Search Result
Gene Summary for ANXA7 Gene
| Official Symbol |
ANXA7 |
Gene Type |
protein-coding |
| Full Name |
annexin A7 |
Entrez |
310
|
| Ensembl ID |
ENSG00000138279 |
HGNC |
545
|
| Aliases |
ANX7, SNX, SYNEXIN
|
Chromosome Location |
Chromosome 10, NC_000010.11 (73375101..73414058, complement)
|
| Expression |
Ubiquitous expression in thyroid (RPKM 52.9), kidney (RPKM 46.7) and 25 other tissues
|
| Summary |
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]
|
Paper for ANXA7 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 18449914 |
Ping-I Hsu |
2008 |
ANXA7 |
A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis. |
Experiment for ANXA7 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
84 |
- |
IHC |
China |
No Reports |
- |
- |
- |
The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor. The loss of expression of ANXA7 expression was significantly related to distant metastasis. |
18449914 |
Function for ANXA7 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for ANXA7 Gene
| Interaction Gene |
Method |
PMID |
|
