Search Result
Gene Summary for AQP3 Gene
| Official Symbol |
AQP3 |
Gene Type |
protein-coding |
| Full Name |
aquaporin 3 (Gill blood group) |
Entrez |
360
|
| Ensembl ID |
ENSG00000165272 |
HGNC |
636
|
| Aliases |
AQP-3, GIL
|
Chromosome Location |
Chromosome 9, NC_000009.12 (33441154..33447596, complement)
|
| Expression |
Biased expression in esophagus (RPKM 430.5), skin (RPKM 178.1) and 9 other tissues
|
| Summary |
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
|
Paper for AQP3 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 23800944 |
Baofei Jiang |
2014 |
AQP3 |
These results provide a mechanism by which AQP3 is upregulated, as well as highlight the importance of miR-874 in gastric cancer development and progression. |
Experiment for AQP3 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
75 |
75 |
Western blot |
China |
Related |
Up |
- |
- |
The protein expression levels of AQP3 were significantly elevated in GCs compared with matched non-GC tissues. AQP3 protein level was closely associated with histological type and lymphatic invasion. H. pylori infection increases the protein level of AQP3 |
23800944 |
Function for AQP3 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for AQP3 Gene
| Interaction Gene |
Method |
PMID |
|
