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Gene Summary for ADGRE5 Gene
| Official Symbol |
ADGRE5 |
Gene Type |
protein-coding |
| Full Name |
adhesion G protein-coupled receptor E5 |
Entrez |
976
|
| Ensembl ID |
ENSG00000123146 |
HGNC |
1711
|
| Aliases |
CD97, TM7LN1
|
Chromosome Location |
Chromosome 19, NC_000019.10 (14381144..14408725)
|
| Expression |
Broad expression in bone marrow (RPKM 63.9), spleen (RPKM 54.1) and 23 other tissues
|
| Summary |
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
|
Paper for ADGRE5 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26034356 |
Chao Li |
2015 |
CD97 |
CD97 promotes gastric cancer cell proliferation and invasion in vitro through exosome-mediated MAPK signaling pathway, and exosomal miRNAs are probably involved in activation of the CD97-associated pathway. |
Experiment for ADGRE5 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Invasion assay |
- |
No Reports |
- |
- |
Exosomes isolated from SGC/wt (high CD97 expression ) cells significantly promoted tumor cell proliferation in a dose-dependent manner in vitro. SGC/wt exosomes also significantly elevated the invasiveness of both SGC/wt and SGC/kd (low CD97 expression) cells as compared to the exosomes released by SGC/kd cells. |
Exosomes isolated from SGC/wt (high CD97 expression ) cells significantly promoted tumor cell proliferation in a dose-dependent manner in vitro. SGC/wt exosomes also significantly elevated the invasiveness of both SGC/wt and SGC/kd (low CD97 expression) cells as compared to the exosomes released by SGC/kd cells. |
26034356 |
Function for ADGRE5 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for ADGRE5 Gene
| Interaction Gene |
Method |
PMID |
|
