MKGC: a curated molecular knowledgebase for gastric cancer


Search Result

 

Gene Summary for BTG2 Gene

Official Symbol BTG2 Gene Type protein-coding
Full Name BTG anti-proliferation factor 2 Entrez 7832
Ensembl ID ENSG00000159388 HGNC 1131
Aliases APRO1, PC3, TIS21 Chromosome Location Chromosome 1, NC_000001.11 (203305519..203309602)
Expression Ubiquitous expression in ovary (RPKM 185.2), esophagus (RPKM 183.2) and 23 other tissues
Summary The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]

Paper for BTG2 Gene

PMID Author Year ID in Paper
 Conclusion
27409164 Lin Zhou 2016 BTG2 miR-27a-3p/BTG2 axis might represent a promising diagnostic biomarker for gastric cancer patients and could be a potential therapeutic target in the management of gastric cancer.

Experiment for BTG2 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
cell line - - Cell proliferation assay; Invasion and migration assays; Flow cytometry; Apotosis assay - No Reports - - Overexpression of BTG2 triggered G1/S cell cycle arrest, induced subsequent apoptosis, and inhibited C-myc activation following Ras/MEK/ERK signaling pathway, which involved in the biological effects of miR-27a-3p/BTG2 axis on gastric carcinogenesis and cancer progression. Overexpression of BTG2 triggered G1/S cell cycle arrest, induced subsequent apoptosis, and inhibited C-myc activation following Ras/MEK/ERK signaling pathway, which involved in the biological effects of miR-27a-3p/BTG2 axis on gastric carcinogenesis and cancer progression. 27409164
cell line - - Luciferase reporter assay - No Reports - - - BTG2 was a direct and functional target of miR-27a-3p in gastric cancer and miR-27a-3p inhibition obviously up-regulated the expression of BTG2. 27409164

Function for BTG2 Gene

Functional Type AUC Overall Survival Disease-free Survival

Interaction for BTG2 Gene

Interaction Gene Method PMID
miR-27a-3p Luciferase reporter assay 27409164
About Us      Admin
备案/许可证编号：苏ICP备2021043822号