Search Result
Gene Summary for AKT3 Gene
| Official Symbol |
AKT3 |
Gene Type |
protein-coding |
| Full Name |
AKT serine/threonine kinase 3 |
Entrez |
10000
|
| Ensembl ID |
ENSG00000117020 |
HGNC |
393
|
| Aliases |
MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
|
Chromosome Location |
Chromosome 1, NC_000001.11 (243488233..243851079, complement)
|
| Expression |
Ubiquitous expression in brain (RPKM 16.6), ovary (RPKM 12.6) and 22 other tissues
|
| Summary |
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
|
Paper for AKT3 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29228422 |
Y Jin |
2017 |
AKT3 |
MiR-582-5p exerted tumor-suppressive effects on gastric cancer growth via targeting AKT3 in vitro, which provided an innovative and candidate target for diagnosis and treatment of gastric cancer |
Experiment for AKT3 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
42 |
42 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
AKT3 was up-regulated in GC tissues when compared with matched normal tissues. |
29228422 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
AKT3 was chosen as the target gene of miR-582-5p. Moreover, restoration of AKT3 could impair tumor suppression role of miR-582-5p on gastric cancer growth. |
29228422 |
Function for AKT3 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for AKT3 Gene
| Interaction Gene |
Method |
PMID |
|
miR-582-5p |
Luciferase reporter assay |
29228422
|
|
