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Gene Summary for APBA2 Gene
| Official Symbol |
APBA2 |
Gene Type |
protein-coding |
| Full Name |
amyloid beta precursor protein binding family A member 2 |
Entrez |
321
|
| Ensembl ID |
ENSG00000034053 |
HGNC |
579
|
| Aliases |
D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L
|
Chromosome Location |
Chromosome 15, NC_000015.10 (28885479..29118315)
|
| Expression |
Biased expression in brain (RPKM 16.8), spleen (RPKM 2.5) and 4 other tissues
|
| Summary |
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017]
|
Paper for APBA2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24385013 |
Jing Han |
2014 |
MINT2 |
Aberrant MINT2 methylation in PPLF/blood may predict peritoneal micrometastasis for GC patients, which is a potential poor prognostic factor in GC. |
Experiment for APBA2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
92 |
92 |
RT-MSP |
China |
No Reports |
Up(Methylation) |
- |
- |
The methylation status of the MINT2 gene was found to be significantly higher in tumor tissues than in adjacent normal tissues. No MINT2 methylation was found in healthy controls.(all P < 0.0001). |
24385013 |
| PPLF/blood |
92 |
- |
RT-MSP |
China |
No Reports |
- |
- |
- |
The frequency of MINT2 methylation in pairing PPLF and blood samples from 92 GC patients was 40.2% (37/92) and 39.1% (36/92), respectively. Methylated MINT2 in tumor tissues, pairing PPLF, and blood samples were very approximate. Aberrant MINT2 methylation in tumor tissues and pairing PPLF or blood samples were closely related to peritoneal dissemination, tumor progression, and poor prognosis. |
24385013 |
Function for APBA2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| diagnosis/prognosis |
0.710/0.696 |
- |
< 0.0001 |
Interaction for APBA2 Gene
| Interaction Gene |
Method |
PMID |
|
