Search Result
Gene Summary for BTG3 Gene
| Official Symbol |
BTG3 |
Gene Type |
protein-coding |
| Full Name |
BTG anti-proliferation factor 3 |
Entrez |
10950
|
| Ensembl ID |
ENSG00000154640 |
HGNC |
1132
|
| Aliases |
ANA, ANA/BTG3, APRO4, TOB5, TOB55, TOFA
|
Chromosome Location |
Chromosome 21, NC_000021.9 (17593653..17612940, complement)
|
| Expression |
Ubiquitous expression in testis (RPKM 24.4), placenta (RPKM 23.0) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
|
Paper for BTG3 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25904053 |
Wen-feng Gou |
2015 |
BTG3 |
BTG3 overexpression might reverse the aggressive phenotypes and be employed as a potential target for gene therapy of gastric cancer |
| 25238703 |
X L Ren |
2015 |
BTG3 |
Down-regulation of BTG3 is closely associated with proliferation, migration and invasion in GC. It may be a novel prognostic biomarker for GC patients. |
Experiment for BTG3 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
38 |
38 |
Western blot; IHC |
Japan |
No Reports |
Down |
- |
- |
BTG3 expression was decreased in gastric cancer in comparison to the adjacent mucosa, and positively correlated with venous invasion and dedifferentiation of cancer. |
25904053 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
BTG3 overexpression inhibited proliferation, induced S/G2 arrest, differentiation, autophagy, apoptosis, suppressed migration and invasion |
BTG3 overexpression inhibited proliferation, induced S/G2 arrest, differentiation, autophagy, apoptosis, suppressed migration and invasion |
25904053 |
| cell line |
- |
- |
qRT-PCR; Cell transfection |
- |
No Reports |
- |
- |
- |
BTG3 transfectants showed a higher mRNA expression of p27, Bax, 14-3-3, Caspase-3, Caspase-9, Beclin 1, NF-κB, IL-1, -2, -4, -10 and -17, but a lower mRNA expression of p21, MMP-9 and VEGF than the control and mock；exposed to cisplatin (DDP), MG132, paclitaxel, and SAHA, BTG3 transfectants showed a lower viability and a higher apoptotic level than the control in both concentration and time-dependent manners |
25904053 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
BTG3 suppresses the growth of gastric cancer cells in nude mice. |
25904053 |
| tissue |
18 |
18 |
qRT-PCR; Western blot |
China |
No Reports |
Down |
- |
- |
BTG3 was obviously down-regulated in GC tissues. |
25238703 |
| tissue |
131 |
131 |
IHC |
China |
No Reports |
- |
- |
- |
The expression of BTG3 was obvi- ously lower in GC tissues than adjacent gastric mucosa. Its expression was positively correlated with distant metastasis. Patients with lower BTG3 expression had shorter overall survival time. |
25238703 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
BTG3 suppressed the proliferation of GC cells in vitro and in vivo. It also inhibited migration and invasion of GC cells in vitro. |
BTG3 suppressed the proliferation of GC cells in vitro. It also inhibited migration and invasion of GC cells in vitro. |
25238703 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
BTG3 suppressed the proliferation of GC cells in vivo. |
25238703 |
Function for BTG3 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
| target/prognosis |
- |
0.001 |
- |
Interaction for BTG3 Gene
| Interaction Gene |
Method |
PMID |
|
