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Gene Summary for BAG3 Gene
| Official Symbol |
BAG3 |
Gene Type |
protein-coding |
| Full Name |
BAG cochaperone 3 |
Entrez |
9531
|
| Ensembl ID |
ENSG00000151929 |
HGNC |
939
|
| Aliases |
BAG-3, BIS, CAIR-1, MFM6
|
Chromosome Location |
Chromosome 10, NC_000010.11 (119651380..119677819)
|
| Expression |
Ubiquitous expression in heart (RPKM 32.6), placenta (RPKM 26.6) and 25 other tissues
|
| Summary |
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
|
Paper for BAG3 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30514177 |
Jae Chang Lee |
2019 |
BAG3 |
BAG3 contributes to HGF-mediated cell proliferation, migration, and invasion via the Egr1 pathway in gastric cancer |
Experiment for BAG3 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
qRT-PCR; Western blot |
- |
No Reports |
- |
- |
- |
BAG3 mRNA and protein levels were increased following treatment with HGF. HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. HGF-mediated BAG3 upregulation is regulated by an ERK and Egr1-dependent pathway. BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway. |
30514177 |
| cell line |
- |
- |
Cell proliferation assay; Flow cytometry |
- |
No Reports |
- |
- |
- |
HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. |
30514177 |
Function for BAG3 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for BAG3 Gene
| Interaction Gene |
Method |
PMID |
|
