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Gene Summary for ANGPTL6 Gene

Official Symbol ANGPTL6 Gene Type protein-coding
Full Name angiopoietin like 6 Entrez 83854
Ensembl ID ENSG00000130812 HGNC 23140
Aliases AGF, ARP5 Chromosome Location Chromosome 19, NC_000019.10 (10092338..10106407, complement)
Expression Ubiquitous expression in liver (RPKM 8.2), spleen (RPKM 5.1) and 25 other tissues
Summary -

Paper for ANGPTL6 Gene

PMID Author Year ID in Paper
 Conclusion
31146977 Erbao Chen 2019 angptl6 ANGPTL6 is an important driver gene of angiogenesis in AFPGC development. These findings provide not only an effective biomarker for diagnosis but also an attractive therapeutic target for use in AFPGC patients.

Experiment for ANGPTL6 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
cell line - - qRT-PCR - No Reports - - - ANGPTL6 was overexpressed in Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) cell lins compared to that of common gastric cell lines; A high level of ANGPTL6 confers a poor prognosis and is correlated with the expression of CD34 (an endothelial cell marker). 31146977
cell line - - HUVEC tube formation assay; HUVEC proliferation assay; Invasion and migration assay; Flow cytometry - No Reports - - ANGPTL6 promotes endothelial cell migration and tube formation, Moreover, ANGPTL6 knockdown inhibits cancer cell apoptosis and invasiveness. Mechanistically, ANGPTL6 activates the ERK1/2 and AKT pathways. Treatment of ERK1/2 or AKT inhibitor can attenuated cell migration and tube formation. ANGPTL6 promotes endothelial cell migration and tube formation, Moreover, ANGPTL6 knockdown inhibits cancer cell apoptosis and invasiveness. Mechanistically, ANGPTL6 activates the ERK1/2 and AKT pathways. Treatment of ERK1/2 or AKT inhibitor can attenuated cell migration and tube formation. 31146977
mice - - Xenograft mice models - No Reports - - - ANGPTL6 loss results in tumor growth in vivo. 31146977

Function for ANGPTL6 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for ANGPTL6 Gene

Interaction Gene Method PMID
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