Gastric Cancer Database

Official Symbol	ADAM9	Gene Type	protein-coding
Full Name	ADAM metallopeptidase domain 9	Entrez	8754
Ensembl ID	ENSG00000168615	HGNC	216
Aliases	CORD9, MCMP, MDC9, Mltng	Chromosome Location	Chromosome 8, NC_000008.11 (38996767..39105261)
Expression	Ubiquitous expression in gall bladder (RPKM 19.8), urinary bladder (RPKM 16.8) and 24 other tissues
Summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

PMID	Author	Year	ID in Paper	Conclusion
29879625	Qi Liu	2018	ADAM9	ADAM9 mRNA expression in GC tissues was significantly higher than that in adjacent normal tissues; was a target of miR-129-5p in GC cells.
28260063	Junqing Wang	2017	ADAM9	ADAM9 functions as a tumor promoter in GC by modulating GC cell proliferation. ADAM9 could possibly be regarded as a biomarker for GC diagnosis and prevention. Moreover, as directly targeted by miR-126 in GC, ADAM9 may be a potential target for GC therapeutic treatment which warrants intensive study.

Sample Type	Sample Number GC	Sample Number nonGC	Method	Region	Hpylori	Normal vs. GC	Early-stage vs. Advanced stage	Biological Functions in GC Cells	Result	PMID
tissue	50	50	qRT-PCR	China	No Reports	Up	-	-	ADAM9 mRNA expression in GC tissues was significantly higher than that in adjacent normal tissues	29879625
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	miR-129-5p	ADMA9 was a target of miR-129-5p in GC cells.	29879625
cell line	-	-	Cell proliferation assay; Invasion assay	-	No Reports	-	-	ADAM9 overexpression enhanced cell proliferation ability and cell invasion ability, but reversed by stranfected with ADAM9+miR-129-5p mimic		29879625
tissue	76	76	qRT-PCR	China	No Reports	Up	-	-	The expression of ADAM9 was significantly correlated with patient clinicopathological features including tumor size, local invasion, lymph node metastasis and TNM stage.	28260063
tissue	76	76	IHC; Western blot	China	No Reports	Up	-	-	ADAM9 is expressed frequently higher in GC tissues when compared with adjacent non-cancerous tissues	28260063
cell line	-	-	Cell proliferation assay; Cell cycle analysis.	-	No Reports	-	-	Knockdown of ADAM9 suppresses cell proliferation and arrests the cell cycle in GC cells.		28260063
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	ADAM9 is a direct target post-transcriptionally regulated by miR-126 in GC cells.	28260063

Functional Type	AUC	Overall Survival	Disease-free Survival
target	-	-	-