Search Result
Gene Summary for ANXA4 Gene
| Official Symbol |
ANXA4 |
Gene Type |
protein-coding |
| Full Name |
annexin A4 |
Entrez |
307
|
| Ensembl ID |
ENSG00000196975 |
HGNC |
542
|
| Aliases |
ANX4, HEL-S-274, P32.5, PAP-II, PIG28, PP4-X, ZAP36
|
Chromosome Location |
Chromosome 2, NC_000002.12 (69643808..69827112)
|
| Expression |
Broad expression in gall bladder (RPKM 187.6), duodenum (RPKM 64.1) and 17 other tissues
|
| Summary |
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
|
Paper for ANXA4 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30837034 |
Jianye Li |
2019 |
Annexin A4 |
reactivation of the miR-203/annexin A4 axis may represent a new strategy for overcoming metastasis of GC. |
Experiment for ANXA4 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
10 |
10 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
Upregulated in GC tissues when compared with normal tissues. Moreover, the low level of miR-203 was associated with increased expression of annexin A4 in GC tissues and cell lines. |
30837034 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-203 Directly Targets Annexin A4 in GC Cells |
30837034 |
Function for ANXA4 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for ANXA4 Gene
| Interaction Gene |
Method |
PMID |
|
miR-203 |
Luciferase reporter assay |
30837034
|
|
