Search Result
Gene Summary for ARID1A Gene
| Official Symbol |
ARID1A |
Gene Type |
protein-coding |
| Full Name |
AT-rich interaction domain 1A |
Entrez |
8289
|
| Ensembl ID |
ENSG00000117713 |
HGNC |
11110
|
| Aliases |
B120, BAF250, BAF250a, BM029, C1orf4, CSS2, ELD, MRD14, OSA1, P270, SMARCF1, hELD, hOSA1
|
Chromosome Location |
Chromosome 1, NC_000001.11 (26696015..26782104)
|
| Expression |
Ubiquitous expression in spleen (RPKM 14.3), lymph node (RPKM 13.2) and 25 other tissues
|
| Summary |
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
Paper for ARID1A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 22808142 |
Dan-dan Wang |
2012 |
ARID1A |
ARID1A may play an important role in gastric cancer and may serve as a valuable prognostic marker and potential target for gene therapy in the treatment of gastric cancer. |
Experiment for ARID1A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
66 |
66 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
Down-regulated in GC tissues compared with non-tumor tissues. |
22808142 |
| tissue |
25 |
66 |
Western blot |
China |
No Reports |
Down |
- |
- |
Down-regulated in GC tissues compared with non-tumor tissues. |
22808142 |
| cell line |
- |
- |
Cell proliferation assay; Colony Formation assay; |
- |
No Reports |
- |
- |
Silencing the expression of ARID1A in GES1 significantly enhanced cell proliferation compared with mock siRNA treatment |
Silencing the expression of ARID1A in GES1 significantly enhanced cell proliferation compared with mock siRNA treatment |
22808142 |
| tissue |
224 |
- |
IHC |
China |
No Reports |
- |
- |
- |
Loss of ARID1A expression was significantly correlated with depth of tumor infiltration (T stage) and tumor grade, but not with age, gender, tumor size, distant metastasis (M stage), and tumor locus or local lymph node metastasis. ARID1A expression as independent predictors of the overall survival of gastric cancer patients. |
22808142 |
Function for ARID1A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.003 |
- |
Interaction for ARID1A Gene
| Interaction Gene |
Method |
PMID |
|
