Search Result
Gene Summary for AGER Gene
| Official Symbol |
AGER |
Gene Type |
protein-coding |
| Full Name |
advanced glycosylation end-product specific receptor |
Entrez |
177
|
| Ensembl ID |
ENSG00000204305 |
HGNC |
320
|
| Aliases |
RAGE, SCARJ1
|
Chromosome Location |
Chromosome 6, NC_000006.12 (32180969..32184380, complement)
|
| Expression |
Biased expression in lung (RPKM 397.6) and spleen (RPKM 11.0)
|
| Summary |
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
|
Paper for AGER Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24441189 |
X C Xu |
2013 |
RAGE |
Upregulation of RAGE expression is associated with lymph node metastases of gastric cancer, and blockade of RAGE signaling suppresses growth and invasion of gastric cancer cells through AKT pathway, suggesting that RAGE may represent a potential therapeutic target for this aggressive malignancy. |
Experiment for AGER Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
40 |
40 |
IHC |
China |
No Reports |
Up |
- |
- |
RAGE was highly expressed in cancer tissues, and correlated with lymph node metastases. |
24441189 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assay; Flow cytometry |
- |
No Reports |
- |
- |
Knockdown of RAGE reduced cell proliferation and invasion of gastric cancer with decreased expression of AKT, PCNA and MMP-2, and induced cell apoptosis and cycle arrest |
Knockdown of RAGE reduced cell proliferation and invasion of gastric cancer with decreased expression of AKT, PCNA and MMP-2, and induced cell apoptosis and cycle arrest |
24441189 |
Function for AGER Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for AGER Gene
| Interaction Gene |
Method |
PMID |
|
