Search Result
Gene Summary for ACTN4 Gene
| Official Symbol |
ACTN4 |
Gene Type |
protein-coding |
| Full Name |
actinin alpha 4 |
Entrez |
81
|
| Ensembl ID |
ENSG00000130402 |
HGNC |
166
|
| Aliases |
ACTININ-4, FSGS, FSGS1
|
Chromosome Location |
Chromosome 19, NC_000019.10 (38647649..38731589)
|
| Expression |
Ubiquitous expression in placenta (RPKM 105.3), kidney (RPKM 104.8) and 25 other tissues
|
| Summary |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
|
Paper for ACTN4 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28581489 |
Xin Liu |
2017 |
a-Actinin-4 |
ACTN4 is significantly upregulated in patients with metastatic GC. ACTN4 reduces cell adhesion and enhances migration and invasion of GC cells and may therefore be a novel therapeutic target for GC. |
Experiment for ACTN4 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
47 |
47 |
qRT-PCR |
China |
No Reports |
Up |
Up |
- |
Upregulated in GC Tissue Samples |
28581489 |
| cell line |
- |
- |
Western blot |
- |
No Reports |
Up |
- |
- |
Upregulated in GC Cell Lines |
28581489 |
| cell line |
- |
- |
Adhesion assay;Migration assay;Invasion assay |
- |
No Reports |
- |
- |
Downregulation of Actn4 enhances GC cell adhesion, suppresses migration and invasion of GC Cells |
Downregulation of Actn4 enhances GC cell adhesion, suppresses migration and invasion of GC Cells |
28581489 |
Function for ACTN4 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for ACTN4 Gene
| Interaction Gene |
Method |
PMID |
|
