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Gene Summary for ABCB1 Gene

Official Symbol ABCB1 Gene Type protein-coding
Full Name ATP binding cassette subfamily B member 1 Entrez 5243
Ensembl ID ENSG00000085563 HGNC 40
Aliases ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 Chromosome Location Chromosome 7, NC_000007.14 (87503017..87713295, complement)
Expression Biased expression in adrenal (RPKM 76.0), small intestine (RPKM 43.0) and 8 other tissues
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Paper for ABCB1 Gene

PMID Author Year ID in Paper
Conclusion
23801278 Wen Qiao 2013 MDR1 Both of the SNPs c.159G > T and c.1564A > T of MDR1 may contribute to the susceptibility to gastric cancer in Chinese Han population and might be used as molecular markers for detecting gastric cancer susceptibility.
1977924 T Mizoguchi 1990 MDR1 The level of expression of the MDR1 gene in gastric carcinomas appears to correlate with the degree of differentiation.

Experiment for ABCB1 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
blood 365 367 CRS-PCR China No Reports - - - The allele and genotype frequencies of c.159G > T and c.1564A > T were statistically different between gastric cancer patients and cancer-free controls. 23801278
tissue 13 5 Slot blot assay Japan No Reports Up - - Moderately differentiated gastric carcinomas contained higher concentrations of MDR1 mRNA than poorly differentiated gastric carcinomas. 1977924

Function for ABCB1 Gene

Functional Type AUC Overall Survival Disease-free Survival
diagnosis - - -

Interaction for ABCB1 Gene

Interaction Gene Method PMID
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