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Gene Summary for CASK Gene
| Official Symbol |
CASK |
Gene Type |
protein-coding |
| Full Name |
calcium/calmodulin dependent serine protein kinase |
Entrez |
8573
|
| Ensembl ID |
ENSG00000147044 |
HGNC |
1497
|
| Aliases |
CAGH39, CAMGUK, CMG, FGS4, LIN2, MICPCH, MRXSNA, TNRC8, hCASK
|
Chromosome Location |
Chromosome X, NC_000023.11 (41514934..41923554, complement)
|
| Expression |
Ubiquitous expression in duodenum (RPKM 8.0), small intestine (RPKM 7.8) and 25 other tissues
|
| Summary |
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, intellectual disability and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
|
Paper for CASK Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25373785 |
Xiaoying Zhou |
2014 |
CASK |
miR-203 functions as a growth-suppressive miRNA in H. pylori related GC, and that its suppressive effects are mediated mainly by repressing CASK expression. |
Experiment for CASK Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
50 |
50 |
qRT-PCR |
China |
Related |
Down |
- |
- |
CASK was over-expressed in tumors and H. pylori positive tissues and its mRNA levels were inversely correlated with miR-203 expression |
25373785 |
Function for CASK Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CASK Gene
| Interaction Gene |
Method |
PMID |
|
