Search Result
Gene Summary for CASC15 Gene
| Official Symbol |
CASC15 |
Gene Type |
lncRNA |
| Full Name |
cancer susceptibility 15 |
Entrez |
401237
|
| Ensembl ID |
- |
HGNC |
28245
|
| Aliases |
CANT, LINC00340, lnc-SOX4-1
|
Chromosome Location |
Chromosome 6, NC_000006.12 (21666413..22195820)
|
| Expression |
Broad expression in ovary (RPKM 2.9), endometrium (RPKM 1.9) and 14 other tissues
|
| Summary |
This gene produces a long non-coding RNA that may regulate cell proliferation. This RNA is upregulated in hepatocellular carcinoma, where it is thought to function as an oncogene. However, some splice variants of this gene may function as a tumor suppressor in neuroblastoma and other tumor types. Circular RNA variants were observed at this gene. [provided by RefSeq, Dec 2017]
|
Paper for CASC15 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29272000 |
X-M Yao |
2017 |
CASC15 |
The expression of LncRNA CASC15 was significantly higher in gastric cancer tissues and its expression was negatively correlated with the overall survival of clinical patients. |
Experiment for CASC15 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
60 |
42 |
qRT-PCR |
China |
No Reports |
Up |
Up |
- |
Expression of lncRNA CASC15 in gastric cancer tissue was higher than normal gastric epithelium. Clinical data analysis showed that the expression level of CASC15 was correlated with tumor size and TNM stage in clinical patients. |
29272000 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
Overexpression of LncRNA CASC15 promoted the proliferation of MKN28 cells. |
Overexpression of LncRNA CASC15 promoted the proliferation of MKN28 cells. |
29272000 |
Function for CASC15 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.013 |
- |
Interaction for CASC15 Gene
| Interaction Gene |
Method |
PMID |
|
