Search Result
Gene Summary for BRD4 Gene
| Official Symbol |
BRD4 |
Gene Type |
protein-coding |
| Full Name |
bromodomain containing 4 |
Entrez |
23476
|
| Ensembl ID |
ENSG00000141867 |
HGNC |
13575
|
| Aliases |
CAP, HUNK1, HUNKI, MCAP
|
Chromosome Location |
Chromosome 19, NC_000019.10 (15235519..15332539, complement)
|
| Expression |
Ubiquitous expression in placenta (RPKM 10.8), testis (RPKM 9.2) and 25 other tissues
|
| Summary |
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
|
Paper for BRD4 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29434197 |
Xingchen Dong |
2018 |
BRD4 |
Our results reveal a novel mechanism by which BRD4 regulates cancer cell proliferation by modulating the cellular senescence through E2F/miR-106b-5p/p21 axis and provide new insights into using BET inhibitors as potential anticancer drugs. |
Experiment for BRD4 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
52 |
52 |
IHC |
China |
No Reports |
Up |
- |
- |
BRD4 is highly overexpressed in gastric cancer tissues. |
29434197 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assay; |
- |
No Reports |
- |
- |
The BET inhibitor JQ1 inhibits gastric cancer cell proliferation by inducing cellular senescence. BRD4 is involved in JQ1-induced cellular senescence. |
The BET inhibitor JQ1 inhibits gastric cancer cell proliferation by inducing cellular senescence. BRD4 is involved in JQ1-induced cellular senescence. |
29434197 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
BRD4 regulates the 3′-UTR of p21. mRNA CDKN1A |
29434197 |
| cell line |
- |
- |
CHIP assay |
- |
No Reports |
- |
- |
- |
BRD4, together with E2F1, regulates miR-106b-5p transcription and cellular senescence. |
29434197 |
Function for BRD4 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for BRD4 Gene
| Interaction Gene |
Method |
PMID |
|
CDKN1A |
Luciferase reporter assay |
29434197
|
|
