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Gene Summary for ACOT7 Gene
| Official Symbol |
ACOT7 |
Gene Type |
protein-coding |
| Full Name |
acyl-CoA thioesterase 7 |
Entrez |
11332
|
| Ensembl ID |
ENSG00000097021 |
HGNC |
24157
|
| Aliases |
ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH
|
Chromosome Location |
Chromosome 1, NC_000001.11 (6264272..6393767, complement)
|
| Expression |
Broad expression in brain (RPKM 26.5), kidney (RPKM 21.3) and 22 other tissues
|
| Summary |
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
|
Paper for ACOT7 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 32469171 |
Huiqin Feng |
2020 |
ACOT7 |
NMRAL2P activation suppresses ACOT7 expression in GC. ACOT7 could be a promising target for the treatment of GC. |
Experiment for ACOT7 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
10 |
10 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
Upregulated in gastric tumor tissues and GC cell lines.Furthermore, NMRAL2P was downregulated in tumor tissues and GC cell lines. |
32469171 |
| cell line |
- |
- |
Cell proliferation assay;Migration assay;Flow cytometry |
- |
No Reports |
- |
- |
ACOT7 silencing inhibits migration and invasion in GC cells and increased apoptosis. |
ACOT7 gene silencing induced a less malignant phenotype and was closely correlated to reduced cell proliferation and migration, altered cell cycle, and increased apoptosis. |
32469171 |
| tissue |
5 |
5 |
Western blot |
China |
No Reports |
Up |
- |
- |
Upregulated in GC tumor tissue at protein level |
32469171 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
NMRAL2P indirectly methylated ACOT7 by binding to DNMT3b, thereby suppressing ACOT7 expression. |
32469171 |
Function for ACOT7 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
0.025 |
- |
Interaction for ACOT7 Gene
| Interaction Gene |
Method |
PMID |
|
NMRAL2P |
Luciferase reporter assay |
32469171
|
|
