein-coding 25904053 Western blot; IHC tissue Japan 38 38 Down - No Reports BTG3 expression was decreased in gastric cancer in comparison to the adjacent mucosa, and positively correlated with venous invasion and dedifferentiation of cancer. target - - -
BTG3 protein-coding 25238703 qRT-PCR; Western blot tissue China 18 18 Down - No Reports BTG3 was obviously down-regulated in GC tissues. target/prognosis 0.001 - -
BTG3 protein-coding 25238703 IHC tissue China 131 131 - - No Reports The expression of BTG3 was obvi- ously lower in GC tissues than adjacent gastric mucosa. Its expression was positively correlated with distant metastasis. Patients with lower BTG3 expression had shorter overall survival time. target/prognosis 0.001 - -
BTG4 protein-coding 19576178 qRT-PCR tissue China 38 38 - - No Reports BTG4 was significantly down-regulated in tumor tissues compared to normal tissues. mechanism - - -
BTG4 protein-coding 19576178 MS-PCR tissue China 38 38 - - No Reports BTG4 was methylated in 28 of 38 primary gastric cancers tested, no methylation was detected in normal gastric samples. Its hypermethylation was corrleated with the type of cell differentiation and metastasis mechanism - - -
C1QTNF6 protein-coding 30431096 Gene microarray tissue China 64 64 Up - No Reports C1QTNF6 was up-regulated in GC tissues. target - - -
C1QTNF6 protein-coding 30431096 IHC tissue China 52 52 Up - No Reports C1QTNF6 was primarily expressed in the cytoplasm and exhibited a diffuse granular distribution. The expression rate of C1QTNF6 in GC tissues was significantly higher than that in the normal gastric tissues target - - -
C8orf76 protein-coding 30733230 CHIP assay tissue China 236 236 - - No Reports DNA copy-number of C8orf76 was frequently gained in gastric cancer. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 qRT-PCR tissue China 146 146 Up - No Reports C8orf76 was upregulated in 69.74% and 65.71% of two independent cohorts of gastric cancers and was positively associated with C8orf76 amplification. Multivariate analysis showed that gastric cancer patients with C8orf76 amplification (cohort I, n = 129; cohort II, n = 107) or overexpression (n = 356) had a significantly shortened survival. C8orf76 significantly promoted gastric cancer cell proliferation, cell-cycle transformation, and migration/invasion, but suppressed cell apoptosis. Silencing C8orf76 expression exerted opposite effects in vitro and significantly inhibited xenograft tumor growth, lung metastasis, and liver metastasis in nude mice. Silencing C8orf76 also significantly suppressed the growth of patient-derived organoids. Mechanically, C8orf76 activated MAPK/ERK signaling cascade. C8orf76 directly bound to the promoter region of lncRNA dual specificity phosphatase 5 pseudogene 1 (DUSP5P1) with a binding motif of AGGCTG and activated DUSP5P1 transcription. DUSP5P1 induced MAPK/ERK signaling and promoted gastric tumorigenesis. Knockdown DUSP5P1 abrogated the effect of C8orf76 in activating MAPK/ERK cascade and the tumor-promoting function. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 IHC tissue China 146 146 Up - No Reports C8orf76 protein expression was significantly higher in primary gastric tumors as compared with adjacent nontumor tissues. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 IHC tissue China 356 - - - No Reports High C8orf76 protein expression was significantly associated with more advanced tumor stage and diffuse-type gastric cancer. C8orf76 is a poor prognostic factor in patients with gastric cancer. prognosis < 0.0001 - -
C8orf76 protein-coding 30733230 Patient-derived gastric cancer organoid model tissue - - - - - No Reports Knockdown of C8orf76 significantly suppressed the gastric cancer cell growth in three PDO models prognosis < 0.0001 - -
CA11 protein-coding 11562744 RNA dot blot tissue China - - - - No Reports Strong expression of the CA l l gene was confirmed in normal stomach tissue - - - -
CA11 protein-coding 11562744 RT-PCR tissue China 50 50 Down - No Reports Expression of the CA11 gene in cancer tissue was down-regulated compared with normal tissue. Semi-quantitative RT-PCR also demonstrated that CA11 gene expression was decreased in 41 out of 50 (82%) of the gastric cancer tissues, when compared with normal stomach tissues, while no relationship was found between CA11 expression and various clinicopathological characteristics. - - - -
CA11 protein-coding 11562744 IHC tissue - - - - - No Reports Immunohistochemical analysis with anti CA11 antibody showed that CA11-positive staining was observed in the surface regions of normal gastric epithelium, but was found faintly or not at all in cancer tissues. - - - -
CACUL1 protein-coding 24004834 qRT-PCR; IHC tissue China 43 43 Up Up Related CACUL1 was highly expressed in gastric cancer tissues and negatively correlated with gastric cancer differentiation and TNM stage. In addition, CACUL1 expression was high in H.pylori-infected tissues compared with H.pylori non-infected tissue. target - - -
CASC15 lncRNA 29272000 qRT-PCR tissue China 60 42 Up Up No Reports Expression of lncRNA CASC15 in gastric cancer tissue was higher than normal gastric epithelium. Clinical data analysis showed that the expression level of CASC15 was correlated with tumor size and TNM stage in clinical patients. prognosis 0.013 - -
CASK protein-coding 25373785 qRT-PCR tissue China 50 50 Down - Related CASK was over-expressed in tumors and H. pylori positive tissues and its mRNA levels were inversely correlated with miR-203 expression target - - -
CAV1 protein-coding 15757532 RT-PCR,IHC tissue China 56 29 Down Down No Reports Positive rate of Caveolin-1 was significantly lower in gastric cancer than in non-cancerous mucosa, intestinal metaplasia, and atypical hyperplasia (17.9% vs. 84.8%, 81.8%, and 57.1%, P<0.05). Positive rate of Caveolin-1 was lower in advanced gastric cancers than in gastric cancer of early stage (16.0% vs. 33.3%), but the difference was not significant (P>0.05). Positive rate of Caveolin-1 was significantly lower in diffuse gastric cancer than in gastric cancer of intestinal type (7.0% vs. 26.9%, P<0.05), significantly lower in the cases with lymph node metastases than in the cases without lymph node metastases (9.7% vs. 31.8%, P<0.05). Protein and mRNA levels of Caveolin-1 in gastric cancer and relevant adjuvant non-cancerous tissues have no significant difference, but its expression was low in MGC803 and BGC823 cells. - - - -
CCAT1 lncRNA 28239816 qRT-PCR tissue China 240 240 Up - No Reports The expression of CARLo-5 in gastric cancer tissues was significantly higher than that of their matched adjacent normal tissues. High CARLo-5 expression was found to be closely correlated with advanced T stage, positive distant metastasis, lymph node involvement, and poor differentiation. Kaplan-Meier analysis demonstrated that gastric cancer patients with high CARLo-5 expression had poorer OS (p < 0.001) and RFS (p < 0.001). Finally, univariate and multivariate Cox analysis indicated that high CARLo-5 expression were independent predictors for both OS and RFS. prognosis < 0.001 - -
CCAT1 lncRNA 28535628 qRT-PCR tissue China 62 62 Up - No Reports The expressions of CCAT1 mRNA in GC tissues were significantly higher than in the normal tissues.The expression of CCAT1 varied significantly among patients with different TNM stage, depth of invasion, and lymph node metastasis. target - - -
CCAT2 lncRNA 28248065 qRT-PCR tissue China 208 208 Up - No Reports lncRNA CCAT2 was upregulated in GC tissues (P=0.000), and positively correlated with TNM stage (P=0.029), lymphatic invasion (P=0.042) and nervous invasion (P=0.024) in GC patients. Furthermore, we also found that high expression of lncRNA CCAT2 was an unfavorable prognostic factor in GC patients. prognosis < 0.05 - -
CCAT2 lncRNA 25755774 qRT-PCR tissue China 85 85 Up - No Reports Expression levels of lncRNA CCAT2 in gastric cancer tissues were significantly higher than those in adjacent non-tumor tissues. High lncRNA CCAT2 expression was observed to be closely correlated with higher incidence of lymph node metastasis and distance metastasis. Moreover, patients with high lncRNA CCAT2 expression had shorter overall survival and progression-free survival compared with the low lncRNA CCAT2 group. Multivariate analyses indicated that high lncRNA CCAT2 expression was an independent poor prognostic factor for gastric cancer patients. prognosis 0.003 - -
CCEPR lncRNA 29771412 qRT-PCR tissue China 77 77 Up - No Reports Expression of lncRNA CCHE1 in the tumor cell lines was increased (p<0.05).Bcl-2 protein expression increased, but Bax protein expression decreased in lncRNA CCHE1 upregulation group (p<0.05); the effect was reversed in lncRNA CCHE1 down-regulation group (p<0.05). target - - -
CCN1 protein-coding 30178386 IHC tissue China 159 42 Up - No Reports CYR61 protein in GC tissues was significantly higher than that in normal gastric tissues.CYR61 expression correlated with distant metastasis and recurrence. Positive CYR61 expression was significantly associated with poor overall survival. prognosis < 0.001 - -
CCN1 protein-coding 27105510 IHC tissue China 214 214 Up - No Reports CYR61 is overexpressed in 44% of the GCA tumor samples. Expression of CYR61 is inversely correlated with cumulative survival of GCA patients (p<0. 001) and significantly associated only with metastatic pathological categories (with N category, p=0. 052; with TNM stage, p=0. 001). prognosis < 0.001 - -
CCND1 protein-coding 30810117 IHC tissue China 30 30 Up - No Reports Cyclin D1 protein expressions were significantly upregulated in cancer tissues.lncRNA HOTAIR was positively correlated with STAT3 and Cyclin D1 protein expressions in gastric cancer tissues. - - - -
CCND1 protein-coding 26955820 qRT-PCR tissue China 60 60 Up - No Reports the cyclin D1 mRNA level was generally higher in GC samples when compared to their matched nontumor counterparts - - - -
CCND1 protein-coding 23383271 qRT-PCR tissue China 86 86 Up - No Reports cyclin D1 was found to be up-regulated and inversely correlated with the expression of miR-9 in gastric cancer tissues and cell lines. mechanism - - -
CCND1 protein-coding 14691913 IHC tissue U.K. 67 67 Up - No Reports Cyclin D1 overexpression (≥5% expression) was seen in 55% of cancers; Cyclin D1 overexpression was associated with poor differentiation and signet ring cell type. - - - -
CCND1 protein-coding 26791264 qRT-PCR tissue China 48 48 Up - No Reports cyclin D1 mRNA expression were upregulated in GC tissues. A significant correlation was found between the expression of HOXA1 and cyclin D1. prognosis < 0.001 < 0.001 -
CCND1 protein-coding 26791264 IHC; Western blot tissue China 264 264 Up - No Reports cyclin D1 protein expression were upregulated in GC tissue; Overexpression of cyclin D1 was significantly associated with differentiation; Cyclin D1 was also significantly associ- ated with DFS and OS. prognosis < 0.001 < 0.001 -
CCND2 protein-coding 14612939 MS-PCR tissue Japan 34 21 Up(Methylation) Up(Methylation) No Reports Hypomethylation of the cyclin D2 promoter was found in 24 (71%) of the 34 tumor tissues and in 6 (29%) of the 21 corresponding non-neoplastic mucosa, the incidence being significantly different (p=0.002; Fisher's exact test). Moreover, hypomethylation of cyclin D2 was more common in stage III and IV tumors than in stage I and II tumors. mechanism - - -
CCND2 protein-coding 14612939 qRT-PCR tissue China 23 23 - - No Reports Levels of cyclin D2 mRNA expression in tumor tissues with cyclin D2 hypomethylation (33.08±45.78) tended to be higher than those with cyclin D2 hypermethylation; levels of cyclin D2 mRNA expression in tumor tissues with metastasis (35.88+45.56) were significantly higher than those in tumors without metastasis. mechanism - - -
CCR7 protein-coding 23519840 IHC tissue China 80 40 Up - No Reports CCR7 protein plays a key role in the metastasis and progression of gastric cancer. The elevated CCR7 protein expression may be caused by the deficiency of let-7a miRNA expression due to the downregulation of DICER1gene expression. The mechanism for the silencing of DICER1 gene expression requires further studies. - - - -
CD151 protein-coding 23533596 qRT-PCR; Western blot tissue China 20 20 Up - No Reports CD151 mRNA and protein expression was increased in HGC tissues and HGC cells than in nontumor tissues and HGEC cells. CD151 overexpression was significantly correlated with high TNM stage, depth of invasion and positive lymph node involvement (p<0.05), and Importantly, the postoperative 5-year overall survival of patients with CD151(low) and/or integrin a3(low) was higher than that of patients with CD151(high) and/or integrin a3(high). target/prognosis 0.007 - -
CD151 protein-coding 23533596 IHC tissue China 76 - - - No Reports CD151 protein immunoreactivity localized to the cell membrane. High expression of CD151 was significantly correlated with tumor size (p = 0.021), depth of invasion (p = 0.004), lymph node involvement (p =0.028) and high tumor stage (p = 0.002). Overexpression of CD151 are Independent Factors Predicting the Prognosis of HGC Patients. target/prognosis 0.007 - -
CD274 protein-coding 29073638 IHC tissue Korea 116 - - - No Reports Among 116 eligible patients, 57 (49.1%) and 66 patients (56.9%) were determined as iTu-PD-L1-positive and str-PD-L1-positive. Intraepithelial tumour cell PD-L1 positivity was found to be significantly associated with lymph node (LN) metastasis and a poor disease-free survival (DFS) (P=0.032), yet not overall survival (P=0.482). In a multivariate analysis, iTu-PD-L1 positivity was independently associated with a poor DFS (P=0.006, hazard ratio=12.085). prognosis 0.482 0.032 -
CD276 protein-coding 25120098 qRT-PCR tissue China 32 32 Up - No Reports B7-H3 expression was significantly higher in the gastric cancer group than that in the normal gaster group. target - - -
CD276 protein-coding 25120098 IHC tissue China 32 32 Up - No Reports B7-H3 expression was significantly higher in the gastric cancer group than that in the normal gaster group. target - - -
CDC42 protein-coding 25152372 Western blot tissue China 18 18 Up - No Reports The protein expression of CDC42 was significantly up-regulated in cancer tissues. mechanism - - -
CDH1 protein-coding 30063010 qRT-PCR tissue China 67 67 Up - No Reports The mRNA level of CDH1 was found reduced in the GC tissues and there is a negative correlation between the expression of CDH1 and miR-217 in the GC samples. mechanism - - -
CDH1 protein-coding 24023308 MS-PCR tissue Korea 72 72 - - No Reports MSP and PS revealed CDH1 promoter methylation in 73.6% (53/72) and 77.8% (56/72) of DGC samples, respectively. PS detected CDH1 methylation in 70.8% (51/72) and 72.2% (52/72) of matched normal mucosa from adjacent and remote foci, respectively. In comparison, CDH1 promoter methylation was detected in 12/24 normal gastric mucosa samples without DGC, and this difference was statistically significant (p=0.016). - - - -
CDK6 protein-coding 30530570 IHC tissue China 40 40 - - No Reports EGFR and CDK6 are up-regulated in GC and negatively correlated with miR-1296-5p - - - -
CDK9 protein-coding 28701053 qRT-PCR tissue China 52 52 Up - No Reports CDK9 was upregulated in gastric cancer and the CDK9 expression levels were inversely correlated with that of miR-613 in gastric cancer tissues. target - - -
CDKL1 protein-coding 22369697 IHC tissue China 66 66 Up - No Reports High expression of CDKL1 protein was observed in gastric cancer tissues compared with matched adjacent tissues. Furthermore, we show that the reduction of CDKL1 with its siRNA stimulates the activation of Bcl-2-interacting killer (Bik) pro-apoptotic protein and attenuated the expression of proliferating cell nuclear antigen PCNA. target - - -
CDKN1A protein-coding 25959498 qRT-PCR tissue China 55 55 Down - No Reports p21 mRNA level was significantly down-regulated in 72.7% of cancer tissues compared with paired normal tissues, which was positively correlated with decreased lncRNA GAS5 expression in tissue specimens - - - -
CDKN2A protein-coding 15818729 S-P tissue China 122 80 Down - No Reports The positive rates of P16 protein expression respectively were 96% (77/80) in normal gastric mucosa, 92% (45/50) in dysplastic gastric mucosa, 48% (58/122) in GC. The positive rates of P16 protein expression in GC were significantly lower than that in normal gastric mucosa and dysplastic gastric mucosa. The positive rate of P16 protein expression in mucoid carcinoma (10%, 1/10) was significantly lower than that in poorly differentiated carcinoma (51%, 21/41), undifferentiated carcinoma (58%, 15/26) and signet ring cell carcinoma (62%, 10/16) (P<0.05). The positive rates of P16 protein in 30 cases of paired primary and lymph node metastatic GC were 47% (14/30) and 17% (5/30) respectively, being significantly lower in the later than in the former. - - - -
CDKN2A protein-coding 15818729 PCR; PCR-SSCP tissue China 25 - - - No Reports There was no mutation in exon 2 of p16 gene in the 25 freshly resected primary GCs. But five cases in the 25 freshly resected primary GCs displayed deletion in exon 2 of p16 gene. - - - -
CDKN2B-AS1 lncRNA 31242038 PCR tissue China 192 - - - No Reports Patients with higher ANRIL survived worse. Expressions of TET2 and ANRIL were negatively correlated in the patient samples. target/prognosis < 0.001 - -
CDKN2B-AS1 lncRNA 30156609 qRT-PCR tissue China 20 20 Up - No Reports ANRIL level was elevated in gastric cancer tissues and cell lines. Furthermore, ANRIL silence down-regulated BMI1 via up-regulating miR-99a. BMI1 silence down-regulated Bcl-2 and key kinases in the Notch and mTOR pathways and up-regulated p16 and cleaved caspases. target - - -
CEBPA protein-coding 20386538 IHC tissue Portugal 54 - - - No Reports In GC, C/EBPa staining was mostly nuclear with some residual cytoplasmic positivity. In GC, C/ EBPa was considered downregulated in 30% of the tumors. No statistical significant relationships were found between C/EBPa expression and any clin- icopathological features of the cases. mechanism - - -
CELF2 protein-coding 29501762 IHC tissue China 104 104 Down - No Reports CELF2 was predominately down regulated in 86 gastric cancer tissues and highly ex- pressed in 18 cancer tissues compared with para-cancer tissues (69 high expressed and 35 low expressed). CELF2 expression was associated with T, N and M stage. Lower expression of CELF2 correlated to shorter period of survival months. prognosis < 0.01 - -
CEMIP protein-coding 28422983 qRT-PCR tissue China 321 - - - No Reports KIAA1199 was upregulated in GC tissue and was an essential independent marker for poor prognosis. KIAA1199 mRNA expression was correlated with the clinical characteristics regarding depth of invasion (T-staging), distant metastasis (M-staging) and TNM staging of GC patients. target/prognosis < 0.001 - -
CEMIP protein-coding 28422983 IHC tissue China 123 - - - No Reports KIAA1199 protein expression was highly expressed in the cytoplasm of GC tissue cells and was correlated with depth of invasion, lymph node status (N-staging), metastasis and TNM staging target/prognosis < 0.001 - -
CHD1L protein-coding 24258459 qRT-PCR tissue China 34 34 Up - No Reports The gene expression levels of CHD1L were higher in fresh samples of GC than in paired adjacent noncancerous tissues. prognosis < 0.001 - -
CHD1L protein-coding 24258459 Western blot tissue China 34 34 Up - No Reports The protein expression levels of CHD1L were higher in fresh samples of GC than in paired adjacent noncancerous tissues. prognosis < 0.001 - -
CHD1L protein-coding 24258459 IHC tissue China 616 616 Up - No Reports Positive expression rates of CHD1L in GC and paired adjacent noncancerous tissues were 58.7 % (361/616) and 7.3 % (45/616), respectively. CHD1L positivity was significantly associated with clinical stage and distant metastasis. GC patients with positive CHD1L expression had shorter overall survival than those with negative CHD1L expression. Multivariate analysis showed that CHD1L was an independent prognostic marker for overall survival [Hazard Ratio (HR) = 5.952, 95 % confidence interval (CI) = 3.194-11.187, P = 0.0043]. prognosis < 0.001 - -
CHD5 protein-coding 19840376 MS-PCR; BGS tissue/cell line - - - - - No Reports Methylation of CHD5 promoter was detected in all of seven gastric cancer cell lines and in the majority of primary gastric carcinoma tissues examined (73%, 11/15). mechanism - - -
CHFR protein-coding 20300977 MS-PCR; BGS tissue China 123 123 Up(Methylation) - No Reports The methylation frequencies of CHFR in cancer tissues were significantly higher than those in corresponding normal gastric mucosae. The methylation status of CHFR was inversely related to the tumor size, tumor invasion depth and tumor differentiation in GC patients mechanism - - -
CHFR protein-coding 20300977 RT-PCR; IHC tissue China 123 - - - No Reports The expression of the protein and mRNA decreased remarkably in the patients with aberrant promoter methylation of CHFR genes. mechanism - - -
CHFR protein-coding 20300977 IHC tissue China 123 - - - No Reports The protein expression of CHFR were significantly correlated with tumor differentiation. mechanism - - -
CIAPIN1 protein-coding 19471113 IHC tissue China 147 147 Down - No Reports The expression of CIAPIN1 in gastric antral mucosa was progressively reduced along the sequence of normal/inflammatory gastric mucosa-atrophy-intestinal metaplasia-dysplasia-adenocarcinoma. The downregulation of CIAPIN1 in cancerous tissues was further confirmed by western blotting. No relationship between the expression level of CIAPIN1 and the clinicopathological parameters such as age, gender, differentiation, TNM stage and the existence of metastasis was found in gastric cancer patients. mechanism - - -
CKS2 protein-coding 21617860 qRT-PCR tissue Japan 109 109 Up - No Reports The expression of CKS2 in gastric cancer is elevated relative to levels in normal tissue, and that CKS2 mRNA overexpression is associated with tumor differentiation, lymph node metastasis, distant metastasis, peritoneal dissemination and poor prognosis. In particular, CKS2 mRNA overexpression is associated with prognosis, as shown by multivariate analyses. prognosis - - -
CKS2 protein-coding 21617860 IHC tissue Japan 109 109 Up - No Reports Staining of CKS2 was markedly stronger in the human gastric cancer tissues than in the corresponding normal tissues. The expression of CKS2 was localized to the cell nucleus. prognosis - - -
CLCN3 protein-coding 30217218 IHC tissue China 90 90 Up - No Reports CLC-3 was overexpressed in human GC tissues and that overexpression of CLC-3 was a poor prognostic biomarker for GC patients (P = 0.012). Higher expression of CLC-3 was correlated with deeper tumor invasion (P = 0.006) and increased lymph node metastasis (P = 0.016) target/prognosis 0.012 - -
CLDN18 protein-coding 24647998 Western blot tissue China 45 45 Down Down No Reports Claudin-18 was downregulated in tumor tissues with larger tumor size, intestinal histologic type, deeper local invasion and more advanced TNM stage. target - - -
CMTM3 protein-coding 24131472 qRT-PCR; Western blot tissue China 6 6 Down - No Reports CMTM3 expression was dramatically downregulated in primary gastric cancer tissues. prognosis 0.041 - -
CMTM3 protein-coding 24131472 IHC tissue China 350 222 Down - No Reports The expression of CMTM3 was remarkably weaker in gastric cancer tissues than in normal mucosae (P = 0.008), and was significantly correlated with gender (P = 0.033), tumor depth (P = 0.049), stage (P = 0.021), and histological grade (P = 0.022). CMTM3 expression was associated with prognosis in gastric cancer patients (P = 0.041), and was a significant independent prognostic indicator. prognosis 0.041 - -
COL10A1 protein-coding 30154451 qRT-PCR; Western blot tissue China 30 30 Up - No Reports COL10A1 was up-regulated in GC. We observed a positive correlation between the expression patterns of SOX9 and COL10A1 in GC cells and tissues. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 qRT-PCR tissue China 103 - - - No Reports The mRNA expression level of COL10A1 was significantly associated with tumor size, lymphatic emboli, lymph node metastasis, serosal invasion, AJCC stage, and recur_x005frence risk. prognosis 0.003/0.000 - -
COL10A1 protein-coding 30154451 IHC tissue China 99 99 Up - No Reports The protein expression level of COL10A1 was significantly upregulated in GC tissues and showed high concordance. The protein expression levels of COL10A1 and SOX9 were significantly correlated with tumor size, tumor differentiation, lymph node metastasis, and serosal invasion. The protein expression level of COL10A1 was associated with AJCC stage. COL10A1 was associated with a poor prognosis in GC patients. prognosis 0.003/0.000 - -
COP1 protein-coding 23091414 qRT-PCR tissue China 40 40 Up - No Reports The COP1 expression level was significantly higher in the 25 (62.5%) tumor-bearing tissues, com_x005fpared with the adjacent non-tumor tissues prognosis < 0.001 - -
COP1 protein-coding 23091414 Western blot tissue China 22 22 Up - No Reports High COP1 protein expression in most tumor-bearing tissues compared with the matched adjacent non-tumor tissues. The correlated protein expression analysis revealed a negative correlation between COP1 and p53 in gastric cancer samples. prognosis < 0.001 - -
COP1 protein-coding 23091414 IHC tissue China 401 - - - No Reports High COP1 expression was significantly correlated with T stage (P=0.030), M stage (P=0.048) and TNM stage (P=0.022). High expression of COP1 was significantly correlated with poor survival in gastric cancer patients (P<0.001). Cox regression analyses showed that COP1 expression was an independent predictor of overall survival. prognosis < 0.001 - -
COPS7A protein-coding 31409899 qRT-PCR tissue China 84 29 Down - No Reports A significant decreased expression of COPS7A at mRNA levels in GC tissues compared with the non_x005ftumorous gastric tissues target - - -
COPS7A protein-coding 31409899 IHC tissue China 84 29 Down - No Reports A significant decreased expression of COPS7A at protein levels in GC tissues compared with the non_x005ftumorous gastric tissues. Lower COPS7A expression was found to be associated with larger tumor size and positive lymph node metastasis. target - - -
CORO1C protein-coding 22974233 IHC tissue China 152 - - - No Reports The expression of coronin 3 was higher in the highly metastatic sub-cell line MKN28-M, which we established in our laboratory. We also demonstrated that the expression of coronin 3 was remarkably higher in lymph lode metastases than in primary gastric cancer tissues, and over-expression of coronin 3 was correlated with the increased clinical stage and lymph lode metastasis. mechanism - - -
CPXM2 protein-coding 31364750 qRT-PCR; Western blot tissue China 15 15 Up - No Reports CPXM2 mRNA and protein were elevated in the GC cases compared with the non-tumors. prognosis 0.007 - -
CPXM2 protein-coding 31364750 IHC tissue China 90 90 Up - No Reports CPXM2 was expressed mainly in the cytoplasm and on the cytosolic side of the membrane, while its expression was stronger in GCs than in non tumors. High CPXM2 expression was significantly associated with larger tumor size and later pTNM stages.High CPXM2 expression had shorter overall survival (OS) times than did those with low expression. prognosis 0.007 - -
CRNDE lncRNA 28490034 qRT-PCR tissue China 20 20 Up - No Reports CRNDE was highly expressed in GC cell lines and tissues; target - - -
CRNDE lncRNA 29243780 qRT-PCR tissue China 118 118 Up - No Reports Expression of CRNDE was higher in GC tissues and cells compared with the normal gastric tissue and normal gastric cell lines. High expression of CRNDE was correlated with invasion depth, TNM stage and lymph node metastasis. Furthermore, high CRNDE expression was associated with shorter overall survival of GC patients. Multivariate analysis confirmed that high CRNDE expression was a significant independent predictor of poor survival in GC. prognosis 0.0066 - -
CTHRC1 protein-coding 25510669 qRT-PCR tissue China 47 47 Down - No Reports Cthrc1 is upegulated in GC and inversely correlated with let-7b expression. mechanism - - -
DDX5 protein-coding 30029874 qRT-PCR tissue China 42 42 Up - No Reports DDX5 expression in gastric cancer is significantly higher in corresponding non-cancerous gastric tissues, and the expression of miR-5590-3p and DDX5 was significantly negatively correlated in gastric cancer mechanism - - -
DICER1 protein-coding 23519840 IHC tissue China 80 40 Up - No Reports Dicer 1 protein expression was found to be significantly reduced; Dicer 1 protein positively correlated with let-7a miRNA level, but negatively correlated with CCR7 protein level in gastric adenocarcinoma; Negative Dicer 1 protein expression significantly correlated with lymph node metastasis, depth of invasion, high clinical TNM stage, and larger tumor size. low expression of Dicer 1 protein is significantly associated with the metastasis and progression of gastric cancer. - - - -
DNMT3A protein-coding 26350239 Western blot tissue China 35 35 Up - No Reports The average expression level of DNMT3A in the tumor tissues was signif_x005ficantly higher than that in the paired adjacent non-tumor tissues. DNMT3A overexpression was strongly correlated with tumor cell differentiation. target - - -
EGFR protein-coding 30530570 IHC tissue China 40 40 - - No Reports EGFR and CDK6 are up-regulated in GC and negatively correlated with miR-1296-5p mechanism - - -
EPHA8 protein-coding 31026069 IHC tissue China 206 92 Up - No Reports Upregulated in GC tissues compared with nontumor tissues; EphA8 expression was also strongly associated with differentiation level, tumor-node-metastasis stage, and poor 5 years survival. A panel of GC cell lines showed reduced proliferation, invasion, and migration capacities after RNA-mediated knockdown of EphA8, concomitant with downregulation of the proliferation-related proteins (cyclin A, cyclin D1, and cyclin-dependent kinase 4) and the metastasis-related (matrix metalloproteinases MMP2, and MMP9). EphA8 knockdown also decreased expression of the protease ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) and ADAM10-related protein AKT, suggesting an interaction between EphA8 and ADAM10. prognosis < 0.001 - -
ERBB4 protein-coding 29620274 Western blot tissue China 27 27 Up - No Reports ERBB4 was highly expressed in gastric cancer tissues when compared to the normal stomach samples. target - - -
ETS1 protein-coding 23383271 qRT-PCR tissue China 86 86 Up - No Reports Ets1 was found to be up-regulated and inversely correlated with the expression of miR-9 in gastric cancer tissues and cell lines. mechanism - - -
EZH2 protein-coding 30952377 IHC tissue China 89 89 Up - No Reports EZH2 levels were increased in gastric cancer tissues compared with adjacent normal tissues. Moreover, patients with high levels of EZH2 expression had a relatively poor prognosis. Furthermore, and vivo. Finally, we found that EZH2 influences gastric cancer cells proliferation partly through regulating p21 expression prognosis 0.001 - -
FADD protein-coding 28848149 qRT-PCR tissue China 34 34 Down - No Reports By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. target - - -
FLJ22763 lncRNA 30716442 qRT-PCR tissue China 5 5 Down - No Reports FLJ22763, a novel lncRNA, had significantly lower expression in GC tissues. target/prognosis 0.003 - -
FLJ22763 lncRNA 30716442 qRT-PCR tissue China 303 - - Down No Reports Decreased expression of FLJ22763 was positively correlated with a lower-level histological grade and the depth of invasion. Patients with high FLJ22763 expression levels had a higher five-year survival rate. target/prognosis 0.003 - -
FOXM1 protein-coding 27086911 qRT-PCR tissue China 14 14 Up - No Reports miR-320a expression correlates inversely with expression of FoxM1, a key cell cycle regulator involved in gastric carcinoma. FOXM1 expression was increased in GC tissues. mechanism - - -
FZD7 protein-coding 29559846 IHC tissue China 251 60 Up - Not Related FZD7 was overexpressed in clinical GC samples, and thus was correlated with tumor invasion, lymphatic and organ metastasis, late TNM stages and poor patient survival. Furthermore, RNA interference-mediated . Moreover, ablation of FZD7 down-regulated EMT and the expression levels of cancer stem cell markers, and these inhibitions were associated with attenuated canonical Wnt/β-catenin signaling target/prognosis < 0.001 < 0.001 -
GAS5 lncRNA 25959498 qRT-PCR tissue China 55 55 Down - No Reports lncRNA GAS5 had lower expression in stomach cancer tissues than the normal counterparts. p21 expression correlates with lncRNA GAS5 expression in stomach cancer tissues. target - - -
GNAQ protein-coding 28350126 IHC tissue China 280 280 Up No No Reports GNAQ was highly expressed in GC patient samples and GNAQ expression was related to patient age, GC differentiation status and adjuvant therapy, as determined by immunohistochemical assay. Mechanistic analysis revealed that knockdown of GNAQ significantly increased the expression of p53 and p21, and decreased cyclin A and p-CDK2 protein expression. Moreover, the phosphorylation of ERK and MEK was also decreased after knockdown of GNAQ as determined by western blotting assay target - - -
H19 lncRNA 28848149 qRT-PCR tissue China 34 34 Up - No Reports H19 was increased in gastric cancer cell lines and tissues. Overexpression of H19 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 inhibited these effects. By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. mechanism - - -
HOTAIR lncRNA 30810117 ISH tissue China 30 30 Up - No Reports HOTAIR expression of cancer tissues was significantly increased compared with that of non_x005ftumor tissues; lncRNA HOTAIR was negatively correlated with miR-454-3p expression in gastric cancer tissues. mechanism - - -
HOXA1 protein-coding 26791264 qRT-PCR tissue China 48 48 Up - No Reports HOXA1 mRNA expression were upregulated in GC tissues. Survival analysis indicated that HOXA1 expression were significantly associated with disease-free survival (DFS) and overall survival (OS). Patients with tumors that were positive for HOXA1 expression showed worse prognosis. Multivariate analysis confirmed that the combination of HOXA1 and cyclin D1 was an independent prognostic indicator for OS and DFS. prognosis < 0.001 < 0.001 -
HOXA1 protein-coding 26791264 IHC tissue China 264 264 Up - No Reports There was a correlation between HOXA1 and cyclin D1 in GC; prognosis < 0.001 < 0.001 -
hsa_circ_0000199 circRNA 30927924 qRT-PCR tissue China 149 0 - - No Reports The expression of circAKT3 was higher in CDDP-resistant GC tissues and cells than in CDDP-sensitive samples. It was an independent risk factor for disease-free survival. target/prognosis - 0.0293 0.91
hsa_circ_0004771 circRNA 30717751 qRT-PCR tissue China 80 80 Up - No Reports Upregulated in GC tissues and GC cells. prognosis 0.0019 0.004 -
hsa_circ_0092303 circRNA 31182928 qRT-PCR tissue China 30 30 Up - No Reports CircCACTIN expression was obviously up-regulated in GC tissues and cell lines. target - - -
ITGA3 protein-coding 23533596 IHC tissue China 76 - - - No Reports The membranes of tumor cells stained positive for integrin a3. In all the tissues analyzed, high levels of integrin a3 expression were detected in 27 HGC tissue samples (35.52%).Patients with high integrin a3 expression were more likely to exhibit aggressive features. Patients with high Integrin a3 showed larger tumors (p =3.46E24), greater depth of invasion (p =0.001), higher tumor stage (p = 0.005), and more lymph node involvement (p = 0.040) than patients with low integrin a3 expression. Overexpression of Integrin a3 is Independent Factors Predicting the Prognosis of HGC Patients. target/prognosis < 0.0001 - -
JAZF1 protein-coding 31357957 qRT-PCR tissue China 120 120 Up - No Reports JAZF1 expression was increased in GC tissues and was positively associated with lymph node metastasis and Borrmann type. Better OS in GC patients with lower JAZF1 expression than in patients with higher JAZF1 expression. prognosis <0.001 - -
KDM4B protein-coding 24077348 IHC tissue China 101 - - - No Reports JMJD2B expression was positively correlated with tumor size, differen_x005ftiation status, invasion, lymph node status, distant metastasis, and TNM stage of patients with gastric cancer target - - -
KRT19P3 lncRNA 31409899 qRT-PCR tissue China 84 29 Down - No Reports KRT19P3 expression was significantly decreased in gastric cancer tissues. Lower expression of KRT19P3 was found to be associated with lager tumor size (≥ 5 cm), advanced TNM stage, Lauren's classification, and positive LNM. Patients with lower KRT19P3 expression had worse overall survival (OS) and disease-free sur_x005fvival (DFS) compared with those patients with higher KRT19P3 expression Univariate analysis demonstrated that patients with lower KRT19P3 expression tended to have a higher risk of death. target/prognosis 0.0016 0.0028 -
LINC01089 lncRNA 29717028 qRT-PCR tissue China 32 32 Up - No Reports lncRNA AK096174 was up-regulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in GC. Our data showed that AK096174 was highly expressed in the GC tissues and cell lines (SGC-7901, AGS, BGC-823, MGC-803), and patients with higher AK096174 expression had a poorer prognosis and shorter overall survival (OS). AK096174 knockdown inhibited the proliferation, migration, and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. Furthermore, mechanistic investigation showed that AK096174 positively correlated with the expression of WD repeat-containing protein 66 (WDR66) gene at the translational level. Knockdown of WRD66 attenuated the positive impact of AK096174 in GC cells target - - -
LINC01234 lncRNA 29386218 qRT-PCR tissue China 50 50 Up - No Reports LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage, lymph node metastasis, and shorter survival time. prognosis <0.001 <0.001 -
LINC02859 lncRNA 31207155 qRT-PCR tissue China 90 90 Down - No Reports LOC101928316 was significantly downregulated in gastric cancer (GC) tissues specimen, GC cell lines, and associated with the GC patients tumor, node, and metastasis (TNM) stage and degree of differentiation. target - - -
MAPK1 protein-coding 32293550 qRT-PCR; Western blot tissue China 30 30 Up - No Reports The mRNA level and protein level of MAPK1 were increased in gastric cancer tissues and cells. There was a positive correlation between levels of MAPK1 and LINC00483 in gastric cancer tissues. mechanism - - -
MIR103A1 miRNA 29754469 qRT-PCR tissue China 33 33 - No Reports miR-103a-3p expression was regulated in GC tissues when compared with non-tissue samples, and was also upregulated in 18 poorly differentiated tumor tissues or in 24 tumor stage III/IV samples. target - - -
MIR106B miRNA 30907988 qRT-PCR; FISH tissue China 10 - - - No Reports miR-106b was increased in the metastasis tissues compared with non-metastasis tissues. mechanism - - -
MIR107 miRNA 26406411 qRT-PCR tissue Iran 36 36 Up - Quantitative RT-PCR analysis on total RNA demonstrated significant overexpression of miR-107 in 36 GC tumor samples, in comparison to the its adjacent normal tissue of the same patients (p = 0.04) target - - -
MIR126 miRNA 25027343 qRT-PCR tissue China 15 15 Down - No Reports MiR-126 expression was frequently and markedly downregulated (p < 0.05) in human gastric cancer tissues. Moreover, overexpression of miR-126 significantly decreased (p < 0.05) the protein levels of Crk, which has previously been identified as a direct target of miR-126. Knockdown of Crk also markedly suppressed GC cells invasion. target - - -
MIR126 miRNA 25027343 qRT-PCR tissue China 110 - - - No Reports Low expression of miR-126 was significantly associated with lymph-node metastasis and poor histological grade. target - - -
MIR1275 miRNA 31357957 qRT-PCR tissue China 120 120 Down - Not Related The expression of miR-1275 was reduced in GC tissues. We validated in 120 GC patients specimens that low miR-1275 expression levels were closely associated with lymph node metastasis, Borrmann type and poor prognosis. prognosis < 0.001 - -
MIR129-1 miRNA 29879625 qRT-PCR tissue China 50 50 Up - No Reports miR-129-5p expression in GC tissues was significantly down regulated than that in adjacent normal tissues; patients with large tumor size and lymph node metastasis significantly associated with lower miR-129-5p expression in GC patients. Patients who had lower miR-129-5p expression predicted poor overall survival time in GC patients. prognosis < 0.05 - -
MIR1296 miRNA 30530570 qRT-PCR tissue China 40 40 - - No Reports miR-1296-5p was down-regulated in gastric cancer tissue and cell lines, and low expression levels of miR-1296-5p were associated with advanced clinical stage. mechanism - - -
MIR1303 miRNA 24647998 qRT-PCR tissue China 45 45 Up Up No Reports miR-1303 was significantly overexpressed whereas claudin-18 was downregulated in GC tissues and cell lines, which was significantly associated with tumor size, location invasion, histologic type and tumor-node-metastasis stage. target - - -
MIR133A1 miRNA 25152372 qRT-PCR tissue China 180 180 Down Down No Reports The expression of miR-133 was significantly down-regulated in gastric cancer tissues compared with that in matched normal tissues. Expression of miR-133 is lower in patients above 65 years old than that of below 65 years old. There was a higher level of miR-133 in smaller size tumor. The expression level of miR-133 was lower in T3 and T4 groups than that in T1 and T2 groups. Decreased miR-133 expression was associated with peripheral organ injury and pathologic stages. The survival rate of high-expression group was significantly higher than that the low_x005fexpression group. prognosis 0.003 - -
MIR137 miRNA 26102366 qRT-PCR tissue China 100 100 Down Down No Reports Expression of miR-137 in GC tissues was lower than that in adjacent tissues in statistically significant differences. The patients who have the lower levels of miR-137 expression were associated with high-grade and late-stage tumors. mechanism - - -
MIR142 miRNA 30178386 qRT-PCR tissue China 101 101 Down - No Reports MiR-142-5p downregulation was significantly associated with the recurrence (P = 0.031) and poor prognosis of GC (P = 0.043). CYR61 was identified as a novel direct target of miR-142-5p by bioinformatics analysis of target prediction and luciferase reporter. The re-expression and knockdown of CYR61 could, respectively, rescue the effects induced by miR-142-5p overexpression and knockdown. MiR-142-5p attenuated GC cell migration and invasion, at least partially, by inactivation of the canonical Wnt/β-catenin signaling pathway through CYR61. target/prognosis 0.001 - -
MIR143 miRNA 28404925 microarray chip; qRT-PCR tissue China 42 42 Down Down Related miR-143-3p was ignificantly increased miRNA in H. pylori-positive gastric cancer tissues and was significantly decreased in gastric cancer tissues and cells, which correlated with late stage and lymph node metastasis. target - - -
MIR145 miRNA 28490034 qRT-PCR tissue China 20 20 Up - No Reports miR-145 expression was significantly decreased in GC tissues compared with that in adjacent normal tissue samples, and miR-145 level had a significant negative correlation with CRNDE level. mechanism - - -
MIR148A miRNA 27518872 qRT-PCR tissue China 41 41 Down - No Reports miR-148a expression was significantly down-regulated in gastric cancer tissues in comparison with the matched normal mucosal tissues, and its expression was statistically associated with lymph node metastasis. target - - -
MIR152 miRNA 28427226 qRT-PCR tissue China 42 42 Down - No Reports The expression of miR-152 in human gastric cancer tissues were significantly lower than that in matched adjacent normal tissues. Meanwhile, lower miR-152 was also found in gastric cancer cell lines. The stage, tumor size and lymph node metastasis rate were significant higher in low-miR-152 group in clinical patients. target - - -
MIR155 miRNA 26955820 qRT-PCR tissue China 60 60 Down Down No Reports miR-155 levels were significantly lower in both GC tissues and GC cell lines than in their normal controls, and its expression inversely correlated with tumor size and the pathologic stage. target - - -
MIR15A miRNA 26894855 qRT-PCR tissue China 21 21 - - No Reports The expression of miR-15a is significantly reduced in gastric cancer and the protein expression levels of Bmi-1 are inversely correlated with miR-15a (P = 0.034) in gastric cancer patient samples. mechanism - - -
MIR15A miRNA 26894855 qRT-PCR; IHC tissue China 21 - - - No Reports The expression of Bmi-1 is inversely correlated with miR-15a in gastric tumor tissues mechanism - - -
MIR181A1 miRNA 24531888 qRT-PCR tissue China 9 9 - - No Reports Compared with three non-tumour tissues, the expression of miR-181a in three gastric cancer cells was significantly increased; miR-181a expression was inversely correlated with ATM. mechanism - - -
MIR187 miRNA 27864146 qRT-PCR tissue China 54 54 Up - No Reports miR-187 was significantly overexpressed in GC tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis (P = 0.048), and TNM stage (P = 0.035). target - - -
MIR191 miRNA 24603541 qRT-PCR tissue China 75 75 Up Up The miR-191 Cluster Is Highly Expressed in Gastric Cancer (GC) target - - -
MIR1915 miRNA 31036603 qRT-PCR tissue China 60 60 Down - No Reports miR-1915-3p exhibited low expression level in differentiated gastric cancer cell lines and gastric cancer tissues. The expressions of miR-1915-3p were significantly correlated to the lymph node metastasis and overall survival of patients with gastric cancer. Further study showed that there was a negative correlation between miR-1915-3p and Bcl-2 (B cell lymphoma/leukemia-2) expression. prognosis 0.01 - -
MIR193B miRNA 27071318 qRT-PCR tissue China 50 50 Down - No Reports miR-193b was significantly reduced in GC tissues compared with the adjacent normal gastric tissues. Moreover, lower-level of miR-193b was also associated with a more aggressive GC phenotype. mechanism - - -
MIR194-1 miRNA 27810403 qRT-PCR tissue China 43 43 Up - No Reports MiRNA-194 was found to be overexpressed in GC cell lines and 43 paired GC tissues. target - - -
MIR199A1 miRNA 30193607 qRT-PCR tissue China 51 51 Down - No Reports The relative expression of miR-199 in gastric carcinoma tissues was significantly lower than that in the adjacent normal tissue . target - - -
MIR19A miRNA 25914465 qRT-PCR tissue China 50 50 Up Up No Reports miR­19a is increased in GC tissue samples and cell lines. Overexpression of miR-19a was significantly associated with metastasis of GC. target - - -
MIR203A miRNA 30837034 qRT-PCR tissue China 10 10 Down - No Reports miR-203 is downregulated in GC tissues and cell lines. Moreover, the low level of miR-203 was associated with increased expression of annexin A4 in GC tissues and cell lines. target - - -
MIR203A miRNA 25373785 qRT-PCR tissue China 50 50 Down - Related miR-203 is significantly down-regulated in H. pylori positive tissues and cells and in tumor tissues with important functional consequences. mechanism - - -
MIR204 miRNA 29386218 CDX tissue 50gc, 50 non-gc - - Not Related LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage, lymph node metastasis, and shorter survival time. Furthermore, knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts. mechanism - - -
MIR204 miRNA 23152059 qRT-PCR tissue Italy 84 84 Down Down No Reports miR-204 is downregulated in gastric tumor samples and advanced stages of GC; miR-204 is a prognostic factor for GCs. prognosis 0.017 - -
MIR208A miRNA 29886152 qRT-PCR tissue China 62 62 Up Up No Reports miR-208a expression was significantly increased in GC tissues compared with adjacent normal tissues. Higher miR-208a expression was association with lymph node metastasis and TNM stage in GC patients. Kaplan-Meier analysis verified that patients with higher miR-208a expression were significantly associated with shorter overall survival (OS) time. miR-208a expression negatively associated with MEG3. target/prognosis < 0.05 - -
MIR208A miRNA 27634902 qRT-PCR tissue China 16 16 Up - No Reports miR-208a-3p was up-regulated in GC tissues target - - -
MIR217 miRNA 30063010 qRT-PCR tissue China 67 67 Up - No Reports The expression of miR-217 was significantly up-regulated in GC tissues. mechanism - - -
MIR27A miRNA 27409164 qRT-PCR tissue China 20 20 Up - No Reports Two isoforms of mature miR-27a, miR-27a-5p and miR-27-3p, were both frequently overexpressed in gastric cancer tissues and cell lines, whereas the expression level of miR-27-3p in gastric cancer was significantly higher than that of miR-27a-5p. target - - -
MIR29A miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR29B1 miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR29C miRNA 25428377 qRT-PCR tissue China 20 20 Down - No Reports Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. target - - -
MIR302B miRNA 28743112 qRT-PCR tissue China 20 20 Down - No Reports MiR-302b-3p expression was decreased in gastric cancer tissues and cell lines. mechanism - - -
MIR320A miRNA 27086911 qRT-PCR tissue China 14 14 Down - No Reports miR-320a expression is decreased in human gastric cancer tissues and correlates inversely with expression of FoxM1, a key cell cycle regulator involved in gastric carcinoma. By contrast, the expression of P27KIP1, a downstream effector of FoxM1, correlates positively with miR-320a levels. mechanism - - -
MIR320A miRNA 29152656 qRT-PCR tissue China 40 40 Down - No Reports Downregulated in GC tumor tissues; miR‑320a is negatively correlated with ADAM10 in tumors target - - -
MIR335 miRNA 21822301 qRT-PCR tissue China 70 70 No Down No Reports Low expression of miR-335 was significantly associated with lymph-node metastasis, poor pT stage, poor pN stage and invasion of lymphatic vessels. Patients with a better pT stage or pN stage had significantly higher miR-335 expression. Patients with a low expression of miR-335 tended to have metastasis invasion into lymphatic vessels. target - - -
MIR338 miRNA 30308487 qRT-PCR tissue China 53 53 Down - No Reports miR-338-3p was down-regulated in both GC tissues (53 paired samples) and cell lines (4 cancer cell lines). The decreased expression of miR-338-3p was found to be significantly associated with the Borrmann stage. target - - -
MIR338 miRNA 26617808 qRT-PCR tissue China 36 36 Down - No Reports Down-regulated in both gastric cancer cell lines and tissues. target - - -
MIR338 miRNA 25945841 qRT-PCR tissue China 20 20 Down Down No Reports miR-338-3p was significantly lower in GC tissues than in the corresponding adjacent noncancerous tissues; mRNA expression of miR-338-3p was even lower in advanced stages of GC compared to that observed in the early stages. target - - -
MIR381 miRNA 28193228 qRT-PCR tissue China 103 103 Down - No Reports MiR-381 was significantly down-regulated in gastric cancer tissues and cell lines. Low expression of miR-381 was negatively related to lymph node metastasis, advanced tumor stage and poor prognosis.miR-381 and TMEM16A revealed the improved prognostic accuracy for gastric cancer patients. target/prognosis 0.024 0.037 -
MIR421 miRNA 25041019 qRT-PCR tissue China 50 50 Up - No Reports miR-421 was over-expressed in gastric cancer tissues and cell lines. Caspase-3 was negatively regulated by miR-421 at the post-transcriptional level. mechanism - - -
MIR448 miRNA 26852749 qRT-PCR tissue China 40 40 Down - No Reports Downregulated in the GC cell and tissue mechanism - - -
MIR454 miRNA 30810117 ISH tissue China 30 30 Down - No Reports miR-454-3p expression of cancer tissues was significantly decreased compared with that of non-tumor tissues. lncRNA HOTAIR was negatively correlated with miR-454-3p expression in gastric cancer tissues. - - - -
MIR490 miRNA 32293550 qRT-PCR tissue China 30 30 Down - No Reports The level of miR-490-3p were decreased in gastric cancer tissues and negative correlated with the level of LINC00483 and MAPK1. Knockdown of LINC00483 or MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. Besides, inhibition of LINC00483 decreased xenograft tumor growth by regulating miR-490-3p/MAPK1 axis. mechanism - - -
MIR519D miRNA 29510377 qRT-PCR tissue China 20 20 Down No Reports miR-519d-3p was downregulated in GC tumor tissues,associated with the clinical stage and lymph node metastasis of GC tissues. Decreased miR-519d-3p expression was associated with advanced stage and lymph node metastasis of GC compared with controls. target - - -
MIR519D miRNA 29510377 qRT-PCR tissue China 20 20 Down No Reports miR-519d-3p was downregulated in GC tumor tissues,associated with the clinical stage and lymph node metastasis of GC tissues. Decreased miR-519d-3p expression was associated with advanced stage and lymph node metastasis of GC compared with controls. target - - -
MIR5590 miRNA 30029874 qRT-PCR tissue China 42 42 Down - No Reports In addition, Ago2-based RIP and dual-luciferase reporter were conducted to study the Next, were used to determine the role of miR-5590-3p in GC tumorigenicity in vivo. whereas . target - - -
MIR582 miRNA 29228422 qRT-PCR tissue China 42 42 No Reports MiR-582-5p was downregulated in gastric cancer tissues when compared with para-carcinoma tissues. target - - -
MIR589 miRNA 30012200 qRT-PCR tissue China 34 34 Up - No Reports MiR-589 expression was significantly higher in tumor tissues and gastric cancer cells than those in matched normal tissues and gastric epithelial cells, respectively. Overexpression of miR-589 is associated with tumor metastasis, invasion and poor prognosis of GC patients. target - - -
MIR613 miRNA 28701053 qRT-PCR tissue China 52 52 Down - No Reports miR-613 was evidently downregulated in gastric cancer tissue and cell. target - - -
MIR615 miRNA 29501762 qRT-PCR tissue China 104 104 Up Up No Reports Aberrant high expression of miR-615-3p and low expression of CELF2 in gastric cancer both in vivo and in vitro. Moreover, miR-615-3p expression correlated to T and M stage. Higher expression of miR-615-3p correlated to shorter period of survival months. prognosis < 0.05 - -
MIR644A miRNA 27983935 qRT-PCR tissue China 107 107 Down Down No Reports The expression of miR-644a was suppressed in GC tissues and was associated with a later clinical stage and tumor metastasis. target - - -
MIR675 miRNA 28848149 qRT-PCR;Western blot tissue China 34 34 Up - No Reports miR-675 were increased in gastric cancer cell lines and tissues. H19 and miR-675 expression was positively correlated in gastric cancer tissues. target - - -
MIR711 miRNA 26735582 qRT-PCR tissue China 28 28 Down - No Reports The expression of miR-711 was lower in the cancer tissues than in the normal tissues. target - - -
MIR874 miRNA 23800944 qRT-PCR tissue China 75 75 Down Down No Reports miR-874 was significantly down-regulated and reversely correlated with AQP3 protein levels in clinical samples. miR-874 expression level was lower in samples with moderately and poorly histological type, lymph node metastasis N1-N3 and stage III–IV. Analysis of the clinicopathological significance showed that miR-874 and AQP3 were closely correlated with GC characteristics. mechanism - - -
MIR9-1 miRNA 21225631 qRT-PCR tissue Japan 27 - - - No Reports Amounts of miR-9 in the CDX2-negative group were significantly higher than those in the CDX2-positive group. mechanism - - -
MIR9-1 miRNA 23383271 qRT-PCR tissue China 86 86 Down - No Reports miR-9 was found to be down-regulated and inversely correlated with the expression of cyclin D1 and v-ets erythroblastosis virus E26 oncogene homolog 1 (Ets1) in gastric cancer tissues and cell lines. The miR-9 expression was significantly lower in gastric cancer cases with deeper gastric wall invasion, lymph node metastasis, distant metastasis, and advanced TNM stage. mechanism - - -
MIR99A miRNA 30156609 qRT-PCR tissue China 20 20 Down - No Reports The miR-99a expression in gastric tumor tissues was significantly lower than that in non-tumorous tissues. mechanism - - -
MIRLET7A1 miRNA 23519840 qRT-PCR tissue China 80 40 Down - No Reports Let-7a miRNA expression was significantly lower in gastric adenocarcinoma tissues than in peritumoral tissues mechanism - - -
MIRLET7B miRNA 25288334 qRT-PCR tissue China 76 76 Down - No Reports let-7b was down-regulated in gastric cancer and its downregulation was associated with poor survival and correlated with lymph node metastasis. AKT2 mRNA expression showed negative correlation with the expression of let-7b in primary tumors. target/prognosis - 0.001 -
MIRLET7B miRNA 25510669 qRT-PCR tissue China 47 47 Down - Related Let-7b was found downregulated remarkably in gastric cancer tissues and was correlated with Helicobacter pylori infection, tumor stage, and lymphatic metastasis. target - - -
MIRLET7G miRNA 25288334 qRT-PCR tissue China 76 76 Down - No Reports let-7g was found down-regulated in gastric cancer and correlated with N-stage and lymph node metastasis. AKT2 mRNA expression showed negative correlation with the expression of let-7g in primary tumors. target - 0.051 -
NMRAL2P pseudogene/lncRNA 32469171 qRT-PCR tissue China 10 10 Down - No Reports NMRAL2P was downregulated in tumor tissues and GC cell lines. mechanism - - -
NOTCH4 protein-coding 25511451 IHC tissue China 75 75 Up - No Reports Notch4 was activated by overexpressing exogenous intracellular domain of Notch4 (ICN4). Activated Notch4 expression levels were up-regulated in GC tissues target - - -
PDCD4 protein-coding 27634902 IHC tissue China 16 16 Down - No Reports PDCD4 protein expression is down-regulated in GC tissues. target - - -
PIK3R1 protein-coding 30927924 qRT-PCR tissue China 44 - - - No Reports PIK3R1 was upregulated in DDP-resistant GC tissues samples when compared with CDDP-senestive groups. target - - -
PKM protein-coding 28588255 IHC tissue China 88 88 Up - No Reports PKM2 protein was predominantly located in the nucleus and cytoplasma, and was observed to have higher IHC scores in gastric cancer samples than in peritumor tissues; PKM2 expression was positively correlated with lymph node metastasis, tumor invasion and TNM staging. target/prognosis 0.006 - -
POU2F1 protein-coding 25678401 IHC tissue China 77 77 Up - No Reports POU2F1 was overexpressed in GC tissues than in normal tissues, and its protein levels had a positive correlation with ACK1protein level. - - - -
RASSF1 protein-coding 26735582 qRT-PCR tissue China 28 28 Down - No Reports The expression of RASSF1A was lower in the cancer tissues than in the normal tissues. target - - -
RB1 protein-coding 15818729 S-P tissue China 122 80 Down - No Reports The positive rates of Rb protein expression respectively were 99% (79/80) in normal gastric mucosa, 80% (40/50) in dysplastic gastric mucosa, 60% (73/122) in GC. The positive rates of Rb protein expression in GC were significantly lower than that in normal gastric mucosa and dysplastic gastric mucosa (P<0.05). The positive rate of both P16 and Rb proteins was 16% (14/90), and the negative rate of both P16 and Rb proteins was 8% (7/90) in 90 GCs. The rate of positive P16 protein with negative Rb protein was 33% (30/90). The rate of negative P16 protein with positive Rb protein was 43% (39/90). There was reverse correlation between P16 and Rb expression in 90 GCs. - - - -
RB1 protein-coding 14691913 IHC tissue U.K. 67 67 - - No Reports pRb expression was lower in lymph node metastases than in the corresponding primary tumors; low pRb expression may be a powerful independent negative prognostic factor. prognosis 0.0027 - -
RUNX3 protein-coding 20300977 MS-PCR; BGS tissue China 123 123 Up(Methylation) - No Reports The methylation frequencies of Runx3 in cancer tissues were significantly higher than those in corresponding normal gastric mucosae. The methylation status of Runx3 was inversely related to the tumor size. - - - -
RUNX3 protein-coding 20300977 RT-PCR; IHC tissue China 123 - - - No Reports The expression of the protein and mRNA decreased remarkably in the patients with aberrant promoter methylation of Runx3 genes. - - - -
RUNX3 protein-coding 20300977 IHC tissue China 123 - - - No Reports The protein expression of Runx3 were significantly correlated with tumor invasion depth. - - - -
SKP2 protein-coding 27572672 Western blot tissue China 47 19 Up - No Reports The expression levels of Skp2 in the gastric cancer tissues were significantly increased, compared with those in the normal gastric tissues target - - -
SNHG7 lncRNA 29131253 qRT-PCR tissue China 68 68 Up - No Reports The qRT-PCR experiment showed that in a total of 68 cases of cancer tissues and tumor-adjacent tissues, the relative expression of SNHG7 was upregulated in 48 cases of gastric cancer tissues and 5 gastric cancer cell lines. target - - -
SNORD105B snoRNA 29554660 qRT-PCR tissue China 109 109 Up - No Reports The snord105b was upregulated in GC tissues and associated with tumor size, differentiation, and pathological stage in GC. target - - -
SOX9 protein-coding 30154451 qRT-PCR; Western blot tissue China 30 30 Up - No Reports SOX9 was up-regulated in GC. We observed a positive correlation between the expression patterns of SOX9 and COL10A1 in GC cells and tissues. prognosis 0 - -
SOX9 protein-coding 30154451 qRT-PCR tissue China 103 - - - No Reports The mRNA expression level of SOX9 was significantly associated with tumor size, lymphatic emboli, lymph node metastasis, serosal invasion, AJCC stage, and recur_x005frence risk. prognosis 0 - -
SOX9 protein-coding 30154451 IHC tissue China 99 99 Up - No Reports The protein expression level of SOX9 was significantly upregulated in GC tissues and showed high concordance. The protein expression levels of COL10A1 and SOX9 were significantly correlated with tumor size, tumor differentiation, lymph node metastasis, and serosal invasion. The protein expression level of COL10A1 was associated with AJCC stage. COL10A1 was associated with a poor prognosis in GC patients. prognosis 0 - -
STAT3 protein-coding 30810117 IHC tissue China 30 30 Up - No Reports STAT3 protein expressions were significantly upregulated in cancer tissues.lncRNA HOTAIR was positively correlated with STAT3 and Cyclin D1 protein expressions in gastric cancer tissues. mechanism - - -
SUFU protein-coding 27810403 IHC tissue China 75 75 Down - No Reports SUFU was significantly down expressed in GCs compared to NSs. The expression level of SUFU was negatively associated with tumor stage. target - - -
SUFU protein-coding 27810403 qRT-PCR tissue China 20 20 Down - No Reports SUFU mRNA was significantly down expressed in GCs; a negative relationship between miRNA-194 and SUFU expression levels target - - -
TET2 protein-coding 31242038 qRT-PCR tissue China 192 - - - No Reports Patients with high TET2 expression had significantly longer survival time. prognosis < 0.01 - -
TGFBR1 protein-coding 31182928 qRT-PCR tissue China 30 30 Up - No Reports TGFBR1 was significantly overexpressed in GC tissues.TGFBR1 expression was positively related to circCACTIN in si-circCACTIN group BGC-823 cells and LV-circCACTIN group MGC-803 cells. mechanism - - -
TMEM41A protein-coding 30015937 qRT-PCR tissue China 147 147 Up Up No Reports TMEM41A was highly expressed in GC tissues, its expression of TMEM41A was observed to be correlated with lymph node metastasis, distant metastasis and advanced tumor, node and metastasis stages.Patients with GC and high expression levels of TMEM41A exhibited a poorer disease‑free survival following radical tumor resection. target - - -
TNK2 protein-coding 25678401 Western blot tissue China 6 6 Up - No Reports ACK1 protein level and ACK1 phosphorylation at Tyr 284 were frequently elevated in GC tissues. target/prognosis < 0.001 - -
TNK2 protein-coding 25678401 IHC tissue China 77 77 Up - No Reports ACK1 overexpression in GC correlates with poor prognosis; positively associated with lymph node metastasis and a more advanced clinical stage in GC target/prognosis < 0.001 - -
UCA1 lncRNA 28569779 qRT-PCR tissue China 39 39 Up - No Reports UCA1 expressed highly in GC tissues and GC cells, overexpression of UCA1 indicated higher tumor stage and lymph node metastasis in GC patients. target - - -
VEGFC protein-coding 24337012 IHC; TMA tissue China 195 - - - No Reports The expression levels of VEGF-C was significantly higher in patients with lymph node metastasis than in those without metastasis. Patients with high expression levels of VEGF-C showed significantly less favorable survival rates compared with patients with low expression levels of it. prognosis 0.039 - -
XRCC5 protein-coding 30217218 IHC tissue China 90 90 Up - No Reports XRCC5 was localized to the nucleus, and its expression was higher in GC tissues than that in normal tissues. The expression of CLC-3 and XRCC5 was positively correlated. High expression of XRCC5 predicted a poor prognosis for GC patients. prognosis < 0.01 - -
ZNF143 protein-coding 27449034 qRT-PCR tissue China 53 53 Up - No Reports ZNF143 level is upregulated in gastric cancer and highly correlated with the presence of lymph node metastasis. target - - -
ZNF143 protein-coding 27449034 IHC tissue China 12 12 Up - No Reports Protein level of ZNF143 is higher in GC tssues and staining in the nucleus of GC cells target - - -
  Summary of Gene Type.
Gene Type Count
circRNA 16
lncRNA 79
miRNA 240
protein-coding 361
pseudogene 3
snoRNA 5
  Summary of Functional Type.
Functional Type Count
diagnosis 5
prognosis 211
mechanism 143
target 360
target,diagnosis 1
target;prognosis 1
  Summary of Interaction.
Gene Interaction Gene PMID
ACOT7 NMRAL2P 32469171
ADAM10 miR-448 26852749
ADAM10 miR-320a 29152656
ADAM9 miR-126 28260063
ADAM9 miR-129-5p 29879625
AGAP2-AS1 CDKN1A; EZH2; LSD1; SP1; 28209205
AKT2 miR-143-3p 28404925
AKT2 miR-29a; miR-29b; miR-29c; 25428377
AKT3 miR-582-5p 29228422
ANKRD40CL miR-490-3p 32293550
ANXA4 miR-203 30837034
ASCL2 miR-223 30106147
ATF7 miR-103a-3p 29754469
BMI1 miR-15a 26894855
BRD4 CDKN1A 29434197
BTG2 miR-27a-3p 27409164
C8orf76 DUSP5P1 30733230
CBFB miR-204-5p 29386218
CCN1 miR-142-5p 30178386
CCND1 miR-9 23383271
CCND1 miR-155 26955820
CCND1 miR-193a-3p 29848678
CD151 ITGA3 23533596
CDC42 CDC42 25152372
CDH1 CDH1 30063010
CDK6 miR-1296-5p 30530570
CDK9 miR-613 28701053
CDKN1A BRD4 29434197
CLCN3 XRCC5 30217218
CLDN18 miR-1303 24647998
COL10A1 SOX9 30154451
COPS7A KRT19P3 31409899
CRMP1 miR-187 27864146
CRNDE MIR145 28490034
CTBP1 miR-644a 27983935
CTHRC1 let-7b 25510669
DDX5 miR-5590-3p 30029874
DNMT3A CDKN2C 26350239
DUSP5P1 C8orf76 30733230
EPHA8 ADAM10 31026069
FADD miR-675 28848149
GAS5 YBX1 25959498
hsa_circ_0000199 miR-198 30927924
hsa_circ_0000993 miR-214-5p 30215537
hsa_circ_0004771 miR-149-5p 30717751
hsa_circ_0092303 miR-331-3p 31182928
ITGA3 CD151 23533596
JAZF1 miR-1275 31357957
KDM4B CTNNB1 24077348
KRT19P3 COPS7A 31409899
LINC01234 Ago2; miR-204-5p; 29386218
MIR103A1 ATF7 29754469
MIR106B ARMCX1 30907988
MIR126 ADAM9 28260063
MIR1275 JAZF1 31357957
MIR1296 CDK6; EGFR; 30530570
MIR1303 CLDN18 24647998
MIR135B PCAT18; CLDN11; 32119960
MIR137 AKT2 26102366
MIR142 CYR61 30178386
MIR145 E2F3 28490034
MIR148A CCKBR 27518872
MIR152 CD274 28427226
MIR155 CCND1 26955820
MIR15A BMI1 26894855
MIR181A1 ATM 24531888
MIR187 CRMP1 27864146
MIR1915 BCL2 31036603
MIR193A ETS1; CCND1; 29848678
MIR194-1 SUFU 27810403
MIR198 hsa_circ_0000199; PIK3R1; 30927924
MIR199A1 TBL1XR1 30193607
MIR203A CASK 25373785
MIR203A ANXA4 30837034
MIR204 CBFB 29386218
MIR208A PDCD4 27634902
MIR208A SFRP1; MEG3; 29886152
MIR27A BTG2 27409164
MIR302B IGF-1R 28743112
MIR320A FOXM1; CDKN1B; 27086911
MIR331 circCACTIN; TGFBR1; 31182928
MIR335 Bcl-w; SP1; 21822301
MIR338 ZEB2 25945841
MIR338 ADAM17 26617808
MIR338 Rab14; Hhat; 30308487
MIR381 TMEM16A 28193228
MIR421 CASP3 25041019
MIR454 STAT3 30810117
MIR490 LINC00483; MAPK1; 32293550
MIR519D BCL6 29510377
MIR5590 DDX5 30029874
MIR582 AKT3 29228422
MIR589 LIFR; c-Jun; 30012200
MIR613 CDK9 28701053
MIR644A CTBP1 27983935
MIR675 H19 28848149
MIR874 AQP3 23800944
MIR9-1 CDX2 21225631
MIR9-1 CDX3 21225631
MIR9-1 CDX4 21225631
MIR9-1 CCND1; ETS1; 23383271
MIRLET7B AURKB 30237418
MIRLET7B CTHRC1 25510669
NMRAL2P ACOT7 32469171
PCAT18 miR-135b 32119960
PDCD4 miR-208a-3p 27634902
POU2F1 ECD 25678401
SFRP1 miR-208a 29886152
SIRT1 JUN 30250020
SNORD105B ALDOA 29554660
SOX9 COL10A1 30154451
STAT3 miR-454-3p 30810117
SUFU miRNA-194 27810403
XRCC5 CLC-3 30217218
YBX1 lncRNA GAS5 25959498

 Interaction graph The select node information.

  Summary of Hpylori.
Hpylori Type Count
Related 7
Not Related 3
No Reports 683
8
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