Search Result
Gene Summary for CBFB Gene
| Official Symbol |
CBFB |
Gene Type |
protein-coding |
| Full Name |
core-binding factor subunit beta |
Entrez |
865
|
| Ensembl ID |
ENSG00000067955 |
HGNC |
1539
|
| Aliases |
PEBP2B
|
Chromosome Location |
Chromosome 16, NC_000016.10 (67029149..67101058)
|
| Expression |
Ubiquitous expression in lymph node (RPKM 12.7), appendix (RPKM 9.3) and 25 other tissues
|
| Summary |
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
Paper for CBFB Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29386218 |
Xin Chen |
2018 |
CBFB |
LINC01234 is significantly overexpressed in gastric cancer, and LINC01234-miR-204-5p-CBFB axis plays a critical role in gastric cancer tumorigenesis. |
Experiment for CBFB Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CBFB is a miR-204-5p target gene and promotes gastric cancer cell growth |
29386218 |
| cell line |
- |
- |
Cell proliferation assay; Cell colony formation assay; |
- |
No Reports |
- |
- |
- |
CBFB promotes gastric cancer cell growth |
29386218 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
knockdown of CBFB could inhibit gastric cancer cell tumor growth in vivo |
29386218 |
Function for CBFB Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.001 |
- |
Interaction for CBFB Gene
| Interaction Gene |
Method |
PMID |
|
miR-204-5p |
Luciferase reporter assay |
29386218
|
|
