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Gene Summary for BIRC5 Gene
| Official Symbol |
BIRC5 |
Gene Type |
protein-coding |
| Full Name |
baculoviral IAP repeat containing 5 |
Entrez |
332
|
| Ensembl ID |
ENSG00000089685 |
HGNC |
593
|
| Aliases |
API4, EPR-1
|
Chromosome Location |
Chromosome 17, NC_000017.11 (78214253..78225635)
|
| Expression |
Biased expression in bone marrow (RPKM 13.2), testis (RPKM 10.8) and 12 other tissues
|
| Summary |
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
|
Paper for BIRC5 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24337012 |
Junyan Zhang |
2014 |
survivin |
Survivin may be a regulator of VEGF-C expression in gastric cancer cells, and is essential in invasion and lymphatic metastasis. |
Experiment for BIRC5 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
195 |
- |
IHC; TMA |
China |
No Reports |
- |
- |
- |
The expression levels of survivin was significantly higher in patients with lymph node metastasis than in those without metastasis. Patients with high expression levels of survivin showed significantly less favorable survival rates compared with patients with low expression levels of those two genes. Moreover, patients with co-expression of the two genes usually had a poorer prognosis. |
24337012 |
Function for BIRC5 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.003 |
- |
Interaction for BIRC5 Gene
| Interaction Gene |
Method |
PMID |
|
