Search Result
Gene Summary for BMI1 Gene
| Official Symbol |
BMI1 |
Gene Type |
protein-coding |
| Full Name |
BMI1 proto-oncogene, polycomb ring finger |
Entrez |
648
|
| Ensembl ID |
ENSG00000168283 |
HGNC |
1066
|
| Aliases |
FLVI2/BMI1, PCGF4, RNF51, flvi-2/
|
Chromosome Location |
Chromosome 10, NC_000010.11 (22321099..22331484)
|
| Expression |
Ubiquitous expression in testis (RPKM 21.4), endometrium (RPKM 20.1) and 25 other tissues
|
| Summary |
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
|
Paper for BMI1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30156609 |
Pei Liu |
2018 |
BMI1 |
provided a novel regulatory mechanism for ANRIL in gastric cancer, in which ANRIL silence down-regulated BMI1 via miR-99a, along with activation of the apoptotic pathway and inhibition of the Notch and mTOR pathways |
| 26894855 |
Changping Wu |
2016 |
Bmi-1 |
The expression of Bmi-1 is regulated by miR-15a in gastric cancer. The prognostic significance of Bmi-1 in gastric cancer supports future multi-center large cohort studies. |
| 18041745 |
Jian-Hua Liu |
2008 |
Bmi-1 |
Bmi-1 may serve as a valuable marker for diagnosis and prognosis of GC. |
Experiment for BMI1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
qRT-PCR; Cell transfection |
- |
No Reports |
- |
- |
- |
expression of BMI1 affected the expression of apoptosis_x005frelated proteins and thus inhibited the activation of the apoptotic pathway. Overexpression of BMI1 could activate the Notch and mTOR signaling pathways |
30156609 |
| tissue |
352 |
- |
qRT-PCR |
China |
No Reports |
- |
Down |
- |
Gastric cancer patients survive better with higher expression levels of Bmi-1, and correlated with smaller tumor size, better pathological differentiation (I-II), less lymph node metastases, earlier T stages, non-metastatic disease (M0), earlier UICC stages. The expression of Bmi-1 is significantly different in stage I-II vs. stage III-IV patients. |
26894855 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
Bmi-1 is a direct target of miR-15a in gastric cancer cell lines. |
26894855 |
| tissue |
21 |
- |
qRT-PCR; IHC |
China |
No Reports |
- |
- |
- |
The expression of Bmi-1 is inversely correlated with miR-15a in gastric tumor tissues |
26894855 |
| tissue |
8 |
8 |
RT-PCR; Western blot |
China |
No Reports |
Up |
- |
- |
RT-PCR and Western blotting showed that Bmi-1 was up-regulated at both the transcriptional and translational levels in the GC tissues compared with the adjacent non-cancerous tissues. |
18041745 |
| tissue |
146 |
- |
IHC |
China |
No Reports |
- |
- |
- |
99 of 146 paraffin-embedded GC samples expressed Bmi-1 extensively. Statistical analysis showed that Bmi-1 overexpression was highly correlated with tumor size, clinical stage, lymph node metastasis and T classification. Patients with Bmi-1 expression had shorter overall survival time than those without Bmi-1 expression (P < 0.01). Multivariate analysis indicated that Bmi-1 expression is an independent prognostic factor of GC. |
18041745 |
Function for BMI1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.024 |
- |
| prognosis |
- |
< 0.01 |
- |
Interaction for BMI1 Gene
| Interaction Gene |
Method |
PMID |
|
miR-15a |
Luciferase reporter assay |
26894855
|
|
