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Gene Summary for AKAP12 Gene
| Official Symbol |
AKAP12 |
Gene Type |
protein-coding |
| Full Name |
A-kinase anchoring protein 12 |
Entrez |
9590
|
| Ensembl ID |
ENSG00000131016 |
HGNC |
370
|
| Aliases |
AKAP250, SSeCKS
|
Chromosome Location |
Chromosome 6, NC_000006.12 (151239815..151358559)
|
| Expression |
Broad expression in testis (RPKM 48.0), fat (RPKM 27.1) and 20 other tissues
|
| Summary |
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
|
Paper for AKAP12 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 15258566 |
Moon-Chang Choi |
2004 |
AKAP12 |
AKAP12A may function as an important negative regulator of the survival pathway in human gastric cancer. |
Experiment for AKAP12 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
MSP |
- |
No Reports |
- |
- |
- |
Two isoforms AKAP12A and AKAP12B are independently expressed and were absent from the majority of human gastric cancer cells. 5' CpG islands of both AKAP12A and AKAP12B are frequently hypermethylated in GC cells. DNA methylation is directly involved in the transcriptional silencing of AKAP12 in gastric cancer cells. |
15258566 |
| cell line |
- |
- |
Cell proliferation assay; Colony formation assay; |
- |
No Reports |
- |
- |
- |
The restoration of AKAP12A in AKAP12-nonexpressing cells reduced colony formation and induced apoptotic cell death |
15258566 |
| tissue |
18 |
18 |
Bisulfite sequencing |
Korea |
No Reports |
- |
- |
- |
Hypermethylation of AKAP12A CpG island was also detected in 56% (10 of 18) of primary gastric tumors. |
15258566 |
Function for AKAP12 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for AKAP12 Gene
| Interaction Gene |
Method |
PMID |
|
