Search Result
Gene Summary for AKT2 Gene
| Official Symbol |
AKT2 |
Gene Type |
protein-coding |
| Full Name |
AKT serine/threonine kinase 2 |
Entrez |
208
|
| Ensembl ID |
ENSG00000105221 |
HGNC |
392
|
| Aliases |
HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
|
Chromosome Location |
Chromosome 19, NC_000019.10 (40230317..40285531, complement)
|
| Expression |
Ubiquitous expression in thyroid (RPKM 30.9), fat (RPKM 28.8) and 25 other tissues
|
| Summary |
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]
|
Paper for AKT2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28404925 |
Fang Wang |
2017 |
AKT2 |
AKT2 plays a crucial role in gastric cancer cell growth, apoptosis, migration and invasion. |
| 25428377 |
Hongkai Zhang |
2015 |
AKT2 |
AKT2 may be one of the targets of miR29s in gastric cancer |
Experiment for AKT2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
Suppression of AKT2 significantly inhibited gasric cancer cell proliferation, induced cell apoptosis and inhibited the migration and invasion of GC cells. |
Suppression of AKT2 significantly inhibited gasric cancer cell proliferation, induced cell apoptosis and inhibited the migration and invasion of GC cells. |
28404925 |
| tissue |
20 |
20 |
Immunoblot |
China |
No Reports |
Up |
- |
- |
Upregulated in GC tissues and had the tendency of inversely relationship with miR-29s expression. |
25428377 |
Function for AKT2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for AKT2 Gene
| Interaction Gene |
Method |
PMID |
|
