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Clonogenic assay; Soft agar colony-forming assay; Flow cytometry; BrdU incorporation assay; Cell viability assay; Invasion and migration assay; Xenograft model |
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No Reports |
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The proliferation, migration, and invasion of GC cell lines were all significantly inhibited by knockdown of XB130. In a xenograft model, tumor growth was markedly inhibited after shXB130-transfected GC cells were implanted into nude mice. After XB130 knockdown, GC cells showed a more epithelial-like phenotype. Silencing of XB130 reduced the expression of p-Akt/Akt, upregulated expression of epithelial markers including E-cadherin, aβ-catenin and β-catenin, and downregulated mesenchymal markers including fibronectin and vimentin. |
The proliferation, migration, and invasion of GC cell lines were all significantly inhibited by knockdown of XB130. In a xenograft model, tumor growth was markedly inhibited after shXB130-transfected GC cells were implanted into nude mice. After XB130 knockdown, GC cells showed a more epithelial-like phenotype. Silencing of XB130 reduced the expression of p-Akt/Akt, upregulated expression of epithelial markers including E-cadherin, aβ-catenin and β-catenin, and downregulated mesenchymal markers including fibronectin and vimentin. |
24387290 |
