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Gene Summary for ADAM17 Gene
| Official Symbol |
ADAM17 |
Gene Type |
protein-coding |
| Full Name |
ADAM metallopeptidase domain 17 |
Entrez |
6868
|
| Ensembl ID |
ENSG00000151694 |
HGNC |
195
|
| Aliases |
ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE
|
Chromosome Location |
Chromosome 2, NC_000002.12 (9488486..9555830, complement)
|
| Expression |
Ubiquitous expression in testis (RPKM 11.1), placenta (RPKM 10.9) and 25 other tissues
|
| Summary |
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020]
|
Paper for ADAM17 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30569104 |
Wei Li |
2019 |
ADAM17 |
In conclusion, the increased expression of ADAM17 promoted the progression of gastric cancer, potentially via Notch and/or Wnt signaling pathway activation, and ADAM17 may serve as a useful prognostic marker. |
Experiment for ADAM17 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
193 |
0 |
qRT-PCR |
China |
No Reports |
- |
- |
- |
Survival times of patients were significantly associated with ADAM17 expression |
30569104 |
| tissue |
15 |
15 |
IHC |
China |
No Reports |
Up |
- |
- |
ADAM17 expression in gastric tumor tissues was significantly upregulated compared to those in adjacent normal tissues, and was also upregulated in positive metastatic lymph node tissues relative to those in the negative tissues. |
30569104 |
| tissue |
5 |
5 |
Western blot |
China |
No Reports |
Up |
- |
- |
ADAM17 expression was significantly upregulated in primary gastric tumor tissues and positive metastatic lymph node tissues |
30569104 |
| cell line |
- |
- |
Cell proliferation assay; Migration assay |
- |
No Reports |
- |
- |
ADAM17 promotes the viability and migration of gastric cancer cells. |
ADAM17 promotes the viability and migration of gastric cancer cells. |
30569104 |
Function for ADAM17 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
0.618 (Mortality risk) |
- |
- |
Interaction for ADAM17 Gene
| Interaction Gene |
Method |
PMID |
|
