Search Result
Gene Summary for ABCB1 Gene
Official Symbol |
ABCB1 |
Gene Type |
protein-coding |
Full Name |
ATP binding cassette subfamily B member 1 |
Entrez |
5243
|
Ensembl ID |
ENSG00000085563 |
HGNC |
40
|
Aliases |
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
|
Chromosome Location |
Chromosome 7, NC_000007.14 (87503017..87713295, complement)
|
Expression |
Biased expression in adrenal (RPKM 76.0), small intestine (RPKM 43.0) and 8 other tissues
|
Summary |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
|
Paper for ABCB1 Gene
PMID |
Author |
Year |
ID in Paper
|
Conclusion |
23801278 |
Wen Qiao |
2013 |
MDR1 |
Both of the SNPs c.159G > T and c.1564A > T of MDR1 may contribute to the susceptibility to gastric cancer in Chinese Han population and might be used as molecular markers for detecting gastric cancer susceptibility. |
1977924 |
T Mizoguchi |
1990 |
MDR1 |
The level of expression of the MDR1 gene in gastric carcinomas appears to correlate with the degree of differentiation. |
Experiment for ABCB1 Gene
Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
blood |
365 |
367 |
CRS-PCR |
China |
No Reports |
- |
- |
- |
The allele and genotype frequencies of c.159G > T and c.1564A > T were statistically different between gastric cancer patients and cancer-free controls. |
23801278 |
tissue |
13 |
5 |
Slot blot assay |
Japan |
No Reports |
Up |
- |
- |
Moderately differentiated gastric carcinomas contained higher concentrations of MDR1 mRNA than poorly differentiated gastric carcinomas. |
1977924 |
Function for ABCB1 Gene
Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
diagnosis |
- |
- |
- |
Interaction for ABCB1 Gene
Interaction Gene |
Method |
PMID |
|