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Gene Summary for BCL6 Gene
| Official Symbol |
BCL6 |
Gene Type |
protein-coding |
| Full Name |
BCL6 transcription repressor |
Entrez |
604
|
| Ensembl ID |
ENSG00000113916 |
HGNC |
1001
|
| Aliases |
BCL5A, LAZ3, ZBTB27, ZNF51, BCL6
|
Chromosome Location |
Chromosome 3, NC_000003.12 (187721377..187745472, complement)
|
| Expression |
Ubiquitous expression in fat (RPKM 29.2), bone marrow (RPKM 20.1) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
|
Paper for BCL6 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29510377 |
Yong-Yuan Li |
2018 |
BCL6 |
miR-519d-3p functions as a tumor suppressor by targeting and downregulating the expression of BCL6 in GC cells. |
Experiment for BCL6 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
BCL6 was upregulated in GC tissues and cell lines and cor_x005frelated with a malignant phenotype in patients with GC. BCL6 overexpression partially abrogated the suppressive function of miR-519d in MGC803 cells |
29510377 |
Function for BCL6 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for BCL6 Gene
| Interaction Gene |
Method |
PMID |
|
