MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for BTG4 Gene

Official Symbol BTG4 Gene Type protein-coding
Full Name BTG anti-proliferation factor 4 Entrez 54766
Ensembl ID ENSG00000137707 HGNC 13862
Aliases APRO3, OOMD8, PC3B Chromosome Location Chromosome 11, NC_000011.10 (111383828..111514734, complement)
Expression Restricted expression toward testis (RPKM 4.9)
Summary The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]

Paper for BTG4 Gene

PMID Author Year ID in Paper
 Conclusion
19576178 Wenjie Dong 2009 BTG4 BTG4 as a candidate tumor suppressor gene that is epigenetically silenced in the majority of gastric cancers.

Experiment for BTG4 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
cell line - - Bisulfite sequencing - No Reports - - - Most CpG dinucleotides were methylated in gastric cancer cell lines, the methylation was absent in GES-1 cells 19576178
tissue 38 38 qRT-PCR China No Reports - - - BTG4 was significantly down-regulated in tumor tissues compared to normal tissues. 19576178
tissue 38 38 MS-PCR China No Reports - - - BTG4 was methylated in 28 of 38 primary gastric cancers tested, no methylation was detected in normal gastric samples. Its hypermethylation was corrleated with the type of cell differentiation and metastasis 19576178
cell line - - Flow cytometry; Cell growth assay - No Reports - - BTG4 reexpression sensitizes gastric cancer cells to proapoptotic stimuli and reduces colony formation in vitro. BTG4 reexpression sensitizes gastric cancer cells to proapoptotic stimuli and reduces colony formation in vitro. 19576178
mice - - Xenograft mice models - No Reports - - - BTG4 reexpression sensitizes tumor growth in mice. 19576178

Function for BTG4 Gene

Functional Type AUC Overall Survival Disease-free Survival
mechanism - - -

Interaction for BTG4 Gene

Interaction Gene Method PMID
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