Search Result
Gene Summary for CCAT1 Gene
| Official Symbol |
CCAT1 |
Gene Type |
lncRNA |
| Full Name |
colon cancer associated transcript 1 |
Entrez |
100507056
|
| Ensembl ID |
- |
HGNC |
45128
|
| Aliases |
CARLO5, CARLo-5, onco-lncRNA-40
|
Chromosome Location |
Chromosome 8, NC_000008.11 (127207382..127219268, complement)
|
| Expression |
Biased expression in esophagus (RPKM 1.4), liver (RPKM 0.8) and 4 other tissues
|
| Summary |
This gene produces a long non-coding RNA that promotes tumor formation and is upregulated in colon cancer and other cancer cell types. This transcript may regulate long range chromosomal interactions, including at the Myc oncoprotein locus. This RNA may also function as a molecular sponge for microRNAs. [provided by RefSeq, Dec 2017]
|
Paper for CCAT1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28535628 |
T Shan |
2017 |
CCAT1 |
CCAT1 is up-regulated in GC and may be significantly correlated with the progression of GC. Decreased expression of CCAT1 can suppress the proliferation of GC cells. CCAT1 might be used as a novel target for GC early diagnosis and treatment. |
| 28239816 |
J-N Liu |
2017 |
CARLo-5 |
CARLo-5 could be considered promising biomarkers for prognosis of gastric cancer. |
Experiment for CCAT1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
62 |
62 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
The expressions of CCAT1 mRNA in GC tissues were significantly higher than in the normal tissues.The expression of CCAT1 varied significantly among patients with different TNM stage, depth of invasion, and lymph node metastasis. |
28535628 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
Down-regulation of CCAT1 in MGC-803 and SGC-7901 cells significantly inhibited the cell proliferation. |
Down-regulation of CCAT1 in MGC-803 and SGC-7901 cells significantly inhibited the cell proliferation. |
28535628 |
| tissue |
240 |
240 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
The expression of CARLo-5 in gastric cancer tissues was significantly higher than that of their matched adjacent normal tissues. High CARLo-5 expression was found to be closely correlated with advanced T stage, positive distant metastasis, lymph node involvement, and poor differentiation. Kaplan-Meier analysis demonstrated that gastric cancer patients with high CARLo-5 expression had poorer OS (p < 0.001) and RFS (p < 0.001). Finally, univariate and multivariate Cox analysis indicated that high CARLo-5 expression were independent predictors for both OS and RFS. |
28239816 |
Function for CCAT1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
| prognosis |
- |
< 0.001 |
- |
Interaction for CCAT1 Gene
| Interaction Gene |
Method |
PMID |
|
