| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
91 |
91 |
qRT-PCR |
China |
No Reports |
Up |
Up |
- |
AFAP1-AS1 expression was dramatically increased in GC tissues and cells, compared with noncancerous gastric tissues and control cells. The higher lncRNA AFAP1-AS1 expression was positively correlated with lymph node metastasis, TNM stage and worse overall survival (OS) time in GC patients. AFAP1-AS1 expression levels were independent prognostic factors of OS in GC patients. |
28975981 |
| cell line |
- |
- |
Cell proliferation assay; Invasion assay; |
- |
No Reports |
- |
- |
Knockdown of lncRNA AFAP1-AS1 significantly inhibited the cell proliferation and cell cycle progression. Reduced lncRNA AFAP1-AS1 also inhibited the cell invasion ability via regulating cell epithelial-mesenchymal transition (EMT) phenomenon in GC. |
Knockdown of lncRNA AFAP1-AS1 significantly inhibited the cell proliferation and cell cycle progression. Reduced lncRNA AFAP1-AS1 also inhibited the cell invasion ability via regulating cell epithelial-mesenchymal transition (EMT) phenomenon in GC. |
28975981 |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
AFAP1-AS1 was up-regulated in GC tissues and GC cells. |
28451917 |
| cell line |
- |
- |
Cell proliferation assay; Colony formation assay; Cell apoptosis assay |
- |
No Reports |
- |
- |
AFAP1-AS1 knockdown suppressed cell viability of SGC7901 transfected with si-AFAP1-AS1. The number of apoptotic SGC7901 cell transfected with si-AFAP1-AS1 was increased by 3.4-fold comparing to that of control. |
AFAP1-AS1 knockdown suppressed cell viability of SGC7901 transfected with si-AFAP1-AS1. The number of apoptotic SGC7901 cell transfected with si-AFAP1-AS1 was increased by 3.4-fold comparing to that of control. |
28451917 |
