MKGC: a curated molecular knowledgebase for gastric cancer


Search Result

 

Gene Summary for BTG1 Gene

Official Symbol BTG1 Gene Type protein-coding
Full Name BTG anti-proliferation factor 1 Entrez 694
Ensembl ID ENSG00000133639 HGNC 1130
Aliases APRO2 Chromosome Location Chromosome 12, NC_000012.12 (92140278..92145846, complement)
Expression Ubiquitous expression in bone marrow (RPKM 117.9), lymph node (RPKM 72.6) and 25 other tissues
Summary This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

Paper for BTG1 Gene

PMID Author Year ID in Paper
 Conclusion
26050197 Hua-chuan Zheng 2015 BTG1 BTG1 overexpression might reverse the aggressive phenotypes and be employed as a potential target for gene therapy of gastric cancer

Experiment for BTG1 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
cell line - - RT-PCR; Western blot; MS-PCR - No Reports - - - BTG1 protein expression (19 kDa) was detectable in gastric cancer and epithelial cell lines; BTG1 mRNA was high expressed in cancer and epithelial cells and a decreased level of methylation of BTG1 after treated with 5-Aza-dC. 26050197
cell line - - Cell proliferation assay; Invasion and migration assays; Flow cytometry - No Reports - - BTG1 overexpression suppressed tumor growth and lung metastasis of gastric cancer cells. BTG1 overexpression suppressed tumor growth and lung metastasis of gastric cancer cells. 26050197
mice - - Xenograft mice models - No Reports - - - BTG1 overexpression enhanced autophagy and apoptosis in xenograft models. 26050197
tissue 613 577 RT-PCR Japan No Reports Down - - BTG1 expression was statistically lower in gastric cancer than non-neoplastic mucosa and metastatic cancer in lymph node. BTG1 expression was positively correlated with depth of invasion, lymphatic and venous invasion, lymph node metastasis, TNM staging and worse prognosis. The diffuse-type carcinoma showed less BTG1 expression than intestinal- and mixed-type ones. 26050197

Function for BTG1 Gene

Functional Type AUC Overall Survival Disease-free Survival
target/prognosis - 0.047 -

Interaction for BTG1 Gene

Interaction Gene Method PMID
About Us      Admin
备案/许可证编号：苏ICP备2021043822号