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Gene Summary for ARHGAP5 Gene
| Official Symbol |
ARHGAP5 |
Gene Type |
protein-coding |
| Full Name |
Rho GTPase activating protein 5 |
Entrez |
394
|
| Ensembl ID |
ENSG00000100852 |
HGNC |
675
|
| Aliases |
GFI2, RhoGAP5, p190-B, p190BRhoGAP
|
Chromosome Location |
Chromosome 14, NC_000014.9 (32072588..32159728)
|
| Expression |
Ubiquitous expression in thyroid (RPKM 21.1), brain (RPKM 17.8) and 25 other tissues
|
| Summary |
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
Paper for ARHGAP5 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30250020 |
Guoying Dong |
2018 |
ARHGAP5 |
SIRT1 suppresses migration and invasion of GC by downregulating ARHGAP5 through an interaction with c-JUN, and these phenomena represent a novel mechanism of the antitumor action of SIRT1. |
Experiment for ARHGAP5 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
90 |
90 |
IHC |
China |
No Reports |
Up |
- |
- |
The expression of ARHGAP5 was increased in GC, and positively correlated with tumor size, tumor infiltration, lymph node metastasis, and clinical stage. And multivariate analyses indicated that ARHGAP5 served as an independent prognostic marker of GC. |
30250020 |
| cell line |
- |
- |
Cell invasion and migration assay; |
- |
No Reports |
- |
- |
ARHGAP5 is involved in SIRT1-induced suppression of GC cell migration and invasion in vitro. |
ARHGAP5 is involved in SIRT1-induced suppression of GC cell migration and invasion in vitro. |
30250020 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
ARHGAP5 acts as an oncogene promoting GC metastasis in vivo. |
30250020 |
Function for ARHGAP5 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.002 |
- |
Interaction for ARHGAP5 Gene
| Interaction Gene |
Method |
PMID |
|
