MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for CCAT2 Gene

Official Symbol CCAT2 Gene Type lncRNA
Full Name colon cancer associated transcript 2 Entrez 101805488
Ensembl ID ENSG00000280997 HGNC 47044
Aliases LINC00873, NCCP1 Chromosome Location Chromosome 8, NC_000008.11 (127400399..127402150)
Expression -
Summary This gene produces a long non-coding RNA that is upregulated in colon cancer and other cancers. This transcript promotes cell proliferation and suppresses apoptosis. It negatively regulates the biogenesis of microRNA 145. [provided by RefSeq, Dec 2017]

Paper for CCAT2 Gene

PMID Author Year ID in Paper
 Conclusion
28248065 Sheng-Wen Wu 2017 CCAT2 lncRNA CCAT2 may serve as a tumor promoter and a new predictive prognostic factor for human gastric cancer.
25755774 Chen-Yu Wang 2015 CCAT2 Up-regulation of lncRNA CCAT2 was correlated with gastric cancer progression, and lncRNA CCAT2 might be a potential molecular biomarker for predicting the prognosis of patients.

Experiment for CCAT2 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 208 208 qRT-PCR China No Reports Up - - lncRNA CCAT2 was upregulated in GC tissues (P=0.000), and positively correlated with TNM stage (P=0.029), lymphatic invasion (P=0.042) and nervous invasion (P=0.024) in GC patients. Furthermore, we also found that high expression of lncRNA CCAT2 was an unfavorable prognostic factor in GC patients. 28248065
cell line - - Cell proliferation assay; Invasion and migration assays - No Reports - - Silencing of lncRNA CCAT2 inhibits gastric cancer cell proliferation and invasion. Silencing of lncRNA CCAT2 inhibits gastric cancer cell proliferation and invasion. 28248065
tissue 85 85 qRT-PCR China No Reports Up - - Expression levels of lncRNA CCAT2 in gastric cancer tissues were significantly higher than those in adjacent non-tumor tissues. High lncRNA CCAT2 expression was observed to be closely correlated with higher incidence of lymph node metastasis and distance metastasis. Moreover, patients with high lncRNA CCAT2 expression had shorter overall survival and progression-free survival compared with the low lncRNA CCAT2 group. Multivariate analyses indicated that high lncRNA CCAT2 expression was an independent poor prognostic factor for gastric cancer patients. 25755774

Function for CCAT2 Gene

Functional Type AUC Overall Survival Disease-free Survival
prognosis - < 0.05 -
prognosis - 0.003 -

Interaction for CCAT2 Gene

Interaction Gene Method PMID
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