Search Result
Gene Summary for CA11 Gene
| Official Symbol |
CA11 |
Gene Type |
protein-coding |
| Full Name |
carbonic anhydrase 11 |
Entrez |
770
|
| Ensembl ID |
ENSG00000063180 |
HGNC |
1370
|
| Aliases |
CA-RP, CA-RP II, CA-XI, CARP-2, CARPX1
|
Chromosome Location |
Chromosome 19, NC_000019.10 (48637946..48646187, complement)
|
| Expression |
Biased expression in brain (RPKM 69.9), ovary (RPKM 14.7) and 2 other tissues
|
| Summary |
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
|
Paper for CA11 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 11562744 |
K Shiozaki |
2001 |
CA11 |
The findings suggest that the loss of CA11 expression in gastric tissues may play an important role in gastric carcinogenesis. |
Experiment for CA11 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
- |
- |
RNA dot blot |
China |
No Reports |
- |
- |
- |
Strong expression of the CA l l gene was confirmed in normal stomach tissue |
11562744 |
| tissue |
50 |
50 |
RT-PCR |
China |
No Reports |
Down |
- |
- |
Expression of the CA11 gene in cancer tissue was down-regulated compared with normal tissue. Semi-quantitative RT-PCR also demonstrated that CA11 gene expression was decreased in 41 out of 50 (82%) of the gastric cancer tissues, when compared with normal stomach tissues, while no relationship was found between CA11 expression and various clinicopathological characteristics. |
11562744 |
| tissue |
- |
- |
IHC |
- |
No Reports |
- |
- |
- |
Immunohistochemical analysis with anti CA11 antibody showed that CA11-positive staining was observed in the surface regions of normal gastric epithelium, but was found faintly or not at all in cancer tissues. |
11562744 |
| cell line |
- |
- |
Cell coloney formation assay |
- |
No Reports |
- |
- |
- |
CA11 transfected MKN28 cells also displayed a marked decrease in the number of colony formations when compared to double normal controls. |
11562744 |
Function for CA11 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for CA11 Gene
| Interaction Gene |
Method |
PMID |
|
