Search Result
Gene Summary for ADRM1 Gene
| Official Symbol |
ADRM1 |
Gene Type |
protein-coding |
| Full Name |
adhesion regulating molecule 1 |
Entrez |
11047
|
| Ensembl ID |
ENSG00000130706 |
HGNC |
15759
|
| Aliases |
ARM-1, ARM1, GP110
|
Chromosome Location |
Chromosome 20, NC_000020.11 (62302061..62308862)
|
| Expression |
Ubiquitous expression in testis (RPKM 31.4), fat (RPKM 17.5) and 25 other tissues
|
| Summary |
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
|
Paper for ADRM1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24968865 |
Seok Hoon Jang |
2014 |
ADRM1 |
ADRM1 is a candidate target gene in the chromosome 20q13.33 amplicon that may possibly be linked to development of gastric cancer. |
Experiment for ADRM1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
ADRM1 promoted cell proliferation by cell cycle progression |
Overexpression of Adrm1 promoted cell proliferation of conditionally-immortalized, mouse ImSt gastric epithelial cells, with increased S1 phase fraction and decreased expression of p21(Cip1). These results collectively indicate that ADRM1 promoted gastric epithelial cell proliferation by cell cycle progression |
24968865 |
| tissue |
32 |
- |
Comparative genomic hybridization |
Korea |
No Reports |
- |
- |
- |
ADRM1 was the third most frequent target for gene amplification |
24968865 |
| tissue |
32 |
21 |
Microarray |
Korea |
No Reports |
Up |
- |
- |
ADRM1 was also overexpressed in 92 cancer patients than in 21 healthy volunteers |
24968865 |
Function for ADRM1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for ADRM1 Gene
| Interaction Gene |
Method |
PMID |
|
