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Gene Summary for ATP6V1A Gene
| Official Symbol |
ATP6V1A |
Gene Type |
protein-coding |
| Full Name |
ATPase H+ transporting V1 subunit A |
Entrez |
523
|
| Ensembl ID |
ENSG00000114573 |
HGNC |
851
|
| Aliases |
ARCL2D, ATP6A11, HO68, IECEE3, VA68, VPP2, Vma1, ATP6V1A
|
Chromosome Location |
Chromosome 3, NC_000003.12 (113747035..113812056)
|
| Expression |
Ubiquitous expression in brain (RPKM 61.4), kidney (RPKM 46.5) and 24 other tissues
|
| Summary |
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]
|
Paper for ATP6V1A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28592880 |
Pin Wang |
2017 |
ATP6V1A |
YY1 may play an important regulatory role in ATP6V1A expression with potential mechanistic and clinical implications in GC. |
Experiment for ATP6V1A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
ChIP-qPCR; qRT-PCR; Western blot |
- |
No Reports |
- |
- |
- |
YY1 transcriptionally regulates ATP6V1A, and the ATP6V1A core promoter region contains three YY1 binding sites. RNAi-mediated knockdown of YY1 in GC cells significantly decreased ATP6V1A mRNA and protein expression, while YY1 overexpression increased ATP6V1A expression level |
28592880 |
Function for ATP6V1A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.01 |
- |
Interaction for ATP6V1A Gene
| Interaction Gene |
Method |
PMID |
|
