| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
5 |
5 |
qRT-PCR; Microarray |
China |
No Reports |
Up |
- |
- |
Expression of lncRNA AK023391 was significantly upregulated in gastric cancer samples and cell lines in comparison to adjacent normal tissues |
29282102 |
| tissue |
77 |
77 |
FISH |
China |
No Reports |
Up |
- |
- |
AK023391 expression was upregulated in GC and was mainly localized in the cytoplasm of the tissue cell, and was positively correlated with poor survival in patients with gastric cancer. The multivariate Cox regression model revealed that AK023391 expression acted as an independent prognostic factor for survival in patients with gastric cancer. |
29282102 |
| cell line |
- |
- |
Cell viability assay; Invasion and migration assay; Colony formation assay; Flow cytometry |
- |
No Reports |
- |
- |
Knockdown of AK023391 inhibits the proliferation, colony formation, DNA synthesis, migration, invasion of GC cells, and induces apoptosis and cell cycle arrest. |
Knockdown of AK023391 inhibits the proliferation, colony formation, DNA synthesis, migration, invasion of GC cells, and induces apoptosis and cell cycle arrest. |
29282102 |
| cell line |
- |
- |
IHC; Western blot |
- |
No Reports |
- |
- |
- |
LncRNA AK023391 is involved in the regulation of the PI3K/Akt signaling pathway |
29282102 |
| mice |
- |
- |
Xenograft mouse models |
- |
No Reports |
- |
- |
Knockdown of lncRNAAK023391 inhibits tumor growth in vivo |
Knockdown of lncRNAAK023391 inhibits tumor growth in vivo |
29282102 |
