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Gene Summary for CAV1 Gene
| Official Symbol |
CAV1 |
Gene Type |
protein-coding |
| Full Name |
caveolin 1 |
Entrez |
857
|
| Ensembl ID |
ENSG00000105974 |
HGNC |
1527
|
| Aliases |
BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21
|
Chromosome Location |
Chromosome 7, NC_000007.14 (116525009..116561185)
|
| Expression |
Biased expression in fat (RPKM 322.1), lung (RPKM 308.8) and 13 other tissues
|
| Summary |
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
|
Paper for CAV1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 15757532 |
Xue Gao |
2005 |
caveolin-1 |
Progressive down-regulation of Caveolin-1 in gastric epithelial cells is correlated to gastric carcinogenesis. |
Experiment for CAV1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
56 |
29 |
RT-PCR,IHC |
China |
No Reports |
Down |
Down |
- |
Positive rate of Caveolin-1 was significantly lower in gastric cancer than in non-cancerous mucosa, intestinal metaplasia, and atypical hyperplasia (17.9% vs. 84.8%, 81.8%, and 57.1%, P<0.05). Positive rate of Caveolin-1 was lower in advanced gastric cancers than in gastric cancer of early stage (16.0% vs. 33.3%), but the difference was not significant (P>0.05). Positive rate of Caveolin-1 was significantly lower in diffuse gastric cancer than in gastric cancer of intestinal type (7.0% vs. 26.9%, P<0.05), significantly lower in the cases with lymph node metastases than in the cases without lymph node metastases (9.7% vs. 31.8%, P<0.05). Protein and mRNA levels of Caveolin-1 in gastric cancer and relevant adjuvant non-cancerous tissues have no significant difference, but its expression was low in MGC803 and BGC823 cells. |
15757532 |
Function for CAV1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for CAV1 Gene
| Interaction Gene |
Method |
PMID |
|
