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Gene Summary for BCL2L2 Gene
| Official Symbol |
BCL2L2 |
Gene Type |
protein-coding |
| Full Name |
BCL2 like 2 |
Entrez |
599
|
| Ensembl ID |
ENSG00000129473 |
HGNC |
995
|
| Aliases |
BCL-W, BCL2-L-2, BCLW, PPP1R51
|
Chromosome Location |
Chromosome 14, NC_000014.9 (23306833..23311751)
|
| Expression |
Ubiquitous expression in brain (RPKM 35.0), fat (RPKM 31.5) and 25 other tissues
|
| Summary |
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
|
Paper for BCL2L2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 16707418 |
In Hwa Bae |
2006 |
Bcl-w |
Bcl-w, which was previously shown to enhance gastric cancer cell survivability, also promotes their invasiveness by inducing MMP-2 expression via the sequential actions of PI3K, Akt, and Sp1. |
Experiment for BCL2L2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
|
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
Bcl-w enhances GC cell invasion and migration. |
Bcl-w enhances GC cell invasion and migration. |
16707418 |
| cell line |
- |
- |
Gelatin zymography; Western blot |
- |
No Reports |
- |
- |
- |
Bcl-w overexpression increased matrix metalloproteinase-2 (MMP-2) expression, and synthetic or natural inhibitors of MMP-2 abolished Bcl-w induced cell invasion. Bcl-w overexpression also activated phosphoinositide 3-kinase (PI3K), Akt, and Sp1. |
16707418 |
Function for BCL2L2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for BCL2L2 Gene
| Interaction Gene |
Method |
PMID |
|
