| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
50 |
50 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Higher AGAP2-AS1 level was associated with larger tumors, advanced pathological stage, and lymph node metastasis. |
28209205 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assay; Cell apoptosis assay; Tumor formation assay |
- |
No Reports |
- |
- |
Knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. |
Knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. |
28209205 |
| cell line |
- |
- |
Luciferase reporter assay; ChIP assay |
- |
No Reports |
- |
- |
- |
SP1 could bind to all of these promoter regions of AGAP2-AS1 |
28209205 |
| cell line |
- |
- |
RNA immunoprecipitation |
- |
No Reports |
- |
- |
- |
AGAP2-AS1 functions as an oncogenic lncRNA by interacting with LSD1 and EZH2 and suppressing CDKN1A (P21) and E-cadherin transcription. |
28209205 |
